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<article xmlns:xlink="http://www.w3.org/1999/xlink">
  <front>
    <journal-meta />
    <article-meta>
      <title-group>
        <article-title>Use of Neural Networks for Monitoring Beam Spectrum of Industrial Electron Accelerators</article-title>
      </title-group>
      <contrib-group>
        <contrib contrib-type="author">
          <string-name>Oleksandr Baiev</string-name>
          <email>oleksandr.baiev@gmail.com</email>
          <xref ref-type="aff" rid="aff0">0</xref>
        </contrib>
        <contrib contrib-type="author">
          <string-name>Valentine Lazurik</string-name>
          <email>lazurik@hotmail.com</email>
          <xref ref-type="aff" rid="aff0">0</xref>
        </contrib>
        <contrib contrib-type="author">
          <string-name>Ievgen Didenko</string-name>
          <email>ievgen.v.didenko@gmail.com</email>
          <xref ref-type="aff" rid="aff0">0</xref>
        </contrib>
        <aff id="aff0">
          <label>0</label>
          <institution>School of Computer Science, V. N. Karazin Kharkiv National University</institution>
          ,
          <addr-line>4, Svobody Sqr., 61022, Kharkiv</addr-line>
          ,
          <country country="UA">Ukraine</country>
        </aff>
      </contrib-group>
      <fpage>118</fpage>
      <lpage>129</lpage>
      <abstract>
        <p>This paper investigates technique for solving spectrometry inverse problem the neural network as method for reconstruction of electron beam spectrum using depth-charge curve. The inverse problem turned into multivariable optimization and the form of spectrum is based on proposed three-parameter model. Radial basis function network calculates the parameters of this model. We developed computational experiment using Monte-Carlo technique to evaluate strengths and weaknesses of proposed approach and compare neural networks with conventional data evaluation methods.</p>
      </abstract>
      <kwd-group>
        <kwd />
        <kwd>Neural nets</kwd>
        <kwd>Inverse problems</kwd>
        <kwd>Monte Carlo</kwd>
        <kwd>Radiation technologies</kwd>
        <kwd>Depth-charge curve</kwd>
      </kwd-group>
    </article-meta>
  </front>
  <body>
    <sec id="sec-1">
      <title>-</title>
      <p>One of the main characteristic of the irradiation processes is an energy of beam.
This parameter in uences on absorbed dose in target. Therefore, standards for
radiation technologies [1, 2] predetermine the upper bound of beam energy to
prevent ionization of the object under irradiation. Because of accelerator
features, electrons in beam have di erent energy. Thus, the beam energy
represented by some function, which shows relations between particles number and
their energies. This function called beam spectrum. In practice at least three
parameters de ne the spectrum: average (Eav) and probably (Ep) energies and
full width on half maximum (Ew). In order to measure beam energy
dosimetric wedge and stack are widely used in centers of radiation technologies. These
devices allow to determine only average and probable energies of beam [1{6].
Of course, these two parameters does not allow to reconstruct full energy
distribution. Thereby developing of new instruments and methods of dosimetric
measurements is actual problem.</p>
      <p>Mentioned devices intend to measure distributions of absorbed dose or charge
[5, 6]. The measured depth-dose (depth-charge) curves relate to beam spectrum
through Fredholm integral equation and nding exact spectrum is an ill-posed
inverse problem [7]. This means that evaluated spectrum obtained by
conventional mathematical methods can di er with true energy distribution. There
are, for example, method of least squares (MLS) or method of Tikhonov
regularization (MTR). Above all, important disadvantage of the MLS and MTR is
impossibility to include additional solution conditions, for example, correlations
between parameters, positivity and other. This lack can bring to violation of
conditions, given by physical lows. It should be mention that in common case
the neural networks (NN) solve approximation tasks and nd solutions based
on existing precedents after supervised training [8{12]. So the one of the way
of improving dosimetry e ectiveness is developing of methods for measurement
results evaluation based on neural networks. In order to apply NN for dosimetric
data processing it is necessary to solve next problems: select networks topology,
obtaining data for NN training, developing methods for data preprocessing and
interpretation, system for evaluation network e ectiveness.</p>
      <p>So current research is about feasibility of using neural networks for
developing system of measurement results evaluation for beam spectrum monitoring
of industrial electron accelerators. We will discuss mathematical model of
measurement process, which was built in order to compile training set for network
learning procedure (Section 2). Section 3 describes methods under investigation.
In section 4, we will show approach for methods evaluation, which contains
computational experiment and comparison criteria. In section 5 given comparison
results of neural networks and conventional methods testing.
2</p>
      <p>Physical process and mathematical model
In order to calculate radiation energy, it is a common practice in eld of radiation
technologies to measure depth-dose curve by dosimetric wedge. However, the
works of recent years propose new devices based on measurement of
depthcharge curve that can realize on-line energy monitoring [3{6]. In this work, we
will consider mathematical abstraction of these devices and will build method
for beam spectrum controlling using depth-charge curve.
2.1</p>
    </sec>
    <sec id="sec-2">
      <title>Devices</title>
      <p>Device [5] consists of two plates only and intend to calculate probable energy
as a value which linearly depends on charge in rst plate to sum charge ratio.
Measurer in [6] contains 10 absorbers. But in order to simplify average energy
calculation the plates were combined and authors use similar to [5] dependency.</p>
      <p>Fig. 1 shows principal schema of measurer. Dosimetric stack consists of set
of plates - absorbers. The absorbers material is often aluminum, because of
radiation ruggedness. The electron beam falls on the sequence of plates. Electrons
stop at di erent depths depending on their energy. Thus, absorbers collect some
charge which can be measured by current integrators connected to corresponding
plate. The set of measured values represents the depth-charge curve.</p>
      <p>
        Mathematical model of the measurement process is based on a semi-empirical
model of the depth-charge distribution for monoenergetic electrons and model
of charge measurement uncertainty. Direct problem describes relation between
known beam spectrum and depth-charge curve through equation:
(
        <xref ref-type="bibr" rid="ref1">1</xref>
        )
(
        <xref ref-type="bibr" rid="ref2">2</xref>
        )
(
        <xref ref-type="bibr" rid="ref3">3</xref>
        )
ER
Z
      </p>
      <p>EL
f (x) =</p>
      <p>Q(x; E)y(E) dE; x 2 [0; xR];
where y(E) - describes relation between number of particles and their energy
(electrons spectrum), f (x) - describes depth distribution of charge, xR
measurer full width, [EL; ER] - operating energy range of accelerator, integral kernel
Q(x; E) corresponds to radiation type ( , , ) and measurer internal
characteristics (including absorbers material). Works [13, 14] describe appropriate
relations for monoenergetic beam and depth-charge curve.</p>
      <p>In the research we neglect charge leakage and suppose that distance between
absorbers is neglectfully small. It means that each particle from initial beam
can stops in absorbers and pass through current integrator or can pass through
whole device with no impact in depth-charge curve.</p>
      <p>The measurement results of charge distribution in absorbers is set f =
ff1; f2; : : : ; fng (see Fig. 1), where n - number of absorbers, fi - integral of
f (x) over the depth for i-th absorber:
xi+ x ER</p>
      <p>Z Z
xi</p>
      <p>EL
fi =</p>
      <p>Q(x; E)y(E) dE dx;
fi =
2x Pj pjE yj [Q(xk + (i</p>
      <p>1) x; Ej )+
+Q(xk + i x; Ej )];
where</p>
      <p>
        x - absorbers width. Equation (
        <xref ref-type="bibr" rid="ref2">2</xref>
        ) can be approximated as:
where i = 1; n, j = 0; m, m = (ER EL)= E - number of steps of function y(E)
discretization over energy axis, E - step of spectrum energy discretization, yj
- value of y(E) in approximation nodes, coe cient pjE de nes method and step
of function y(E) approximation. Then the measurement process can be shown
as system of linear equations:
where elements of matrix A are:
In order to approximate y(E) by method of trapezoids, coe cients pjE are:
pjE =
      </p>
      <p>EE=2 j =oth0e_rwj i=sem :</p>
      <p>It's obvious that complexity of spectrum reconstruction grows with increasing
of m (dimension of vector y). In order to reduce problem the we used
parameterization of y(E). As mentioned above, the general practice is denoting spectrum
by parameters: Ep, Eav, Ew. Therefore, it is reasonable to make model of the
beam spectrum, which use three parameters.
2.2</p>
    </sec>
    <sec id="sec-3">
      <title>Model of electrons spectrum</title>
      <p>{ Emax { maximal particles energy in the beam,
{ Ep { most probable energy,
{ Es { energy of 10 times decreasing of the intensity compared to Ep electrons
along left slope.</p>
      <p>In the future discussion the will denotes set of spectrum parameters, i.e.
= fEs; Ep; Emaxg.</p>
      <p>Parameters of the model correspond to characteristics of beam used in
practice according to:</p>
      <p>Ep = Ep;
Ew = llnn00::51 (Ep
Eav = Es + ln</p>
      <p>Es) + Emax Ep</p>
      <p>
        2
Emax Ep + 0:45(Es Ep)
4 ln0:1
and mathematical expression for spectrum is:
(
        <xref ref-type="bibr" rid="ref4">4</xref>
        )
(
        <xref ref-type="bibr" rid="ref5">5</xref>
        )
(
        <xref ref-type="bibr" rid="ref6">6</xref>
        )
(
        <xref ref-type="bibr" rid="ref7">7</xref>
        )
      </p>
      <p>h
0.5h
0.1h</p>
      <p>Es</p>
      <p>Ep</p>
      <p>Emax</p>
      <sec id="sec-3-1">
        <title>Emax</title>
        <p>; k2 =
hEmax</p>
      </sec>
      <sec id="sec-3-2">
        <title>Emax</title>
        <p>Ep
;
where E 2 [0; 1], h = y(Ep) - maximum of function y(E) and was obtained
with supposition of</p>
        <p>Emax
Z
Es</p>
        <p>y(E)dE = 1:
Therefore, maximum of energy distribution is:
h = y(Ep) = [0:9</p>
        <p>Es Ep + 0:5(Emax
ln(0:1)</p>
        <p>Ep)] 1:</p>
        <p>It should be mention, that in accordance to physical laws the function y(E)
is positive or equal zero for all accepted E and parameters correlates as:
0 &lt; Es &lt; Ep</p>
      </sec>
      <sec id="sec-3-3">
        <title>Emax:</title>
        <p>2.3</p>
      </sec>
    </sec>
    <sec id="sec-4">
      <title>Model of measurement</title>
      <p>In the real experiment measured fi di er with its real value. This error grounded
on weaknesses of measurer and external in uence. We will mark set of true values
of f (x) as f , and use f~ to mark set of values complemented with measurement
uncertainty:</p>
      <p>
        f~ = (1 + " )f;
where " - value of standard deviation of measurement error, - random variable
distributed in accordance to standard normal distribution:
(
        <xref ref-type="bibr" rid="ref8">8</xref>
        )
(
        <xref ref-type="bibr" rid="ref9">9</xref>
        )
(
        <xref ref-type="bibr" rid="ref10">10</xref>
        )
(
        <xref ref-type="bibr" rid="ref11">11</xref>
        )
(
        <xref ref-type="bibr" rid="ref12">12</xref>
        )
(
        <xref ref-type="bibr" rid="ref13">13</xref>
        )
(
        <xref ref-type="bibr" rid="ref14">14</xref>
        )
where r1, r2 - random variables which ate distributed in accordance with
standard uniform distribution.
      </p>
      <p>We will use similar signature to denote evaluated parameters ~ , E~s, E~p, and
E~max reconstructed spectrum y~ instead their true values without tilde.
3
3.1</p>
      <p>Methods for spectrum reconstruction</p>
    </sec>
    <sec id="sec-5">
      <title>Neural networks</title>
      <p>In order to apply NN for solving spectrometry inverse problem reconstruction of
spectrum can be represented as multivariable function tting. Suppose that
function implements measurement process of depth-charge curve, i.e. f~ = ( ).
Therefore, inverse function ~ = 1(f~) realizes transformation from
depthcharge curve to beam spectrum. So approximation of 1 can be used to get
spectrum using depth-charge curve. In the work we used general regression
neural network (GRNN) [15] to t 1. This network needs set of precedence for
supervised learning. Consider algorithm of training set creation.</p>
      <p>
        Implemented measurement models allow to create pairs s = (f~; ), where f~
calculates from parameters set . The collection of s is based on di erent and
represents a reference points for 1 tting:
(
        <xref ref-type="bibr" rid="ref15">15</xref>
        )
(
        <xref ref-type="bibr" rid="ref16">16</xref>
        )
where N - number of elements in training set. For future discussion, we will
denote each unique in training and testing sets as reference spectrum. Note,
that each values of parameters for all from training set was normalized in
accordance to [EL; ER] ! [0; 1]. Of course, outputs of network were scaled back
during testing.
Consider methods, which is traditionally used for measurement results
evaluation. The data which were obtained by these methods is a base level to determine
NN e ectiveness for solving spectrum reconstruction problem. The method of
least squares calculates parameters as:
~ MLS = arg min
      </p>
      <p>Ay~
f~ ;
where k k - Euclidian norm. Method of Tikhonov regularization expands MLS
through additional stabilizer function:
~ MT R = arg min</p>
      <p>
        Ay~
f~ +
ky~ k ;
where &gt; 0 - regularization parameter. It should be remind that using of
mathematical model of measurement process gives true values of electrons spectrum.
So can be calculated from [7]:
= arg min ky y~ k : (
        <xref ref-type="bibr" rid="ref18">18</xref>
        )
kyk
      </p>
      <p>
        In the work we applied Nelder-Mid simplex method numerical solution of
(
        <xref ref-type="bibr" rid="ref16">16</xref>
        ), (
        <xref ref-type="bibr" rid="ref17">17</xref>
        ) and (
        <xref ref-type="bibr" rid="ref18">18</xref>
        ).
4
      </p>
      <p>Algorithm for evaluation methods preparing and
testing
4.1</p>
    </sec>
    <sec id="sec-6">
      <title>Comparison approach</title>
      <p>Implemented models of spectrum, measurement process and methods for data
evaluation compose computational experiment (Fig. 3 shows sequential
diagram). The experiment aim is comparison of methods for spectrum
reconstruction. The approach which was used to build experiment uses Monte-Carlo
technique: system generate measurement results, each methods reconstruct spectra
using samples of depth-charge cure, system calculates statistical characteristics
of reconstruction error. Computational experiment consists of three steps:
preparation, main part (loop Common) and results interpretation.</p>
      <p>Preparation of an experiment includes setting parameters of models and
methods. Main part is a series of subexperiments with varied measurement
uncertainty ". Each of them contains two steps: training of NN and selected
methods comparison. Both processes include generation of pairs s = (f~; ) which is
based on prede ned set of . But these sets of reference spectrum are di erent.
Testing procedure (loop Data Evaluation) repeats sampling of f~, evaluates
appropriate by each method and collects reconstruction error based on truth and
calculated spectra based on proposed set of indicators. The results processing
step aims to build relationships that show correlations between accuracy of
spectrum reconstruction and varied error of measurement.</p>
      <p>Software for experiment execution implemented in MATLAB with Neural
Network Toolbox (function newgrnn as NN), Optimization Toolbox (function
fminsearch as MLS and MTR). In order to speed up computational experiment,
software was executed on high performance cluster [16] with Distributed
Computing Toolbox.
4.2</p>
    </sec>
    <sec id="sec-7">
      <title>Comparison indicators</title>
      <p>
        In order to assess the e ectiveness of methods for reconstruction of beam energy
characteristics we suggested set of indicators. The set consists of the standard
statistical estimates of data evaluation error and indicator of methods reliability.
There are two indicators type: mismatch along energy axis (estimate shift of
reconstructed spectrum along horizontal axis) and common indicator. Consider
details of each indicators.
1. Mismatch along energy axis. Average M (r) and standard deviation r of
distance along intensity axis between reconstructed and true spectra are
based on:
2. Common characteristics. Probability of method failure P . We suppose that
the method failure is a case when applying mathematical methods leads to
impossible (due to physical lows) solution, i.e. the solution brakes condition
(
        <xref ref-type="bibr" rid="ref12">12</xref>
        ). It is obvious that value 1 P characterize method reliability.
5
5.1
      </p>
      <sec id="sec-7-1">
        <title>Results and discussions</title>
      </sec>
    </sec>
    <sec id="sec-8">
      <title>Parameters of computation experiment</title>
      <p>In order to evaluate methods e ectiveness with suggested indicators we made
computational experiment with parameters shown in Table 1.</p>
      <p>The training and testing sets include reference spectra with parameters:
1
n
r =
(y
y~)2;
(19)</p>
      <p>As shown in Table 1 the device consists of 15 absorbers. This con guration
is chosen based on previous research [18] which was aimed to nd optimal
discretization step of depth-charge curve for spectrum reconstruction by NN. It
should be mention that in works [17, 18] sets for methods testing and
preparation based on reference spectra with xed Ew parameter and same maximum
h = 1. Therefore, seeking of optimal absorbers width is open for future research.
M(r)
σr
0.5</p>
      <p>As an opposite to conventional methods, the solutions obtained by NN have
smaller dependency between evaluation error and input data uncertainty.
Furthermore as shown on Fig. 5a, 5b the GRNN evaluates spectra more accurate
than MLS and MTR for measurement uncertainty more than 5-7%. The main
advantage of NN method is that GRNN reconstruct beam spectrum
parameters with no failures (see Fig 5c), i.e. all obtained solutions are compliance with
physical lows.
6</p>
      <sec id="sec-8-1">
        <title>Conclusion</title>
        <p>The work shows GRNN method e ectiveness for solving inverse dosimetry
problem of electron spectrum reconstruction using depth-charge curve. The main
advantages of proposed technique compared to conventional methods is allowance
to apply additional solutions conditions. It lids to getting robust evaluation
method. As shown in the work methods based on NN can be used for building
on-line energy monitoring systems in centers of radiation technologies.</p>
        <p>Furthermore, we proposed comparison approach based on Monte-Carlo
technique and set of e ectiveness indicators. The approach allows testing di erent
types of evaluation methods and can be used for methods optimization in order
to select or apply technique for industrial problems solving.</p>
      </sec>
    </sec>
  </body>
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