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  <front>
    <journal-meta />
    <article-meta>
      <title-group>
        <article-title>The medGIFT Group in ImageCLEFmed 2012</article-title>
      </title-group>
      <contrib-group>
        <contrib contrib-type="author">
          <string-name>Alba G. Seco de Herrera</string-name>
          <email>alba.garcia@hevs.ch</email>
          <xref ref-type="aff" rid="aff0">0</xref>
        </contrib>
        <contrib contrib-type="author">
          <string-name>Dimitrios Markonis</string-name>
          <xref ref-type="aff" rid="aff0">0</xref>
        </contrib>
        <contrib contrib-type="author">
          <string-name>Ivan Eggel</string-name>
          <xref ref-type="aff" rid="aff0">0</xref>
        </contrib>
        <contrib contrib-type="author">
          <string-name>Henning Mu¨ller</string-name>
          <xref ref-type="aff" rid="aff0">0</xref>
        </contrib>
        <aff id="aff0">
          <label>0</label>
          <institution>University of Applied Sciences Western Switzerland (HES-SO) Sierre</institution>
          ,
          <country country="CH">Switzerland</country>
        </aff>
      </contrib-group>
      <abstract>
        <p>This article presents the participation of the medGIFT group in ImageCLEFmed 2012. Since 2004, the group has participated in the medical image retrieval tasks of ImageCLEF each year. There are three types of tasks for ImageCLEFmed 2012: modality classification, imagebased retrieval and case-based retrieval. The medGIFT group participated in all three tasks. MedGIFT is developing a system named ParaDISE (Parallel Distributed Image Search Engine), which is the successor of GIFT (GNU Image Finding Tool). The alpha version of ParaDISE was used to run most of the experiments in the competition. Results show that our approach using Bag-of-Visual-Words (BoVW), Bag-of-Colors (BoC) and Lucene for the image captions is the best run for mixed modality classification. The same approach is also the best for the image retrieval task in terms of bpref. In the case-based retrieval task, the Lucene baseline is the best run in terms of mean average precision (MAP). We were the only group presenting mixed and visual runs in these tasks.</p>
      </abstract>
    </article-meta>
  </front>
  <body>
    <sec id="sec-1">
      <title>-</title>
      <p>
        ImageCLEF is the cross–language image retrieval track1 of the Cross Language
Evaluation Forum (CLEF). ImageCLEFmed is part of ImageCLEF focusing on
medical images [
        <xref ref-type="bibr" rid="ref1 ref2 ref3 ref4 ref5">1–5</xref>
        ]. The medGIFT2 research group has participated in
ImageCLEFmed since 2004. MedGIFT is currently developing ParaDISE (Parallel
Distributed Image Search Engine), which is the successor of GIFT3 (GNU
Image Finding Tool). The alpha version of ParaDISE was used to run most of the
experiments.
      </p>
      <p>
        The Bag–of–Visual–Words (BOVW) and Bag–of–Colors (BOC) approaches
were used for visual retrieval and the textual baseline is based on the open source
Lucene4 system. In ImageCLEFmed 2011, the BoVW approach was applied
using the Scale Invariant Feature Transform (SIFT) [
        <xref ref-type="bibr" rid="ref6">6</xref>
        ] but color information
was not used. In 2012, there are two main novelties in our system: first, we
introduce the BoC [
        <xref ref-type="bibr" rid="ref7">7</xref>
        ] descriptor that represents local image colors. We combine
      </p>
    </sec>
    <sec id="sec-2">
      <title>1 http://www.imageclef.org/</title>
    </sec>
    <sec id="sec-3">
      <title>2 http://medgift.hevs.ch/</title>
    </sec>
    <sec id="sec-4">
      <title>3 http://www.gnu.org/software/gift/</title>
    </sec>
    <sec id="sec-5">
      <title>4 http://lucene.apache.org/</title>
      <p>BoC with BoVW and textual descriptors in order to yield better results. Second,
we use training set expansion strategies since for some of the image categories
only very few annotated examples were available. This significantly improves
classification performance.</p>
      <p>
        The widely used BoVW [
        <xref ref-type="bibr" rid="ref8">8</xref>
        ] method is applied as follows: a training set of
images is chosen and a number of local descriptors are extracted from each image
of this set. The descriptors are then clustered using a clustering method (such
as k–means or DENCLUE). The centroids of the clusters are treated as visual
words that represent the specific local patterns. Hence, we have a visual–word
vocabulary describing all types of local image patterns. Local features are then
also extracted from each image in the database and mapped onto the visual–word
vocabulary. An image is then represented as a histograms of the visual–word
occurrences, the BoVW used as feature vector in the classification task. When
an image is queried, a similarity measure (such as histogram intersection) is
used to compare the query image histogram and the database image histogram,
providing a similarity score.
      </p>
      <p>The BoC representation is analogous to the BoVW representation and to the
Bag–of–Words representation of text documents. As the two methods are quite
complementary and as the representations as histograms are very similar, the
two approaches can easily be fused for medical image classification.</p>
      <p>In Section 2, we describe the datasets and the techniques used. We evaluate
the runs submitted to the ImageCLEFmed 2012 benchmark in Section 3. Finally,
conclusions are presented in Section 4.
2</p>
      <sec id="sec-5-1">
        <title>Datasets and Techniques</title>
        <p>
          This section describes the basic techniques used in ImageCLEFmed 2012 by the
medGIFT group. For the the majority of the runs, the alpha version of ParaDISE
(Parallel Distributed Image Search Engine) developed by the medGIFT group is
used. This image search engine is built on top of Hadoop [
          <xref ref-type="bibr" rid="ref9">9</xref>
          ], a MapReduce [
          <xref ref-type="bibr" rid="ref10">10</xref>
          ]
paradigm of parallel computing and the Cassandra 5 DBMS (Database
Management System). This allows for computational and storage scalability. The
ParaDISE component–based architecture is designed to simplify the plugin of
different image features and representations. Apart from the 3 baseline visual
runs that were also given publicly to the participants, we submitted 10 runs (2
textual, 4 visual and 2 mixed runs) to the image–based retrieval task, 8 runs (2
textual, 4 visual and 2 mixed runs) to the case–based retrieval task and 8 runs
(4 visual and 4 mixed runs) to the modality classification task.
2.1
        </p>
        <p>Image Collection
We used the database provided by ImageCLEFmed 2012. The database contains
over 300,000 images of 75’000 articles of the biomedical open access literature.
This is a subset from the PubMed Central6 database containing over one million</p>
      </sec>
    </sec>
    <sec id="sec-6">
      <title>5 http://cassandra.apache.org/</title>
    </sec>
    <sec id="sec-7">
      <title>6 http://www.ncbi.nlm.nih.gov/pmc/</title>
      <p>
        images. This set of articles contains all articles in PubMed that are open access
but the exact copyright for redistribution varies among the journals. A more
detailed description of the ImageCLEFmed 2012 setup is given in [
        <xref ref-type="bibr" rid="ref4">4</xref>
        ].
2.2
      </p>
      <p>Textual Techniques
For text retrieval the standard settings of the Apache Lucene text retrieval
system are used. The documents containing the journal texts are cleaned off their
XML elements and only the remaining text is used.</p>
      <p>Two indexations were done for ImageCLEF 2012: (1) the full text of all
articles was indexed on an article basis, and (2) the captions were indexed on a
figure basis. In the past it was shown that for case–based retrieval an indexation
of the full text had best results whereas for image–based retrieval the caption
text delivered much better results.
2.3</p>
      <p>Visual Techniques
The baseline for the visual description of the image is the Bag–of–Visual–Words
(BoVW) approach. In this approach, local SIFT descriptors are extracted from
each image. Then, the descriptors of the image are quantized, assigning each
one to its nearest neighbour from a fixed set of local descriptors, called “visual
vocabulary”. The image is then represented by a histogram of the frequency
of the “visual words“. Similarity between two images can be quantified using a
distance metric to measure the distance between the two histograms.</p>
      <p>
        In our runs, the SIFT implementation in the fiji7 image processing
package was used for the extraction of the local descriptors as in our participation
in ImageCLEFmed 2011. In order to create the visual vocabulary, our
implementation of the density–based clustering algorithm DENCLUE [
        <xref ref-type="bibr" rid="ref11">11</xref>
        ] was used.
The reasons for this choice are the features and the nature of the data set that
needs to be clustered. The data set to be clustered is large (1,000 training
images produce approximately 2’500’000 descriptors) and high dimensional (SIFT
descriptors are 128–dimensional). The DENCLUE algorithm is highly efficient
for clustering large–scale data sets, can detect arbitrarily shaped clusters and
handles outliers and noise well. Moreover, opposed to other density–based
clustering algorithms it performs well for high–dimensional data. However, when
using a density–based clustering algorithm care needs to be taken for data sets
containing clusters of different densities. To deal with this, the parameter that
controls the significance of the candidate cluster in respect to its density was set
to zero. The same visual vocabulary used in last year’s participation [
        <xref ref-type="bibr" rid="ref12">12</xref>
        ] was
also used for the creation of the bags of visual words.
      </p>
      <p>
        Based on the BoVW approach, the Bag–of–Colors (BoC) [
        <xref ref-type="bibr" rid="ref7">7</xref>
        ] is an image
description technique introduced in [
        <xref ref-type="bibr" rid="ref13">13</xref>
        ]. Similarly to the BoVW, the technique
uses a color vocabulary C previously learned on a sub set of the collection to
represent the image. A color vocabulary C = fc1; : : : ; ckc g, with ci = (Li; ai; bi) 2
      </p>
    </sec>
    <sec id="sec-8">
      <title>7 http://fiji.sc/wiki/index.php/Fiji</title>
      <p>
        CIELab is constructed by finding the most frequently occurring colors in each
image of a sub set of the collection. The modality classification training set was
used for the creation of the color vocabulary. The CIE (International Commission
on Illumination) 1976 L*a*b (CIELab) space was used, being a perceptually
uniform color space. CIELab is a space defined by L for luminance and a, b for
the color–opponent dimensions for chrominance [
        <xref ref-type="bibr" rid="ref14 ref15">14, 15</xref>
        ]. The BoC of an image I
is defined as a vector hBoC = fc¯1; : : : ; c¯kg such that, for each pixel pk 2 I 8k 2
f1; : : : ; npg, with np being the number of pixels of the image I:
      </p>
      <p>np np
c¯i = ∑ ∑ gj (pk) 8i 2 f1; : : : ; kcg</p>
      <p>
        k=1 j=1
where
gj (p) =
{ 1 if d"(p; cj )
0 otherwise
d"(p; cl) 8l 2 f1; : : : ; kcg
(1)
From experiments on the modality classification task of ImageCLEFmed 2012,
kc = 100 and kvw = 238 were chosen as the sizes of the color and visual
vocabulary, respectively. For the comparison of the images the histogram
intersection [
        <xref ref-type="bibr" rid="ref16">16</xref>
        ] is used as distance measure.
2.4
      </p>
      <p>Fusion Techniques
In image retrieval and classification tasks, often different features, systems and
results can be combined to deliver improved results. Moreover, multiple query
images can describe in more detail the visual characteristics to be retrieved.
In these cases a fusion strategy needs to be used. Two main fusion strategies
exist, early and late fusion. In the early fusion, the vectors of the features or the
systems are merged into a single vector. For the early fusion of multiple positive
and/or negative query images, Rocchio’s algorithm can be used:
qm =
qo +
1</p>
      <p>∑
jDrj dj2Dr
dj</p>
      <p>1
jDnrj dj2Dnr
∑
dj
(2)
where ; and are weights, qm is the modified query, qo is the original query,
Dr is the set of relevant images and Dnr is the set of non–relevant images. In our
scenario there is a lack of non–relevant images, so only the second term of the
right part of the equation is used. This algorithm can be applied only for vectors
of the same feature spaces so it is not applicable for the fusion of different visual
features or retrieval systems, in general.</p>
      <p>
        In the late fusion, the retrieval results of the features or the systems are
fused. Two main categories of late fusion techniques exist, the score–based and
rank–based methods. In 2009, the ImageCLEF@ICPR fusion task was organized
to compare late fusion techniques using the best ImageCLEFmed visual and
textual results [
        <xref ref-type="bibr" rid="ref17">17</xref>
        ]. Studies such as [
        <xref ref-type="bibr" rid="ref18">18</xref>
        ] show that combSUM (3) and combMNZ(4),
score–based methods, proposed by [19] in 1994 are robust fusion strategies. With
the data from the ImageCLEF@ICPR fusion task, combMNZ performed slightly
better than combSUM but the difference was small and not statistically
significant.
      </p>
      <p>ScombSUM(i) =</p>
      <p>Nk
∑ Sk(i)
k=1</p>
      <p>ScombMNZ(i) = F (i) ScombSUM(i)
where F (i) is the frequency of image i being returned by one input system with
a non–zero score, and S(i) is the score assigned to image i.</p>
      <p>In general, rank–based fusion (RRF) worked better than score–based fusion.
The reciprocal rank fusion [20] is a simple fusion method based on ranks(5).
(3)
(4)
(5)
RRF score(d 2 D) = ∑
r2R</p>
      <p>1
k + r(d)
where, D is the set of documents retrieved, R is the set of rankings of the
documents and k = 60.
3</p>
      <sec id="sec-8-1">
        <title>Results</title>
        <p>This section details the techniques that were used to produce the runs for
ImageCLEFmed 2012 and then evaluates the runs.
3.1</p>
        <p>Image and Case Retrieval Techniques
Two strategies were compared for the fusion of the multiple queries, early fusion
and late fusion (see Section 2.4). For the fusion of visual features and the fusion
of visual and textual systems, late fusion was applied. Score–based and rank–
based fusion techniques were compared. To summarize, fusion was used in three
cases:
{ fusing multiple visual features to produce visual runs;
{ fusing textual and visual runs to produce mixed runs;
{ fusing vectors (early fusion) of query images which belong to the same topic
or their results (late fusion).</p>
        <p>In the image retrieval task, as the fulltext search retrieved articles instead of
images, an article–to–image mapping was used. If an image was contained in
multiple articles, only the article with the highest score was taken into account
giving its score to the image. If multiple images were contained in the same
article, all the images received the common article’s score.</p>
        <p>The same strategy was applied in the case–based task, because the image
search retrieved images instead of articles. The article received the score of the
best scored image that it contained. If multiple articles contained the same image
they all received the common image’s score.</p>
        <p>
          Table 1 contains a summary of the techniques used, while Tables 2 and 3
show the details of the submitted runs.
Driven by the good performance of [
          <xref ref-type="bibr" rid="ref3">3</xref>
          ] in the ImageCLEFmed 2011 modality
classification task, a similar approach was followed by the medGIFT group in
2012. The approach involves automatically expanding the labelled training set
to improve the performance of the classification for classes that are poorly
represented (e.g. the training set containing very few images of that class). To achieve
this, training images are used as queries in the full 300,000 images of the
ImageCLEFmed 2012 data set and the l highest ranked retrieved images are added as
training images into the class of the query image.
        </p>
        <p>Two methods of expanding the training set were used. In the first expansion
technique, s images taken randomly of each class were used as queries. As in
the original training set the number of images per class varies from 5 to 50,
by choosing s = 5; l = 20 we can theoretically obtain a relatively balanced
training set (105–150 per class) of 4,100 images. In the second, all the training
images were queried, resulting in a larger non–balanced training set. E. g. for
l = 20 an expanded training set of 21,000 images can be obtained theoretically.
In practice, smaller sizes were obtained, mainly because of two reasons: retrieved
images that are already contained in the training set were discarded and images
retrieved multiple times by query images of different classes were discarded as
well.</p>
        <p>For a run to qualify as visual, we considered that the expanded training set
used in this run needs to be created only by visual means. This means that the
queries on the full data set used only visual features for the retrieval. Similarly,
this was repeated using mixed (visual and textual) queries for the mixed runs.
This resulted in a final number of 5 training sets (2 balanced, 2 non–balanced
and the original training set).</p>
        <p>
          A k nn classifier using weighted voting was used to classify the test images.
For the choice of the classifier parameters the results of [
          <xref ref-type="bibr" rid="ref7">7</xref>
          ] were taken into
account and k = 11; k = 7 were used for the visual runs. However, since the
non–balanced expanded training set was significantly larger, double the value
k = 14 was also tested for this case. The inverse of the similarity score of the
k nn images was used to weight the voting.
        </p>
        <p>Table 4 gives the details of the submitted runs.
3.3</p>
        <p>Image Retrieval Evaluation
Table 5 displays the results of the medGIFT runs for the image retrieval task.
ir9, a mixed approach, achieved the highest MAP, GM–MAP and bpref among
all our submitted runs in the image–based retrieval task. This result highlights
the potential benefits of combining textual and visual features.</p>
        <p>For the visual runs, the baseline of BoVW, ir1 and ir2, did not demonstrate
good results. However, when BoVW is fused with BoC the results improve
significantly. Furthermore, when using RRF for the fusion of techniques the MAP
decreases, which contradicts our hypothesis.</p>
        <p>Our best results in early precision (P10 and P30) on the other hand were
obtained with a text retrieval approach, ir8. This is in contradiction with past
results where the best overall results were often textual whereas early precision
was often better with combined or visual approaches.
Table 6 shows the results of the medGIFT runs for the case based retrieval
task. In this task, cr8 achieved the highest MAP (0,169) among all submitted
runs. It demonstrates that a Lucene baseline still obtains very good results with
relatively low effort. MedGIFT was the only lab that submitted purely visual
and mixed runs for the case–based task. Although the results of our visual runs
are lower than textual runs, cr9, a mixed approach, performs better than the
average of all submitted runs in this task.</p>
        <p>As all of the best results are from text retrieval runs it becomes clear that
visual techniques need to be used in different ways than was the case for obtaining
good results. Most likely a matching of image occurrences in articles in a more
complex way would be necessary for obtaining good results for the case–based
tasks using visual data.
3.5</p>
        <p>Modality Classi cation Evaluation
Finally, Table 7 presents the classification accuracy of the submitted medGIFT
runs for the modality classification task. The runs c8, mc6, mc7 achieved the
three best accuracies in the mixed run category. The visual runs achieved an
average performance with the inclusion of BoC as a global descriptor to
improving the classification accuracy. It can be observed that the runs mc4, mc8
using the non–balanced expanded training sets and k = 14 are outperforming
the runs mc6, mc2 that use the original training set. These runs also perform
better than the runs mc3, mc7 that use k = 7, confirming our hypothesis that
using a larger k can improve results. Moreover, in experiments not submitted
as official runs using larger values of k leads to a better performance, with the
mixed run reaching an accuracy of 68.5% using the triple value k = 21.
4</p>
      </sec>
      <sec id="sec-8-2">
        <title>Conclusions</title>
        <p>This article describes the methods and results of the the medGIFT group for
the ImageCLEF 2012 medical tasks. We submitted ten runs each for the ad–
hoc image retrieval and the modality classification tasks and nine runs for the
case–based retrieval task.</p>
        <p>In ImageCLEFmed 2012 we concentrated on fusion methods of the visual
and textual features and training set expansion strategies. We included the BoC
approach, which significantly improves classification performance.</p>
        <p>In the image–based retrieval task, our strategy leads to limited results
obtained by our submitted runs. However, we still need to do a more detailed
analysis to try to understand what is hurting performance in these runs. Our
Lucene baseline achieves the best MAP for the case–based retrieval task.
Finally, in the modality classification task we submitted the three runs with the
best accuracies in the mixed run category and with only one group delivering
better results with a visual approach.</p>
        <p>Future work will to go beyond in the work of fusion methods, as well as
further research in new visual features. Visual information can be used in better
ways, for example to classify images by modality and if modality names appear
in a query then filtering by this modality. If the same modalities occur in a query
and an article this can also give evidence for a higher relevance.
5</p>
      </sec>
      <sec id="sec-8-3">
        <title>Acknowledgments</title>
        <p>The research leading to these results has received funding from the European
Union’s Seventh Framework Programme under grant agreement 257528
(KHRESMOI), 249008 (Chorus+) and 258191 (Promise).
19. Fox, E.A., Shaw, J.A.: Combination of multiple searches. In: Text REtrieval</p>
        <p>Conference. (1993) 243–252
20. Cormack, G.V., Clarke, C.L.A., Bu¨ttcher, S.: Reciprocal rank fusion outperforms
condorcet and individual rank learning methods. In: Proceedings of the 32nd
international ACM SIGIR conference on Research and development in information
retrieval, New York, NY, USA, ACM (2009) 758–759</p>
      </sec>
    </sec>
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