<!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Archiving and Interchange DTD v1.0 20120330//EN" "JATS-archivearticle1.dtd">
<article xmlns:xlink="http://www.w3.org/1999/xlink">
  <front>
    <journal-meta />
    <article-meta>
      <title-group>
        <article-title>Bioingenium at ImageCLEF 2012: Textual and Visual Indexing for Medical Images</article-title>
      </title-group>
      <contrib-group>
        <contrib contrib-type="author">
          <string-name>Jorge A. Vanegas</string-name>
          <email>javanegasr@unal.edu.co</email>
          <xref ref-type="aff" rid="aff0">0</xref>
        </contrib>
        <contrib contrib-type="author">
          <string-name>Juan C. Caicedo</string-name>
          <email>jccaicedoru@unal.edu.co</email>
          <xref ref-type="aff" rid="aff0">0</xref>
        </contrib>
        <contrib contrib-type="author">
          <string-name>Jorge E. Camargo</string-name>
          <email>jecamargom@unal.edu.co</email>
          <xref ref-type="aff" rid="aff0">0</xref>
        </contrib>
        <contrib contrib-type="author">
          <string-name>Raul Ramos-Pollan</string-name>
          <xref ref-type="aff" rid="aff0">0</xref>
        </contrib>
        <contrib contrib-type="author">
          <string-name>Fabio A. Gonzalez</string-name>
          <email>fagonzalezo@unal.edu.co</email>
          <xref ref-type="aff" rid="aff0">0</xref>
        </contrib>
        <aff id="aff0">
          <label>0</label>
          <institution>Bioingenium Research Group Universidad Nacional de Colombia</institution>
        </aff>
      </contrib-group>
      <abstract>
        <p>This paper describes the participation of the Bioingenium research group of Universidad Nacional de Colombia in the ImageCLEF2012 Medical Retrieval challenge, speci cally in the ad-hoc image-based retrieval task. The methods used for solving textual and visual queries with which we submitted uni-modal runs are described. They were ranked 1st and 3rd respectively. These results have been obtained by using our own implementation of Okapi-BM25 weighting scheme for text retrieval, and by adding spatial layouts to the CEDD descriptors for visual retrieval. We also used these uni-modal features to learn multimodal representations using matrix factorization for solving visual queries. Despite the potential of multimodal indexes to improve the quality of visual queries, these experiments were not as successful as uni-modal indexes. We discuss the main ndings of all these experiments.</p>
      </abstract>
      <kwd-group>
        <kwd>Image Retrieval</kwd>
        <kwd>Medical Images</kwd>
        <kwd>Multimodal Indexing</kwd>
      </kwd-group>
    </article-meta>
  </front>
  <body>
    <sec id="sec-1">
      <title>-</title>
      <p>
        This paper describes the participation of the Bioingenium research group of
Universidad Nacional de Colombia in the 2012 version of the Medical Image
Retrieval challenge at ImageCLEF [
        <xref ref-type="bibr" rid="ref7">7</xref>
        ]. Our rst motivation was to investigate
the extent to which textual and visual indexes may be improved for searching
in the collection of medical images, using keywords and visual examples
separately. We aimed at designing suitable textual and visual representations by
extending models that were successful in previous years, and preparing these
representations for subsequent multimodal analysis.
      </p>
      <p>For text indexing, we developed our own implementation of Okapi-BM25,
which allows to determine limits on the number of terms used in the vector
representation, by pruning irrelevant terms and keeping the most informative ones.
For visual indexing, we introduced a spatial pyramid of CEDD features, making
recursive partitions of the image and computing descriptors in each subregion.
This representation extends the popular CEDD descriptor with spatial
information, which results in an improved performance. We also implemented spatial
extensions for bag-of-features histograms.</p>
      <p>Our second motivation was to build an enhanced image index using both
modalities, but for searching with visual examples only. The goal was to learn
a multimodal representation that incorporates textual and visual information in
the database, and then predict the multimodal representation for queries using
visual features. This represents a very challenging problem since the medical
image collection, with more than 300K images, constitutes a very large training
set that poses computational di culties for most learning algorithms. Other
problems arise from this large multimodal image collection, such as the high
dimensionality of textual and visual representations, and the presence of noise.</p>
      <p>The results obtained with uni-modal strategies were successful in the
general pooling, which ranked rst in the case of textual queries among 54 other
submissions, and third in the case of visual queries among 36 experiments. We
consider that the multimodal indexing submission was not successful since it did
not improve upon our own visual indexing strategy, which was the original goal.
However, further experiments conducted o competition demonstrate interesting
improvements. We believe that further research in this front may help to design
more accurate image search systems working with the query-by-visual-example
paradigm.</p>
      <p>The structure of this paper is as follows: Section 2 brie y describes the
medical image collection, Section 3 describes our text indexing approach, Section 4
presents the visual indexing strategies, Section 5 discusses the multimodal
indexing approach for visual queries, and nally, conclusions and future works are
outlined in Section 6.
2</p>
    </sec>
    <sec id="sec-2">
      <title>The Data Set</title>
      <p>The medical retrieval task of ImageCLEF 2012 is based on a subset of PubMed
Central papers, containing 305,000 images extracted from biomedical articles.
Participants have access to the selected images as well as all content of the
corresponding articles. This year, a set of 22 topics was released for evaluation
of the retrieval systems, where each one is composed of a variable number of
images and associated text in 4 languages.
3</p>
    </sec>
    <sec id="sec-3">
      <title>Text Indexing</title>
      <p>
        Images in the collection belong to a medical article, so they can be indexed
using the surrounding text content. Our goal was to build a term-document
matrix using a vector space model with the Okapi-BM25 weighting scheme [
        <xref ref-type="bibr" rid="ref6">6</xref>
        ].
We developed an indexing tool using the Natural Language Toolkit for Python
[
        <xref ref-type="bibr" rid="ref1">1</xref>
        ], which provides a clean API and extensive functionalities for common text
processing tasks.
      </p>
      <p>The text representation adopted in this work included information from the
title of the paper and the image caption, which can be found in the XML le
corresponding to each image in the data set. With that, a text corpus for the
image collection was built, and standard text processing operations were applied,
including tokenization, stemming, and stop-word removal. These operations
determined the initial list of indexing terms.</p>
      <p>We designed a prunning criterion to discard irrelevant terms from the initial
list, thus, preserving only the most informative ones. A limit for the number of
terms was established depending on their document frequency. If it is outside of
a prede ned interval, the term is removed from the indexing list. The thresholds
were computed according to a minimum and maximum number of documents in
which a term is allowed to occur. The criterion is as follows:
keep(t) =
(true</p>
      <p>if min &lt; dft &lt; max
f alse otherwise
where dft is the number of documents that contain the term t, and min
and max are parameters that de ne the minimum and maximum number of
documents in which the term should appear. The de nitive list of indexing terms
is obtained by applying this rule, which is very useful to limit the dimensionality
of the resulting vector space for indexing.</p>
      <p>
        The term-document matrix is built using term frequencies in each document,
and Okapi-BM25 [
        <xref ref-type="bibr" rid="ref6">6</xref>
        ] is used to highlight the importance of the most relevant
terms. Usually, BM25 is used as a ranking function that involves di erent
factors including: term frequencies, inverse document frequencies, and the length of
both, the document and the query. However, in our approach, we wanted to use
the ideas of BM25 as a term weighting scheme so that we can apply further
processes to the term-document matrix (such as multimodal fusion). The following
equation describes the BM25-based term weighting used:
(1)
(2)
weight(t; d) = log
      </p>
      <p>N
dft
2
4</p>
      <p>(k1 + 1) tft;d
k1 (1
b) + b</p>
      <p>
        Ld
Lavg
+ tft;d
3
5
where tft;d is the frequency of term t in document d, Ld and Lavg are the
length of document d and the average document length in the collection,
respectively, and, k1 and b are positive tuning parameters to calibrate the term
frequency scaling. We xed k1 = 1:5 and b = 0:75 according to the suggestions
presented by Manning et al. [
        <xref ref-type="bibr" rid="ref6">6</xref>
        ]. For queries, we only used term frequencies
without weighting, and the dot product similarity score was employed for document
ranking.
3.1
      </p>
      <sec id="sec-3-1">
        <title>Results</title>
        <p>We submitted 2 textual runs using the indexing strategy described above, with
the goal of evaluating the di erence in performance after pruning the list of
indexing terms. In both cases, we set a minimum frequency of 20 documents
in which a term should be present to keep it in the list. The rst experiment
used 20,000 documents as maximum frequency, and the second experiment used
5,000 documents. These parameters resulted in vector spaces with approximately
28,000 and 18,000 dimensions, respectively.</p>
        <p>An additional experiment was evaluated after the competition nished to
assess the contribution of the pruning strategy with respect to a longer list
of terms. This experiment used 50,000 documents as maximum frequency, and
produced a list of 29,000 terms. Notice how the number of indexing terms is
controlled by the use of these two parameters, which remove rare terms as well
as too common terms. We used this property to control the dimensionality of
the resulting term-document matrix for further analysis, as is described later in
Section 5.</p>
        <p>Table 1 reports performance measures for the three experiments, the two rst
submitted to the o cial pooling and a third experiment run after the challenge.
These results show the impact of the pruning strategy in the precision of the
retrieval task, showing how the performance decreases by keeping or removing
the wrong terms. The best response was obtained by the index limited by a
frequency of 20,000 documents. This result ranked rst in the category of textual
experiments, and is the second best performance overall in the poolings for adhoc
image-based medical retrieval.</p>
        <p>Our second submission used 18,633 indexing terms, resulting in a signi cant
dimensionality reduction, but also an important reduction in performance. This
di erence dropped the MAP performance in about 6%, leaving this experiment
in the position number 14. However, notice that keeping more terms than those
actually needed, can hurt the general retrieval precision even more. The
additional experiment shows that a slight increase in the number of terms resulted
in a decrease in performance of about 9%.
4</p>
      </sec>
    </sec>
    <sec id="sec-4">
      <title>Visual Indexing</title>
      <p>Our research group is currently leading an initiative to develop a framework for
large scale image analysis for academic and scienti c applications. The
framework, named BIGS[8], is implemented in the Java programming language and
integrates a wide variety of image processing tools, including feature extraction
and learning algorithms. One of the most remarkable characteristics of BIGS is
that it can easily run in a distributed environment with heterogeneous computing
resources, from laptop and desktop computers to high-performance servers.</p>
      <p>Obtaining a good quality representation for image contents in large databases
is a challenging task, and BIGS was used to tune up image indexes by conducting
experiments on the ImageCLEFmed 2011 data set. The experiments were run on
di erent servers scattered throughout our lab, using BIGS to process all images
stored on an HBase NoSQL database1. In spite of the large size of the image
collection, having an lightweight experimental lifecycle as provided by BIGS was
key to be able to gain understanding on how to better tune up image indexes.</p>
      <p>
        As a result, we designed two indexes for content-based image retrieval for
this year's data set, focusing on including spatial information in the
representation, since it can help to better discriminate medical image arrangements. The
Color and Edge Directivity Descriptor (CEDD) [
        <xref ref-type="bibr" rid="ref3">3</xref>
        ] was used as basic low-level
characteristic in both indexes, since it has demonstrated good performance in
image retrieval tasks, while keeping a small and compact representation.
4.1
      </p>
      <sec id="sec-4-1">
        <title>Spatial Pyramid CEDD</title>
        <p>The CEDD descriptor is a compact representation of the image content,
consisting in a histogram of 144 bins to codify information of colors and edges. The
small size of this descriptor makes it an excellent choice for indexing large scale
image collections. This descriptor has been previously evaluated in the context
of medical image retrieval at ImageCLEF, exhibiting a competitive performance
due to the variety of image modalities and visual con gurations in this data set.</p>
        <p>
          We extended this representation by computing the CEDD descriptor in a
recursive partition of the image in quadrants, forming a pyramid of spatially
organized regions [
          <xref ref-type="bibr" rid="ref5">5</xref>
          ]. We employed a con guration using the full image plus 2
pyramid levels, which results in 21 spatially distributed regions, ending up in a
visual representation with 3,024 features. These descriptors were computed from
high-resolution images, i.e., as they are distributed in the ImageCLEFmed data
set.
        </p>
        <p>This descriptor was computed by the BIGS framework using 40 workers
deployed in several computers at our lab. The total time required to index the full
image collection of 305,000 images using this strategy was 37 minutes. Finally,
the similarity between two images is calculated on this descriptor using the
Tanimoto coe cient. Assuming that x and y are vector representations of the spatial
pyramids for two images, this is computed as:</p>
        <p>TD = t(x; y) =</p>
        <p>xT y
xT x + yT y
xT y
(3)
4.2</p>
      </sec>
      <sec id="sec-4-2">
        <title>Spatial Bag-of-Features</title>
        <p>
          An image index using the bag-of-features representation [
          <xref ref-type="bibr" rid="ref4">4</xref>
          ] was introduced in
our experiments as well. The bag-of-features methodology is comprised of 3 main
procedures: extraction of local features from images, construction of a dictionary
of visual words, and the computation of the histogram for each image. Spatial
layouts can be added to enhance the representation with the relative position of
words in the image plane. In that sense, this representation incorporates local,
1 http://hbase.apache.org/
low-level information of images as well as global, spatially distributed
arrangements.
        </p>
        <p>For local features, we extracted blocks of 32 32 pixels on a regular grid and
the CEDD descriptor is computed in these patches. The k-means algorithm is
used to cluster a large sample of patches extracted from the collection, for
building a dictionary of 5,000 visual terms. The histogram is constructed by counting
the occurrence of dictionary words in each image. Besides the global counting of
visual patterns, each image is also split in 3 horizontal, non-overlapping strips,
and an additional histogram is computed there to estimate the spatial
distribution of visual words. This results in four bag-of-features histograms that are
bounded together in a single image descriptor with 20,000 features.</p>
        <p>This representation was also computed using the BIGS framework with 40
workers deployed in several computers at our lab. The total time required to
extract this representation for all images in the collection was 116 minutes, which
is less than one hour and a half. The similarity measure computed for this
representation is the histogram intersection, for two images with histograms x and
y:</p>
        <p>KHI (x; y) =
n
Xmin fxi; yig
i=1
4.3</p>
      </sec>
      <sec id="sec-4-3">
        <title>Visual Queries with Multiple Images</title>
        <p>The topics proposed for this year's challenge included 22 di erent queries with
multiple images, some of them with 6 or even 7 example images. Since a single
ranking is required for queries with multiple image examples, a similarity
integration rule was employed. The similarity score for a database image d with
respect to a multi-image query q = fq1; q2; :::; qng, is obtained as follows:
score(d; q) =
n
Xsimilarity(d; qk)
k=1
(4)
(5)
4.4</p>
      </sec>
      <sec id="sec-4-4">
        <title>Results</title>
        <p>We submitted two runs, one using the spatial pyramid of CEDD features and
another with the spatial bag-of-features. The results are reported in Table 2, and
shows that the spatial pyramid obtains a signi cantly better performance than
the bag-of-features, both in general precision (MAP) and early precision (P@10
and P@30). The di erence can also be observed in the positions obtained by
these experiments in the general poolings, the spatial pyramid was ranked 3rd,
whereas the bag-of-features was ranked 14th.</p>
        <p>The spatial pyramid extension for the CEDD descriptor demonstrated to be
an e ective representation to discriminate more relevant images in this task. In
addition, computing the spatial pyramid did not result in an excessive load of
both, computational e ort and representation length. This representation is still
very light to compute with respect to the bag-of-features and keeps a compact
descriptor with about 3,000 features.</p>
        <p>In our preliminary experiments, we observed that adding a spatial layout
on the image representation improves the performance of the medical image
retrieval task. The two visual representations proposed in this work include spatial
information using recursive computations of the same descriptor in partitions of
the image. One of the reasons the spatial pyramid CEDD presented better
performance than the bag-of-features is because of the level of granularity in the
recursive partition, that allows to introduce more spatial details. This can be
achieved because of the short length of the original CEDD descriptor, as opposed
to the large dictionary of visual features that we employed in these experiments.
One of our motivations to design textual and visual indexes for medical image
collections is to develop a multimodal framework to integrate both modalities in a
common representation. We focus our attention to the speci c case of enhancing
visual search functionalities by introducing available text information into the
visual index. Thus, the goal is to improve the retrieval response using multimodal
information even when users search with example images only.</p>
        <p>
          In this work, we employed a multimodal latent factors model proposed in [
          <xref ref-type="bibr" rid="ref2">2</xref>
          ]
for learning the relationships between visual features and text terms. The method
is based on a matrix factorization algorithm, that proceeds with a multimodal
decomposition of the visual and text matrices on a training data set. The matrix
factorization problem is de ned as follows:
min
P;Q;H 2
1
kV
        </p>
        <p>P Hk2F + kT</p>
        <p>QHk2F +
kP k2F + kQk2F + kHk2F
(6)
where V 2 Rn ` is the matrix of n visual features for ` training examples,
T 2 Rm ` is the matrix of textual information with m terms, P 2 Rn r is
the transformation from the visual space to a multimodal space with r factors,
Q 2 Rm r is the transformation from the textual space to the multimodal space,
and H 2 Rr ` is the multimodal latent representation for the training images.
is a regularization parameter for this learning problem.</p>
        <p>
          The solution to this problem presented in [
          <xref ref-type="bibr" rid="ref2">2</xref>
          ] is an online matrix factorization
algorithm that can be scaled up to large data sets. This is specially useful for the
ImageCLEFmed 2012 collection, which has a large number of images that can be
used for learning multimodal relationships between visual and textual
information. When the linear transformation functions P and Q have been learned, new
images can be projected to the multimodal space using the following equation:
h = P T P +
        </p>
        <p>QT Q
1 P T v
(7)
where h is the multimodal representation for an image with visual features
v, and is a regularization parameter. The purpose of using these algorithms is
to obtain a multimodal latent factor representations for all images, even if they
do not have available text annotations, as may be the case of the queries. Using
the multimodal representation, the ranking of images is computed using the dot
product similarity measure, which indicates the extent to which two images share
the same latent factors.</p>
        <p>This strategy has demonstrated to be an e ective method to learn multimodal
relationships from image collections with attached texts, resulting in a
datadriven representation for images that incorporates both modalities. Previous
studies have shown important performance gains for these approaches, since
visual features are complemented by the semantics of text descriptions, providing
an enhanced mechanism of representing images.
5.1</p>
      </sec>
      <sec id="sec-4-5">
        <title>Results</title>
        <p>To construct a multimodal index for image search, we employed the matrices of
text terms and visual features described in Sections 3 and 4, respectively. More
speci cally, we used the term-document matrix with 18,000 terms weighted with
Okapi-BM25, and the visual matrix with 3,024 spatial pyramid CEDD features.
One of the reasons we were interested in designing textual and visual indexes
with bounded dimensionality is to reduce the computational cost of learning
multimodal relationships.</p>
        <p>The online multimodal matrix factorization (OMMF) algorithm was trained
with the full collection of images in this challenge, i.e., using the 305,000 images
with their corresponding text annotations. An implementation of the algorithm
in the Java programming language was employed, which decomposed the
matrices of 18,000 rows for text data, and 3,024 rows for visual data, with 305,000
columns in both cases, in 131 minutes in average. This algorithm has been
designed to learn from as many examples as possible in a short time.</p>
        <p>To tune up the learning algorithm and determine appropriate parameters for
the factorization, experiments were conducted with the ImageCLEFmed 2011
collection. We found good parameters to solve queries in the previous year's
challenge, that included 600 multimodal latent factors and other regularization
parameters as needed. The criteria to select parameters for this algorithm is
to observe improvements with respect to the direct visual matching, i.e., with
respect to the visual indexing methods presented in Section 4, since the queries
used in this experiment are also based on example images only.</p>
        <p>With the parameters that showed improvements in the 2011 collection, we
prepared and submitted a run to the o cial poolings. Table 3 reports the results
of this submission, as well as two other experiments for comparison. The rst
experiment in the Table is our baseline method, based on direct matching of
visual features. The second result is the performance of the prepared run that
has shown a decrease in performance with respect to the baseline. This loss is
mainly explained by the use of parameters tuned to improve the performance in
the 2011 challenge.</p>
        <p>There are several di erences between the challenge of 2011 and 2012. First,
the nature of the proposed topics varied signi cantly, as this year's queries
included more example images per topic, in average. Second, the size of the
collection was increased, which resulted in bigger matrices in both dimensions. Third,
this year's visual queries seem to be more di cult to answer, judging by the
relative decrease in MAP observed in the results from 2011 to 2012. All these
aspects may require a di erent con guration for the learning algorithm, in order
to make it e ective to retrieve more relevant results.</p>
        <p>The results reported in the third row of Table 3 present the performance
measures for an additional experiment run o competition to estimate the
potential of the OMMF algorithm to improve upon the baseline. This result was
obtained by tuning the algorithm parameters more appropriately for this year's
task, and shows an important relative improvement.</p>
        <p>The main goal of a multimodal algorithm in this context is to extract
meaningful relationships between visual features and text terms. An additional
challenge that makes the multimodal indexing strategy di cult to setup correctly,
is attributed to the properties of the textual modality, which is very noisy and
unstructured. Extracting semantic information useful for image analysis in this
condition is still a very interesting research problem that requires further
analysis.
6</p>
      </sec>
    </sec>
    <sec id="sec-5">
      <title>Conclusions And Future Work</title>
      <p>This paper presented the participation of the Bioingenium research group of
Universidad Nacional de Colombia in the ad-hoc image-based medical retrieval task
at ImageCLEF 2012. We submitted 5 runs: 2 textual and 3 visual, from which
one was ranked rst in the text modality and another was ranked third in the
visual modality. These results were obtained by incorporating simple and e ective
extensions to well-known strategies for this task. We also explored multimodal
indexing to answer visual queries, which is a very challenging and interesting
research problem, that still requires further analysis. We believe that this is a
promising research direction for improving image search systems, and the study
of these models are the focus of our future research.</p>
      <p>One of the main di culties of this year's challenge was the size of the
database, which required e cient computational tools to process and index the
collection. In this work, we supported all of our visual indexing experiments on
a distributed computing framework for large scale image analysis, named BIGS
[8]. This framework allowed us to accelerate the exploration of visual indexing
strategies, and investigate new image representation designs, such as the spatial
pyramid CEDD that ranked third among 36 other experiments. We also used
online learning algorithms for extracting multimodal relationships e ciently by
training with the full collection of medical images in short execution times.</p>
    </sec>
    <sec id="sec-6">
      <title>Acknowledgments</title>
      <p>This work was partially funded by the project Anotacion Automatica y
Recuperacion por Contenido de Imagenes Radiologicas Usando Semantica Latente,
number 110152128803 and project Sistema para la Recuperacion de Imagenes
Medicas Utilizando Indexacion Multimodal, number 110152128767 by
Convocatoria Colciencias 521 de 2010.
8. Raul Ramos-Pollan, Fabio A. Gonzalez, Juan C. Caicedo, Angel Cruz-Roa, Jorge E.</p>
      <p>Camargo, Jorge A. Vanegas, John E Arevalo, Paola K Rozo, Santiago A Perez,
Jose D Bermeo, and Juan S Otalora. BIGS: A framework for large-scale image
processing and analysis over distributed and heterogeneous computing resources. In
IEEE International Conference on eScience. To appear, 2012.</p>
    </sec>
  </body>
  <back>
    <ref-list>
      <ref id="ref1">
        <mixed-citation>
          1.
          <string-name>
            <given-names>Steven</given-names>
            <surname>Bird</surname>
          </string-name>
          .
          <source>Nltk: The natural language toolkit</source>
          ,
          <year>2002</year>
          .
        </mixed-citation>
      </ref>
      <ref id="ref2">
        <mixed-citation>
          2.
          <string-name>
            <surname>Juan</surname>
            <given-names>C.</given-names>
          </string-name>
          <string-name>
            <surname>Caicedo</surname>
            and
            <given-names>Fabio A.</given-names>
          </string-name>
          <string-name>
            <surname>Gonzalez</surname>
          </string-name>
          .
          <article-title>Online matrix factorization for multimodal image retrieval</article-title>
          .
          <source>In 17th Iberoamerican Congress on Pattern Recognition, CIARP</source>
          ,
          <year>2012</year>
          .
        </mixed-citation>
      </ref>
      <ref id="ref3">
        <mixed-citation>
          3.
          <string-name>
            <surname>Savvas</surname>
            <given-names>A</given-names>
          </string-name>
          .
          <article-title>Chatzichristo s and Yiannis S. Boutalis. Cedd: color and edge directivity descriptor: a compact descriptor for image indexing and retrieval</article-title>
          .
          <source>In Proceedings of the 6th international conference on Computer vision systems</source>
          ,
          <source>ICVS'08</source>
          , pages
          <fpage>312</fpage>
          {
          <fpage>322</fpage>
          , Berlin, Heidelberg,
          <year>2008</year>
          . Springer-Verlag.
        </mixed-citation>
      </ref>
      <ref id="ref4">
        <mixed-citation>
          4.
          <string-name>
            <given-names>G.</given-names>
            <surname>Csurka</surname>
          </string-name>
          ,
          <string-name>
            <given-names>C.</given-names>
            <surname>Bray</surname>
          </string-name>
          ,
          <string-name>
            <given-names>C.</given-names>
            <surname>Dance</surname>
          </string-name>
          , and
          <string-name>
            <given-names>L.</given-names>
            <surname>Fan</surname>
          </string-name>
          .
          <article-title>Visual categorization with bags of keypoints</article-title>
          .
          <source>Workshop on Statistical Learning in Computer Vision</source>
          , ECCV, pages
          <volume>1</volume>
          {
          <fpage>22</fpage>
          ,
          <year>2004</year>
          .
        </mixed-citation>
      </ref>
      <ref id="ref5">
        <mixed-citation>
          5.
          <string-name>
            <given-names>Svetlana</given-names>
            <surname>Lazebnik</surname>
          </string-name>
          , Cordelia Schmid, and
          <string-name>
            <given-names>Jean</given-names>
            <surname>Ponce</surname>
          </string-name>
          .
          <article-title>Beyond bags of features: Spatial pyramid matching for recognizing natural scene categories</article-title>
          .
          <source>In Proceedings of the 2006 IEEE Computer Society Conference on Computer Vision</source>
          and Pattern Recognition - Volume
          <volume>2</volume>
          , CVPR '
          <volume>06</volume>
          , pages
          <fpage>2169</fpage>
          {
          <fpage>2178</fpage>
          , Washington, DC, USA,
          <year>2006</year>
          . IEEE Computer Society.
        </mixed-citation>
      </ref>
      <ref id="ref6">
        <mixed-citation>
          6.
          <string-name>
            <surname>Christopher</surname>
            <given-names>D.</given-names>
          </string-name>
          <string-name>
            <surname>Manning</surname>
            , Prabhakar Raghavan, and
            <given-names>Hinrich</given-names>
          </string-name>
          <string-name>
            <surname>Schtze</surname>
          </string-name>
          . Introduction to Information Retrieval. Cambridge University Press, New York, NY, USA,
          <year>2008</year>
          .
        </mixed-citation>
      </ref>
      <ref id="ref7">
        <mixed-citation>
          7.
          <string-name>
            <given-names>Jayashree</given-names>
            <surname>Kalpathy-Cramer Dina Demner Fushman Sameer Antani Ivan Eggel Mu</surname>
          </string-name>
          ller, Alba Garcia Seco de Herrera.
          <article-title>Overview of the imageclef 2012 medical image retrieval and classi cation tasks</article-title>
          .
          <year>2012</year>
          .
        </mixed-citation>
      </ref>
    </ref-list>
  </back>
</article>