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      <title-group>
        <article-title>GAIL: A Genetics Argumentation Inquiry Learning System</article-title>
      </title-group>
      <contrib-group>
        <contrib contrib-type="author">
          <string-name>Nancy L. Green</string-name>
          <email>nlgreen@uncg.edu</email>
          <xref ref-type="aff" rid="aff0">0</xref>
        </contrib>
        <contrib contrib-type="author">
          <string-name>Mark Hinshaw</string-name>
          <xref ref-type="aff" rid="aff0">0</xref>
        </contrib>
        <contrib contrib-type="author">
          <string-name>Carl Martensen</string-name>
          <xref ref-type="aff" rid="aff0">0</xref>
        </contrib>
        <contrib contrib-type="author">
          <string-name>Meghana Narasimhan</string-name>
          <xref ref-type="aff" rid="aff0">0</xref>
        </contrib>
        <contrib contrib-type="author">
          <string-name>Tshering Tobgay</string-name>
          <xref ref-type="aff" rid="aff0">0</xref>
        </contrib>
        <aff id="aff0">
          <label>0</label>
          <institution>Department of Computer Science University of North Carolina Greensboro Greensboro</institution>
          ,
          <addr-line>NC 27402</addr-line>
          <country country="US">USA</country>
        </aff>
      </contrib-group>
      <abstract>
        <p>This paper discusses ongoing work to build an argumentation inquiry learning system, GAIL. The purpose of GAIL is to support students in constructing scientific arguments in an undergraduate genetics course in order to facilitate deeper learning and improve argumentation skill. Students can construct argument diagrams using a dragand-drop graphical user interface. The system constructs arguments on-the-fly to use as a knowledge source for evaluating the learners' arguments and providing intelligent feedback.</p>
      </abstract>
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    <sec id="sec-1">
      <title>Introduction</title>
      <p>
        Argumentation plays an important role in science. There
has been significant interest within the field of science
education in argumentation. However, students’
arguments have been shown to be deficient in a number of
ways, e.g., lacking support for claims
        <xref ref-type="bibr" rid="ref1 ref1">(Bell and Linn
2000; Jiménez-Aleixandre, Rodríguez and Duschl 2000)</xref>
        ,
failing to provide alternative explanations
        <xref ref-type="bibr" rid="ref11 ref8">(Lawson 2003;
Schwarz et al. 2003)</xref>
        , and using inaccurate or irrelevant
support
        <xref ref-type="bibr" rid="ref16 ref18">(Zohar and Nemet 2002)</xref>
        . Computer-supported
cooperative learning systems for argumentation have been
developed
        <xref ref-type="bibr" rid="ref9">(Kirschner et al. 2003; Scheuer et al. 2010;
Pinkwart and McLaren 2012)</xref>
        but they do not provide
human-level expertise in evaluating student
argumentation. Furthermore, in larger-enrollment classes
human teachers may not have sufficient time to evaluate
learners’ arguments nor to provide one-on-one feedback
as the learner works on an argumentation lesson.
      </p>
      <p>To address this problem we are implementing a
prototype genetics argumentation inquiry learning system,
GAIL. GAIL will support learning to argue about cases in
human genetics. This is a field that applies findings from
genetics research to biomedical reasoning. GAIL is
designed for use in an introductory genetics course for
undergraduates that many biology majors find the most
challenging course in the biology core curriculum. We
hope that use of GAIL will improve argumentation skill,
facilitate deeper learning of genetics, and increase interest
and engagement in science.</p>
      <p>
        Each GAIL lesson requires learners to construct
arguments for and against certain hypotheses about a
genetics case, e.g., about an infant who may have an
inherited metabolic disorder or someone who inherited a
genetic variant that is associated with increased risk of
colon cancer. A prototype user interface is shown in
Figure 1 (see last page). Information relevant to the lesson
is provided by GAIL on the left-hand side of the screen:
the Problem (to give a certain argument); Hypotheses
(which can be used in the argument, but note that some
are incorrect); Data from medical records about the
patient and the patient’s biological family; and
Connections, a list of facts or principles of genetics. The
center of the screen shows two arguments constructed by a
learner. To construct the arguments, the learner searched
for text components on the left-hand side of the screen,
dragged them into the workspace in the center of the
screen, and connected the components. Arrows point from
support to conclusion. The connection between support
and conclusion – known as the warrant in argumentation
theory
        <xref ref-type="bibr" rid="ref13">(Toulmin 1998)</xref>
        – is linked by a line to the arrow.
      </p>
      <p>In Figure 1, the problem is to give two arguments for
the hypothesis that the patient (referred to as J.B.) has
cystic fibrosis, i.e., has two variant alleles of the CFTR
gene. The leftmost “chain” of arguments begins with data
(at the bottom of the argument diagram) about J.B.’s
respiratory problems. The learner used that data to support
an intermediate hypothesis that J.B. has thickened mucus
in the lungs, which is used to support an intermediate
hypothesis that J.B. has abnormal CFTR protein, which is
used to support the main hypothesis/conclusion that J.B.
has cystic fibrosis. Branching from the right hand side of
the diagram, connections (warrants) provide justification
for each step of the argument. The second argument for
the same hypothesis begins with data about J.B.’s lab test
result.</p>
      <p>GAIL’s innovation is that the system can generate
arguments for evaluating the correctness of the learner’s
arguments, rather than requiring the arguments to be
constructed by a teacher. Use of the generated arguments
enables GAIL to provide intelligent feedback on both the
structure and content of the learner’s argument.</p>
      <sec id="sec-1-1">
        <title>The author of an argumentation lesson to be used in</title>
        <p>GAIL creates an XML-formatted file that contains: (1)
strings of natural language text -- the problem, hypotheses,
data, and connections -- to be displayed to learners on the
left-hand side of the graphical user interface as shown in
Figure 1; (2) a specification of an internal causal domain
model; and (3) mapping of the natural language strings in
(1) to concepts and relations in the domain model. GAIL’s
Authoring Tool provides (1) to the user interface, uses
(2) to build an internal Knowledge Base, and stores (3) to
enable GAIL’s Argument Evaluator to semantically
interpret learners’ argument diagrams, to avoid the
challenge of interpreting natural language input.</p>
        <p>
          Based on our previous work on modeling genetics
          <xref ref-type="bibr" rid="ref4">(Green 2005)</xref>
          , a Knowledge Base (KB) describes (i)
instances of small set of concepts in human genetics (e.g.
genotype, protein, phenotype) and (ii) causal relations
between these concepts. Causal relations are defined in
terms of influence and synergy relations of a qualitative
probabilistic network (QPN)
          <xref ref-type="bibr" rid="ref2">(Druzdzel and Henrion
1993)</xref>
          . Different genetics KBs can be constructed
automatically from XML-language descriptions of the
causal model specified using the Authoring Tool.
        </p>
        <p>
          Argumentation schemes are descriptions of acceptable,
but often defeasible, patterns of reasoning
          <xref ref-type="bibr" rid="ref14">(Walton, Reed
and Macagno 2008)</xref>
          . Following the same approach as in
our previous research on argument generation (Green,
Dwight, Navoraphan and Stadler 2011), GAIL’s
Argument Generator creates arguments by instantiating
abstract argumentation schemes with concepts and
relations from a QPN. The argumentation schemes are
formalized in structures including claim/conclusion, data,
and warrant. The propositions used as claim or data
describe states of variables in a QPN. The warrant
expresses formal constraints on the nodes of the QPN in
terms of probabilistic influence and synergy relations. The
distinction between premises as data and warrant reflects
their difference in function and source of information.
Data premises refer to a particular case, whereas warrants
describe biomedical principles and other generalized
knowledge. The condition of GAIL’s argumentation
schemes is used to represent possible exceptions.
        </p>
        <p>For example, the argumentation scheme for reasoning
from effect to cause, shown in Figure 2, can be
instantiated from a KB to create an argument that a patient
has HNPCC (a mutation in the MLH1 gene, a hereditary</p>
      </sec>
      <sec id="sec-1-2">
        <title>Claim: A ≥ a Data: B ≥ b Warrant: S+(&lt;A,a&gt;, &lt;B,b&gt;) Condition: ¬ exists C X-({C,A},&lt;B,b&gt;): C ≥ c</title>
        <p>condition predisposing one to colon cancer) based upon
the data that genetic testing showed a variant MLH1 allele,
and the connection (warrant) that having HNPCC
typically leads to that test result. (The exception condition
for this argumentation scheme asks whether there is an
alternative explanation for the data.) An argument
diagram representing this argument is shown in Figure 3;
to save space, instead of natural language text from the
graphical user interface, the diagram uses letters
representing propositions, where A is the conclusion, B is
the data, and S+(A,B) is the warrant.</p>
        <p>A
B</p>
        <p>S+(A,B)
argument. After each try, the Feedback Generator selects
the most general (lowest level) unused message for an
error; each time the student makes the same error on a
subsequent try, the next more specific (next higher level)
message is selected. A positive message is generated when
an error is corrected on the next try. Currently, the
Feedback Generator displays only the message for the
most serious error to the student, but writes all of the
detected errors to a logfile for inspection by the teacher.</p>
      </sec>
    </sec>
    <sec id="sec-2">
      <title>Feedback Example</title>
      <p>To illustrate the learner’s interaction with GAIL,
suppose the problem was to give an argument for the
hypothesis that J.B.’s brother might have malnutrition and
poor growth. Internally, GAIL generates a chained
argument beginning with the data that J.B.’s brother has
been diagnosed as having cystic fibrosis, which supports
an intermediate hypothesis that his CFTR protein is
abnormal, which supports an intermediate hypothesis that
he might have pancreatic abnormality, which supports the
main hypothesis that he might have malnutrition and poor
growth. (The warrants of GAIL’s argument are not
described here to save space.) However, on the first try
the learner’s argument contains the main claim that J.B.
(rather than J.B.’s brother) has cystic fibrosis, which does
not match the problem. Since this type of error has been
given the highest severity code, GAIL would tell the
student that the main claim of his argument does not
match the problem. On the second try, the student fixes
the main claim and constructs a new argument. GAIL
informs him that the problem noted on the last try has
been fixed. However, the student’s argument is missing
the intermediate hypothesis that J.B.’s brother might have
pancreatic abnormality, so GAIL also informs the student
that one or more intermediate hypotheses are missing
between J.B.’s brother having abnormal CFTR protein
and J.B.’s brother having malnutrition and poor growth.
On the third try, the student adds the missing hypothesis
but provides an irrelevant warrant. GAIL would inform
the student that he has made progress but that the warrant
he just added is irrelevant to that subargument.</p>
    </sec>
    <sec id="sec-3">
      <title>Conclusion</title>
      <p>This paper discusses ongoing work to build an
argumentation inquiry learning system, GAIL. The
purpose of GAIL is to support students in constructing
scientific arguments in an undergraduate genetics course
in order to facilitate deeper learning and improve
argumentation skill. The system generates arguments
onthe-fly to use as a knowledge source for evaluating the
learners’ arguments and providing formative and
summative intelligent feedback.</p>
      <p>All of the components described in this paper have
been implemented in Java. Future work includes
improvements to the user interface and the Feedback
Generator. The Feedback Generator will be made more
intelligent to address certain types of errors that we have
observed in our formative evaluation studies. For
example, a learner “flattened” a chained argument into a
one-level structure by conjoining together all of the data
and intermediate hypotheses. Note that in this case, the
learner has selected the correct content but has just not
structured the argument properly into subarguments and
shown how one subargument builds upon another
subargument. Because the Feedback Generator has access
to arguments constructed by GAIL’s Argument Generator,
the Feedback Generator will be able to detect this type of
error and provide more meaningful feedback than systems
that do not have access to content. After these
improvements are made, we plan to evaluate GAIL’s
effectiveness in an undergraduate genetics course.</p>
    </sec>
    <sec id="sec-4">
      <title>Acknowledgments</title>
      <p>Former graduate students Mark Hinshaw, Carl Martensen,
Meghana Narasimhan, and Tshering Tobgay contributed
to the implementation of GAIL for their MS Projects.
Former graduate students Benjamin Wyatt and Chris Cain
also contributed to the implementation of GAIL. Wyatt
and Martensen received support from a UNCG Regular
Faculty grant and Cain received support from the
Computer Science Department. Dr. Malcolm Schug of the
UNCG Department of Biology has provided helpful
feedback on the project.</p>
      <p>Figure 1. Screen shot of prototype GAIL user interface</p>
    </sec>
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