<!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Archiving and Interchange DTD v1.0 20120330//EN" "JATS-archivearticle1.dtd">
<article xmlns:xlink="http://www.w3.org/1999/xlink">
  <front>
    <journal-meta />
    <article-meta>
      <title-group>
        <article-title>An Unobtrusive System to Monitor Physical Functioning of the Older Adults: Results of a Pilot Study</article-title>
      </title-group>
      <contrib-group>
        <contrib contrib-type="author">
          <string-name>Miriam Cabrita</string-name>
          <xref ref-type="aff" rid="aff0">0</xref>
          <xref ref-type="aff" rid="aff1">1</xref>
        </contrib>
        <contrib contrib-type="author">
          <string-name>Mohammad Hossein Nassabi</string-name>
          <xref ref-type="aff" rid="aff1">1</xref>
        </contrib>
        <contrib contrib-type="author">
          <string-name>Harm op den Akker</string-name>
          <xref ref-type="aff" rid="aff0">0</xref>
          <xref ref-type="aff" rid="aff1">1</xref>
        </contrib>
        <contrib contrib-type="author">
          <string-name>Monique Tabak</string-name>
          <xref ref-type="aff" rid="aff0">0</xref>
          <xref ref-type="aff" rid="aff1">1</xref>
        </contrib>
        <contrib contrib-type="author">
          <string-name>Hermie Hermens</string-name>
          <xref ref-type="aff" rid="aff0">0</xref>
          <xref ref-type="aff" rid="aff1">1</xref>
        </contrib>
        <contrib contrib-type="author">
          <string-name>Miriam Vollenbroek</string-name>
          <xref ref-type="aff" rid="aff0">0</xref>
          <xref ref-type="aff" rid="aff1">1</xref>
        </contrib>
        <aff id="aff0">
          <label>0</label>
          <institution>Roessingh Research and Development, Telemedicine group</institution>
          ,
          <addr-line>Enschede</addr-line>
          ,
          <country country="NL">the Netherlands</country>
        </aff>
        <aff id="aff1">
          <label>1</label>
          <institution>University of Twente, Faculty of Electrical Engineering</institution>
          ,
          <addr-line>Mathematics and Computer Science</addr-line>
          ,
          <institution>Telemedicine group</institution>
          ,
          <addr-line>Enschede</addr-line>
          ,
          <country country="NL">the Netherlands</country>
        </aff>
      </contrib-group>
      <abstract>
        <p>The Aging phenomenon entails increased costs to health care systems worldwide. Prevention and self-management of age-related conditions receive high priority in public health research. Multidimensionality of impairments should be considered when designing interventions targeting the older population. Detection of slow or fast changes in daily functioning can enable interventions that counteract the decline, e.g. through behavior change support. Technology facilitates unobtrusive monitoring of daily living, allowing continuous and real-time assessment of the health status. Sensing outdoors remains a challenge especially for non physiological parameters. In this paper we present the results of a pilot study on monitoring physical functioning using an accelerometer and experience sampling method on a smartphone. We analyzed the relation between daily physical activity level and a number of di erent properties of daily living (location, social component, activity type and the weekday). Five healthy older adults participated in the study during approximately one month. Our results show that location, social interactions, type of activities and day of the week in uence signi cantly the daily activity level of the participants. Results from this study will be used in the further development of an unobtrusive monitoring and coaching system to encourage active behavior on a daily basis.</p>
      </abstract>
      <kwd-group>
        <kwd>monitoring</kwd>
        <kwd>physical functioning</kwd>
        <kwd>physical activity</kwd>
        <kwd>daily living</kwd>
        <kwd>older adults</kwd>
        <kwd>experience sampling method</kwd>
      </kwd-group>
    </article-meta>
  </front>
  <body>
    <sec id="sec-1">
      <title>-</title>
      <p>
        The World Health Organization estimates that the percentage of world
population aged above 60 will double between 2010 and 2050 from 11% to 22% [
        <xref ref-type="bibr" rid="ref1">1</xref>
        ]. The
problem is particularly apparent in the Western world where it is expected that
by 2060 approximately 30% of the population in the European Union will be
aged above 65 years old [
        <xref ref-type="bibr" rid="ref2">2</xref>
        ]. Such demographic change brings socio-demographic
challenges, of which the increased burden on the healthcare system is one of the
most relevant. It is expected that by 2060, 8.5% of the global GDP in EU-27 will
be spent on healthcare and 3.4% on long-term care [
        <xref ref-type="bibr" rid="ref3">3</xref>
        ]. There is a growing trend
towards developing technologies that aim to reduce the burden on health care
systems by improving self-management skills and delaying institutionalization.
      </p>
      <p>
        Frailty is an age-related condition with high prevalence worldwide. The exact
estimates di er according to the de nition of frailty adopted, with rates among
community dwelling older adults varying between 7% [
        <xref ref-type="bibr" rid="ref4">4</xref>
        ] and 40-50% [
        <xref ref-type="bibr" rid="ref5">5</xref>
        ]. In this
paper we use the following de nition: \[frail elderly are] older adults who are at
increased risk for future poor clinical outcomes, such as development of disability,
dementia, falls, hospitalization, institutionalization or increased mortality" [
        <xref ref-type="bibr" rid="ref6">6</xref>
        ].
Frailty can be associated with, but is distinct from, natural age-related
impairments and it often predicts disabilities in activities of daily living [
        <xref ref-type="bibr" rid="ref7">7</xref>
        ].
Therefore, prevention of frailty relates to early detection of daily functioning decline.
Daily functioning monitoring requires a multi-domain approach in which physical
functioning is one of the domains addressed. Regular monitoring through
conventional methods such as self-assessment questionnaires can be time consuming
and troublesome. Technological developments provide reliable substitutes. From
robotic companions to smart and caring homes, researchers are working on
unobtrusive solutions to monitor the daily life of the elderly. Much of these solutions
concern the home environment, while monitoring outdoors remains a challenge.
Recent developments in ambulant sensing allow for easy monitoring
physiological parameters such as physical activity or heart rate. Experience sampling (also
known as ecological sampling) is also becoming a widely adapted method to
study daily life.
      </p>
      <p>
        The use of technology for health monitoring can be of value as a tool to create
self-awareness as well as to improve the health care delivery through
communication of the gathered information to health care professionals. Technology allows
in-time alerts and interaction with the user, if necessary. Furthermore, the data
acquired can serve as input to health behavior change recommendation systems,
for example sending motivational messages that, based on the current status,
encourage the user to adopt healthier lifestyles [
        <xref ref-type="bibr" rid="ref8">8</xref>
        ]. When designing technological
interventions for the aging population one should take into account the
multidimensionality in impairments of the target population and possible changes
over time. As such, there is a need for personalized interventions that adapt to
the health status of the user over time. Personalization is not a new term in
healthcare. Concepts such as personalized medicine and personalized healthcare
have been used in the literature when tailoring treatment to individual patients'
needs and characteristics [
        <xref ref-type="bibr" rid="ref9">9</xref>
        ]. Speci cally in Telemedicine systems that aim to
provide health services remotely, personalization can range from decision
support systems to aid healthcare professional when selecting treatments [
        <xref ref-type="bibr" rid="ref10 ref11">10, 11</xref>
        ],
to computer based health interventions to improve patient's health conditions
[12{14] and increase patients' health literacy [
        <xref ref-type="bibr" rid="ref15">15</xref>
        ].
      </p>
      <p>This paper presents the initial ideas for the development of an ambulant
monitoring and coaching system that continuously monitors daily functioning of the
older adults, physical functioning being one of the domains addressed. To do so,
a pilot study was performed to investigate the relation between several
determinants of physical functioning in a sample of robust elderly. The paper is outlined
as follows. Section 2 refers to physical functioning monitoring on the daily life.
A pilot study on ambulant monitoring of physical functioning is introduced in
Section 3. Finally, a discussion of the results and insights for future work is given
in Section 4 and conclusions of the work are stated in Section 5.
2</p>
    </sec>
    <sec id="sec-2">
      <title>Physical Functioning Monitoring</title>
      <p>Physical functioning is one of the domains contributing to daily functioning
decline and also the focus of our study. As an initial step for our ambulant
monitoring system, we analyze the relation between physical activity level and
parameters of daily living as, for example, location and social interactions.</p>
      <p>
        An active lifestyle is of great importance during the whole lifespan.
Physical activity plays a crucial role in the prevention and management of chronic
conditions [
        <xref ref-type="bibr" rid="ref16">16</xref>
        ] and the practice of physical activity only 1-2 times per week is
associated with decreased mortality [
        <xref ref-type="bibr" rid="ref17">17</xref>
        ]. Physical activity has also shown
bene ts in improving mental health of older adults [
        <xref ref-type="bibr" rid="ref18 ref19">18, 19</xref>
        ]. Daily activities such
as walking or cycling, household tasks, or playing games are seen as important
contributors to the general level of physical activity. Physical activity can be
monitored using self-administered questionnaires (e.g. PASE questionnaire [
        <xref ref-type="bibr" rid="ref20">20</xref>
        ])
or, unobtrusively, using wearable accelerometer-based sensors.
      </p>
      <p>
        Besides the contribution of daily activities to the overall level of physical
activity, changes in the daily living of the elderly can be a good indicator for daily
functioning decline. Before disabilities in activities of daily living manifest (i.e.
bathing, dressing, toileting, transferring, continence and feeding), older adults
might, to some extent, change their extra activities | i.e. activities on top of
what the elderly minimally need to do | as for example the leisure activities.
Performance of leisure activities seems inversely related to frailty and positively
related to delay of functional decline [
        <xref ref-type="bibr" rid="ref21">21</xref>
        ]. Daily living (or performance of daily
tasks/activities) can be monitored through self-reported measurements as
answering a validated questionnaire of (instrumental) activities of daily living (e.g.
[
        <xref ref-type="bibr" rid="ref22">22</xref>
        ]). In this type of questionnaire, individuals are asked about their ability
to independently perform activities such as shopping or laundry. This solution
might be time consuming and cumbersome when applied for a long period of
time. We support the idea of using a smartphone application to monitor daily
living through Experience Sampling Method [
        <xref ref-type="bibr" rid="ref23">23</xref>
        ]. This method can be used to
ask several questionnaires at random moments throughout the day regarding,
e.g. current activities. With the experience sampling method it is possible to get
an overview of the daily living of the participants as well as to obtain indices of
behavior.
      </p>
      <p>In the next section of this paper we describe a pilot study developed in the
Netherlands which aimed at studying the relation between daily physical activity
level of a sample of older adults and their daily living using a wearable sensor
and a smartphone.
3
3.1</p>
    </sec>
    <sec id="sec-3">
      <title>Pilot study</title>
      <sec id="sec-3-1">
        <title>Methods</title>
        <p>
          Five older adults aged 67.2 2.3 years (3 female) participated in the study during
29 3 days. Before the start of the experiment, the participants answered several
questionnaires to assess the current health status. Among others, the level of
frailty was assessed through two self-rated questionnaires | Groningen Frailty
Indicator [
          <xref ref-type="bibr" rid="ref24">24</xref>
          ] and the INTERMED [
          <xref ref-type="bibr" rid="ref25 ref26">25, 26</xref>
          ], to guarantee that all participants
were robust.
        </p>
        <p>Daily Living { Three properties of daily living were assessed using the
experience sampling method on a smartphone application (Figure 1): activity category
(what are you doing? ), location (where are you? ) and social interaction (with
whom are you? ) (Figure 1). Questions were prompted approximately every hour
from 08:00 till 20:00. A set of common activities (e.g. preparing food, eating,
resting, and playing with children) was shown on the screen as well as the option
to enter an additional activity. Common examples were also shown regarding
location and social interaction.</p>
        <p>Daily Physical Activity { Physical activity was assessed continuously over
the measurement period with the Activity Coach, a system composed of a 3D
accelerometer counting energy expenditure as the Integral Module of the Bodily
Outdoors
Indoors</p>
        <p>Location
GoSoutS|S</p>
        <p>Relaxation
Commuting</p>
        <p>
          EatS|SCare
Acceleration (IMA) [
          <xref ref-type="bibr" rid="ref27">27</xref>
          ] averaged per 10 seconds intervals and a smartphone
application [
          <xref ref-type="bibr" rid="ref28">28</xref>
          ]. Participants were told to wear the sensor from 08:00 to 20:00.
No goal or feedback on the physical activity level was received during the
experiment.
3.2
        </p>
      </sec>
      <sec id="sec-3-2">
        <title>Data Analysis</title>
        <p>The daily activity level day was de ned based on the sum of IMA values for
each day and it was represented by a nominal variable with three categories:
`Inactive', `Moderately Active' and `Highly Active'. The K-means clustering
algorithm was used to categorize the activity level of each day as it could adapt
to each participant's activity level in contrast to using pre-de ned cuto points
for all participants.</p>
        <p>Answers from participants were categorized as shown in Figure 2. Each set of
questions answered was considered an Event. Each Event has four properties:</p>
      </sec>
      <sec id="sec-3-3">
        <title>Location, Social Component, Activity Category and Time, each having</title>
        <p>at least one possible value. After this categorization, the frequency of episodes
with a certain value registered per day was calculated.</p>
        <p>We investigated the relationship between physical activity level and daily
living properties with Nominal Regression analysis. Variables associated at p &lt; :15
were tested for their association with activity level with a Kruskal-Wallis test.
Variables associated with the activity level were entered in the univariate
Nominal Regression analysis. We did not perform multivariate analysis considering
the clear dependency between the properties of the events (e.g. `commuting' will
always be performed `outdoors'). All statistical calculations were performed with
SPSS statistical package.</p>
        <p>Alone
Event</p>
        <p>Partner</p>
        <p>Social
Component</p>
        <p>Family</p>
        <p>FriendsS|S</p>
        <p>Colleagues</p>
        <p>Unknown
Time</p>
        <p>Weekday
Activity
Category</p>
        <p>WorkS|SStudy
Association</p>
        <p>Household
3.3</p>
      </sec>
      <sec id="sec-3-4">
        <title>Results</title>
        <p>Participants have shown di erent levels of daily physical activity on the total
of 146 days analyzed (Figure 3). Subject 3 was the least active amongst other
participants while subject 1 and 5 were, on average, the most active. Moreover,
the outliers in the boxplot suggest that there have been some days in which
the participants had been highly physical active or have had a very sedentary
behavior.</p>
        <p>)004000
0
1
/
IAM3000
(
y
iit
v
tc2000
A
l
a
c
iys1000
h
P
0</p>
        <p>Subject 1</p>
        <p>Subject 2</p>
        <p>Subject 3</p>
        <p>Subject 4</p>
        <p>Subject 5</p>
        <p>Each cluster centroid represents the average value of physical activity of a
speci c participant for a cluster and is tailored to the participant's daily physical
activity in the study period (Table 1). As an example, a daily physical activity
value of 1000 can label the activity level of that day as `Moderately Active' for
subject 3, but will label the day as `Inactive' for subject 2 due to his/her being
generally more active. Table 1 also shows the frequency of days falling within
each cluster.</p>
        <sec id="sec-3-4-1">
          <title>Inactive</title>
        </sec>
        <sec id="sec-3-4-2">
          <title>Moderately Active</title>
        </sec>
        <sec id="sec-3-4-3">
          <title>Highly Active Subject</title>
          <p>Centroid Frequency</p>
          <p>Centroid Frequency</p>
          <p>Centroid Frequency
1
2
3
4
5
935.9
1103.6
453.4
436.3
1252.6
30.3
62.1
16.7
23.3
41.7
1568.8
1602.6
988.4
1094.8
1564.1
57.6
31.0
63.3
50.0
41.7
2085.6
3511.7
1535.4
1609.9
2191.6
12.1
6.9
20.0
26.7
16.7</p>
          <p>All 924.3 34.2 1560.6 49.3 2827.2 16.4
Table 1. Overview of results from K-means clustering showing the cluster centroids
(in IMA/1000) and frequency (%) of days falling within the de ned clusters. The last
row shows the centroids and frequencies of each cluster when data from all subjects
was considered.</p>
          <p>A total of 1534 experience sampling (ES) points were collected. Participants
reported most of their events at home (65.7%-82.6%). Regarding the social
component, the majority of the events were reported as `alone' (34.5%-52.8%),
followed by `with partner' (24.7%-56.6%), `family' (5.0%-15.1%) and nally `friends
or colleagues' (6.8%-10.4%). The most frequent activity reported was `relaxation
or going out' (32.8%-40.5%), followed by `eat or care' (20.7%-31.1%), `household'
(8.6%-23.3%), `commuting' (7.7%-20.2%), and nally `work or study'
(0.7%11.1%). Only two subjects reported `association' activities (0.9%-1.3%) | i.e.
participation in religious, political or sports associations. Figure 4 shows the
relative frequency of the values registered for each one of the properties of daily
living.</p>
          <p>Subjectk1</p>
          <p>Subjectk2</p>
          <p>Subjectk3</p>
          <p>Subjectk4</p>
          <p>Subjectk5</p>
          <p>Location</p>
          <p>Indoors</p>
          <p>Outdoors
Participant</p>
          <p>Alone
Partner
Family
Friendsk|kColleagues</p>
          <p>Unknown
ActivitykCategory</p>
          <p>Workk|kStudy
Relaxationk|kGokout
Commuting
Eatk|kCare
Household
Association</p>
          <p>Concerning the data from all subjects, `indoors' (property Location), `friends
or colleagues' (property Social Companion), `work or study', `relaxation or go
out', `commuting', `eat or care' and `association' (property Activity Category ),
and `weekday' (property Time) showed association with the physical activity
levels (p &lt; :15). Also, within each subject separately the association between the
frequency of each value and physical activity level was tested, only minor changes
were detected. The data of one of the subjects did not show any signi cant
association between values of daily living and the physical activity level. Nominal
Regression analysis was used to further analyze the relation between each one of
the values aforementioned and the physical activity level. Considering that we
are interested in predictors of physical activity in the daily living, \Inactivity"
was set as reference in Table 2.</p>
          <p>An increase in frequency events reported `indoors' decreases the chance of
having a highly physically active day compared to an inactive day. This means
that days with higher frequency of events reported outside the home environment
are more likely to be highly physically active days. An increase in the frequency
of events with `friends or colleagues' gave a 0.663 fold risk of `Moderately Active'
days compared to `Inactive days'. Concerning the Activity Category property,
the frequency of events classi ed as `relaxation or go out' had a 0.721- and
0.619fold increased risk of `Moderately Active' or `Highly Active', respectively. The
frequency of `Work' events on a day had a 1.9 fold increased risk of `Highly
Active' versus `Inactive'. Finally concerning the property Activity Category, the
frequency of `Eat and Care' events on a day had a 1.475 fold increased risk of
`Moderately Active' versus `Inactive' days. Regarding time, participants seem to
be more likely to have `Moderately Active' days at the end of the week. Within
subject analysis resulted in similar results with a few notable cases. For one of
the subjects, the frequency of events reported with `friends or colleagues' gave a
3.836 fold increased risk of having a highly active day compared to an inactive
day. For two subjects an increase in the frequency of being alone gives a higher
chance of `Moderately'- and `Highly Active' days compared to an `Inactive' day.</p>
        </sec>
        <sec id="sec-3-4-4">
          <title>Values</title>
          <p>Indoors
Friends j Colleagues
Work j Study
Relaxation j Go-out
Commuting
Eat j Care</p>
        </sec>
        <sec id="sec-3-4-5">
          <title>Moderately Active vs. Inactive</title>
        </sec>
        <sec id="sec-3-4-6">
          <title>Highly Active vs. Inactive</title>
          <p>OR
95%CI
p</p>
          <p>OR
95% CI
p
Weekday 1.251 1.037-1.509 0.019 1.120 0.874-1.435 0.369
Table 2. Nominal regression analysis of the values from the experience sampling events
vs. physical activity level.
4</p>
        </sec>
      </sec>
    </sec>
    <sec id="sec-4">
      <title>Discussion</title>
      <p>The aim of the pilot study was to investigate the relation between physical
activity level (as either inactive, moderately active, or highly active) and daily
living through a set of di erent properties of daily events reported on a
smartphone. The rst step of the data analysis consisted of clustering the physical
activity data of each participant in three categories. Inactive days of subject 5
are almost three times more active than inactive days of subject 3 or 4. Similar
di erences are seen in the other clusters. This justi es our choice in performing
within-subject clustering analysis and emphasizes the need for developing
personalized interventions to coach physical activity of the older population. Such
applications should also adapt to the user following the behavior change over
time.</p>
      <p>
        The second step was the categorization of the events. Useful insights were
gained into the daily life of the older adults during this phase. It is noteworthy
that most of the events were reported in the home environment, suggesting that
this might be a good place for interaction with the elderly users of a behavior
change coaching system. Such a system can provide reminders or motivational
messages at the right moment to increase adherence to the telemedicine platform
and to facilitate behavior change in the older adults. In what concerns the social
companion, looking at our results, most of the events were reported alone or with
a partner. Other social interactions counted only for 8.9%-25.4% of the events.
Socialization is mentioned as a motivator of physical activity by active and
inactive groups in the study from [
        <xref ref-type="bibr" rid="ref29">29</xref>
        ]. This endorses the idea of recommending
physical activity with peers as a way to encourage physical activity and stimulate
social activities which are very important also in older age [
        <xref ref-type="bibr" rid="ref30">30</xref>
        ]. Regarding the
type of activity, relaxation related activities count for a big part of the day.
Only approximately half of the events reported related to eat, care, household
or commuting. Knowing the time when these routine activities take place can
also optimize the timing when a motivational message is sent and increase the
compliance. Our results relate to a certain extend with the study performed by
Chad et al. with 764 Canadian older adults, in which housekeeping activities
had the greatest contribution to the PASE score [
        <xref ref-type="bibr" rid="ref31">31</xref>
        ]. The PASE questionnaire
assesses physical activity level of the elderly by, among other factors, the time
spent on occupational, household and caring activities [
        <xref ref-type="bibr" rid="ref20">20</xref>
        ].
      </p>
      <p>
        Next steps in the development of the monitoring system include improvement
of the sensing mechanism. During the time of the experiment the number of
events reported per day varied but did not decrease over time. However, all the
subjects were aware that the data would be used for research purposes and were
motivated to nish the study. We believe that in normal daily life, without a
research purpose, answering questions every-hour can be troublesome and lead
to disuse of the technology after a certain period of time. Longer studies with
monitoring of other parameters could be interesting to ascertain whether changes
in daily living precede or succeed changes in health status. The results can be
used to model participant's behavior and provide tailored recommendations on
how to maintain a healthy lifestyle. Initial ideas for such a system are found in
[
        <xref ref-type="bibr" rid="ref32">32</xref>
        ].
      </p>
      <p>The present study has a number of limitations. The small sample size means
that the participants might not be representative of the typical elderly
population making our results inconsistent. However, the amount of data gathered per
subject is large, enabling our detailed qualitative study. We have a total of 146
days of measured physical activity and a total of 1534 experience sampling events
acquired. Therefore, we consider that our data is useful to receive insights in the
daily living and physical activity of the older adults. Another limitation concerns
the categorization of the events. Subjects were asked to report their daily events
approximately every hour. In the rst question they had to select the category
of the activity. When analyzing our data we realized that the categorization is
vulnerable to subjectivity, meaning that the same event can fall into a category
for one subject and other category for other subject. For example, two subjects
reported \taking care of the grandchildren" as \care" while others reported as
\relaxation". This means that the same activities fall into di erent categories
according to the each subject. The fact that the data was acquired only between
08:00 and 20:00 can exclude relevant data. In any case, we consider that our
study is relevant for getting insights on diurnal behavioral of older adults.
5</p>
    </sec>
    <sec id="sec-5">
      <title>Conclusion</title>
      <p>In this work we studied physical activity and daily living in a sample of robust
older adults. We underline the importance of learning physical activity levels
from personal data instead of using general cut-o points when studying the
older population. Our results show that location, social interactions, type of
activity and day of the week signi cantly in uence the daily physical activity of the
participants. Instead of motivating people to get physically active, a coaching
strategy could thus be to motivate people to engage in outdoor- or social
activities, increasing physical activity indirectly. This motivation by proxy could add
to the diversity of coaching of such systems and potentially increase adherence
and pleasure in using the system.</p>
      <sec id="sec-5-1">
        <title>Acknowledgments</title>
        <p>The work presented in this paper is being carried out within the PERSSILAA
project3 and funded by the European Union 7th Framework Programme.</p>
      </sec>
    </sec>
  </body>
  <back>
    <ref-list>
      <ref id="ref1">
        <mixed-citation>
          1. World Health Organization:
          <article-title>Ageing and life Course - Facts about ageing</article-title>
          . www.who.int/ageing/about/facts/en/ (
          <year>2014</year>
          ) [Online; accessed 10-March-2015].
        </mixed-citation>
      </ref>
      <ref id="ref2">
        <mixed-citation>
          2. Directorate-
          <article-title>General for Research and Innovation: Population ageing in Europe</article-title>
          .
          <source>Technical report, European Commission</source>
          (
          <year>2014</year>
          )
        </mixed-citation>
      </ref>
      <ref id="ref3">
        <mixed-citation>
          3. European Parliamentary Research Service:
          <article-title>Ageing population: projections 2010- 2060 for the EU27</article-title>
          . www.europarl.europa.eu/eplibrary/LSS-Ageing-population.
          <source>pdf</source>
          (
          <year>2013</year>
          ) [Online; accessed 10-March-2015].
        </mixed-citation>
      </ref>
      <ref id="ref4">
        <mixed-citation>
          4.
          <string-name>
            <surname>Fried</surname>
            ,
            <given-names>L.P.</given-names>
          </string-name>
          ,
          <string-name>
            <surname>Tangen</surname>
            ,
            <given-names>C.M.</given-names>
          </string-name>
          ,
          <string-name>
            <surname>Walston</surname>
            ,
            <given-names>J.</given-names>
          </string-name>
          , Newman, a.B.,
          <string-name>
            <surname>Hirsch</surname>
            ,
            <given-names>C.</given-names>
          </string-name>
          ,
          <string-name>
            <surname>Gottdiener</surname>
            ,
            <given-names>J.</given-names>
          </string-name>
          ,
          <string-name>
            <surname>Seeman</surname>
            ,
            <given-names>T.</given-names>
          </string-name>
          ,
          <string-name>
            <surname>Tracy</surname>
            ,
            <given-names>R.</given-names>
          </string-name>
          ,
          <string-name>
            <surname>Kop</surname>
            ,
            <given-names>W.J.</given-names>
          </string-name>
          ,
          <string-name>
            <surname>Burke</surname>
            ,
            <given-names>G.</given-names>
          </string-name>
          ,
          <string-name>
            <surname>McBurnie</surname>
            ,
            <given-names>M.</given-names>
          </string-name>
          <year>a</year>
          .:
          <article-title>Frailty in older adults: evidence for a phenotype</article-title>
          .
          <source>Journal of Gerontology: MEDICAL SCIENCES 56A</source>
          (
          <year>2001</year>
          )
          <volume>146</volume>
          {
          <fpage>156</fpage>
        </mixed-citation>
      </ref>
      <ref id="ref5">
        <mixed-citation>
          5.
          <string-name>
            <surname>Slaets</surname>
            ,
            <given-names>J.P.:</given-names>
          </string-name>
          <article-title>Vulnerability in the Elderly: Frailty</article-title>
          .
          <source>The Medical Clinics of North America</source>
          <volume>90</volume>
          (
          <year>2006</year>
          )
          <volume>593</volume>
          {
          <fpage>601</fpage>
        </mixed-citation>
      </ref>
      <ref id="ref6">
        <mixed-citation>
          6.
          <string-name>
            <given-names>European</given-names>
            <surname>Innovation</surname>
          </string-name>
          <article-title>Partnership on Active and Healthy Ageing (EIP-AHA): Action plan on Prevention and early diagnosis of frailty and functional decline, both physical and cognitive in older people</article-title>
          . www.ec.europa.eu/research/innovationunion/pdf/ (
          <year>2012</year>
          ) [Online; accessed 10-March-2015].
        </mixed-citation>
      </ref>
      <ref id="ref7">
        <mixed-citation>
          7.
          <string-name>
            <surname>Fried</surname>
            ,
            <given-names>L.P.</given-names>
          </string-name>
          ,
          <string-name>
            <surname>Ferrucci</surname>
            ,
            <given-names>L.</given-names>
          </string-name>
          ,
          <string-name>
            <surname>Darer</surname>
            ,
            <given-names>J.</given-names>
          </string-name>
          ,
          <string-name>
            <surname>Williamson</surname>
            ,
            <given-names>J.D.</given-names>
          </string-name>
          ,
          <string-name>
            <surname>Anderson</surname>
            ,
            <given-names>G.</given-names>
          </string-name>
          :
          <article-title>Untangling the concepts of disability, frailty, and comorbidity: implications for improved targeting and care</article-title>
          .
          <source>The journals of gerontology. Series A, Biological sciences and medical sciences 59</source>
          (
          <year>2004</year>
          )
          <volume>255</volume>
          {
          <fpage>263</fpage>
        </mixed-citation>
      </ref>
      <ref id="ref8">
        <mixed-citation>
          8. op den Akker, H.,
          <string-name>
            <surname>Cabrita</surname>
            ,
            <given-names>M.</given-names>
          </string-name>
          , op den Akker, R.,
          <string-name>
            <surname>Jones</surname>
            ,
            <given-names>V.</given-names>
          </string-name>
          ,
          <string-name>
            <surname>Hermens</surname>
          </string-name>
          , H.:
          <article-title>Tailored Motivational Message Generation: A Model and Practical Framework for RealTime Physical Activity Coaching</article-title>
          .
          <source>Journal of Biomedical</source>
          Informatics (to appear) (
          <year>2015</year>
          )
        </mixed-citation>
      </ref>
      <ref id="ref9">
        <mixed-citation>
          9.
          <string-name>
            <surname>Godman</surname>
            ,
            <given-names>B.</given-names>
          </string-name>
          ,
          <string-name>
            <surname>Finlayson</surname>
            ,
            <given-names>A.E.</given-names>
          </string-name>
          ,
          <string-name>
            <surname>Cheema</surname>
            ,
            <given-names>P.K.</given-names>
          </string-name>
          ,
          <string-name>
            <surname>Zebedin-Brandl</surname>
            ,
            <given-names>E.</given-names>
          </string-name>
          ,
          <string-name>
            <surname>GutierrezIbarluzea</surname>
          </string-name>
          , I.,
          <string-name>
            <surname>Jones</surname>
            ,
            <given-names>J.</given-names>
          </string-name>
          , Malmstrom, R.E.,
          <string-name>
            <surname>Asola</surname>
            ,
            <given-names>E.</given-names>
          </string-name>
          , Baumgartel,
          <string-name>
            <given-names>C.</given-names>
            ,
            <surname>Bennie</surname>
          </string-name>
          ,
          <string-name>
            <given-names>M.</given-names>
            ,
            <surname>Bishop</surname>
          </string-name>
          ,
          <string-name>
            <given-names>I.</given-names>
            ,
            <surname>Bucsics</surname>
          </string-name>
          ,
          <string-name>
            <given-names>A.</given-names>
            ,
            <surname>Campbell</surname>
          </string-name>
          ,
          <string-name>
            <given-names>S.</given-names>
            ,
            <surname>Diogene</surname>
          </string-name>
          ,
          <string-name>
            <given-names>E.</given-names>
            ,
            <surname>Ferrario</surname>
          </string-name>
          ,
          <string-name>
            <given-names>A.</given-names>
            , Furst, J.,
            <surname>Garuoliene</surname>
          </string-name>
          ,
          <string-name>
            <given-names>K.</given-names>
            ,
            <surname>Gomes</surname>
          </string-name>
          ,
          <string-name>
            <given-names>M.</given-names>
            ,
            <surname>Harris</surname>
          </string-name>
          ,
          <string-name>
            <given-names>K.</given-names>
            ,
            <surname>Haycox</surname>
          </string-name>
          ,
          <string-name>
            <given-names>A.</given-names>
            ,
            <surname>Herholz</surname>
          </string-name>
          ,
          <string-name>
            <given-names>H.</given-names>
            ,
            <surname>Hviding</surname>
          </string-name>
          ,
          <string-name>
            <given-names>K.</given-names>
            ,
            <surname>Jan</surname>
          </string-name>
          ,
          <string-name>
            <given-names>S.</given-names>
            ,
            <surname>Kalaba</surname>
          </string-name>
          ,
          <string-name>
            <given-names>M.</given-names>
            ,
            <surname>Kvalheim</surname>
          </string-name>
          ,
          <string-name>
            <given-names>C.</given-names>
            ,
            <surname>Laius</surname>
          </string-name>
          ,
          <string-name>
            <surname>O.</surname>
          </string-name>
          , Loov,
          <string-name>
            <given-names>S.A.</given-names>
            ,
            <surname>Malinowska</surname>
          </string-name>
          ,
          <string-name>
            <given-names>K.</given-names>
            ,
            <surname>Martin</surname>
          </string-name>
          ,
          <string-name>
            <given-names>A.</given-names>
            ,
            <surname>McCullagh</surname>
          </string-name>
          ,
          <string-name>
            <given-names>L.</given-names>
            ,
            <surname>Nilsson</surname>
          </string-name>
          ,
          <string-name>
            <given-names>F.</given-names>
            ,
            <surname>Paterson</surname>
          </string-name>
          ,
          <string-name>
            <given-names>K.</given-names>
            ,
            <surname>Schwabe</surname>
          </string-name>
          ,
          <string-name>
            <given-names>U.</given-names>
            ,
            <surname>Selke</surname>
          </string-name>
          ,
          <string-name>
            <given-names>G.</given-names>
            ,
            <surname>Sermet</surname>
          </string-name>
          ,
          <string-name>
            <given-names>C.</given-names>
            ,
            <surname>Simoens</surname>
          </string-name>
          ,
          <string-name>
            <given-names>S.</given-names>
            ,
            <surname>Tomek</surname>
          </string-name>
          ,
          <string-name>
            <given-names>D.</given-names>
            ,
            <surname>Vlahovic-Palcevski</surname>
          </string-name>
          ,
          <string-name>
            <given-names>V.</given-names>
            ,
            <surname>Voncina</surname>
          </string-name>
          ,
          <string-name>
            <given-names>L.</given-names>
            ,
            <surname>Wladysiuk</surname>
          </string-name>
          , M.,
          <string-name>
            <surname>van Woerkom</surname>
            ,
            <given-names>M.</given-names>
          </string-name>
          ,
          <string-name>
            <surname>Wong-Rieger</surname>
            ,
            <given-names>D.</given-names>
          </string-name>
          ,
          <string-name>
            <surname>Zara</surname>
            ,
            <given-names>C.</given-names>
          </string-name>
          ,
          <string-name>
            <surname>Ali</surname>
            ,
            <given-names>R.</given-names>
          </string-name>
          ,
          <string-name>
            <surname>Gustafsson</surname>
            ,
            <given-names>L.L.</given-names>
          </string-name>
          :
          <article-title>Personalizing health care: feasibility and future implications</article-title>
          .
          <source>BMC medicine 11</source>
          (
          <year>2013</year>
          )
          <fpage>179</fpage>
        </mixed-citation>
      </ref>
      <ref id="ref10">
        <mixed-citation>
          10.
          <string-name>
            <surname>Bouamrane</surname>
            ,
            <given-names>M.M.</given-names>
          </string-name>
          ,
          <string-name>
            <surname>Rector</surname>
            ,
            <given-names>A.</given-names>
          </string-name>
          ,
          <string-name>
            <surname>Hurrell</surname>
            ,
            <given-names>M.</given-names>
          </string-name>
          :
          <article-title>Using OWL ontologies for adaptive patient information modelling and preoperative clinical decision support</article-title>
          .
          <source>Knowledge and Information Systems</source>
          <volume>29</volume>
          (
          <year>2011</year>
          )
          <volume>405</volume>
          {
          <fpage>418</fpage>
        </mixed-citation>
      </ref>
      <ref id="ref11">
        <mixed-citation>
          11. Rian~o,
          <string-name>
            <given-names>D.</given-names>
            ,
            <surname>Real</surname>
          </string-name>
          ,
          <string-name>
            <given-names>F.</given-names>
            ,
            <surname>Lopez-Vallverdu</surname>
          </string-name>
          ,
          <string-name>
            <given-names>J.A.</given-names>
            ,
            <surname>Campana</surname>
          </string-name>
          ,
          <string-name>
            <given-names>F.</given-names>
            ,
            <surname>Ercolani</surname>
          </string-name>
          ,
          <string-name>
            <given-names>S.</given-names>
            ,
            <surname>Mecocci</surname>
          </string-name>
          ,
          <string-name>
            <given-names>P.</given-names>
            ,
            <surname>Annicchiarico</surname>
          </string-name>
          ,
          <string-name>
            <given-names>R.</given-names>
            ,
            <surname>Caltagirone</surname>
          </string-name>
          ,
          <string-name>
            <surname>C.</surname>
          </string-name>
          :
          <article-title>An ontology-based personalization of healthcare knowledge to support clinical decisions for chronically ill patients</article-title>
          .
          <source>Journal of Biomedical Informatics</source>
          <volume>45</volume>
          (
          <year>2012</year>
          )
          <volume>429</volume>
          {
          <fpage>446</fpage>
        </mixed-citation>
      </ref>
      <ref id="ref12">
        <mixed-citation>
          12.
          <string-name>
            <surname>Lustria</surname>
            ,
            <given-names>M.L.a.</given-names>
          </string-name>
          ,
          <string-name>
            <surname>Cortese</surname>
            ,
            <given-names>J.</given-names>
          </string-name>
          ,
          <string-name>
            <surname>Noar</surname>
            ,
            <given-names>S.M.</given-names>
          </string-name>
          ,
          <string-name>
            <surname>Glueckauf</surname>
            ,
            <given-names>R.L.</given-names>
          </string-name>
          :
          <article-title>Computer-tailored health interventions delivered over the web: Review and analysis of key components</article-title>
          .
          <source>Patient Education and Counseling</source>
          <volume>74</volume>
          (
          <year>2009</year>
          )
          <volume>156</volume>
          {
          <fpage>173</fpage>
        </mixed-citation>
      </ref>
      <ref id="ref13">
        <mixed-citation>
          13.
          <string-name>
            <surname>Krebs</surname>
            ,
            <given-names>P.</given-names>
          </string-name>
          ,
          <string-name>
            <surname>Prochaska</surname>
            ,
            <given-names>J.O.</given-names>
          </string-name>
          ,
          <string-name>
            <surname>Rossi</surname>
            ,
            <given-names>J.S.:</given-names>
          </string-name>
          <article-title>A meta-analysis of computer-tailored interventions for health behavior change</article-title>
          .
          <source>Preventive Medicine</source>
          <volume>51</volume>
          (
          <year>2010</year>
          )
          <volume>214</volume>
          {
          <fpage>221</fpage>
        </mixed-citation>
      </ref>
      <ref id="ref14">
        <mixed-citation>
          14. op den Akker, H.,
          <string-name>
            <surname>Jones</surname>
            ,
            <given-names>V.M.</given-names>
          </string-name>
          ,
          <string-name>
            <surname>Hermens</surname>
            ,
            <given-names>H.J.:</given-names>
          </string-name>
          <article-title>Tailoring real-time physical activity coaching systems: a literature survey and model. User Modeling</article-title>
          and
          <string-name>
            <surname>User-Adapted Interaction</surname>
          </string-name>
          (
          <year>2014</year>
          )
          <volume>351</volume>
          {
          <fpage>392</fpage>
        </mixed-citation>
      </ref>
      <ref id="ref15">
        <mixed-citation>
          15.
          <string-name>
            <surname>Dijkstra</surname>
            ,
            <given-names>A.</given-names>
          </string-name>
          ,
          <string-name>
            <surname>De Vries</surname>
          </string-name>
          , H.:
          <article-title>The development of computer-generated tailored interventions</article-title>
          .
          <source>Patient Education and Counseling</source>
          <volume>36</volume>
          (
          <year>1999</year>
          )
          <volume>193</volume>
          {
          <fpage>203</fpage>
        </mixed-citation>
      </ref>
      <ref id="ref16">
        <mixed-citation>
          16.
          <string-name>
            <surname>Warburton</surname>
            ,
            <given-names>D.E.R.</given-names>
          </string-name>
          ,
          <string-name>
            <surname>Nicol</surname>
            ,
            <given-names>C.W.</given-names>
          </string-name>
          ,
          <string-name>
            <surname>Bredin</surname>
            ,
            <given-names>S.S.D.</given-names>
          </string-name>
          :
          <article-title>Health bene ts of physical activity: the evidence</article-title>
          .
          <source>Canadian Medical Association Journal</source>
          <volume>174</volume>
          (
          <year>2006</year>
          )
          <volume>801</volume>
          {
          <fpage>9</fpage>
        </mixed-citation>
      </ref>
      <ref id="ref17">
        <mixed-citation>
          17.
          <string-name>
            <surname>Wu</surname>
            ,
            <given-names>C.Y.</given-names>
          </string-name>
          ,
          <string-name>
            <surname>Hu</surname>
            ,
            <given-names>H.Y.</given-names>
          </string-name>
          ,
          <string-name>
            <surname>Chou</surname>
            ,
            <given-names>Y.C.</given-names>
          </string-name>
          ,
          <string-name>
            <surname>Huang</surname>
            ,
            <given-names>N.</given-names>
          </string-name>
          ,
          <string-name>
            <surname>Chou</surname>
            ,
            <given-names>Y.J.</given-names>
          </string-name>
          ,
          <string-name>
            <surname>Li</surname>
            ,
            <given-names>C.P.:</given-names>
          </string-name>
          <article-title>The association of physical activity with all-cause, cardiovascular, and cancer mortalities among older adults</article-title>
          .
          <source>Preventive Medicine</source>
          <volume>72</volume>
          (
          <year>2015</year>
          )
          <volume>23</volume>
          {
          <fpage>29</fpage>
        </mixed-citation>
      </ref>
      <ref id="ref18">
        <mixed-citation>
          18.
          <string-name>
            <surname>Netz</surname>
            ,
            <given-names>Y.</given-names>
          </string-name>
          ,
          <string-name>
            <surname>Wu</surname>
            ,
            <given-names>M.J.</given-names>
          </string-name>
          ,
          <string-name>
            <surname>Becker</surname>
            ,
            <given-names>B.J.</given-names>
          </string-name>
          ,
          <string-name>
            <surname>Tenenbaum</surname>
          </string-name>
          , G.:
          <article-title>Physical activity and psychological well-being in advanced age: a meta-analysis of intervention studies</article-title>
          .
          <source>Psychology and aging 20</source>
          (
          <year>2005</year>
          )
          <volume>272</volume>
          {
          <fpage>84</fpage>
        </mixed-citation>
      </ref>
      <ref id="ref19">
        <mixed-citation>
          19.
          <string-name>
            <surname>de Souto Barreto</surname>
            ,
            <given-names>P.</given-names>
          </string-name>
          :
          <article-title>Direct and indirect relationships between physical activity and happiness levels among older adults: a cross-sectional study</article-title>
          .
          <source>Aging &amp; mental health</source>
          (
          <year>2014</year>
          )
          <volume>37</volume>
          {
          <fpage>41</fpage>
        </mixed-citation>
      </ref>
      <ref id="ref20">
        <mixed-citation>
          20.
          <string-name>
            <surname>Washburn</surname>
            ,
            <given-names>R.A.</given-names>
          </string-name>
          ,
          <string-name>
            <surname>Smith</surname>
            ,
            <given-names>K.W.</given-names>
          </string-name>
          ,
          <string-name>
            <surname>Jette</surname>
            ,
            <given-names>A.M.</given-names>
          </string-name>
          ,
          <string-name>
            <surname>Janney</surname>
            ,
            <given-names>C.A.</given-names>
          </string-name>
          :
          <article-title>The Physical Activity Scale for the Elderly (PASE): Development and Evaluation</article-title>
          .
          <source>J Clin Epidemiol</source>
          <volume>46</volume>
          (
          <year>1993</year>
          )
          <volume>153</volume>
          {
          <fpage>162</fpage>
        </mixed-citation>
      </ref>
      <ref id="ref21">
        <mixed-citation>
          21.
          <string-name>
            <surname>Simone</surname>
            ,
            <given-names>P.M.</given-names>
          </string-name>
          ,
          <string-name>
            <surname>Haas</surname>
            ,
            <given-names>A.L.</given-names>
          </string-name>
          :
          <article-title>Frailty, Leisure Activity and Functional Status in Older Adults: Relationship With Subjective Well Being</article-title>
          .
          <source>Clinical Gerontologist</source>
          <volume>36</volume>
          (
          <year>2013</year>
          )
          <volume>275</volume>
          {
          <fpage>293</fpage>
        </mixed-citation>
      </ref>
      <ref id="ref22">
        <mixed-citation>
          22.
          <string-name>
            <surname>Lawton</surname>
            ,
            <given-names>M.P.</given-names>
          </string-name>
          ,
          <string-name>
            <surname>Brody</surname>
            ,
            <given-names>E.M.:</given-names>
          </string-name>
          <article-title>Assessment of older people: self-maintaining and instrumental activities of daily living</article-title>
          .
          <source>The Gerontologist</source>
          <volume>9</volume>
          (
          <year>1969</year>
          )
          <volume>179</volume>
          {
          <fpage>86</fpage>
        </mixed-citation>
      </ref>
      <ref id="ref23">
        <mixed-citation>
          23.
          <string-name>
            <surname>Csikszentmihalyi</surname>
            ,
            <given-names>M.</given-names>
          </string-name>
          ,
          <string-name>
            <surname>Larson</surname>
          </string-name>
          , R.:
          <article-title>Validity and reliability of the ExperienceSampling Method</article-title>
          .
          <source>The Journal of nervous and mental disease 175</source>
          (
          <year>1987</year>
          )
          <volume>526</volume>
          {
          <fpage>36</fpage>
        </mixed-citation>
      </ref>
      <ref id="ref24">
        <mixed-citation>
          24.
          <string-name>
            <surname>Steverink</surname>
            ,
            <given-names>N.</given-names>
          </string-name>
          ,
          <string-name>
            <surname>Slaets</surname>
            ,
            <given-names>J.P.J.</given-names>
          </string-name>
          ,
          <string-name>
            <surname>Schuurmans</surname>
            , H., Van Lis,
            <given-names>M.</given-names>
          </string-name>
          :
          <article-title>Measuring frailty: developing and testing the GFI (Groningen Frailty Indicator)</article-title>
          .
          <source>Gerontologist</source>
          <volume>41</volume>
          (
          <year>2001</year>
          )
          <fpage>236</fpage>
        </mixed-citation>
      </ref>
      <ref id="ref25">
        <mixed-citation>
          25.
          <string-name>
            <surname>Wild</surname>
            ,
            <given-names>B.</given-names>
          </string-name>
          ,
          <string-name>
            <surname>Lechner</surname>
            ,
            <given-names>S.</given-names>
          </string-name>
          ,
          <string-name>
            <surname>Herzog</surname>
            ,
            <given-names>W.</given-names>
          </string-name>
          ,
          <string-name>
            <surname>Maatouk</surname>
            ,
            <given-names>I.</given-names>
          </string-name>
          ,
          <string-name>
            <surname>Wesche</surname>
            ,
            <given-names>D.</given-names>
          </string-name>
          ,
          <string-name>
            <surname>Raum</surname>
            ,
            <given-names>E.</given-names>
          </string-name>
          , Muller, H.,
          <string-name>
            <surname>Brenner</surname>
            ,
            <given-names>H.</given-names>
          </string-name>
          ,
          <string-name>
            <surname>Slaets</surname>
            ,
            <given-names>J.</given-names>
          </string-name>
          ,
          <string-name>
            <surname>Huyse</surname>
            ,
            <given-names>F.</given-names>
          </string-name>
          , Sollner, W.:
          <article-title>Reliable integrative assessment of health care needs in elderly persons: the INTERMED for the Elderly (IM-E)</article-title>
          .
          <source>Journal of psychosomatic research 70</source>
          (
          <year>2011</year>
          )
          <volume>169</volume>
          {
          <fpage>78</fpage>
        </mixed-citation>
      </ref>
      <ref id="ref26">
        <mixed-citation>
          26.
          <string-name>
            <surname>Peters</surname>
            ,
            <given-names>L.L.</given-names>
          </string-name>
          ,
          <string-name>
            <surname>Boter</surname>
            ,
            <given-names>H.</given-names>
          </string-name>
          ,
          <string-name>
            <surname>Slaets</surname>
            ,
            <given-names>J.P.J.</given-names>
          </string-name>
          ,
          <string-name>
            <surname>Buskens</surname>
            ,
            <given-names>E.</given-names>
          </string-name>
          :
          <article-title>Development and measurement properties of the self assessment version of the INTERMED for the elderly to assess case complexity</article-title>
          .
          <source>Journal of psychosomatic research 74</source>
          (
          <year>2013</year>
          )
          <volume>518</volume>
          {
          <fpage>22</fpage>
        </mixed-citation>
      </ref>
      <ref id="ref27">
        <mixed-citation>
          27.
          <string-name>
            <surname>Bouten</surname>
            ,
            <given-names>C.V.</given-names>
          </string-name>
          ,
          <string-name>
            <surname>Verboeket-van de Venne</surname>
            ,
            <given-names>W.P.</given-names>
          </string-name>
          ,
          <string-name>
            <surname>Westerterp</surname>
            ,
            <given-names>K.R.</given-names>
          </string-name>
          ,
          <string-name>
            <surname>Verduin</surname>
            ,
            <given-names>M.</given-names>
          </string-name>
          ,
          <string-name>
            <surname>Janssen</surname>
            ,
            <given-names>J.D.</given-names>
          </string-name>
          :
          <article-title>Daily physical activity assessment: comparison between movement registration and doubly labeled water</article-title>
          .
          <source>Journal of applied physiology (Bethesda</source>
          , Md. :
          <year>1985</year>
          )
          <volume>81</volume>
          (
          <year>1996</year>
          )
          <volume>1019</volume>
          {
          <fpage>26</fpage>
        </mixed-citation>
      </ref>
      <ref id="ref28">
        <mixed-citation>
          28. Op den Akker, H.,
          <string-name>
            <surname>Tabak</surname>
            ,
            <given-names>M.</given-names>
          </string-name>
          , Marin-perianu,
          <string-name>
            <given-names>M.</given-names>
            ,
            <surname>Huis</surname>
          </string-name>
          ,
          <string-name>
            <given-names>R.</given-names>
            ,
            <surname>Valerie</surname>
          </string-name>
          ,
          <string-name>
            <given-names>M.</given-names>
            ,
            <surname>Hofs</surname>
          </string-name>
          ,
          <string-name>
            <given-names>D.</given-names>
            ,
            <surname>Thijs</surname>
          </string-name>
          ,
          <string-name>
            <given-names>M.T.</given-names>
            ,
            <surname>Schooten</surname>
          </string-name>
          ,
          <string-name>
            <given-names>B.W.V.</given-names>
            ,
            <surname>Miriam</surname>
          </string-name>
          ,
          <string-name>
            <surname>M.R.</surname>
          </string-name>
          :
          <article-title>Development and Evaluation of a Sensor-Based System for Remote Monitoring and Treatment of Chronic Diseases</article-title>
          .
          <source>In: 6th International Symposium on eHealth Services and Technologies</source>
          , Geneva, Switzerland, SciTePress - Science and Technology
          <string-name>
            <surname>Publications</surname>
          </string-name>
          (
          <year>2012</year>
          )
          <volume>19</volume>
          {
          <fpage>27</fpage>
        </mixed-citation>
      </ref>
      <ref id="ref29">
        <mixed-citation>
          29.
          <string-name>
            <surname>Costello</surname>
            ,
            <given-names>E.</given-names>
          </string-name>
          ,
          <string-name>
            <surname>Kafchinski</surname>
            ,
            <given-names>M.</given-names>
          </string-name>
          ,
          <string-name>
            <surname>Vrazel</surname>
            ,
            <given-names>J.</given-names>
          </string-name>
          ,
          <string-name>
            <surname>Sullivan</surname>
            ,
            <given-names>P.</given-names>
          </string-name>
          : Motivators, barriers, and
          <article-title>beliefs regarding physical activity in an older adult population</article-title>
          .
          <source>Journal of geriatric physical therapy</source>
          (
          <year>2001</year>
          )
          <volume>34</volume>
          (
          <year>2011</year>
          )
          <volume>138</volume>
          {
          <fpage>47</fpage>
        </mixed-citation>
      </ref>
      <ref id="ref30">
        <mixed-citation>
          30.
          <string-name>
            <surname>Huxhold</surname>
            ,
            <given-names>O.</given-names>
          </string-name>
          ,
          <string-name>
            <surname>Miche</surname>
            ,
            <given-names>M.</given-names>
          </string-name>
          , Schuz,
          <string-name>
            <surname>B.</surname>
          </string-name>
          :
          <article-title>Bene ts of Having Friends in Older Ages: Di erential E ects of Informal Social Activities on Well-Being in Middle-Aged and Older Adults. The journals of gerontology</article-title>
          . Series B,
          <source>Psychological sciences and social sciences</source>
          (
          <year>2013</year>
          )
          <volume>1</volume>
          {
          <fpage>10</fpage>
        </mixed-citation>
      </ref>
      <ref id="ref31">
        <mixed-citation>
          31.
          <string-name>
            <surname>Chad</surname>
            ,
            <given-names>K.E.</given-names>
          </string-name>
          ,
          <string-name>
            <surname>Reeder</surname>
            ,
            <given-names>B.a.</given-names>
          </string-name>
          ,
          <string-name>
            <surname>Harrison</surname>
            ,
            <given-names>E.L.</given-names>
          </string-name>
          ,
          <string-name>
            <surname>Ashworth</surname>
            ,
            <given-names>N.L.</given-names>
          </string-name>
          ,
          <string-name>
            <surname>Sheppard</surname>
            ,
            <given-names>S.M.</given-names>
          </string-name>
          ,
          <string-name>
            <surname>Schultz</surname>
            ,
            <given-names>S.L.</given-names>
          </string-name>
          ,
          <string-name>
            <surname>Bruner</surname>
            ,
            <given-names>B.G.</given-names>
          </string-name>
          , Fisher,
          <string-name>
            <given-names>K.L.</given-names>
            ,
            <surname>Lawson</surname>
          </string-name>
          ,
          <string-name>
            <surname>J.a.</surname>
          </string-name>
          :
          <article-title>Pro le of Physical Activity Levels in Community-Dwelling Older Adults</article-title>
          .
          <source>Medicine &amp; Science in Sports &amp; Exercise</source>
          <volume>37</volume>
          (
          <year>2005</year>
          )
          <volume>1774</volume>
          {
          <fpage>1784</fpage>
        </mixed-citation>
      </ref>
      <ref id="ref32">
        <mixed-citation>
          32.
          <string-name>
            <surname>Nassabi</surname>
            ,
            <given-names>M.H.</given-names>
          </string-name>
          , op den Akker, H.,
          <string-name>
            <surname>Vollenbroek</surname>
            ,
            <given-names>M.:</given-names>
          </string-name>
          <article-title>An ontology-based recommender system to promote physical activity for pre-frail elderly</article-title>
          .
          <source>In: Mensch &amp; Computer</source>
          <year>2014</year>
          {Workshopband:
          <fpage>14</fpage>
          .
          <string-name>
            <surname>Fachu</surname>
          </string-name>
          <article-title>bergreifende Konferenz fur Interaktive und Kooperative Medien{Interaktiv unterwegs-Freiraume gestalten</article-title>
          , Walter de Gruyter GmbH &amp;
          <string-name>
            <surname>Co KG</surname>
          </string-name>
          (
          <year>2014</year>
          )
          <fpage>181</fpage>
        </mixed-citation>
      </ref>
    </ref-list>
  </back>
</article>