<!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Archiving and Interchange DTD v1.0 20120330//EN" "JATS-archivearticle1.dtd">
<article xmlns:xlink="http://www.w3.org/1999/xlink">
  <front>
    <journal-meta />
    <article-meta>
      <title-group>
        <article-title>IIITH at BioASQ Challange 2015 Task 3b: Bio-Medical Question Answering System</article-title>
      </title-group>
      <contrib-group>
        <contrib contrib-type="author">
          <string-name>Harish Yenala</string-name>
          <email>harish.yenala@research.iiit.ac.in</email>
          <xref ref-type="aff" rid="aff0">0</xref>
        </contrib>
        <contrib contrib-type="author">
          <string-name>Avinash Kamineni</string-name>
          <email>avinash.kamineni@research.iiit.ac.in</email>
          <xref ref-type="aff" rid="aff0">0</xref>
        </contrib>
        <contrib contrib-type="author">
          <string-name>Manish Shrivastava</string-name>
          <email>m.shrivastava@iiit.ac.in</email>
          <xref ref-type="aff" rid="aff0">0</xref>
        </contrib>
        <contrib contrib-type="author">
          <string-name>Manoj Chinnakotla</string-name>
          <email>manojc@microsoft.com</email>
          <xref ref-type="aff" rid="aff1">1</xref>
        </contrib>
        <aff id="aff0">
          <label>0</label>
          <institution>International Institute of Information Technology Hyderabad</institution>
          ,
          <country country="IN">India</country>
        </aff>
        <aff id="aff1">
          <label>1</label>
          <institution>Microsoft</institution>
          ,
          <country country="IN">India</country>
        </aff>
      </contrib-group>
      <abstract>
        <p>In this paper, we describe our participation in the 2015 BioASQ challenge on Bio-Medical Question Answering. For Question Answering task (Task 3b), teams were provided with natural language questions and asked to retrieve responses from PubMed corpus in the form of documents, snippets, concepts and RDF triplets (Phase A) and direct answers (Phase B). For Phase A, we took the support of PubMed search engine and our snippet extraction technique. In our QA system, apart from the standard techniques discussed in literature, we tried the following novel techniques to - a) leverage web search results for improving question processing and b) identify domain words and de ne a new answer ranking function based on number of common domain words. We scored an F-measure of 0.193 for document extraction and F-measure of 0.0717 in snippet generation.</p>
      </abstract>
      <kwd-group>
        <kwd>PubMed</kwd>
        <kwd>Biomedical Question Answering</kwd>
        <kwd>Information Retrieval</kwd>
      </kwd-group>
    </article-meta>
  </front>
  <body>
    <sec id="sec-1">
      <title>-</title>
      <p>
        The present innovations in the bio-medical domain is leading to the creation
of large amounts of data. The bio-medical literature growth can be understood
from the vast data in PubMed [
        <xref ref-type="bibr" rid="ref2">2</xref>
        ] database of National Library of Medicine
(NLM) which contains more than 14 million articles and hundreds of thousands
more are being added every year [
        <xref ref-type="bibr" rid="ref3">3</xref>
        ]. However, such a huge repository of data is
useful only if it can be easily accessed and the contents retrieved as per the user
requirements [
        <xref ref-type="bibr" rid="ref14">14</xref>
        ]. Question Answering (QA) systems enable the user to express
their information need in the form of natural language questions and retrieves
the precise answers to them.
      </p>
      <p>
        QA has been a well studied research area [
        <xref ref-type="bibr" rid="ref15 ref18 ref7 ref8">7, 15, 8, 18</xref>
        ]. However, QA in
BioMedical Domain has its own challenges like presence of complex technical terms,
compound words and domain speci c semantic ontologies [
        <xref ref-type="bibr" rid="ref16">16</xref>
        ]. BioASQ-QA
(Task 3b) [
        <xref ref-type="bibr" rid="ref17">17</xref>
        ] is a Bio-Medical Question Answering task which uses
benchmark datasets containing development and test questions, in English, along with
gold standard answers. The benchmark datasets contain at least 500 questions.
The participants have to respond with relevant concepts (from designated
terminologies and ontologies), relevant articles (in English, from designated article
repositories), relevant snippets, relevant RDF triples, exact answers (e.g., named
entities in the case of factoid questions) and Ideal (summary) answers.
      </p>
      <p>In this paper, we describe the approach taken by the IIIT-Hyderabad team
for Task 3b of BioASQ Challenge. For retrieving documents as answers, we used
chunking, stop word removal and search query formulation techniques. Later,
from the top documents, we lter the most relevant phrases as snippets. For
extracting the exact and Ideal answers from the snippets, we used cosine similarity
and noun chunk identi cation techniques.</p>
      <p>The rest of the paper is organized as follows: Section 2, describes the previous
work done in Bio-Medical QA. Section 3 describes our approach in more detail.
Section 4 gives the experimental results. Finally, Section 5 concludes the paper
with future work.
2</p>
    </sec>
    <sec id="sec-2">
      <title>Related Work</title>
      <p>The Bio-medical Question Answering has been a challenge from past few years.
There has been not much progress since then. The major challenge for this
was a very complex domain. So, only domain expert could understand the inner
details for system to be built. Major concentration was done on the factoid based
questions and yes/no questions.</p>
      <p>
        MedQA [
        <xref ref-type="bibr" rid="ref11">11</xref>
        ] is a bio-medical question answering system which has
information retrieval, extraction, and summarization techniques to automatically
generate paragraph-level answers for de nitional questions. However, it is still limited
due to its ability to answer only de nitional questions. BioinQA [
        <xref ref-type="bibr" rid="ref14">14</xref>
        ] uses the
technique of entity recognition and matching. It is based on the search in context
and utilizes syntactic information. BioinQA also answers the comparison type
questions from multiple documents, a feature which contrasts sharply with the
existing search engines, which merely return answers from single document or
passage.
      </p>
      <p>
        The jikitou [
        <xref ref-type="bibr" rid="ref5">5</xref>
        ] system's architecture is composed of four subsystems:
knowledge base, question analysis, answer agents, and user interface. Multiple software
agents nd possible answers to questions, and the most relevant one is presented
to the user. Additional relevant information is presented to the user establishing
a kind of dialog with the user to obtain feedback to re ne the query.
      </p>
      <p>
        OHSU (Oregon Health &amp; Science University) [
        <xref ref-type="bibr" rid="ref6">6</xref>
        ] does multiple iterations of
basic QA with each iteration successively re ning the original question such as
synonymy expansion, ranked series of topic queries and a range of speci cities.
Finally, they retrieve all the likely relevant passages in ranked order.
      </p>
      <p>
        In [
        <xref ref-type="bibr" rid="ref13">13</xref>
        ] and [
        <xref ref-type="bibr" rid="ref19">19</xref>
        ], similarity between the question and snippet was computed
using cosine similarity and was also used for ranking. They also used domain
speci c tools like MetaMap [
        <xref ref-type="bibr" rid="ref4">4</xref>
        ] for identifying concepts. Only few [
        <xref ref-type="bibr" rid="ref9">9</xref>
        ] have worked
on extracting triples, from di erent linked data domains like disease ontology [
        <xref ref-type="bibr" rid="ref10">10</xref>
        ]
and MeSH hierarchy [
        <xref ref-type="bibr" rid="ref1">1</xref>
        ]. While coming to document extraction, most systems
uses PubMed Search, which has better ranking ability based on tf-idf [
        <xref ref-type="bibr" rid="ref12">12</xref>
        ] scores.
      </p>
      <p>Our current approach di ers with the above approaches in the following ways:
a) We leverage web search results in question processing and b) We de ne new
similarity metrics based on common domain words.
3</p>
    </sec>
    <sec id="sec-3">
      <title>IIITH Bio-Medical QA System</title>
      <p>We have designed an algorithm to extract the high informative documents for a
given question from PubMed articles.
3.1</p>
      <sec id="sec-3-1">
        <title>System Architecture</title>
        <p>The architecture of the system is shown in Figure 1
3.2</p>
      </sec>
      <sec id="sec-3-2">
        <title>Document Retrieval</title>
        <p>This Algorithm takes a bio medical question 'Q' and outputs a set of 10 PubMed
documents which are having high probability to contain answer 'A' for given Q.
Detailed explanation of each step of algorithm is given below.
1. Question Processing: Let the given question be Q, we need to process
the question to make it e cient and optimized for searching. For this we
have sequence of sub steps which are explained below.
(a) Cleaning: We clean the question for making the search e cient. In
this step all unnecessary symbols like question mark(?) , dot(.) etc are
removed. We have found that (-) makes the chunking task little di cult
and wrong which is crucial task in this step. So Hyphens are replaced
with some Named Entity Words.</p>
        <p>Algorithm 1 Domain Word Extraction Algorithm
1: N N um Of T op Results(20)
2: domainU rlP atterns f\nlm:nih:gov"; \webmd:com"; \medicine"; \biocare"; \drugs"; :::g
3: function DomainWordIdentification(chunk; domainU rlP atterns)
4: topResults SearchAPI(chunk; N )
5: f ocusW ord null
6: for all result 2 topResults do
7: if result 2 domainU rlP atterns then
8: f ocusW ord chunk
9: else
10: remove(chunk)
11: end if
12: end for
13: return f ocusW ord
14: end function
15: function SearchAPI(chunk; N )
16: results GoogleAP I=BingAP I(chunk; N )
17: return results
18: end function
(b) Chunking: We need to do chunking to get the phrases(chunks) to the
modi ed Question Q. These chunks will be very useful to avoid removal
of important(Focus) words which will be done in the next step. We used
Annotator module from NLTK3 Package for chunker.
(c) Stop Word Removal: The chunks with all the stop words will be
removed. As they don't help at all in a keyword based search. This step
makes the question more optimized. We have used NLTK corpus English
StopWords list for this task.
(d) Domain Word Identi cation: In the processed query sentence Q,
there will be generic words which may not be stop words. But, they
contribute nothing in getting the relevant documents. Focus Word
Identi cation step nds only the chunks which are Domain-words, Important
Words. The pseudocode for identifying the focus word/chunk is shown
at Algorithm 1.</p>
        <p>We have observed the following list of url patterns that are most relevant to
Bio-Medical domain4.</p>
        <p>After the question processing step, the question Q will be modi ed into set
of Focus words, namely Set FQ.
2. PubMed Search: The words in the Focus Word Set will be combined(concatenated)
to make a single string. This string will be red/searched in PubMed search
engine and top 200 documents will be retrieved.
3 Natural Language Toolkit http://www.nltk.org/
4 Patterns in website urls which store bio-medical information \nlm.nih.gov",
\webmd.com", \medicine", \biocare", \drugs"
Algorithm 2 Document Re-Ranking Algorithm
1: Q Query
2: relDocs</p>
        <p>relaventDocuments
3: function RankAllDocuments(Q; relDocs)
4: Q RemoveStopWords(Q)
5: scores fg
6: for all doci 2 relDocs do
7: Ti doci:title
8: Ti RemoveStopWords(Ti)
9: scores[i] CosineSim(Q; Ti)
10: end for
11: scores; topDocs
12: return topDocs
13: end function</p>
        <p>
          SortScores(scores; relDocs)
3. Document Re-Ranking: As our question processing is not a standard
one, we don't completely depend on PubMed ranking of documents. So we
rank the obtained 200 documents again with our approaches.
(a) Cosine similarity [
          <xref ref-type="bibr" rid="ref13">13</xref>
          ]:
        </p>
        <p>We take the original query Q, and Document Title T.
(b) Existence Test Score: This measure tells number of common Focus
words (Domain words) present in Question Q and title of the document
Ti.</p>
        <p>Scores[i] = ExistenceT estScore(Q; Ti)
(1)
(c) Hybrid Approach: Finally, we combined both the approaches giving
them separate weights and interestingly the scores were better. In this
approach the score[i] will be de ned as below,</p>
        <p>Score[i] =</p>
        <sec id="sec-3-2-1">
          <title>CosSim(Q; Ti) +</title>
        </sec>
        <sec id="sec-3-2-2">
          <title>ExistT estScore(Q; Ti)</title>
          <p>(2)
; are normalization constants.</p>
          <p>After this step, high ranked which are most relevant 10 documents to the
given query Q will be retrieved and output to the system.
3.3</p>
        </sec>
      </sec>
      <sec id="sec-3-3">
        <title>Snippet Generation and Ranking</title>
        <p>This section explains about retrieving top 10 snippets for given question Q. The
algorithm for Snippet Generation and Ranking is shown in Figure 2</p>
        <p>Initially we take the query Q and send in to the`Document Retrieval
algorithm. From this step, we will get top 10 documents for the query Q.</p>
        <p>After obtaining top 10 most relevant documents (D1...D10 ) we take abstracts
of all those documents. From all the abstracts we extract all the sentences and
make a set S.</p>
        <p>For all the sentences s in S, we compute similarity scores with query Q. After
nding similarity scores for all the sentences we sort and take top 10 sentences
matching most with the query Q. We call those High-Matching sentences and
snippets and output them to the system.</p>
        <p>As we have parsed the PubMed web(search) page to get the abstracts and
pmids, we have used Regular Expressions to identify abstracts and also to
split sentences correctly. While nding similarity score between sentences s and
query Q, we have used above explained 3 approaches and found hybrid
approach(Cosine similarity score+Existence Test score) performance was good.</p>
        <p>This algorithms gave good snippets in which always at least 4 of them
contained the exact answer.</p>
      </sec>
      <sec id="sec-3-4">
        <title>3.4 Ideal Answer Extraction</title>
        <p>Here a Question and related snippets will be given to our algorithm and it should
nd Ideal answer i.e. a one or two line answer which perfectly answers the given
query.</p>
        <p>For this task we have taken all the sentences from the given snippets and
calculated similarity scores with the approaches explained in section 3.2. Top 10
Ideal answers with highest similarity scores will be returned.
In this section we will be given with a query and set of snippets. We should
result the exact one or two word answers. We have designed an algorithm for
giving exact answers for Factoid questions. That approach is explained as a ow
chart in Figure 3.</p>
        <p>As shown in the Figure 3, we start with query Q and all snippets S. We
apply, Phase A algorithm for nding top Ideal answers. For each, Ideal answer
we nd chunks and we consider only \Noun chunks" as we are dealing with only
Factoid questions. Each time, we modify the given query Q by replacing question
words (like what, when, who etc. ) with the considered \Noun chunk", then we
name that new query as Q. Then, we nd the similarity score between Q and
Ideal answer Idi. Similarly, we repeat the same procedure for all ideal answers
and their noun chunks. At the end, we sort the similarity scores and output
top 10 related noun chunks as exact answers. In this algorithm, we used NLTK
parser and Cosine similarity measurement. We got good results with proposed
approaches.</p>
      </sec>
    </sec>
    <sec id="sec-4">
      <title>Experiments and Results</title>
      <p>As part of the BioASQ 3b challenge 2015, we have participated in the batch
wise submissions. We could perform relatively better than the baseline System.
These results of all submissions for documents and snippets are shown in Table
1 and Table 2.
4.1</p>
      <sec id="sec-4-1">
        <title>Dataset Details</title>
        <p>
          Task 3b of BioASQ 2015 released a training dataset [
          <xref ref-type="bibr" rid="ref17">17</xref>
          ] of 810 question-answer
pairs and testing data comprising of 100 questions was released for ve
consecutive weeks. The average length of each question was 10 words. Out of 100
questions, on an average 30 factoid questions, 25 list type, 25 yesno type and 20
summary type of questions were there.
4.2
        </p>
      </sec>
      <sec id="sec-4-2">
        <title>Evaluation Metrics</title>
        <p>
          The evaluation metrics used in this task are mean precision, mean recall, and
mean F -measure of the documents, snippets, exact and ideal answers returned
by the system [
          <xref ref-type="bibr" rid="ref17">17</xref>
          ].
4.3
        </p>
      </sec>
      <sec id="sec-4-3">
        <title>Experimental Setup</title>
        <p>Di erent experiments have been conducted to improve the accuracy of system
such as:
1. Increased the retrieved documents after PubMed Search step from 60
documents to 100 documents.
2. De ned new similarity measure called Existance Similarity and combined it
with cosine similarity, which increased the accuracy of the system.</p>
        <p>Our best results in snippet extraction for Task 3b Phase A has been achieved(see
table 2, bold). Our system name for submission was \qaiiit system 1". In fact
that was achieved in statistical approach. This approach was found better
compared to baseline system.</p>
        <p>In Table 3, from the snippets given by the BioASQ, we found most relevant
snippet based on hybrid similarity match and returned respective snippet as the
ideal answer. By using this method, rougue score was about 0.303, just below
the baseline of 0.46.
5</p>
      </sec>
    </sec>
    <sec id="sec-5">
      <title>Conclusion and Future Work</title>
      <p>In this paper, we describe the approach taken by IIIT-H team for the Bio-Medical
Question Answering task of BioASQ task 3B. Apart from the standard QA
techniques, our current approach di ers in the following ways - a) We leverage
web search results in question processing and b) We de ne new similarity metrics
based on common domain words. By applying our approach, we obtained
Fmeasure of 0.193 for document extraction and F-measure of 0.0717 in snippet
generation.</p>
      <p>As part of the future work, we would be working on the Triples extraction,
which is still under progress, as no one has even attempted it. We will also be
using more domain speci c entity recognition tools, for more cleaner way of
identifying the exact answer. For the ideal answer or summary type answers, we are
working on answer generation techniques from snippets of multiple documents.</p>
    </sec>
  </body>
  <back>
    <ref-list>
      <ref id="ref1">
        <mixed-citation>1. Medical Subject Headings https://www.nlm.nih.gov/mesh/.</mixed-citation>
      </ref>
      <ref id="ref2">
        <mixed-citation>2. Search Engine of Medline database http://www.ncbi.nlm.nih.gov/pubmed.</mixed-citation>
      </ref>
      <ref id="ref3">
        <mixed-citation>3. U.S. National Library of Medicine https://www.nlm.nih.gov/.</mixed-citation>
      </ref>
      <ref id="ref4">
        <mixed-citation>
          4.
          <string-name>
            <given-names>A. R.</given-names>
            <surname>Aronson</surname>
          </string-name>
          .
          <article-title>E ective Mapping of Biomedical Text to the UMLS Metathesaurus: The Metamap Program</article-title>
          .
          <source>Proc AMIA Symp</source>
          , pages
          <volume>17</volume>
          {
          <fpage>21</fpage>
          ,
          <year>2001</year>
          .
        </mixed-citation>
      </ref>
      <ref id="ref5">
        <mixed-citation>
          5.
          <string-name>
            <given-names>Michael</given-names>
            <surname>Anton</surname>
          </string-name>
          <article-title>Bauer. The jikitou Biomedical Question Answering System: Facilitating the Next Stage in the Evolution of Information Retrieval</article-title>
          ,
          <year>2008</year>
          .
        </mixed-citation>
      </ref>
      <ref id="ref6">
        <mixed-citation>
          6.
          <string-name>
            <surname>Aaron</surname>
            <given-names>M.</given-names>
          </string-name>
          <string-name>
            <surname>Cohen</surname>
          </string-name>
          , Jianji Yang, Seeger Fisher, Brian Roark, and
          <string-name>
            <surname>William</surname>
            <given-names>R.</given-names>
          </string-name>
          <string-name>
            <surname>Hersh</surname>
          </string-name>
          .
          <article-title>The OHSU Biomedical Question Answering System Framework</article-title>
          . In Ellen M.
          <article-title>Voorhees</article-title>
          and Lori P. Buckland, editors,
          <source>TREC, volume Special Publication 500- 274. National Institute of Standards and Technology (NIST)</source>
          ,
          <year>2007</year>
          .
        </mixed-citation>
      </ref>
      <ref id="ref7">
        <mixed-citation>
          7.
          <string-name>
            <surname>Richard J Cooper and Stefan M Ru</surname>
          </string-name>
          <article-title>ger. A Simple Question Answering System</article-title>
          .
          <source>In TREC</source>
          ,
          <year>2000</year>
          .
        </mixed-citation>
      </ref>
      <ref id="ref8">
        <mixed-citation>
          8.
          <string-name>
            <surname>David</surname>
            <given-names>A.</given-names>
          </string-name>
          <string-name>
            <surname>Ferrucci</surname>
          </string-name>
          .
          <source>Ibm's Watson/Deepqa. SIGARCH Comput. Archit. News</source>
          ,
          <volume>39</volume>
          (
          <issue>3</issue>
          ):{,
          <year>June 2011</year>
          .
        </mixed-citation>
      </ref>
      <ref id="ref9">
        <mixed-citation>
          9.
          <string-name>
            <given-names>Konrad</given-names>
            <surname>Ho</surname>
          </string-name>
          <article-title> ner and Jens Lehmann. Towards Question Answering on Statistical Linked Data</article-title>
          .
          <source>In Proceedings of the 10th International Conference on Semantic Systems, SEM '14</source>
          , pages
          <fpage>61</fpage>
          {
          <fpage>64</fpage>
          , New York, NY, USA,
          <year>2014</year>
          . ACM.
        </mixed-citation>
      </ref>
      <ref id="ref10">
        <mixed-citation>
          10.
          <string-name>
            <surname>Warren</surname>
            <given-names>A.</given-names>
          </string-name>
          <string-name>
            <surname>Kibbe</surname>
            , Cesar Arze, Victor Felix, Elvira Mitraka, Evan Bolton, Gang Fu,
            <given-names>Christopher J.</given-names>
          </string-name>
          <string-name>
            <surname>Mungall</surname>
          </string-name>
          ,
          <string-name>
            <surname>Janos</surname>
            <given-names>X.</given-names>
          </string-name>
          <string-name>
            <surname>Binder</surname>
          </string-name>
          , James Malone, Drashtti Vasant, Helen Parkinson, and
          <string-name>
            <surname>Lynn</surname>
            <given-names>M.</given-names>
          </string-name>
          <string-name>
            <surname>Schriml</surname>
          </string-name>
          .
          <source>Disease Ontology 2015 update: An Expanded</source>
          and
          <article-title>Updated Database of Human Diseases for Linking Biomedical Knowledge through Disease Data</article-title>
          .
          <source>Nucleic Acids Research</source>
          ,
          <volume>43</volume>
          (
          <issue>D1</issue>
          )
          <article-title>:D1071{D1078</article-title>
          ,
          <year>January 2015</year>
          .
        </mixed-citation>
      </ref>
      <ref id="ref11">
        <mixed-citation>
          11.
          <string-name>
            <surname>Minsuk</surname>
            <given-names>Lee</given-names>
          </string-name>
          , James Cimino, Hai Ran Zhu, Carl Sable, Vijay Shanker, John Ely, and
          <string-name>
            <given-names>Hong</given-names>
            <surname>Yu</surname>
          </string-name>
          .
          <article-title>Beyond Information RetrievalMedical Question Answering</article-title>
          .
          <source>In AMIA annual symposium proceedings</source>
          , volume
          <year>2006</year>
          , page 469. American Medical Informatics Association,
          <year>2006</year>
          .
        </mixed-citation>
      </ref>
      <ref id="ref12">
        <mixed-citation>
          12.
          <string-name>
            <surname>Christopher D. Manning</surname>
          </string-name>
          , Prabhakar Raghavan, and Hinrich Schutze. Introduction to Information Retrieval. Cambridge University Press, New York, NY, USA,
          <year>2008</year>
          .
        </mixed-citation>
      </ref>
      <ref id="ref13">
        <mixed-citation>
          13.
          <string-name>
            <surname>Yuqing</surname>
            <given-names>Mao</given-names>
          </string-name>
          ,
          <string-name>
            <surname>Chih-Hsuan Wei</surname>
            , and
            <given-names>Zhiyong</given-names>
          </string-name>
          <string-name>
            <surname>Lu</surname>
          </string-name>
          .
          <article-title>NCBI at the 2014 BioASQ challenge task: Large-scale Biomedical Semantic Indexing and Question Answering</article-title>
          . In Working Notes for CLEF 2014 Conference,
          <article-title>She eld</article-title>
          ,
          <source>UK, September 15-18</source>
          ,
          <year>2014</year>
          ., pages
          <volume>1319</volume>
          {
          <fpage>1327</fpage>
          ,
          <year>2014</year>
          .
        </mixed-citation>
      </ref>
      <ref id="ref14">
        <mixed-citation>
          14.
          <string-name>
            <surname>Sparsh</surname>
            <given-names>Mittal</given-names>
          </string-name>
          , Saket Gupta, Ankush Mittal, and
          <string-name>
            <given-names>Sumit</given-names>
            <surname>Bhatia</surname>
          </string-name>
          .
          <article-title>Bioinqa: Addressing Bottlenecks of Biomedical Domain through Biomedical Question Answering System</article-title>
          .
          <source>In The International Conference on Systemics, Cybernetics and Informatics (ICSCI-2008)</source>
          , pages
          <fpage>98</fpage>
          {
          <fpage>103</fpage>
          ,
          <year>2008</year>
          .
        </mixed-citation>
      </ref>
      <ref id="ref15">
        <mixed-citation>
          15.
          <string-name>
            <surname>Jun-Ping Ng</surname>
          </string-name>
          and
          <string-name>
            <surname>Min-Yen Kan</surname>
          </string-name>
          .
          <article-title>QANUS: An Open-Source Question-Answering Platform</article-title>
          .
          <source>arXiv preprint arXiv:1501.00311</source>
          ,
          <year>2015</year>
          .
        </mixed-citation>
      </ref>
      <ref id="ref16">
        <mixed-citation>
          16.
          <string-name>
            <surname>Stefan</surname>
            <given-names>Schulz</given-names>
          </string-name>
          ,
          <string-name>
            <given-names>Martin</given-names>
            <surname>Honeck</surname>
          </string-name>
          , and
          <string-name>
            <given-names>Udo</given-names>
            <surname>Hahn</surname>
          </string-name>
          .
          <article-title>Biomedical Text Retrieval in Languages with a Complex Morphology</article-title>
          .
          <source>In Proceedings of the ACL-02 workshop on Natural language processing in the biomedical domain-Volume</source>
          <volume>3</volume>
          , pages
          <fpage>61</fpage>
          {
          <fpage>68</fpage>
          . Association for Computational Linguistics,
          <year>2002</year>
          .
        </mixed-citation>
      </ref>
      <ref id="ref17">
        <mixed-citation>
          17.
          <string-name>
            <surname>George</surname>
            <given-names>Tsatsaronis</given-names>
          </string-name>
          , Georgios Balikas, Prodromos Malakasiotis, Ioannis Partalas, Matthias Zschunke, Michael R Alvers, Dirk Weissenborn, Anastasia Krithara, Sergios Petridis,
          <string-name>
            <given-names>Dimitris</given-names>
            <surname>Polychronopoulos</surname>
          </string-name>
          , et al.
          <article-title>An Overview of the BioASQ LargeScale Biomedical Semantic Indexing and Question Answering Competition</article-title>
          .
          <source>BMC bioinformatics</source>
          ,
          <volume>16</volume>
          (
          <issue>1</issue>
          ):
          <fpage>138</fpage>
          ,
          <year>2015</year>
          .
        </mixed-citation>
      </ref>
      <ref id="ref18">
        <mixed-citation>
          18. Menno van Zaanen.
          <article-title>Multi-Lingual Question Answering using OpenEphyra</article-title>
          .
          <source>In Working Notes of CLEF</source>
          <year>2008</year>
          ,
          <year>2008</year>
          .
        </mixed-citation>
      </ref>
      <ref id="ref19">
        <mixed-citation>
          19.
          <string-name>
            <surname>Dirk</surname>
            <given-names>Weissenborn</given-names>
          </string-name>
          , George Tsatsaronis, and
          <string-name>
            <given-names>Michael</given-names>
            <surname>Schroeder</surname>
          </string-name>
          .
          <article-title>Answering Factoid Questions in the Biomedical Domain</article-title>
          . In
          <string-name>
            <surname>Axel-Cyrille Ngonga</surname>
          </string-name>
          Ngomo and George Paliouras, editors,
          <source>BioASQ@CLEF</source>
          , volume
          <volume>1094</volume>
          <source>of CEUR Workshop Proceedings. CEUR-WS.org</source>
          ,
          <year>2013</year>
          .
        </mixed-citation>
      </ref>
    </ref-list>
  </back>
</article>