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  <front>
    <journal-meta />
    <article-meta>
      <title-group>
        <article-title>Supporting Navigated Surgery with Pan-Tilt Controlled Laser Pointer</article-title>
      </title-group>
      <contrib-group>
        <contrib contrib-type="author">
          <string-name>L. Chen</string-name>
          <email>longquan.chen@uni-bremen.de</email>
          <xref ref-type="aff" rid="aff1">1</xref>
        </contrib>
        <contrib contrib-type="author">
          <string-name>D. Ojdanić</string-name>
          <xref ref-type="aff" rid="aff0">0</xref>
        </contrib>
        <contrib contrib-type="author">
          <string-name>K. Michels</string-name>
          <xref ref-type="aff" rid="aff1">1</xref>
        </contrib>
        <contrib contrib-type="author">
          <string-name>H.О. Peitgen</string-name>
          <xref ref-type="aff" rid="aff0">0</xref>
        </contrib>
        <aff id="aff0">
          <label>0</label>
          <institution>Fraunhofer MEVIS</institution>
          ,
          <addr-line>Bremen</addr-line>
          ,
          <country>Germany Contact:</country>
        </aff>
        <aff id="aff1">
          <label>1</label>
          <institution>University Bremen, Institute of Automation</institution>
          ,
          <addr-line>Bremen</addr-line>
          ,
          <country country="DE">Germany</country>
        </aff>
      </contrib-group>
      <pub-date>
        <year>2011</year>
      </pub-date>
      <fpage>3</fpage>
      <lpage>6</lpage>
      <abstract>
        <p>This work introduces a laser guidance system for improving the performance of surgical navigation. It consists of a laser pointer mounted on a pan-tilt platform calibrated with the tracking system from the navigation platform. With two pan-tilt rotation axes, the laser beam of a green laser pointer can reach any location in 3D space. The calibration between the pan-tilt platform and the tracking system is done by using Levenberg-Marquardt and Least-Squares Estimation of Transformation algorithms. The registration between organ and 3D virtual model is obtained by the tracking system and therefore, the laser is also implicitly registered. Therefore, important points or the resection path of the 3D model can be projected precisely on the surface of the organ with the laser pointer.</p>
      </abstract>
    </article-meta>
  </front>
  <body>
    <sec id="sec-1">
      <title>Problem</title>
    </sec>
    <sec id="sec-2">
      <title>Methods</title>
      <sec id="sec-2-1">
        <title>Modeling</title>
        <p>The transformation matrix between the laser pointer and the mounting plate is calculated using the following method
(explained in figure2): Rotate the pan-tilt axes so that the laser beam points at the grid board and record the coordinates
of this point with respect to the base of the pan-tilt platform, after which the coordinates of this point with respect to the
mounting plate can be calculated using the rotation angles. The tracking system is used to measure the distance between
the pointer outlet and the point on the board, and the distance can represent the coordinates of this point in the laser
coordinate system. In the same way, acquire coordinates of four points in both coordinate systems. Thereafter, using the
least-squares estimation of transformation algorithm [4], the transformation matrix between the laser pointer and the
mounting plate on the pan-tilt platform can be calculated. After modeling, the whole pan-tilt platform will be mounted
on the navigation system.</p>
      </sec>
      <sec id="sec-2-2">
        <title>Calibration</title>
        <p>At the beginning of the process, the registration between the tracking system and the 3D model is achieved by matching
two point patterns acquired in both coordinate systems.</p>
        <p>To acquire the transformation matrix between the tracking system and the pan-tilt platform, the coordinates of four
points in both coordinate systems should be obtained. The key problem of this project is to calculate the coordinates of
four points in the pan-tilt coordinate system.</p>
        <p>The solution is this: The laser pointer points at four arbitrary points one by one (showed in figure 4); the angles of two
rotation axes with respect to each point are received from the pan-tilt platform. Simultaneously, use the tracking
instrument to acquire the coordinates of each point with respect to the tracking coordinate system. Then the distances of
any two points can be calculated using the acquired coordinates.</p>
        <p>Knowing the distances and angles, six equations with four variables {KA, KB, KC, KD} can be formulated. To solve this
nonlinear over-determined equation set, the Levenberg-Marquardt algorithm is used [5]. After calculating {KA, KB, KC,
KD}, the coordinates of these four points with respect to the pan-tilt base can be calculated using angle information
again.</p>
        <p>Finally, as the coordinates of these four points in both coordinate systems are available, the calibration of pan-tilt
platform and tracking system is achieved by using the least-squares estimation of transformation algorithm.
Registration of</p>
        <p>tracking
system and 3D</p>
        <p>model</p>
        <p>Laser beam points
at 4 points one by</p>
        <p>one</p>
        <p>Tracking
system reads
the coordinate</p>
        <p>Get the
rotation angles
of pan-tilt
platform</p>
        <p>Calculate
distances
between any
two points</p>
        <p>Apply
LevenbergMarquardt
method</p>
        <p>The coordinates
of 4 points in
pan-tilt platform</p>
        <p>Calibration of
pan-tilt platform
and tracking
system
To evaluate the calibration, a millimetre grid board and a tracking instrument are used.</p>
        <p>The evaluation method is explained in figure 5: Put the tracking instrument on the cross of a millimetre board and make
the laser beam follow the instrument tip. Due to inaccuracy in modeling, calibration error, and resolution limits of the
pan-tilt platform, the laser beam will be shifted a slight amount from the instrument tip. The distance between the
instrument tip and the laser beam is defined as the error. Altogether, 144 measurements were recorded, for which six
calibrations were done. In each of the four predefined regions on the millimetre board, six errors were measured.</p>
        <p>The total average mean and variance of the 144 measurements are 1.21 mm and 0.045 mm2; however, the laser mark
has an elliptic size of 5 x 3 mm, which is much larger than the error. So, a better laser pointer will be used in the future
development to match the accuracy of the calibration.
4</p>
      </sec>
    </sec>
    <sec id="sec-3">
      <title>Discussion</title>
      <p>The proposed laser guidance system offers a meaningful improvement of navigation systems, in that the user can easily
see the critical points on the organ. The surgeon can choose a point on the 3D virtual model, for which the laser pointer
will efficiently display that point. Furthermore, the pointer can slowly follow a line marked on the virtual model, e.g.,
resection line, which gives seamless guidance for the surgeon. Also, visually assessing the registration error could fit
well in overall workflow: A visible organ landmark can be targeted with the laser pointer.</p>
      <p>Compared to a projector, the laser guidance system is not capable of showing the anatomy of the organ in detail.
However, it can compete with the brightness of the light in the operating room. From another point of view, the laser
system can complement a projector.</p>
      <p>Another open issue is the organ motion, which is often present in navigated surgery. Until now, only static models were
used in the lab environment. Further development of this system would take organ motion into account. If the motion is
known or measurable, registration could be updated in real time. In this way, the laser beam will synchronise with the
organ’s motion and continuously point at the defined target.
5</p>
    </sec>
  </body>
  <back>
    <ref-list>
      <ref id="ref1">
        <mixed-citation>
          <string-name>
            <surname>Hansen</surname>
          </string-name>
          , “
          <article-title>Illustrative Visualization of 3D Planning Models for Augmented Reality in Liver Surgery”</article-title>
          ,
          <source>International Journal of Computer Assisted Radiology and Surgery</source>
          , volume
          <volume>5</volume>
          ,
          <fpage>133</fpage>
          -
          <lpage>141</lpage>
          ,
          <year>2010</year>
          .
        </mixed-citation>
      </ref>
      <ref id="ref2">
        <mixed-citation>
          <string-name>
            <given-names>S</given-names>
            <surname>Lavall</surname>
          </string-name>
          <article-title>′ee</article-title>
          , J Troccaz,
          <string-name>
            <given-names>P</given-names>
            <surname>Sautot</surname>
          </string-name>
          , et al.,
          <article-title>“Computer-Assisted Spinal Surgery Using AnatomyBased Registration”</article-title>
          , The MIT Press, Cambridge, Massachusetts, pp.
          <fpage>425</fpage>
          -
          <lpage>449</lpage>
          ,
          <year>1996</year>
          .
        </mixed-citation>
      </ref>
      <ref id="ref3">
        <mixed-citation>
          <string-name>
            <given-names>Toshihiko</given-names>
            <surname>Sasama</surname>
          </string-name>
          , Nobuhiko Sugano, “
          <article-title>A Novel Laser Guidance System for Alignment of Linear Surgical Tools”</article-title>
          .
          <source>MICCAI</source>
          <year>2002</year>
          , LNCS 2489, pp.
          <fpage>125</fpage>
          -
          <lpage>132</lpage>
          ,
          <year>2002</year>
          .
        </mixed-citation>
      </ref>
      <ref id="ref4">
        <mixed-citation>
          <string-name>
            <given-names>Shinji</given-names>
            <surname>Umeyama</surname>
          </string-name>
          , “
          <article-title>Least-Squares Estimation of Transformation Parameters between Two Point Patterns”</article-title>
          ,
          <source>IEEE Transaction on Pattern Analysis and Machine Intelligence</source>
          ,
          <year>1991</year>
          .
        </mixed-citation>
      </ref>
      <ref id="ref5">
        <mixed-citation>
          <string-name>
            <surname>Ajoy K. Palit</surname>
          </string-name>
          , Dobrivoje Popovic, “Computational Intelligence in Time Series Forecasting”, Springer, 2005 Ruby Shamir, Ruby Shamir, “
          <article-title>An augmented reality guidance probe and method for image-guided surgical navigation”</article-title>
          ,
          <source>IEEE International symposium on robotics and automation</source>
          ,
          <source>ISRA'</source>
          <year>2006</year>
          ,
          <string-name>
            <surname>August</surname>
          </string-name>
          ,
          <year>2006</year>
          .
        </mixed-citation>
      </ref>
      <ref id="ref6">
        <mixed-citation>
          <string-name>
            <given-names>M.</given-names>
            <surname>Peterhans</surname>
          </string-name>
          ,
          <string-name>
            <given-names>A. Vom</given-names>
            <surname>Berg</surname>
          </string-name>
          ,
          <string-name>
            <given-names>B.</given-names>
            <surname>Dagon</surname>
          </string-name>
          ,
          <string-name>
            <given-names>D.</given-names>
            <surname>Inderbitzin</surname>
          </string-name>
          , “
          <article-title>A navigation system for open liver surgery: design, workflow and first clinical applications”</article-title>
          ,
          <source>The International Journal of Medical Robotics and Computer Assisted Surgery</source>
          , Volume
          <volume>7</volume>
          ,
          <issue>Issue1</issue>
          , page 7-16, March,
          <year>2011</year>
          .
        </mixed-citation>
      </ref>
    </ref-list>
  </back>
</article>