<!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Archiving and Interchange DTD v1.0 20120330//EN" "JATS-archivearticle1.dtd">
<article xmlns:xlink="http://www.w3.org/1999/xlink">
  <front>
    <journal-meta />
    <article-meta>
      <title-group>
        <article-title>Cadaveric validation of a novel planning and navigation system for peri-acetabular osteotomy (PAO)</article-title>
      </title-group>
      <contrib-group>
        <contrib contrib-type="author">
          <string-name>L. Liu</string-name>
          <email>li.liu@istb.unibe.ch</email>
          <xref ref-type="aff" rid="aff0">0</xref>
        </contrib>
        <contrib contrib-type="author">
          <string-name>T. Ecker</string-name>
          <xref ref-type="aff" rid="aff1">1</xref>
        </contrib>
        <contrib contrib-type="author">
          <string-name>S. Schumann</string-name>
          <xref ref-type="aff" rid="aff0">0</xref>
        </contrib>
        <contrib contrib-type="author">
          <string-name>K. Siebenrock</string-name>
          <xref ref-type="aff" rid="aff1">1</xref>
        </contrib>
        <contrib contrib-type="author">
          <string-name>L.-P. Nolte</string-name>
          <xref ref-type="aff" rid="aff0">0</xref>
        </contrib>
        <contrib contrib-type="author">
          <string-name>G. Zheng</string-name>
          <xref ref-type="aff" rid="aff0">0</xref>
        </contrib>
        <aff id="aff0">
          <label>0</label>
          <institution>Institute for Surgical Technology and Biomechanics, University of Bern</institution>
          ,
          <country country="CH">Switzerland</country>
        </aff>
        <aff id="aff1">
          <label>1</label>
          <institution>Orthopaedic Department, Inselspital, University of Bern</institution>
          ,
          <country country="CH">Switzerland</country>
        </aff>
      </contrib-group>
      <fpage>26</fpage>
      <lpage>29</lpage>
      <abstract>
        <p>This paper presents a cadaveric validation of a novel planning and navigation system for peri-acetabular osteotomy (PAO). In total 8 computer assisted PAO procedures was performed on 4 cadavers (each cadaver has two hip joints). By comparing the pre-operatiely planned situation and the intra-operatively achieved situation, an average error of 0.65°, 0.56° and 0.91° was found respectively along three motion components: External Rotation/Internal Rotation, Abduction/Adduction and Extension/Flexion.</p>
      </abstract>
      <kwd-group>
        <kwd>Peri-acetabular Osteotomy</kwd>
        <kwd>Navigation</kwd>
        <kwd>Validation</kwd>
      </kwd-group>
    </article-meta>
  </front>
  <body>
    <sec id="sec-1">
      <title>Introduction</title>
      <p>PAO planning module. The aim of this module is to allow the virutal simulation of the reorientation
procedure using the surface models generated from the model generation module. It starts with a fully automatic
detection of the acetabular rim, which allows for computing important information quantifying the
acetabular orientation such as coverage, extrusion index, lateral centre-edge (LCE) angle, version and
inclination. This module provides a graphical user interface allowing the surgeon to conduct a virtual
osteoomy and to further reorient the acetabular fragment until an optimal realignment is achieved.</p>
      <p>Intra-operative navigation module. Based on an optoelectronical tracking technique, this module aims for
providing intra-operative visual feedback during acetabular fragment reorientation until the pre-operatively
planned orientation is achieved.</p>
      <p>In order to validate this newly developed planning and navigation system for PAO, a cadaveric study was conducted.
In total 8 computer assisted PAO procedures was performed on 4 cadavers (each cadaver has two hip joints).
Preoperative planning was conducted with the PAO planning module. Subsequently the intra-operative navigation
module was used to track acetabular and pelvic fragments, supporting and guiding the surgeon during the
osteotomies around the acetabulum. After separation of the acetabular fragment from the pelvis, the navigation system then
guided the surgeon during the reorientation of the acetabulum until the pre-operative plan was achieved. Acetabular
reorientation measured by the version and inclination Angle can be planned preoperatively and subsequently
realized intraoperatively without significant difference. In order to assess the error difference between the
preoperatively planned and the intra-operatively achieved acetabular orientation, we compared the decomposed rotation
components derived from the acetabular fragment reorientation between the planned and intra-operative situations
because the instant version and inclination Angle correspond a specific decomposed rotation components of
acetabular fragment.
3</p>
    </sec>
    <sec id="sec-2">
      <title>Results</title>
      <p>As shown in Fig.2, the decomposed rotation components of the acetabular fragment between the pre-operatively
planned situation and the intra-operatively achieved situation were compared. According to Table 1, 8 groups of
acetabular reorientation data were obtained. It can be seen that the average errors along three motion components
(External Rotation/Internal Rotation, Abduction/Adduction and Extension/Flexion ) are 0.65°, 0.56° and 0.91°,
respectively, which are accurate enough for PAO surgical intervention. The maximal error is from the 4th cadaver with
the biggest registration error. It was found that the 4th cadaver has prosthesis implanted, which made it difficult to
segment high quality model from its CT data. This is why mean error of the 4th cadaver is slightly worse than those
of the rest of cadavers.
Cadaver1
Cadaver2
Cadaver3
Cadaver4
left hip
right hip
left hip
right hip
left hip
right hip
left hip
right hip</p>
    </sec>
    <sec id="sec-3">
      <title>Conclusions</title>
      <p>In this paper, we present a cadaveric validation of a comprehensive planning and navigation system for PAO. Our
experimental results demonstrate the accuracy of this newly developed system. A clinical trial is planned to further
validate the effacicy of the developed system for PAO interventions. Our experimental results demonstrated that
there is no significant difference between the pre-operatively planned and final intra-operative acetabular
orientation, measured by decomposed rotation angles. We concluded that preoperative planning and subsequent conduction
of acetabular reorientaion in PAO is technically feasible and is associated with good accuracy in the experimental
cadaveric setup.
5</p>
    </sec>
  </body>
  <back>
    <ref-list>
      <ref id="ref1">
        <mixed-citation>
          <string-name>
            <surname>Murphy</surname>
            <given-names>SB</given-names>
          </string-name>
          ,
          <string-name>
            <surname>Millis</surname>
            <given-names>MB</given-names>
          </string-name>
          ,
          <string-name>
            <surname>Hall</surname>
            <given-names>JE</given-names>
          </string-name>
          ,
          <article-title>Surgical correction of acetabular dysplasia in the adult. A Boston experience</article-title>
          ,
          <source>Clin Orthop</source>
          ,
          <volume>363</volume>
          :
          <fpage>38</fpage>
          -
          <lpage>44</lpage>
          (
          <year>1999</year>
          )
          <string-name>
            <surname>Ganz</surname>
            <given-names>R</given-names>
          </string-name>
          ,
          <string-name>
            <surname>Klaue</surname>
            <given-names>K</given-names>
          </string-name>
          ,
          <string-name>
            <surname>Vinh</surname>
            <given-names>T</given-names>
          </string-name>
          ,
          <string-name>
            <surname>Mast</surname>
            <given-names>J</given-names>
          </string-name>
          ,
          <article-title>A new periacetabular osteotomy for the treatment of hip dysplasia. Technique and preliminary results</article-title>
          ,
          <source>Clin Orthop</source>
          ,
          <volume>232</volume>
          :
          <fpage>26</fpage>
          -
          <lpage>36</lpage>
          (
          <year>1988</year>
          )
          <string-name>
            <surname>Hipp</surname>
            <given-names>JA</given-names>
          </string-name>
          ,
          <string-name>
            <surname>Sugano</surname>
            <given-names>N</given-names>
          </string-name>
          ,
          <string-name>
            <surname>Millis</surname>
            <given-names>MB</given-names>
          </string-name>
          ,
          <string-name>
            <surname>Murphy</surname>
            <given-names>SB</given-names>
          </string-name>
          ,
          <article-title>Planning acetabular redirection osteotomies based on joint contact pressures</article-title>
          ,
          <source>Clin Orthop</source>
          ,
          <volume>364</volume>
          :
          <fpage>134</fpage>
          -
          <lpage>142</lpage>
          (
          <year>1999</year>
          )
          <article-title>Crockaress</article-title>
          J Jr,
          <string-name>
            <surname>Trousdale</surname>
            <given-names>RT</given-names>
          </string-name>
          ,
          <string-name>
            <surname>Cabanela</surname>
            <given-names>ME</given-names>
          </string-name>
          ,
          <string-name>
            <surname>Berry</surname>
            <given-names>DJ</given-names>
          </string-name>
          ,
          <article-title>Early experience and results with the periacetabular osteotomy</article-title>
          .
          <source>The Mayo Clinic experience, Clin Orthop</source>
          ,
          <volume>363</volume>
          :
          <fpage>45</fpage>
          -
          <lpage>53</lpage>
          (
          <year>1999</year>
          ) A.
          <string-name>
            <surname>C. Rodriguez</surname>
            ,
            <given-names>J.M.</given-names>
          </string-name>
          <string-name>
            <surname>Buckley</surname>
            ,
            <given-names>M.</given-names>
          </string-name>
          <string-name>
            <surname>Diab</surname>
            , and
            <given-names>S.</given-names>
          </string-name>
          <string-name>
            <surname>Burch</surname>
          </string-name>
          ,
          <article-title>An Evaluation of the Accuracy of Computer Assisted Surgery in Preoperatively Three Dimensionally Planned Periacetabular Osteotomies</article-title>
          ,
          <source>in 56th Annual Meeting of the Orthopaedic Research Society</source>
          .
          <year>2009</year>
          : New Orleans.
        </mixed-citation>
      </ref>
      <ref id="ref2">
        <mixed-citation>
          <string-name>
            <surname>P.H. Hsieh</surname>
            ,
            <given-names>Y.H.</given-names>
          </string-name>
          <string-name>
            <surname>Chang</surname>
            , and
            <given-names>C.H.</given-names>
          </string-name>
          <string-name>
            <surname>Shih</surname>
          </string-name>
          ,
          <article-title>Image-guided periacetabular osteotomy: computer-assisted navigation compared with the conventional technique: a randomized study of 36 patients followed for 2 years</article-title>
          .
          <source>Acta Orthop</source>
          ,
          <volume>77</volume>
          (
          <issue>4</issue>
          ):
          <fpage>591</fpage>
          -
          <lpage>597</lpage>
          (
          <year>2006</year>
          )
          <string-name>
            <given-names>M.</given-names>
            <surname>Jäger</surname>
          </string-name>
          ,
          <string-name>
            <given-names>B.</given-names>
            <surname>Westhoff</surname>
          </string-name>
          ,
          <string-name>
            <given-names>A.</given-names>
            <surname>Wild</surname>
          </string-name>
          , and
          <string-name>
            <given-names>R.</given-names>
            <surname>Krauspe</surname>
          </string-name>
          ,
          <article-title>Computer-assisted periacetabular triple osteotomy for treatment of dysplasia of the hip</article-title>
          .
          <source>Z Orthop Ihre Grenzgeb</source>
          ,
          <volume>142</volume>
          (
          <issue>1</issue>
          ):
          <fpage>51</fpage>
          -
          <lpage>59</lpage>
          (
          <year>2004</year>
          )
          <string-name>
            <surname>Langlotz</surname>
            <given-names>F</given-names>
          </string-name>
          ,
          <string-name>
            <surname>Bachler</surname>
            <given-names>R</given-names>
          </string-name>
          ,
          <string-name>
            <surname>Berlemann</surname>
            <given-names>U</given-names>
          </string-name>
          ,
          <string-name>
            <surname>Nolte</surname>
            <given-names>LP</given-names>
          </string-name>
          ,
          <string-name>
            <surname>Ganz</surname>
            <given-names>R</given-names>
          </string-name>
          , Computer assistance for pelvic osteotomies,
          <source>Clin Orthop</source>
          ,
          <volume>354</volume>
          :
          <fpage>92</fpage>
          -
          <lpage>102</lpage>
          (
          <year>1998</year>
          )
        </mixed-citation>
      </ref>
    </ref-list>
  </back>
</article>