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  <front>
    <journal-meta />
    <article-meta>
      <title-group>
        <article-title>Semantically-enabled Personal Medical Information Recommender</article-title>
      </title-group>
      <contrib-group>
        <contrib contrib-type="author">
          <string-name>Haridimos Kondylakis</string-name>
          <email>kondylak@ics.forth.gr</email>
          <xref ref-type="aff" rid="aff0">0</xref>
        </contrib>
        <contrib contrib-type="author">
          <string-name>Lefteris Koumakis</string-name>
          <email>koumakis@ics.forth.gr</email>
          <xref ref-type="aff" rid="aff0">0</xref>
        </contrib>
        <contrib contrib-type="author">
          <string-name>Maria Psaraki</string-name>
          <email>psaraki@ics.forth.gr</email>
          <xref ref-type="aff" rid="aff0">0</xref>
        </contrib>
        <contrib contrib-type="author">
          <string-name>Georgia Troullinou</string-name>
          <email>troullin@ics.forth.gr</email>
          <xref ref-type="aff" rid="aff0">0</xref>
        </contrib>
        <contrib contrib-type="author">
          <string-name>Maria Chatzimina</string-name>
          <email>hatzimin@ics.forth.gr</email>
          <xref ref-type="aff" rid="aff0">0</xref>
        </contrib>
        <contrib contrib-type="author">
          <string-name>Eleni Kazantzaki Kostas Marias</string-name>
          <email>elenikaz@ics.forth.gr</email>
          <xref ref-type="aff" rid="aff0">0</xref>
        </contrib>
        <contrib contrib-type="author">
          <string-name>Manolis Tsiknakis</string-name>
          <email>tsiknaki@ics.forth.gr</email>
          <xref ref-type="aff" rid="aff0">0</xref>
        </contrib>
        <aff id="aff0">
          <label>0</label>
          <institution>Institute of Computer Science</institution>
          ,
          <addr-line>FORTH, Heraklion, Crete</addr-line>
          ,
          <country country="GR">Greece</country>
        </aff>
      </contrib-group>
      <pub-date>
        <year>2011</year>
      </pub-date>
      <abstract>
        <p>Word wide web has become the first choice of patients to inform themselves about their disease, side effects and possible treatments. While patient's knowledge from internet is widely regarded as having a positive influence on the treatment, a lot of criticism exists for the quality and the diversity of the available information. In this paper we demonstrate the Personal Medical Information Recommender (PMIR), a semantically-enabled, intelligent platform that empowers patients to search in a high quality set of web documents for relevant medical knowledge. In addition, the platform automatically provides intelligent and personalized recommendations, according to the individual preferences and medical conditions. To demonstrate the platform example patients will be used to show the functionality of the system. Then we will allow conference participants to directly interact with the system to test its capabilities.</p>
      </abstract>
    </article-meta>
  </front>
  <body>
    <sec id="sec-1">
      <title>-</title>
      <p>
        During the last decade, the number of users who look for health and medical
information has dramatically increased. However despite the increase in those numbers and
the vast amount of information currently available online, one important challenge is
the problem of the quality and the amount of information that can be found online [
        <xref ref-type="bibr" rid="ref1">1</xref>
        ].
It is widely accepted that it is very hard for a patient to accurately judge the relevance
of some information to his own case.
      </p>
      <p>
        Although similar approaches exist already, on the e-Health (such as WebMD
(www.webmd.com) and HONSearch (www.hon.ch/HONsearch/Patients/)) and other
domains [
        <xref ref-type="bibr" rid="ref2">2</xref>
        ], they are not dynamically adapted according to patient’s preferences or
his/her medical record. In this paper we demonstrate a Personal Medical Information
Recommender (PMIR). PMIR [
        <xref ref-type="bibr" rid="ref3 ref4 ref5">3-5</xref>
        ] is targeted at improving the opportunities that
patients have to inform themselves in the internet about their disease and possible
treatments, and providing to them personalized information and recommendations. The
PMIR is integrated into an existing personal health record (PHR) as a set of individual
apps. One of those apps is the Document Registry app which medical experts are using
to register and annotate high-quality web documents. Then, the patient is able to select
the PMIR search app to look for useful information. In addition, as the patient logs in
to his PHR account, automatically, appropriate useful documents are recommended to
him by the Automatic Recommendation app. Both the search engine and the automatic
recommendation mechanism exploit the individual patient profile and patient
preferences to provide personalized information. To the best of our knowledge PMIR is the
only platform that exploits individual patient’s profiles to provide recommendations.
2
      </p>
    </sec>
    <sec id="sec-2">
      <title>Architecture</title>
      <p>frequency of the annotations in the document and the collection. On the other hand user
requests are represented as vectors r = (w1,Q,…, wt,Q, w1,P,…, wm,P, w1,I, …, wn,I,) where
wj,Q is a weight for the jth annotation of the input query Q, wiP is a weight for the ith
annotation of patient profile P and wkI is the weight of the inferred annotations I.
Weights wk,Q and wmP are calculated based on the term frequency inverse document
frequency of the annotations in the collection and patient profiles respectively.
Concerning the inferred annotations, for each annotation on the user query and the profile
we call Semantic Reasoning service to get its three super-classes and sub-classes that
are similarly used for matching annotations in documents.</p>
      <p>The documents are first ranked by the cosine of the angle between the document
vectors and the request vector, and these weights are multiplied by preference weights
that change the order of the presented results. The preference weights are calculated
based on personalized preferences (user clicks and ratings). Finally, documents with
low similarity (below a threshold) are discarded, so as to exclude irrelevant document.
Null queries can be submitted as well, that correspond to retrieval of documents
pertaining to the medical record and the patient’s preferences. This is used when calling
the Automatic Recommendation App. Finally when no preferences are available (the
cold start problem) they are not considered for recommendations.
3</p>
    </sec>
    <sec id="sec-3">
      <title>Demonstration &amp; Conclusion</title>
      <p>To demonstrate the functionalities of the PMIR system, dummy patients will be used.
A first prototype of the Demo is online (http://139.91.210.42/ - login: peter, password:
peter123 and select the Recommender App). A richer and more stable version of the
platform is about to be released. The demonstration will proceed in five phases, the
main components of which are shown in Fig. 2: (1) Semantic Annotator: The
demonstration will start by presenting the app that the medical experts are using to register,
delete and modify external documents that contain useful information to a targeted set
of patients. The annotations performed automatically will be explained and some
examples will be presented. (2) Patient Medical Record: Then, the demonstration will
proceed by presenting the information a dummy patient has already stored in his
account and how this information is also annotated using the semantic annotator service.
(3) Semantic Search Engine: In this phase, we will search for useful information using
the semantic search engine. Modifications will be performed to the patient profile and
then the adaptation of these results according to the modified patient profile will be
demonstrated. In addition some results will be rated and clicked and the change in the
order of the results will also be shown. (4) Intelligent Recommendations: Besides
allowing the patient to search information by himself we will also present some
recommendations proposed to him automatically. Again, we will demonstrate how these
recommendations are adapted dynamically by changing the profile of the user. (5)
Handson” phase: In this phase conference participants will be invited to directly interact with
the system, either guided or by accessing the online PHR system using their laptops.
To conclude, in this demonstration, we present a new platform that focuses on making
the available information timelier and more relevant with respect to dynamic influences
in the individual patient's treatment. The idea is that even if two patients suffer from
the same disease and they are in the same phase of the treatment, their interests on
available information may differ based on various factors such as additional
comorbidities, patient preferences etc. We demonstrate our platform and allow the
direct participation of the conference participants to test its capabilities. The extensive
evaluation performed shows excellent result that will be published in a follow-up paper.
To the best of our knowledge no other system, providing medical information, is able
to be dynamically adapted in such a diverse environment.</p>
      <p>Acknowledgments.</p>
      <p>This work was partially supported by the iManageCancer (H2020-643529), the
pMedicine (FP7-270089) and the EURECA (FP7-288048) EU projects
4</p>
    </sec>
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