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  <front>
    <journal-meta />
    <article-meta>
      <title-group>
        <article-title>AberOWL: an ontology portal with OWL EL reasoning</article-title>
      </title-group>
      <contrib-group>
        <contrib contrib-type="author">
          <string-name>Luke Slater</string-name>
          <email>luke.slater@kaust.edu.sa</email>
          <xref ref-type="aff" rid="aff0">0</xref>
        </contrib>
        <contrib contrib-type="author">
          <string-name>Georgios V Gkoutos</string-name>
          <xref ref-type="aff" rid="aff1">1</xref>
        </contrib>
        <contrib contrib-type="author">
          <string-name>Paul N Schofield</string-name>
          <xref ref-type="aff" rid="aff2">2</xref>
        </contrib>
        <contrib contrib-type="author">
          <string-name>Robert Hoehndorf</string-name>
          <xref ref-type="aff" rid="aff0">0</xref>
        </contrib>
        <aff id="aff0">
          <label>0</label>
          <institution>Computational Bioscience Research Center, King Abdullah University of Science and Technology</institution>
          ,
          <addr-line>4700 KAUST, 23955-6900, Thuwal</addr-line>
          ,
          <country country="SA">Saudi Arabia</country>
        </aff>
        <aff id="aff1">
          <label>1</label>
          <institution>Department of Computer Science, Aberystwyth University</institution>
          ,
          <addr-line>Aberystwyth, SY23 3DB, Wales</addr-line>
          ,
          <country country="UK">United Kingdom</country>
        </aff>
        <aff id="aff2">
          <label>2</label>
          <institution>Department of Physiology, Development and Neuroscience, University of Cambridge</institution>
          ,
          <addr-line>Downing Street, CB2 3EG, England</addr-line>
          ,
          <country country="UK">United Kingdom</country>
        </aff>
      </contrib-group>
      <pub-date>
        <year>2015</year>
      </pub-date>
      <abstract>
        <p>The field of biological and biomedical science quickly generate large quantities of data and knowledge; often, domain knowledge is formalised using ontologies expressed in the Web Ontology Language (OWL). Ontology repositories such as Bioportal and Ontobee have been an important infrastructural component for managing ontologies, specifically to search, browse and download ontologies over the Web. We present the AberOWL system, a novel ontology repository that allows access to multiple ontologies through automated reasoning, utilizing parts of the OWL of the ontologies alongside a web interface and web services. AberOWL contains over 300 ontologies and integrates reasoning over ontologies with access to literature and SPARQL endpoints.</p>
      </abstract>
    </article-meta>
  </front>
  <body>
    <sec id="sec-1">
      <title>1 INTRODUCTION</title>
      <p>
        Major ontology repositories such as BioPortal
        <xref ref-type="bibr" rid="ref12">(Noy et al., 2009)</xref>
        ,
OntoBee
        <xref ref-type="bibr" rid="ref22">(Xiang et al., 2011)</xref>
        , and the Ontology Lookup Service
        <xref ref-type="bibr" rid="ref2">(Cote et al., 2006)</xref>
        , have existed for a number of years, and
currently contain several hundred ontologies. They allow ontology
creators to upload, manage and release their work to the wider
community. For the end-user, they provide a web front-end for
browsing, comparing, visualising, downloading, searching, and
otherwise processing ontologies.
      </p>
      <p>One feature that the existing ontology repositories lack is to
utilize automated reasoning over ontologies to enrich the set of
services they provide. Automated reasoning over the axioms in the
ontologies enables the use of deductive inference when processing
an ontology, which can improve the utility of many services
provided by an ontology repository:</p>
      <p>Verify Consistency and coherence – The releases and updates
of ontologies can be automatically classified by the repository,
checking them for logical consistency and existence of
unsatisfiable classes, and informing the ontology maintainers and
the users of the result.</p>
      <p>
        Semantic Query – Searching can make use of inferred knowledge
‘created’ during the reasoning process. Furthermore, the results
can be integrated in retrieval of text documents or data
characterized with ontologies accessible through through public
SPARQL endpoints
        <xref ref-type="bibr" rid="ref1 ref18 ref21 ref8">(Jupp et al., 2014; The Uniprot Consortium,
2007; Belleau et al., 2008; Williams et al., 2012)</xref>
        .
      </p>
      <p>Versioning – Ontology versions can be compared semantically
based on the inferred knowledge.</p>
      <p>Reasoning API – Applications building on the platform have
access to classified data, and may build applications requiring
ontology semantics and inferred knowledge without having to
classify the ontology on the client-side.</p>
      <p>
        However, enabling automated reasoning over multiple ontologies
is a challenging task since automated reasoning can be highly
complex and costly in terms of time and memory consumption
        <xref ref-type="bibr" rid="ref19">(Tobies, 2000)</xref>
        . In particular, ontologies formulated in the Web
Ontology Language (OWL)
        <xref ref-type="bibr" rid="ref4">(Grau et al., 2008)</xref>
        can utilise
statements based on highly expressive description logics
        <xref ref-type="bibr" rid="ref7">(Horrocks
et al., 2000)</xref>
        , and therefore queries that utilise automated reasoning
cannot, in general, be guaranteed to finish in a reasonable amount
of time.
      </p>
      <p>
        Previous approaches to reasoning over a large set of ontologies
have often involved working with existing collections of ontologies,
usually from one of the large repositories such as Bioportal
        <xref ref-type="bibr" rid="ref16 ref3">(Del Vescovo et al., 2011; Sazonau et al., 2013)</xref>
        . Several approaches
have employed RDFS reasoning
        <xref ref-type="bibr" rid="ref13">(Patel-Schneider et al., 2004)</xref>
        for answering queries over Bioportal’s set of ontologies through
a SPARQL interface
        <xref ref-type="bibr" rid="ref14 ref15">(Salvadores et al., 2012, 2013)</xref>
        . However,
RDFS semantics is different from the semantics of OWL in which
most of the ontologies are formalized. Alternatively, systems such
as OntoQuery
        <xref ref-type="bibr" rid="ref20">(Tudose et al., 2013)</xref>
        provide access to ontologies
through automated reasoning but limit the number of ontologies.
      </p>
      <p>
        The AberOWL
        <xref ref-type="bibr" rid="ref6">(Hoehndorf et al., 2015)</xref>
        system is a novel
ontology repository which allows access to multiple ontologies
through automated reasoning, utilising the OWL semantics of the
ontologies. AberOWL mitigates the complexity challenge by using
a reasoner which supports only a subset of OWL (i.e., the OWL
EL profile
        <xref ref-type="bibr" rid="ref11">(Motik et al., 2009)</xref>
        ), ignoring ontology axioms and
queries that do not fall within this subset. This enables the provision
of polynomial-time reasoning, which is sufficiently fast for many
practical uses even when applied to large ontologies.
      </p>
      <p>In the demonstration, we will show AberOWL and its
functionality, highlighting the differences between our system
over traditional ontology repositories that do not utilize automated
reasoning.
2</p>
    </sec>
    <sec id="sec-2">
      <title>ABEROWL</title>
      <p>AberOWL consists of an ontology repository, web services which
facilitate semantic queries over specific ontologies or the entire set
of ontologies contained in the repository, and a user interface. It
aims to provide a full framework for interacting with ontologies
through an automated reasoner.
2.1</p>
      <sec id="sec-2-1">
        <title>AberOWL Server</title>
        <p>The core of AberOWL is a server which handles the loading,
classification of and interaction with ontologies, exposing its
Slater et al
functionality through a JSON REST API. Specifically, the
AberOWL server provides the possibility to query one or all
ontologies using the Manchester OWL Syntax. It also supports
classifying new ontologies and new versions of existing ontologies,
immediately making these available through the API.</p>
        <p>
          Additionally, the AberOWL server provides a searchable index
of all classes available in its set of ontologies, including class
labels, synonyms, description and other associated information. It
utilises an Apache Lucene
          <xref ref-type="bibr" rid="ref9">(Lucene, 2005)</xref>
          index to provide quick
searching for classes over the entire set of ontologies. Search over
the Lucene index is currently used to facilitate autocompletion in the
web interface and provide information about classes in the ontology.
2.2
        </p>
      </sec>
      <sec id="sec-2-2">
        <title>AberOWL Sync</title>
        <p>Another component of AberOWL scans existing ontology
repositories, such as BioPortal, and a set of URLs, for new
ontologies and new versions of existing ontologies. When a new
ontology or a new version of an ontology is found, a request is sent
to the AberOWL server to load the new ontology or to retrieve and
classify a new version of an existing ontology.
2.3</p>
      </sec>
      <sec id="sec-2-3">
        <title>AberOWL Repository</title>
        <p>The AberOWL repository is a web frontend to AberOWL which
interacts with the AberOWL server to provide a user interface for
querying ontologies, alongside features found in other ontology
repositories such as ontology upload, browsing of ontologies, and
downloading ontologies and their versions. New ontologies and
new versions of ontologies can be uploaded, after which they are
immediately classified by the AberOWL server and made available
for querying.</p>
        <p>The prime goal of the AberOWL repository is to have a
userinterface in which all structural information about ontologies is
derived in real time from the AberOWL reasoning server. Currently,
the interface can be used to upload and classify new ontologies,
browse and query ontologies, visualize ontology structure and
retrieve information on ontology classes.
3</p>
      </sec>
    </sec>
    <sec id="sec-3">
      <title>CONCLUSION AND FUTURE WORK</title>
      <p>In the future, we plan to improve AberOWL’s potential to retrieve
a single class based on search of the class’ metadata and axioms.
Furthermore, we intend to provide the possibility for the visual
comparison of ontology versions, utilizing automated reasoning to
show differences in the inferences that can be drawn from both
ontologies.</p>
      <p>A second area of research is to increase AberOWL’s integration
with biomedical data. In particular, we aim to more closely integrate
AberOWL with publicly available SPARQL endpoints to enable
access to these SPARQL endpoints through automated reasoning
over ontologies.</p>
    </sec>
    <sec id="sec-4">
      <title>ACKNOWLEDGEMENTS REFERENCES</title>
    </sec>
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