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    <journal-meta />
    <article-meta>
      <title-group>
        <article-title>Development of a discharge ontology to support postanesthesia discharge decision making</article-title>
      </title-group>
      <contrib-group>
        <contrib contrib-type="author">
          <string-name>Lucy L Wang</string-name>
          <email>lucylw@uw.edu</email>
          <xref ref-type="aff" rid="aff0">0</xref>
        </contrib>
        <contrib contrib-type="author">
          <string-name>Yong Choi</string-name>
          <xref ref-type="aff" rid="aff0">0</xref>
        </contrib>
        <aff id="aff0">
          <label>0</label>
          <institution>Department of Biomedical Informatics and Medical Education, School of Medicine, University of Washington</institution>
          ,
          <addr-line>850 Republican St, Seattle, WA 98195</addr-line>
          ,
          <country country="US">USA</country>
        </aff>
      </contrib-group>
      <pub-date>
        <year>2015</year>
      </pub-date>
      <abstract>
        <p>Postanesthesia discharge decision making is a challenging process due to the high complexity and variability of care provided to postoperative patients. We built an ontology-based decision support system that generates discharge recommendations for patients who have undergone surgical procedures. Discharge decisions are made based on patient vitals, symptoms, medical history and details of the surgical procedure. The output recommendations of our system can aid healthcare providers in discharge decision-making and potentially reduce readmissions due to improper discharge. This project demonstrates the potential uses of ontologies in medical decision support systems, especially in areas that use specific scoring guidelines to aid decision-making.</p>
      </abstract>
    </article-meta>
  </front>
  <body>
    <sec id="sec-1">
      <title>1 INTRODUCTION</title>
      <p>
        Evidence-based discharge decision making and planning is a
critical care process that can improve patient outcomes and reduce
readmission rates. Inappropriate discharge can cause additional
pain and suffering for patients and their families and consume
unnecessary hospital resources
        <xref ref-type="bibr" rid="ref2">(Anderson et al., 2011)</xref>
        . For surgical
procedures, the risks associated with early discharge may be even
higher. When planning for discharge, healthcare professionals have
to account for multiple variables such as age, vitals, comorbidities,
medications and social issues. A tool like the Aldrete scoring
system is commonly used to help healthcare professionals determine
when patients can be safely discharged
        <xref ref-type="bibr" rid="ref1">(Aldrete, 1995)</xref>
        . However,
there are no standardized guidelines routinely used by healthcare
professionals to assist them in making postoperative discharge
decisions. A knowledge-based decision support tool based on
standardized procedures can enhance discharge decision making
and reduce errors. In
        <xref ref-type="bibr" rid="ref3">Bouamrane et al., 2010</xref>
        , the authors built an
ontology to model preoperative domain knowledge. In this paper,
we use a similar approach to create a postoperative ontology-based
decision support system to assist discharge decision making.
      </p>
    </sec>
    <sec id="sec-2">
      <title>METHODS</title>
      <p>
        Our goal is to create an ontology to aid in post-surgery discharge
decision-making. Following surgery, patients generally go from
phase I postanesthesia care to phase II before being discharged
to home. Phase I care immediately follows surgery and involves
intensive monitoring of patient status. Phase II care is less intensive
and sees the patient recovering well from anesthesia. The goals
of our system are (i) to detect patients who may be suitable for
discharge, (ii) to determine the appropriate discharge workflow, and
(iii) to generate a list of additional recommendations for physicians.
Many clinics have specified their own modified criteria for
postanesthesia discharge. We begin by assembling resources
published online by various surgical units. Among these resources,
many are based on the Aldrete scoring system, with additional
modifications tailored to clinic-specific workflow. Criteria from
Stanford Hospital and Clinics, Loyola University Medical Center
and others are used to construct a global discharge rule set
        <xref ref-type="bibr" rid="ref4 ref6">(Stanford
Hospital and Clinics, 2010; Brown et al., 2008)</xref>
        . The
        <xref ref-type="bibr" rid="ref5">Phillips et al.,
2011</xref>
        systematic review of postanesthesia discharge protocols is also
used to determine levels of evidence for various scoring criteria.
Scoring guidelines present in all or most resources we studied are
included as criteria in our ontology-based decision support system.
      </p>
      <p>Based on the the criteria in these resources, we build a set of
SWRL rules, which in turn guides our development of an OWL
ontology. We first create a full set of postanesthesia discharge
criteria using information from our source documents. We then
translate these criteria into SWRL rule syntax to facilitate reasoning.
Afterwards, we use these rules to guide the creation of OWL classes,
as well as the definition of object and data properties.</p>
      <p>The modified Aldrete score, for example, consists of five primary
criteria: consciousness, respiration, circulation, movement and pain.
Some of these, such as respiration and circulation, can be broken
down further. For example, respiration consists of breathing quality,
breath rate and oxygen saturation.</p>
      <p>Aldrete subscores, along with the total score, are used as criteria
for discharge. For each Aldrete subscore, a patient receives a score
on a 2 point scale, where 0 means a low functional level and 2
means a normal functional level. We create a data property that
corresponds to each primary criteria. The value of this data property
is determined using SWRL rules and assigned to a patient based
on his/her current status in the system. An example data property
hasAldreteScoreConsciousness may take on the values of 0, 1 or 2
if the patient is unresponsive, responsive but drowsy, and responsive
and fully alert respectively.</p>
      <p>Another example is the circulation subscore, where the patient’s
blood pressure must fall within a pre-specified range from the
baseline blood pressure. Within 20 mmHg yields a score of 2,
within 20-50 mmHg yields a score of 1, and anything outside
of that range yields a score of 0. These specific differences can
be automatically calculated by our reasoner, which then assigns a
score to the patient. This reduces the need for healthcare workers to
perform time-consuming numerical calculations.</p>
      <p>An example SWRL rule for oxygen saturation is:
P atient(?pt); hasSpO2(?pt; ?SpO2); greaterT han(?SpO2; 95)
! hasAldreteScoreOxygen(?pt; 2)
which assigns 2 points to the Aldrete oxygen subscore if a
patient’s oxygen saturation is greater than 95%. The sum of points
assigned to all Aldrete criteria is then calculated and used to
determine whether a patient fits the basic criteria for discharge. If
a patient satisfies this condition, she/he is assigned into the class
DISCHARGE FROM PHASE I POSTANESTHETIC CARE.</p>
      <p>Our ontology classifies patients for discharge from phase I to
phase II care, as well as from phase II care to home. Additionally,
our discharge ontology makes recommendations for healthcare
provider actions. For example, a patient receiving a sciatic block
may require clutches at discharge (Figure 1), or a patient with
high pain levels may require additional pain management. These
recommendations can be used by healthcare providers to prioritize
patient care and to generate discharge notes.</p>
    </sec>
    <sec id="sec-3">
      <title>RESULTS &amp; DISCUSSION</title>
      <p>In this project, we demonstrated our work in building a
knowledgebased decision support system that generates decision support
recommendations to determine patient discharge eligibility after
surgical procedures. We were able to model appropriate discharge
decision making in several example patients (Figure 1). In addition
to making the correct discharge decision, our system also generates
a list of recommendations for clinicians which should be followed
before the actual discharge.</p>
      <p>Our decision support system operated with a number of
limitations. First of all, the recommendations and guidelines issued
by our system are constrained by the accuracy of the guidelines that
we modeled. Therefore, any errors or flaws present in the model
guidelines will be systematically replicated by our system. Also, due
to the lack of a standard discharge protocol, we could only capture
a representative set of criteria. Our ontology, therefore, may need to
be modified for use in any specific clinical environment.</p>
      <p>Additionally, we should align our system with pre-existing
medical ontologies for morbidity classification such as ICD-10 or
SNOMED-CT. We believe that such integration is critical for the
future interoperability of our system. Future work will also involve
extracting information from electronic health records or in-room
patient sensors (Figure 2) to increase the accuracy, timeliness and
reliability of patient medical data. Some obvious challenges to this
work are the semantic plurality of clinical data representation and
non-standard data exchange protocols between platforms.</p>
      <p>Another future direction is to expand our system to create
automated discharge summary notes to assist in the transition of
care. The discharge summary notes can be generated for two
groups of users: (1) healthcare professionals, and (2) patients and
caregivers. Discharge notes generated for healthcare professionals
can be used to facilitate continuity of care. Notes generated for
patients and caregivers can contain care instructions specifically
tailored to the patient to help guide them through the complex
post-discharge care process.
4</p>
    </sec>
    <sec id="sec-4">
      <title>CONCLUSION</title>
      <p>The discharge decision-making process relies on a set of predefined
clinical criteria that must be interpreted correctly to reach the
appropriate discharge decision. Our ontology integrates patient
vitals, symptoms, and surgical and medical information, and outputs
recommendations for discharge and healthcare provider actions.
This decision support tool could simplify postanesthesia discharge
procedures and may help reduce adverse events based on improper
or early discharge.</p>
    </sec>
    <sec id="sec-5">
      <title>ACKNOWLEDGEMENTS</title>
      <p>This study was supported in part by National Library of Medicine
(NLM) Training Grant T15LM007442.</p>
    </sec>
  </body>
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