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  <front>
    <journal-meta />
    <article-meta>
      <title-group>
        <article-title>KnowSense: A Semantically-enabled Pervasive Framework to Assist Clinical Autonomy Assessment</article-title>
      </title-group>
      <contrib-group>
        <contrib contrib-type="author">
          <string-name>Georgios Meditskos</string-name>
          <xref ref-type="aff" rid="aff0">0</xref>
        </contrib>
        <contrib contrib-type="author">
          <string-name>Thanos G. Stavropoulos</string-name>
          <xref ref-type="aff" rid="aff0">0</xref>
        </contrib>
        <contrib contrib-type="author">
          <string-name>Stelios Andreadis</string-name>
          <email>andreadisst@iti.gr</email>
          <xref ref-type="aff" rid="aff0">0</xref>
        </contrib>
        <contrib contrib-type="author">
          <string-name>Ioannis Kompatsiaris</string-name>
          <xref ref-type="aff" rid="aff0">0</xref>
        </contrib>
        <aff id="aff0">
          <label>0</label>
          <institution>Information Technologies Institute, Centre for Research and Technology Hellas</institution>
          ,
          <country country="GR">Greece</country>
        </aff>
      </contrib-group>
      <abstract>
        <p>The KnowSense framework, presented in this work, supports monitoring behavioral aspects of individuals in goal-oriented scenarios, within controlled, pervasive environments. Semantic Web technologies, such as OWL 2, are extensively employed in KnowSense to represent sensor observations and application domain specifics as well as to implement hybrid activity recognition and problem detection solutions. Although the framework can be beneficial in a variety of domains that require multi-sensing and goal-oriented data analytics such as smart homes, it is currently applied in the eminent field of healthcare. In this proof-of-concept health application, it provides the semantic models and intelligent detection of Instrumental Activities of Daily Living (IADLs) to assist in the clinical assessment of autonomy at different stages of dementia.</p>
      </abstract>
      <kwd-group>
        <kwd>ontologies</kwd>
        <kwd>rules</kwd>
        <kwd>sensors</kwd>
        <kwd>autonomy</kwd>
        <kwd>ambient assisted living</kwd>
      </kwd-group>
    </article-meta>
  </front>
  <body>
    <sec id="sec-1">
      <title>-</title>
      <p>
        A key clinical feature of the Alzheimer’s disease (AD) is impairment in daily
function, reflected on the difficulty to perform complex tasks, such as the Instrumental
Activities of Daily Living (IADL) [
        <xref ref-type="bibr" rid="ref14">14</xref>
        ]. IADLs are daily tasks, characteristic of an
independent lifestyle, such as making phone calls, shopping, preparing food, housekeeping
and laundry. Inability to perform IADLs is notable at early stages of the disease
affecting autonomy maintenance and quality of life, leading to loss of independence, and
increasing the burden of caregivers [
        <xref ref-type="bibr" rid="ref1">1</xref>
        ].
      </p>
      <p>Treatment of AD begins with its diagnosis, based on behavioral and cognitive
assessment that highlight quantitative and qualitative changes in cognitive functions,
behaviors and ADLs. Currently, such methods involve questionnaires and clinical rating
scales, which unfortunately, cannot often provide objective and fine-grained
information. In contrast, pervasive technologies promise to overcome such limitations using
sensor networks and intelligent analysis to capture the disturbances associated with
autonomy and goal-oriented cognitive functions. This way, they could extract objective
and meaningful information about individuals’ condition for timely diagnosis.</p>
      <p>In this direction, the paper presents KnowSense, a semantically-enriched framework
for monitoring IADL activities in goal-oriented scenarios. KnowSense aims to provide
the means to formally capture and integrate sensory observations, describe
domainspecific use case scenarios of IADL, and support intelligent data analytics,
interpretation and assessment services pertinent to each deployment. To this end, KnowSense
follows an ontology-driven approach to data modelling and analysis, using OWL 2
ontologies to capture deployment-specific properties and sensory observations, while
interpretation and assessment are performed using DL reasoning and rules.</p>
      <p>
        KnowSense was derived from the Dem@Care suite [
        <xref ref-type="bibr" rid="ref17">17</xref>
        ], which enables monitoring
and assessment in confined environments, but also extends it to a much larger set of
functions and scenarios, such as daily, constant monitoring of health conditions e.g. in
a residential setting. On the contrary, KnowSense focuses entirely on confined, lab
environments, addressing their peculiarities. The chosen lab setting aims to provide
feedback to clinical experts about IADLs that have been missed, repeated or took excessive
amounts of time, helping them assess the autonomy of participants. The scope of this
paper is to present the technologies that underpin the deployment of KnowSense in a
lab, leaving out the clinical procedure to classify individuals as cognitively healthy,
MCI (Mild Cognitive Impairment), or dementia1. KnowSense has been deployed in the
day center of the Greek Association of Alzheimer Disease and Relative Disorders and
already used effectively to monitor and assess hundreds of participants.
      </p>
      <p>The rest of the paper is structured as follows: Section 2 presents relevant work.
Section 3 gives an overview of the framework, while Section 4 describes the ontologies
used to represent goal-oriented scenarios and sensory observations. Sections 5 and 6
elaborate on data analytics, presenting the activity recognition and problem detection
capabilities of KnowSense. Section 7 describes the GUIs supported by the framework
to provide feedback to the clinical experts and Section 8 concludes the paper.
2</p>
    </sec>
    <sec id="sec-2">
      <title>Related Work</title>
      <p>
        Pervasive technologies have already been employed in several ambient sensing
environments [
        <xref ref-type="bibr" rid="ref11">11</xref>
        ][
        <xref ref-type="bibr" rid="ref6">6</xref>
        ], traditionally driven by various domain requirements such as sensor
modalities and analytics in each existing framework. The proposed framework
complements such developments, by integrating a wide range of sensor modalities and
highlevel analytics to support IADL monitoring towards tailored autonomy assessment.
      </p>
      <p>
        OWL has been widely used for modelling human activity semantics, reducing
complex activity definitions to the intersection of their constituent parts [
        <xref ref-type="bibr" rid="ref3">3</xref>
        ]. In most cases,
activity recognition involves the segmentation of data into snapshots of atomic events,
fed to the ontology reasoner for classification. Time windows [
        <xref ref-type="bibr" rid="ref9">9</xref>
        ] and slices [
        <xref ref-type="bibr" rid="ref13">13</xref>
        ]
background knowledge about the order or duration [
        <xref ref-type="bibr" rid="ref12">12</xref>
        ] of activities are common approaches
for segmentation. In this paradigm, ontologies are used to model domain information,
whereas rules, widely embraced to compensate for OWL’s expressive limitations [
        <xref ref-type="bibr" rid="ref19 ref8">8,
19</xref>
        ], aggregate activities, describing the conditions that drive the derivation of complex
activities e.g. temporal relations. KnowSense follows a hybrid reasoning scheme, using
DL reasoning for activity detection and SPARQL to extract clinical problems.
      </p>
      <sec id="sec-2-1">
        <title>1 More details about clinical validation can be found in [7].</title>
        <p>
          Focusing on medical care and ambient sensing, the work in [
          <xref ref-type="bibr" rid="ref15">15</xref>
          ] uses web cameras
to monitor IADL in home. The framework presented in [
          <xref ref-type="bibr" rid="ref5">5</xref>
          ] evaluates activity
performance i.e. completion of a tasks based on sensor data in a smart home. The work in
[
          <xref ref-type="bibr" rid="ref18">18</xref>
          ] has deployed infrared motion sensors in clinics accurately identifying sleep
disturbances according to questionnaires. However, it reveals some limitations of using a
single, only, sensor. Similarly, the work in [
          <xref ref-type="bibr" rid="ref2">2</xref>
          ] is a sensor network deployment in
nursing homes in Taiwan to continuously monitor vital signs of patients, lacking the ability
to fuse more sensor modalities, with limited interoperability. Such concepts have been
described in the E-monitor framework for ambient sensing and fusion in a clinical
context [
          <xref ref-type="bibr" rid="ref4">4</xref>
          ]. KnowSense implements and extends these concepts in a unified framework for
sensor interoperability.
3
        </p>
      </sec>
    </sec>
    <sec id="sec-3">
      <title>KnowSense Overview</title>
      <p>KnowSense supports a rich selection of ambient and wearable sensors, listed on
Table 1, which introduce multiple data modalities, such as image and video for specialized
analysis, and more self-contained measurements, such as physical activity2, object
motion and presence. A core objective of KnowSense is to recognize activity events which
may be relevant to direct sensor outputs, e.g. activation of motion sensors, or even
require intermediate data analysis e.g. posture recognition on video data. Its conceptual
architecture, as depicted in Fig. 1, consists of three core layers:
 Semantic Knowledge Graphs: OWL vocabularies are used to build semantic
knowledge graphs capturing (i) domain protocols, (ii) sensor and analysis
observation types and (iii) IADL contextual models. The GraphDB3 triple store is used for
persisting ontologies and data.</p>
      <p>Semantic Knowledge Graphs</p>
      <p>Activity Recognition
OWL Ontologies RDF Triple Store</p>
      <p>Activity Models OWL Reasoning
Observations &amp; Events</p>
      <p>Problem Detection
Feedback</p>
      <p>
        SPARQL Queries
2 A wrist-worn 3D-accelarometer device provides physical activity metrics as described in [
        <xref ref-type="bibr" rid="ref10">10</xref>
        ].
3 http://ontotext.com/products/ontotext-graphdb/
      </p>
      <p>KnowSense allows end users to model domain knowledge about (i) goal-oriented
protocols, (ii) domain observation entities and events and (iii) IADL contextual models
i.e. semantics of complex activities involved in each scenario.</p>
      <p>A protocol (or scenario) is represented as instance of the Protocol class and is used
to store information about its date, the participating individual and the involved steps
(Fig. 2). The Participant instances allow profile-related assertions about participants
to be defined, such as demographic, clinical and experimental records. A protocol step
involves some tasks and has a start and an end timestamp. Our deployment implements
three protocol steps, relevant to directed activities, semi-directed activities and
discussion with the clinicians. Fig. 2 depicts the conceptualization of the semi-directed task
step, along with some examples of IADL tasks involved.
4.2</p>
      <sec id="sec-3-1">
        <title>Observations and Activities</title>
        <p>
          Sensor observations, intermediate analysis results (e.g. posture) and recognized
activities are captured by extending the leo:Event class of LODE [
          <xref ref-type="bibr" rid="ref16">16</xref>
          ] (Fig. 3). The agents
of the events and the temporal context are captured using constructs from DUL4 and
OWL Time5, respectively. In the current deployment, KnowSense allows end-user to
model information about location, posture, actions and objects as subclasses of the
Observation class, while complex activities are defined as subclasses of the Activity
class. Instances of the Activity class are also instances of the IADL class in Fig. 2 (and
vice versa), which is captured as a mutual subclass relationship Activity  IADL.
4.3
        </p>
      </sec>
      <sec id="sec-3-2">
        <title>Activity Models</title>
        <p>KnowSense provides a simple pattern (Fig. 4) for modelling the context of complex
activities (IADL) i.e. semantics for activity recognition. Each activity context is
described through class equivalence axioms that link them with lower-level observations.</p>
        <sec id="sec-3-2-1">
          <title>4 http://www.loa.istc.cnr.it/ontologies/DUL.owl 5 http://www.w3.org/TR/owl-time/</title>
          <p>The instantiation of this pattern is used by the underlying reasoner to classify context
instances, generated during the execution of the protocol, as complex activities. The
instantiation involves linking IADLs with context containment relations through class
equivalence axioms. For example, given that the activity PrepareTea involves the
observations KettleOn, CupMoved, KettleMoved, TeaBagMoved, KettleOff, TeaZone, its
semantics are defined as:

≡ 
⊓ ∃
.</p>
          <p>⊓ ∃
⊓ ∃
⊓ ∃</p>
          <p>⊓ ∃
⊓ ∃
. 
. 
. 
 
Read
article
Water
plant
Prepare pillbox</p>
          <p>Calculator</p>
          <p>Answer phone
Estabblaislhanaccecount
(a)</p>
          <p>Turn
radio on
Prepare tea</p>
          <p>(b)
. 
.</p>
          <p>KnowSense implements a location-driven context generation and classification
approach. The deployment room is divided into zones, according to the location each
activity takes place (Fig. 5 (a)). When a participant enters a zone, KnowSense generates
a Context instance and starts associating it with collected observations using contain
property assertions, until he leaves it. The resulting context instances generated in each
session are fed into the ontology reasoner to classify them in the activity hierarchy.</p>
          <p>Fig. 5 (b) depicts two example context instances associated with a set of observations
relevant to tea preparation. Based on the semantics of PrepareTea described in Section
4.3, c1 will be classified in this class, since all existential restrictions are satisfied.
However, c2 will not be classified as tea preparation, since the context is not associated with
any observation of type KettleOn, but rather translated into an incomplete activity, as
described in Section 6.</p>
          <p>Table 2 summarizes the performance on KnowSense on a dataset of 50 participants.
TP is the number of IADLs correctly recognized, FP is the number of IADLs incorrectly
recognized and FN is the number of IADLs that have not been recognized. Our
approach achieves the best accuracy for “Prepare tea”, “Answer phone”, “Watch TV”,
“Water the plant”, and “Write check”, whose activity models encapsulate richer
contextual information, compared to “Prepare pill box” and “Read article”. On the other
hand, the recall of these activities is relatively low, as they entail richer contextual
dependencies and are, therefore, more susceptible to false negatives.</p>
          <p>Notably, the activity contexts do not involve temporal restrictions. E.g. the semantics
of PrepareTea in Section 4.3 do not involve temporal relations6. As activities do not
usually manifestate in a predefined order, KnowSense uses loosely coupled activity
models, based on containment relations, instead of highly structured ones.
6</p>
        </sec>
      </sec>
    </sec>
    <sec id="sec-4">
      <title>Problem Detection</title>
      <p>The clinical experts highlighted the fact that, apart from recognizing protocol activities,
the derivation of problematic situations would further support them for the
diagnosis/assessment. Towards supporting this requirement, KnowSense has been enriched
with a set of SPARQL queries to detect and highlight situations of possibly problematic
behavior and of critical value to the clinical experts. Currently, abnormal situations
detected include highly repeated, excessively long, incomplete and missed (absent)
activities. The closed-world reasoning (e.g. instance counting or negation as failure) required
to detect them, was implemented with SPARQL queries.</p>
      <p>1: select ?x ?s ?e
2: where {
3: {
4:
5:
6:
7: }
8:
9:
10:}
}
FILTER (?n &gt; 1)
select (count(?o) as ?n) ?x ?s ?e {
?x a :Context; :contains ?o; :starts ?s; :ends ?e.</p>
      <p>
        FILTER NOT EXISTS {?x a :Activity.}
6 The native OWL semantics do not support temporal reasoning. However, it can be simulated
using custom property assertions, as described in [
        <xref ref-type="bibr" rid="ref13">13</xref>
        ].
      </p>
      <p>Activity repetitions correspond to the number of context instances classified into
each activity type, highlighting a problem if there is more than one of them. Activity
duration, computed from start and end activity timestamps, is compared to a reference
duration per IADL suggested by the clinical experts. Missed activities correspond to
IADLs not performed i.e. absent in the knowledge base while incomplete activities
correspond to orphan context instances, i.e. those with more than one contains property
assertion, but with no pertinent Activity classification.</p>
      <p>The query in Fig. 6 defines a nested graph pattern (lines 3 to 8) to retrieve context
instances ?x not classified as activities (line 6), while counting their contains property
assertions (line 4). In order for the query to be successfully pattern matched, there
should be more than one associated observations (line 9) apart from the location-related
observation associated with all context instances. This helps eliminate cases where
participants just enter zones without performing any action. In case of a match, the query
returns the context instance ?x along with its start and end timestamps, used to provide
pertinent feedback to the end users.
7</p>
    </sec>
    <sec id="sec-5">
      <title>End-User Assessment Applications</title>
      <p>At the application level, KnowSense provides a multitude of user interfaces to assist
clinical staff, summarizing an individual’s performance and highlighting abnormal
situations. Fig. 7 depicts the Assessment screen, prior to the initialization of a protocol,
where users can check the status and activate/deactivate sensors, according to the
current protocol step, as described in Section 4.2. An example of the Results page for 4
IADLs is shown in Fig. 8 where both complete and incomplete activities are visualized
(highlighted in green and red respectively). Various additional details for each activity
are provided, such as their relative order, total duration and number of repetitions.</p>
      <p>Fig. 7. KnowSense assessment application with real-time data collection</p>
      <p>
        Meanwhile, the bottom of the screen shows a line-chart of the person’s moving
intensity, indicative of the time he has been walking (beginning and end of the session), as
measured by the DTI-2 sensor. The KnowSense framework deployment in Greece has
already been successfully carried out for more than a hundred participants, achieving a
mean accuracy of clinical assessment close to 83% among healthy and MCI participants
[
        <xref ref-type="bibr" rid="ref7">7</xref>
        ], compared to direct observation annotation and neuropsychological assessment
scores. According to KnowSense results, activity frequency differed significantly
between MCI and healthy participants (p &lt; 0.05). In addition, differences in execution
time have been identified among the groups for all activities. Correlation analysis
demonstrated that some parameters, such as the activity execution time, correlate
significantly with neuropsychological test results, e.g. MMSE and FAB scores.
8
      </p>
    </sec>
    <sec id="sec-6">
      <title>Conclusion and Future Work</title>
      <p>KnowSense enables complex task monitoring of individuals in controlled pervasive
environment. The framework is currently applied in the field of healthcare, providing
the semantic models and detection of IADLs to assist in the clinical assessment of
autonomy and cognitive decline.</p>
      <p>The activity recognition capabilities of KnowSense present certain limitations,
significant to consider as future research directions. First, it cannot handle missing
information, since activity semantics are modelled using fixed TBox axioms that should be
all satisfied. Second, it does not handle uncertainty and conflicts, as it assumes that all
observations have the same confidence. Although these limitations do not significantly
impact the current lab deployment (given the predefined activity zones that simplifies
activity recognition and compensates for sensor errors), deployment in more realistic
environments, e.g. in homes, imposes additional challenges to be met.</p>
    </sec>
  </body>
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