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  <front>
    <journal-meta />
    <article-meta>
      <title-group>
        <article-title>An Ontological Representation for the Transtheoretical Theory</article-title>
      </title-group>
      <contrib-group>
        <contrib contrib-type="author">
          <string-name>Hua Min</string-name>
          <xref ref-type="aff" rid="aff1">1</xref>
        </contrib>
        <contrib contrib-type="author">
          <string-name>Julie Wright</string-name>
          <xref ref-type="aff" rid="aff0">0</xref>
        </contrib>
        <contrib contrib-type="author">
          <string-name>Robert H. Friedman</string-name>
          <xref ref-type="aff" rid="aff2">2</xref>
        </contrib>
        <aff id="aff0">
          <label>0</label>
          <institution>Department of Exercise and Health Science, University of Massachusetts</institution>
          ,
          <addr-line>Boston, MA 02125</addr-line>
          ,
          <country country="US">USA</country>
        </aff>
        <aff id="aff1">
          <label>1</label>
          <institution>Department of Health Administration and Policy, George Mason University</institution>
          ,
          <addr-line>Fairfax, VA 22030</addr-line>
          ,
          <country country="US">USA</country>
        </aff>
        <aff id="aff2">
          <label>2</label>
          <institution>Medical Information System Unit, Boston University</institution>
          ,
          <addr-line>Boston, MA 02118</addr-line>
          ,
          <country country="US">USA</country>
        </aff>
      </contrib-group>
      <abstract>
        <p>-Ontologies are widely used in computer science and medicine. Ontologies may be useful in health promotion and disease prevention for intervention development. Interventionists usually use theory to guide intervention design and evaluation, but there is no standard vocabulary for health behavior theory. A formal mechanism for converting theory to a computer-based representation may provide a tool that can assist in the development of computer-based interventions. This paper demonstrates how ontology can be used to represent a health behavior theory using the Transtheoretical Model (TTM) of behavior change as an example.</p>
      </abstract>
      <kwd-group>
        <kwd>Ontology</kwd>
        <kwd>Health Behavior Theory</kwd>
        <kwd>Transtheoretical Model</kwd>
      </kwd-group>
    </article-meta>
  </front>
  <body>
    <sec id="sec-1">
      <title>I. INTRODUCTION</title>
      <p>
        Ontology is crucial in data exchange, integration, and reuse
in biomedical research [
        <xref ref-type="bibr" rid="ref1 ref2 ref3">1-3</xref>
        ]. Another potential ontology
application is in the field of health promotion and disease
prevention, specifically in designing effective theory-driven
computer-based interventions. Health behavior theories
provide an organized and efficient tool to design and evaluate
health behavior interventions [
        <xref ref-type="bibr" rid="ref4 ref5 ref6">4-6</xref>
        ]. Most health behavior
theories, however, have not been formally defined using
ontologies. The interpretation of health behavior theories and
their constructs often vary across research labs, making
comparisons difficult. This paper discusses how ontology can
assist interventionists with designing effective theory-guided
interventions, and provides an example of a health behavior
ontology using Transtheoretical Model (TTM) [
        <xref ref-type="bibr" rid="ref10 ref7 ref8 ref9">7-10</xref>
        ].
      </p>
      <p>The TTM is comprised of 15 constructs: (a) Stages of
Change, (b) Pros and Cons, (c) Situational Self-efficacy and
Temptation, and (d) the 10 Processes of Change. The central
organizing construct of the model is the Stages of Change.
Stage is defined by an individual’s intention to meet a specified
health criterion (e.g., Perform 150 minutes/week of moderate
intensity exercise or not smoke). The pros and cons of
changing are the two decision making constructs. Situational
Self-efficacy is an individual’s confidence in successfully
performing a healthful behavior whereas Situational
Temptation is one’s ability to resist engaging in the unhealthful
behavior in challenging situations. The processes of change are
the cognitive and behavioral activities or strategies that
promote behavior change. These constructs are expressed to a
greater or lesser extent depending on the individual’s stage,
and can be targeted in an intervention to facilitate progression
through the stages of change.</p>
      <p>II.</p>
      <p>
        An ontology of the TTM was created. The description of
the TTM was gathered from books [
        <xref ref-type="bibr" rid="ref11 ref5">5, 11</xref>
        ], literature [
        <xref ref-type="bibr" rid="ref10 ref7 ref8 ref9">7-10</xref>
        ],
and domain experts. Domain experts were asked to respond to
a list of core competency questions (e.g., “What variables in
the theory may be involved in each stage transition?”). A list
of important terms was created (see Table 1). Those terms are
organized based on parent-child relationship. Protégé was
used to construct the TTM ontology [
        <xref ref-type="bibr" rid="ref12">12</xref>
        ]. The ontology’s class
and logical consistency was evaluated with the FaCT++ [
        <xref ref-type="bibr" rid="ref13">13</xref>
        ].
The resulting ontology defined 82 classes including stages of
change, processes of changes, and self-efficacy and 12 types
of relationships including parent-child, hasComponent, and
hasApplication.
      </p>
      <p>Table 1: Important terms in the TTM ontology</p>
      <p>Stages of Change
Precontemplation (PC)
Contemplation (C)
Preparation (PR)
Action (A)
Maintenance (M)
Termination (T)</p>
      <p>Decisional Balance
Pros of changing
Cons of changing</p>
      <p>Temptation
Habit Addictive
Negative Affective
Positive Social</p>
      <p>Processes of Change
Consciousness Raising (CR)
Dramatic Relief (DR)
Environmental Re-evaluation (ER)
Social Liberation (SO)
Self-reevaluation (SR)
Reinforcement Management (RM)
Counter Conditioning (CC)
Helping Relationships (HR)
Stimulus Control (SC)
Self-liberation (SL)</p>
      <p>Self-efficacy
Confidence</p>
      <p>Temptation</p>
    </sec>
    <sec id="sec-2">
      <title>III. DISSCUSION</title>
      <sec id="sec-2-1">
        <title>A. TTM Ontology</title>
        <p>
          This work demonstrated how to use an ontology application
to represent a health behavior theory. An ontology provides a
way to communicate between domain experts and ontology
users. Domain experts provide knowledge of the TTM during
ontology construction. Users (e.g., interventionists and IT
professionals) can implement the TTM knowledge with
assistance of the ontology. For example, ontology can be used
to guide the development of computer-based behavior
interventions such as an automated telephony system [
          <xref ref-type="bibr" rid="ref14">14</xref>
          ].
        </p>
        <p>
          Ontology has been widely adopted in science especially in
biomedical filed. Scientists rely on definitions and taxonomy
in order to communicate with each other, disseminate their
work and advance scientific knowledge. Behavioral scientists
have realized the importance of standards and ontologies.
Several ongoing projects aim to establish repositories for
standard behavioral measures including grid-enabled measures
(GEM)[
          <xref ref-type="bibr" rid="ref18">18</xref>
          ], consensus measures for phenotypes and
exposures (PhenX) [
          <xref ref-type="bibr" rid="ref19">19</xref>
          ], patient-reported outcomes
measurement information system (PROMIS) [
          <xref ref-type="bibr" rid="ref20">20</xref>
          ], NIH
toolbox for the assessment of neurologic and behavioral
functioning [
          <xref ref-type="bibr" rid="ref21">21</xref>
          ], and the national collaborative on childhood
obesity research [
          <xref ref-type="bibr" rid="ref22">22</xref>
          ]. The National Cancer Institute has
developed a grid infrastructure to share behavioral data
through the GEM and registered them in the cancer data
standards registry and repository (caDSR) [
          <xref ref-type="bibr" rid="ref23">23</xref>
          ].
        </p>
        <p>
          A theory-linked taxonomy of behavior change techniques
(BCTs) used in interventions has been developed [
          <xref ref-type="bibr" rid="ref24 ref25 ref26">24-27</xref>
          ].
This taxonomy provides standard definitions for 93 BCTs. It
provides a foundation to identify content of complex BCTs
and facilitates the development of more effective interventions
to improve health. The taxonomy, however, does not represent
theories, only techniques of BCT. In this paper, we developed
an ontology for one behavioral model using description logic.
The difference between taxonomy and ontology is that
taxonomy contains hierarchical relationship of concepts (i.e.
parent/child, or subClass/superClass, or broader/narrower)
while an ontology has arbitrary complex
relations between concepts.
        </p>
      </sec>
      <sec id="sec-2-2">
        <title>C. Limitations</title>
        <p>This study explores the ontology representation (OWL) for
one health behavior theory. Thus, it lacks testing for general
ontology representation of other health behavior theories.</p>
        <p>IV.</p>
      </sec>
    </sec>
    <sec id="sec-3">
      <title>CONCLUSION</title>
      <p>This work demonstrated that an ontology can be utilized to
represent the TTM knowledge. The TTM Ontology provides a
starting point for ontology research in behavior theories.</p>
    </sec>
  </body>
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