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  <front>
    <journal-meta>
      <journal-title-group>
        <journal-title>” Journal of ITC
Standardization</journal-title>
      </journal-title-group>
    </journal-meta>
    <article-meta>
      <title-group>
        <article-title>Improving computing issues in Internet of Things driven e-health systems</article-title>
      </title-group>
      <contrib-group>
        <contrib contrib-type="author">
          <string-name>Mirjana Maksimović</string-name>
          <email>mirjana@etf.unssa.rs.ba</email>
          <xref ref-type="aff" rid="aff0">0</xref>
        </contrib>
        <aff id="aff0">
          <label>0</label>
          <institution>Faculty of Electrical Engineering University of East Sarajevo East Sarajevo</institution>
          ,
          <country country="BA">Bosnia and Herzegovina</country>
        </aff>
      </contrib-group>
      <pub-date>
        <year>2012</year>
      </pub-date>
      <volume>3</volume>
      <fpage>1</fpage>
      <lpage>6</lpage>
      <abstract>
        <p>-The Internet of Things (IoT) progress shows a positive influence on all aspects of healthcare. Enabling access to high-quality healthcare to anyone, from anywhere are the main advantages of the IoT-driven e-health systems. Increasing numbers of medical devices and sensors and 24/7 monitoring of health parameters, consequently lead to enormous quantities and varieties of data. Having in mind the amounts of generated data and importance of on-time diagnosis and decision making as well as a significance of fast reactions in a case of detected abnormalities, transmitting all data to the Cloud for analysis may not be appropriate. For that reason, implementing a Fog computing, which realizes mini analytic processing centers at the edge of the network, appears as a better approach. This paper analyzes the manners and benefits of implementing Fog computing in the IoT-driven e-health systems. It is expected that the IoT and Fog computing together will revolutionize healthcare like nothing else before.</p>
      </abstract>
      <kwd-group>
        <kwd>Internet of Things (IoT)</kwd>
        <kwd>e-health</kwd>
        <kwd>Cloud</kwd>
        <kwd>Fog computing</kwd>
      </kwd-group>
    </article-meta>
  </front>
  <body>
    <sec id="sec-1">
      <title>INTRODUCTION</title>
      <p>
        The right to healthcare is a fundamental right of every
human being and includes anytime and anywhere accessible,
available, acceptable and high-quality all medical services.
Improving access to healthcare and quality of healthcare appear
as one of the primary objectives of the modern society. The
design of healthcare systems and their improvements are
guided by the key human rights standards such as: universal
access, availability, dignity, acceptability, non-discrimination,
quality, transparency, participation, and accountability [
        <xref ref-type="bibr" rid="ref1">1</xref>
        ]. The
recent intensive technology advancements have dramatically
changed the healthcare of today. The Information and
Communication Technologies (ICTs) have an impact on many
aspects of healthcare, creating a new vision, namely e-health.
The term e-health, sometimes called health information
technology, encompasses the utilization of modern ICTs
solutions to enable more accessible and high-quality healthcare
when and where it’s demanded.
      </p>
      <p>The significant part in the realization of this vision has the
Internet of Things (IoT). The IoT is a worldwide network of
intercommunicating physical objects, devices or “things” that
are connected to the Internet, controllable and available from
anywhere, anyhow and anytime. As such, the IoT brings
numerous benefits in diverse application domains (Fig. 1).</p>
    </sec>
    <sec id="sec-2">
      <title>Copyright © 2017 held by the authors</title>
      <p>The IoT devices are embedded with electronics, software,
sensors, and network connectivity, which enable sensing,
collecting and exchanging information among each other, as
well as with the environment, with or without human
intervention. The realization of the IoT vision, connecting
people and things, with anything and anyone, at anyplace and
using any path/network and any service, requires dramatic
changes in systems, architectures, and communications which
should be: flexible, adaptive, secure, and pervasive without
being intrusive [3].</p>
      <p>The coupling IoT and healthcare leads to the IoT-driven
ehealth solutions which have the power to completely
revolutionize the healthcare industry. With the help of small,
powerful and intelligent sensing devices, and the IoT concepts,
availability and accessibility of healthcare are improved, more
“personalized” systems are created alongside realized
highquality cost-effective healthcare delivery [3].</p>
      <p>The increasing number of sensing devices used for
healthcare purposes will generate a large amount of data. These
data have to be processed accurately and on time in order to
enable adequate diagnosis and care. Hence, it is essential to
analyze, capture, search, share, store, and visualize
largevolume, complex, growing health-related datasets [3]. Posting
large quantities of data to the Cloud for analysis and storage is
not practical, and it takes some time what can induce a negative
influence in decision-making processes relating health. It is
believed that current Cloud computing systems will not be
capable of managing the total burden of data generated by IoT,
and an adequate solution is seen in Fog computing. Fog
computing is sort of a middle layer between the Cloud and the
hardware and it reduces the quantities of data which needs to
be sent to the Cloud by implementing more efficient data
processing, analysis, and storage [4].</p>
      <p>This paper represents the analysis of computing issues in
IoT-driven e-health systems. Hence, the rest of the paper is
organized as follows. The second section presents the
fundamental characteristics of data produced by IoT-driven
ehealth systems and challenges for their processing and
analyzing. The principles of Fog computing and how it can
help in dealing with health-related data are shown in Section 3.
The last section contains the concluding remarks.</p>
      <p>II.</p>
    </sec>
    <sec id="sec-3">
      <title>IOT-DRIVEN E-HEALTH SYSTEMS: HOW TO DEAL WITH A</title>
    </sec>
    <sec id="sec-4">
      <title>LARGE AMOUNT OF VARIOUS HEALTH-RELATED DATA?</title>
      <p>To realize the vision of IoT-related healthcare systems,
the integration of IoT principles in e-health is essential. Hence,
a variety of sensors, embedded in a device, internally
embedded, wearable by users or stationary devices, are utilized
to gather diverse patient medical data. These data are further
processed, analyzed and transmitted wirelessly to medical
professionals for further medical analysis, the remote control of
certain medical treatments or parameters or real-time feedback
(Fig.2) [3, 5, 6].</p>
      <p>There are several estimations of the total number of IoT
devices anticipated to be in operation by 2019, ranging from 19
billion to 40 billion devices. Regardless of the correct expected
increase in the total number of IoT devices, the large-volume,
complex and constantly growing datasets represent the future
serious challenge. According to [7], an overall increase in</p>
      <p>
        Alongside a voluminous nature of data, variety, velocity,
value and veracity, are also the foundational characteristics of
health-associated data. The IoT-based systems include medical
and healthcare information such as: personal information,
radiology images, personal medical records, 3D imaging,
genomics, biometric sensor readings, etc. These data are
classified into structured information (e.g. clinical data) and
unstructured or semi-unstructured (e.g. office medical records,
doctor notes, paper prescriptions, images, and radiograph
films). The velocity of healthcare data increases with daily
measurements and readings from medical devices, while
highquality data and its value are essential in making a diagnosis,
predicting outcomes at earlier stages, making real-time
decisions, promoting patients’ health, enhancing medicine,
reducing costs, etc [
        <xref ref-type="bibr" rid="ref2">2</xref>
        ]. Hence, a voluminous, rapidly growing,
and mostly unstructured medical data are the consequence of
increased digitalization, the continuous optimization of
diagnostic laboratory and imaging sensors, increased
monitoring with sensors of all kinds and so on, and represents
one of the biggest challenges in healthcare systems nowadays.
These data are usually stored in the Cloud while a variety of
techniques and big data analytics are used to extract useful
information, perform predictive modeling and make actionable
decisions from the resulting massive volumes of
highdimensional observations [
        <xref ref-type="bibr" rid="ref2">2</xref>
        ].
      </p>
      <p>Healthcare organizations often use virtualization and Cloud
computing for manipulation, storage and use of such a complex
data structure. Ideally, this “real-time analytics” could only
take minutes, but in the life or death situation, it is
unacceptable [8]. The additional problem with Cloud
computing is bandwidth. A growing number of smart devices
today are generating too much data to be sent to the Cloud for
processing. The bandwidth is not adequate and costs too much
[9]. Also, Cloud-based applications are typically widely
distributed. The data are far away from the application logic
and may be far away from the consumer. This may lead to
latency and even reliability issues [10]. These challenges can
be overcome by operating at the edge of the Cloud. In other
words, the data are processed in smart devices where it is
generated instead of routing everything over Cloud channels.
In this manner data processing is faster, the response time is
improved while the need for bandwidth is scaled down.
Consequently, costs are lowered and efficiency is enhanced [9,
11]. This approach is known as Fog computing or Fog
networking and holds the potential to revolutionize IoT-driven
e-health solutions and make them truly useful.</p>
      <p>III.</p>
    </sec>
    <sec id="sec-5">
      <title>FOG COMPUTING AND ITS ROLE IN IOT-POWERED E</title>
      <p>HEALTH SOLUTIONS</p>
      <p>Fog computing adds a middle layer of computing power
between the devices and the Cloud. In other words, it allows
individual devices to conduct critical analytics and thus
become processing nodes that can handle smaller,
timesensitive computational decisions without having to send all
their data up to the Cloud. In this way, time from request to
answer is significantly reduced and the link with the Cloud is
free for larger-scale analytics work [8]. The smart gateway,
shown in Fig. 3, is an example of Fog computing layer. By
allowing real-time computing it minimizes the latency,
provides location awareness and facilitates handling of the
mobility requirements of the nodes [12].</p>
      <p>It has to be highlighted that the Fog computing is not a
replacement for Cloud computing. Fog computing vision
retains the benefits of Cloud (e.g. agility, flexibility and
distributed computing) while allowing communication of the
data over the IoT devices much easier than Cloud [13]. Hence,
Fog computing extends the Cloud computing paradigm at the
edge of the network (Table 1) and it is developed to address
applications and services that do not fit the paradigm of the
Cloud, including [9, 13]:
 Applications that require very low and predictable
latency;
 Applications in which thousands or millions of things
across a large geographic area are generating data;
 Fast mobile applications; and
 Large-scale distributed control systems.</p>
      <p>The IoT-driven e-health system consists of various sensors
within or on the human body as well as those attached in
ambient surroundings. With the help of these devices,
highdimensional, high-velocity and high-variety health-related data
is being generated on a daily base. Sending all that data to the
Cloud and transmitting response data back requires a larger
bandwidth, a considerable amount of time and can suffer from
latency issues. Fog computing, creating an additional
computing layer between sensors and Cloud computing
(consists of the gateways and distributed databases) can get
around these barriers [8, 15, 16]. This middle layer acts as a
miniature data processing center that exchange data without the
need for the Cloud. The sensed data is being analyzed at this
level using various data mining techniques and data analytics.
The found patterns are stored and unique patterns are
transmitted to the Cloud alongside clinically relevant
information extracted (Fig. 3). Hence, computations are
performed only where the data originates: at the hospital or
physician office that holds the patient record, while patient
health data could be exposed to each device through a shared
interface, using predefined authorization and user protocols
[15].</p>
      <p>Implementing the concept of Fog computing in
IoTpowered e-health systems, the smart gateway as a middle layer
between IoT-connected medical devices and sensors, and
Cloud, enable applications of advanced data mining
techniques, distributed storage, and notification service at the
edge of a network [16]. Turning devices into their own
minianalytics centers, the Fog computing offers big benefits for
healthcare:
 Fog layer easily deals with challenges such as
heterogeneity of devices and data sources,
interoperability and bandwidth while connection of
health data from disparate organizations is enabled
through the IoT;
 Splitting big data to sub data in the Fog layer leads to
the easing data manage and process. In addition, it is
simpler to extract useful key information when the
data are processed in smart devices where it is
generated.
 Fog layer enables real-time and online analytic even
in event of loss of connectivity or poor connection
with the Cloud;
 Having in mind that the latency is highly associated
with proximity, moving the applications and services
close to the end users contributes to significantly
reduced latency. Hence, Fog computing implies less
congestion and faster real-time interaction what
enables instantly alerting healthcare providers in a
case of emergency.
 Data privacy is easier to be provided since Fog
computing separates the public and private data.</p>
    </sec>
    <sec id="sec-6">
      <title>CONCLUDING REMARKS</title>
      <p>Healthcare, as almost every other aspect of our lives, has
not been immune to technology advancements. The evolution
of the IoT has completely revolutionized healthcare industry,
especially monitoring and delivering of healthcare. At the same
time, a great number of diverse IoT-connected medical devices
and sensors create an escalating volume of health-associated
data. Instead of sending all these data to the Cloud,
implementing a miniature data processing centers that
exchange data without the need for the Cloud has been shown
as a better approach. Problems with the bandwidth, a
considerable amount of time, and latency in a case of Cloud
computing utilization justify the implementation of Fog
computing. The benefits that Fog computing offers (low
latency, low bandwidth, heterogeneity, interoperability,
scalability, security and privacy, real-time processing and
actions) are of immense importance in health monitoring and
delivering healthcare. Moving powerful processing, currently
only available in the Cloud, to the edge of the network, Fog
computing holds the potential to make IoT-driven e-health
systems reliable, simpler, scalable, and exceptionally high
performance. However, Fog computing will not totally replace
the Cloud computing. Complementing each other they will be a
powerful tool to achieve numerous benefits in various aspects
of the healthcare domain.
[Online]:
[14] Cisco, “Fog Computing and the Internet of Things: Extend the Cloud to
Where the Things Are,” 2015. [Online]:
https://www.cisco.com/c/dam/en_us/solutions/trends/iot/.../computingoverview.pdf
[16] T. N. Gia, M. Jiang, A.-M. Rahmani, T. Westerlund, T. Liljeberg, H.</p>
      <p>Tenhunen, “Fog Computing in Healthcare Internet-of-Things: A Case
Study on ECG Feature Extraction,” IEEE International Conference on
Computer and Information Technology; Ubiquitous Computing and
Communications; Dependable, Autonomic and Secure Computing;
Pervasive Intelligence and Computing (CIT/IUCC/DASC/PICOM),
2015</p>
    </sec>
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