<!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Archiving and Interchange DTD v1.0 20120330//EN" "JATS-archivearticle1.dtd">
<article xmlns:xlink="http://www.w3.org/1999/xlink">
  <front>
    <journal-meta />
    <article-meta>
      <title-group>
        <article-title>Biomedical Abbreviation Recognition and Resolution by PROSA-MED</article-title>
      </title-group>
      <contrib-group>
        <contrib contrib-type="author">
          <string-name>Soto Montalvo</string-name>
        </contrib>
        <contrib contrib-type="author">
          <string-name>Maite Oronoz</string-name>
        </contrib>
        <contrib contrib-type="author">
          <string-name>Horacio Rodr guez</string-name>
        </contrib>
        <contrib contrib-type="author">
          <string-name>Raquel Mart nez</string-name>
        </contrib>
        <contrib contrib-type="author">
          <string-name>soto.montalvo@urjc.es</string-name>
        </contrib>
        <contrib contrib-type="author">
          <string-name>UPV/EHU</string-name>
        </contrib>
        <contrib contrib-type="author">
          <string-name>maite.oronoz@ehu.eus</string-name>
        </contrib>
        <contrib contrib-type="author">
          <string-name>horacio@cs.upc.edu</string-name>
        </contrib>
        <contrib contrib-type="author">
          <string-name>IR Group</string-name>
        </contrib>
        <contrib contrib-type="author">
          <string-name>raquel@lsi.uned.es</string-name>
        </contrib>
      </contrib-group>
      <pub-date>
        <year>2017</year>
      </pub-date>
      <fpage>247</fpage>
      <lpage>254</lpage>
      <abstract>
        <p>The amount of abbreviations used in biomedical literature increases constantly. Despite the existence of acronym dictionaries, it is not viable to keep them updated with new creations. Thus, in the processing of biomedical texts, discovering and disambiguating acronyms and their expanded forms are essential aspects and this is the objective proposed by BARR task at IberEval 2017 Workshop. This paper presents our participation in this task. We propose ve systems that deal with the problem in di erent ways. Three of the systems are atomic approaches, while two of them are combinations of the atomic systems. One of the systems clearly outperforms the others, both in the detection of entities (F-score of 0.749 in the test set) as well as identifying relations between short-long forms (F-score of 0.697 in the test set).</p>
      </abstract>
      <kwd-group>
        <kwd>abbreviation recognition</kwd>
        <kwd>abbreviation disambiguation</kwd>
        <kwd>patterns</kwd>
        <kwd>dictionaries</kwd>
      </kwd-group>
    </article-meta>
  </front>
  <body>
    <sec id="sec-1">
      <title>-</title>
      <p>
        The volume of biomedical texts is greater and greater, and at the same time,
the number of biomedical abbreviations is growing rapidly, being the
ambiguity of biomedical abbreviations a challenge. Particularly, handling abbreviations
without nearby de nitions is a critical issue [
        <xref ref-type="bibr" rid="ref3">3</xref>
        ].
      </p>
      <p>
        The acronyms have a high reference value, in the sense that they most of
the time act as reference anchors of textual context [
        <xref ref-type="bibr" rid="ref6">6</xref>
        ]. Because of this and
the common problem of recognition of abbreviations, acronyms and symbols,
and their disambiguation (the same short form can have several di erent long
forms), the Biomedical Abbreviation Recognition and Resolution (BARR) track
is proposed [
        <xref ref-type="bibr" rid="ref2">2</xref>
        ].
      </p>
      <p>Usually, existing work on acronym recognition in medical domain is proposed
for English biomedical documents, being di cult to adapt these proposals to
other languages. The BARR track has the aim to promote the development and
evaluation of biomedical abbreviation identi cation systems in Spanish
biomedical documents.</p>
      <p>In this paper we present the approaches proposed by our team, in particular
ve di erent proposals.</p>
      <p>The remainder of this paper is organized as follows. Section 2 presents the
proposed systems. Section 3 summarizes the results and discuss about them.
Finally, conclusions are presented in Section 4.
2</p>
    </sec>
    <sec id="sec-2">
      <title>Proposed Systems</title>
      <p>We propose di erent approaches to identify entities, both short and long forms,
in the texts and also the relations between them. Our team is composed by
members of di erent universities, in a way that we propose a method by each
university (URJC and UNED propose one method together) and two additional
methods which combine the other three proposal in some way. Following we
describe all the methods.
2.1</p>
      <sec id="sec-2-1">
        <title>EHU atomic approach</title>
        <p>
          This system tries to take advantage of an already developed linguistic analyser,
called FreelingMed [
          <xref ref-type="bibr" rid="ref7">7</xref>
          ]. This analyzer has been adapted to provide all the possible
expansions for the abbreviations and acronyms that are already stored in its
dictionaries. FreelingMed tokenizes the text, assigns the o sets to each token
and identi es the medical terms appearing in SNOMED CT [
          <xref ref-type="bibr" rid="ref11">11</xref>
          ] as multiword
terms. The output of the analyzer is usually given in XML but we have changed
it to a format that is easier to manage (see Figure 1).
        </p>
        <p>For the detection of entities, three main approaches are considered: i) an
heuristic that marks word-forms that follow certain pattern usually appearing
in abbreviations and acronyms; ii) elements that come marked as abbreviation
or acronym from the dictionaries of FreelingMed; and, iii) elements that come
from Freeling (in the basis of FreelingMed) marked as abbreviations referring to
units of weight (e.g. mg ), length (e.g. cm), time (e.g. min) etc.
2.2</p>
      </sec>
      <sec id="sec-2-2">
        <title>UPC atomic approach</title>
        <p>
          The second atomic system is based on the combination of three acronym /
expansion pair extractors covering roughly the three most frequent cases of acronym
/ expansion mentions:
{ Similarity-based. This approach tries to detect in a document (within the
title and the abstract) mentions of single words or multiwords likely to be an
acronym (short form) and an expansion (long form) so that the two forms are
likely able to be mapped using a set of 13 hand crafted mapping rules. These
mapping rules are applied in decreasing order of con dence. For recognizing
the short forms we have used the set of regular expressions proposed in [
          <xref ref-type="bibr" rid="ref5">5</xref>
          ]
constrained for satisfying the strict form of the word shapes proposed in [
          <xref ref-type="bibr" rid="ref1">1</xref>
          ]5.
For long form candidates we have collected all the ngrams up to 5 words,
constrained for satisfying loose word shapes, and discarding the candidates
starting or ending by a stopword. The set of allowed word shapes has been
built from the annotations in the training set. The most frequent and most
accurate rule can be paraphrased as following: \The length of the acronym
in chars has to be equal to the number of expansion tokens. Each character
of the acronym should correspond to the rst letter of the corresponding
token in the expansion".
{ Gazetteer-based. We have used a big terminology of the medical domain
obtained from several sources (containing 103,169 terms). The terminology,
which covers six languages was compiled following an iterative approach in a
way that at each iteration available resources for one language were included
and then mapped, when possible, to other languages using dbpedia links
("sameAs" and "label"). The main source of resources includes for English
Bioportal 6 and DrugBank 7, for Spanish CIE10 8 and CIMA9, and for French
pyMedTermino10. The terminology includes both short forms and long forms
and we have obtained possible pairs using the Similarity-based approach
described above. 14,360 pairs were obtained in this way. An example of such
5 A word shape is a simple pattern aiming to represent the character level form of a
word (case, letter, number, punctuation mark, space), e.g. the strict form shape of
'DM2' is 'AA0' while the loose shape is 'A0'.
6 https://bioportal.bioontology.org/
7 https://www.drugbank.ca/
8 CIE10.org
9 https://www.aemps.gob.es/cima/
10 https://bitbucket.org/jibalamy/pymedtermino
patterns (represented as a regular expression) is u' (LPC) .0,15 (linfoma
primario cerebral) '.
{ Distance-based. We have collected a set of patterns acronym / expansion
occurring closely and frequently in the training set. The most frequent
pattern is represented by the regular expression ([A-Za-z][^]+ [A-Za-z][^]+
[AZa-z][^]+) ([A Z]3; 3), covering, for instance, \enfermedad renal cronica
(ERC)". This pattern occurs 73 times in the training set.
2.3
        </p>
      </sec>
      <sec id="sec-2-3">
        <title>UNED atomic approach</title>
        <p>This system combines a pattern-based approach with a dictionary-based
approach, and consists on two steps: abbreviations detection and de nition
matching for them.</p>
        <p>
          In the rst step, we detect terms in capital letters or combination of capital
letters with lowercased letters, numbers and other characters. We use
parenthetical constructions as indicator of a possible abbreviation [
          <xref ref-type="bibr" rid="ref8">8</xref>
          ]. Once the
abbreviation (short form) is located and validated, the second step searches for its
de nition (long form) on the left side of the open parenthesis using the
algorithm proposed by Schwartz and Hearst [
          <xref ref-type="bibr" rid="ref10">10</xref>
          ]. We select each word, one by one
and combining them in each iteration, until a combination of them match with
the short form. We have extended the algorithm of Schwartz and Hearst in
order to allow the words of the long form do not appear necessarily in the same
order that the characters of the short form. The number of words we combine
searching the long form do not exceed the double of the characters of the short
form.
        </p>
        <p>In addition, some special cases for the approach based on patterns are
considered. For instance, the following text has two relation pairs for the same acronym
and two di erent de nitions, one per language: \amino-terminal propeptide of
procollagen type 1 (P1NP, propeptido aminoterminal del procolageno 1)".</p>
        <p>In case of the pattern-based approach does not nd a valid de nition for the
abbreviation, we use a dictionary where each entry is an abbreviation and its
possible long forms. In the same order that long forms appear in the dictionary,
we search each one in the same sentence where the abbreviation is, and the rst
one that matches is selected as the long form of the pair of the relation. The
dictionary used has 7,916 entries.
2.4</p>
      </sec>
      <sec id="sec-2-4">
        <title>Output Combination</title>
        <p>We have implemented three simple combination mechanisms named as and, or,
and vot, that are applied over the results of the atomic systems. and accepts
an annotation only in the case all three atomic systems propose it. or accepts
all the annotations of the atomic systems just checking that no contradictions
(partial overlapping) occur in the mentions. vot implements a democratic
votation schema, i.e. an annotation is accepted in the case at least two of the atomic
systems have proposed it.</p>
        <p>For our nal submission only and and or combinations were submitted.
3</p>
      </sec>
    </sec>
    <sec id="sec-3">
      <title>Results and Discussion</title>
      <p>In this section we present the results obtained identifying entities and relations
abbreviation-de nition.</p>
      <p>
        The evaluation metric used for evaluating the participating systems of the
BARR track has been the F-score micro measure. The organization has provided
an adaptation of the Markyt platform for the evaluation [
        <xref ref-type="bibr" rid="ref9">9</xref>
        ]. This platform
allows to visualize and compare generated predictions against the Gold Standard
annotations.
      </p>
      <p>
        The organization has provided training, test and background collections [
        <xref ref-type="bibr" rid="ref4">4</xref>
        ].
Table 1 shows the results of the six systems over the training 1 data set. The
rst column shows the system, and the columns 2-4 and 5-7 show the values of
precision, recall and F-score respectively, for the identi cation of Entities and
Relations. On the other hand, the three rst rows show the results for the atomic
systems, and the last three rows the results for the systems that combine the
previous ones. In both cases the systems are ordered by F-score value.
      </p>
      <p>The UNED system obtains high precision values, specially identifying
entities. This con rm that an approach based on patterns is suitable for this problem.
The recall values are a bit lower due to this system does not detect nested
entities. Moreover, it is probably the patterns did not detect all special cases that
could appear in texts. The system considers some special cases which implies
variations in the patterns, but it is possible that exist more special cases not
considered.</p>
      <p>The F-score is lower identifying relations because not for all entities detected
the system nds a valid long form. The system searches long forms in a maximum
number of words on the left of an acronym and it can be out of this window.</p>
      <p>The main objective of the EHU system has been to reuse a linguistic analyzer
that was already developed. This approximation is limited as it only can detect
abbreviations already gathered in the dictionaries of FreelingMed and analyzed
as an unique element in its long form. Table 1 shows in its relation column that a
recall of 0.1 is obtained but with a precision of 0.9. Those results, in our opinion,
are clearly related to the type of approach.</p>
      <p>The results of UPC system were bad. There are several explanations for this:
{ The Gazetteer-based component had a very small contribution to the global
system.
{ The acronym detector resulted in the training phase on many failures (about
50 false negatives and more than 200 false positive). Specially in the case of
one character abbreviations the results were bad.
{ Also the detection of long form candidates resulted in many false positives,
specially single word terms and multiterms starting or ending with a non
valid POS.
{ Finally, some of the mapping rules, specially those involving a single word
long form, presented a low accuracy.</p>
      <p>Table 2 presents the results over the test set. For the test set only the and
and or combinations were done between the UNED and UPC systems output.</p>
      <p>Due to the big volume of data in the test set, only the 22.5 % of the corpus
was analyzed in time in the EHU approach and there were some computer
memory problems in the UPC approach. FreelingMed is quite slow (39 sec. to analyze
an abstract of 178 tokens) due to the volume of the dictionaries it uses: a
token dictionary of 578,539 entries and a multiword dictionary of 474,800 entries.
To detect words usually used with a non-medical meaning, for instance \bar",
with a medical meaning (e.g. \bacilo acidorresistente"), a second analysis phase
is applied with a dictionary of around 930,000 entries. In addition a mapping
between SNOMED-CT and the Uni ed Medical Language (UMLS11)(1,007,705
entries) is applied. Not all these resources are needed for the BARR task, but
they are already included in FreelingMed. The time problem with FreelingMed
and the memory problems in the UPC approach have a direct relationship with
the results in the recall column shown in Table 2.</p>
      <p>As can be seen on both tables (Tables 1 and 2), the UNED approach
outperforms by large extent every other one for both tasks and all measures. Taking
into account this high di erence, combinations produce no improvement. It is
11 https://www.nlm.nih.gov/research/umls/
worth noting, however, that and combination reach the best precision for both
tasks, at a cost of a extremely low recall. The NESTED type has not been treated
in the entities identi cation task.
4</p>
    </sec>
    <sec id="sec-4">
      <title>Conclusions</title>
      <p>This paper has described our participation in the BARR task at IBEREVAL
2017 workshop, which goal is to nd acronyms and acronyms-long form relations.
We have proposed ve di erent approaches, three atomic systems and two more
systems, which combine on di erent ways the atomic proposals.</p>
      <p>The UNED system clearly stands out among the presented systems. Being
so clear the di erence in results with the two other atomic approaches, the
combinations are not able of improving the UNED system results.</p>
      <p>Dictionary-based approaches are language dependent while the ones based
on the use of regular expressions or patterns show to be more exible.</p>
      <p>There is, obviously, room for improvements. We plan to focus on performing
combination not only as a nal process but using partial results from the other
atomic sources.
5</p>
    </sec>
    <sec id="sec-5">
      <title>Acknowledgments</title>
      <p>This work has been funded by the Spanish Ministry of Science and Innovation
(PROSA-MED Project: TIN2016-77820-C3, TADEEP Project:
TIN2015-70214P).</p>
    </sec>
  </body>
  <back>
    <ref-list>
      <ref id="ref1">
        <mixed-citation>
          1.
          <string-name>
            <surname>Dai</surname>
          </string-name>
          , HJ. &amp;
          <string-name>
            <surname>Lai</surname>
            ,
            <given-names>PT.</given-names>
          </string-name>
          &amp;
          <string-name>
            <surname>Chang</surname>
            ,
            <given-names>YC.</given-names>
          </string-name>
          &amp;
          <string-name>
            <surname>Tzong-Han</surname>
            <given-names>Tsai</given-names>
          </string-name>
          ,
          <string-name>
            <surname>R.</surname>
          </string-name>
          :
          <article-title>Enhancing of chemical compound and drug name recognition using representative tag scheme and negrained tokenization</article-title>
          .
          <source>Journal of Cheminformatics 2015 7(S-1)</source>
          (
          <year>2015</year>
          )
        </mixed-citation>
      </ref>
      <ref id="ref2">
        <mixed-citation>
          2.
          <string-name>
            <surname>Intxaurrondo</surname>
            ,
            <given-names>A.</given-names>
          </string-name>
          &amp;
          <string-name>
            <surname>Perez-Perez</surname>
            ,
            <given-names>M.</given-names>
          </string-name>
          &amp;
          <string-name>
            <surname>Perez-Rodr guez</surname>
          </string-name>
          , G. &amp;
          <string-name>
            <surname>Lopez-Martin</surname>
            ,
            <given-names>J.A.</given-names>
          </string-name>
          &amp;
          <article-title>Santamar a</article-title>
          , J. &amp; de la Pen~a,
          <string-name>
            <given-names>S.</given-names>
            &amp;
            <surname>Villegas</surname>
          </string-name>
          ,
          <string-name>
            <given-names>M.</given-names>
            &amp;
            <surname>Akhondi</surname>
          </string-name>
          ,
          <string-name>
            <given-names>S.A.</given-names>
            &amp;
            <surname>Valencia</surname>
          </string-name>
          ,
          <string-name>
            <given-names>A.</given-names>
            &amp;
            <surname>Lourenco</surname>
          </string-name>
          ,
          <string-name>
            <given-names>A.</given-names>
            &amp;
            <surname>Krallinger</surname>
          </string-name>
          ,
          <string-name>
            <surname>M.:</surname>
          </string-name>
          <article-title>The Biomedical Abbreviation Recognition and Resolution (BARR) track: benchmarking, evaluation and importance of abbreviation recognition systems applied to Spanish biomedical abstracts</article-title>
          .
          <source>SEPLN</source>
          <year>2017</year>
          , (
          <year>2017</year>
          )
        </mixed-citation>
      </ref>
      <ref id="ref3">
        <mixed-citation>
          3.
          <string-name>
            <surname>Kim</surname>
            ,
            <given-names>S.</given-names>
          </string-name>
          &amp;
          <string-name>
            <surname>Yoon</surname>
            ,
            <given-names>J.</given-names>
          </string-name>
          :
          <article-title>Link-topic model for biomedical abbreviation disambiguation</article-title>
          .
          <source>Journal of Biomedical Informatics</source>
          ,
          <volume>53</volume>
          :
          <fpage>367</fpage>
          -
          <lpage>380</lpage>
          . (
          <year>2015</year>
          )
        </mixed-citation>
      </ref>
      <ref id="ref4">
        <mixed-citation>
          4.
          <string-name>
            <surname>Krallinger</surname>
            ,
            <given-names>M.</given-names>
          </string-name>
          &amp;
          <string-name>
            <surname>Intxaurrondo</surname>
            ,
            <given-names>A.</given-names>
          </string-name>
          &amp;
          <string-name>
            <surname>Lopez-Martin</surname>
            ,
            <given-names>J.A.</given-names>
          </string-name>
          &amp;
          <string-name>
            <surname>de la Pen</surname>
          </string-name>
          <article-title>~a, S. &amp;</article-title>
          <string-name>
            <surname>PerezPerez</surname>
            ,
            <given-names>M.</given-names>
          </string-name>
          &amp;
          <string-name>
            <surname>Perez-Rodr guez</surname>
          </string-name>
          , G. &amp;
          <string-name>
            <surname>Santamara</surname>
            ,
            <given-names>J.</given-names>
          </string-name>
          &amp;
          <string-name>
            <surname>Villegas</surname>
            ,
            <given-names>M.</given-names>
          </string-name>
          &amp;
          <string-name>
            <surname>Akhondi</surname>
            ,
            <given-names>S.A.</given-names>
          </string-name>
          &amp;
          <string-name>
            <surname>Lourenco</surname>
            ,
            <given-names>S.</given-names>
          </string-name>
          &amp;
          <string-name>
            <surname>Valencia</surname>
            ,
            <given-names>V.</given-names>
          </string-name>
          :
          <article-title>Resources for the extraction of abbreviations and terms in Spanish from medical abstracts: the BARR corpus, lexical resources and document collection</article-title>
          .
          <source>SEPLN</source>
          <year>2017</year>
          , (
          <year>2017</year>
          )
        </mixed-citation>
      </ref>
      <ref id="ref5">
        <mixed-citation>
          5.
          <string-name>
            <surname>Larkey</surname>
            ,
            <given-names>L.S</given-names>
          </string-name>
          &amp; Ogilvie,
          <string-name>
            <given-names>P.</given-names>
            &amp;
            <surname>Price</surname>
          </string-name>
          ,
          <string-name>
            <given-names>M.A.</given-names>
            &amp;
            <surname>Tamilio</surname>
          </string-name>
          ,
          <string-name>
            <surname>B.</surname>
          </string-name>
          :
          <article-title>Acrophile: an automated acronym extractor and server</article-title>
          .
          <source>Proceedings of the fth ACM conference on Digital libraries (ACM DL)</source>
          , pp.
          <fpage>205</fpage>
          -
          <lpage>214</lpage>
          . (
          <year>2000</year>
          )
        </mixed-citation>
      </ref>
      <ref id="ref6">
        <mixed-citation>
          6.
          <string-name>
            <surname>Maud</surname>
            ,
            <given-names>E.</given-names>
          </string-name>
          &amp; della
          <string-name>
            <surname>Rocca</surname>
            ,
            <given-names>L.</given-names>
          </string-name>
          &amp;
          <string-name>
            <surname>Steinberger</surname>
            ,
            <given-names>R.</given-names>
          </string-name>
          &amp;
          <string-name>
            <surname>Tanev</surname>
          </string-name>
          , H.:
          <article-title>Acronym recognition and processing in 22 languages</article-title>
          .
          <source>Proceedings of the 9th Conference Recent Advances in Natural Language Processing (RANLP)</source>
          , pp.
          <fpage>237244</fpage>
          . (
          <year>2013</year>
          )
        </mixed-citation>
      </ref>
      <ref id="ref7">
        <mixed-citation>
          7.
          <string-name>
            <surname>Oronoz</surname>
            ,
            <given-names>M.</given-names>
          </string-name>
          &amp;
          <string-name>
            <surname>Casillas</surname>
            ,
            <given-names>A.</given-names>
          </string-name>
          &amp;
          <string-name>
            <surname>Gojenola</surname>
            ,
            <given-names>K.</given-names>
          </string-name>
          &amp;
          <string-name>
            <surname>Perez</surname>
            ,
            <given-names>A.</given-names>
          </string-name>
          :
          <article-title>Automatic Annotation of Medical Records in Spanish with Disease</article-title>
          ,
          <source>Drug and Substance Names. Lecture Notes in Computer Science</source>
          ,
          <volume>8259</volume>
          . Progress in Pattern Recognition, ImageAnalysis, ComputerVision, and
          <article-title>Applications 18th Iberoamerican Congress</article-title>
          ,
          <source>CIARP 2013 Havana, Cuba, November</source>
          <volume>20</volume>
          -
          <fpage>23</fpage>
          . (
          <year>2013</year>
          )
        </mixed-citation>
      </ref>
      <ref id="ref8">
        <mixed-citation>
          8.
          <string-name>
            <surname>Park</surname>
            ,
            <given-names>Y.</given-names>
          </string-name>
          &amp;
          <string-name>
            <surname>Byrd</surname>
            ,
            <given-names>R.J.</given-names>
          </string-name>
          :
          <article-title>Hybrid Text Mining for Finding Abbreviations and Their De nitions</article-title>
          .
          <source>Proceedings of the 2001 Conference on Empirical Methods in Natural Language Processing</source>
          , pp.
          <fpage>126</fpage>
          -
          <lpage>133</lpage>
          . (
          <year>2001</year>
          )
        </mixed-citation>
      </ref>
      <ref id="ref9">
        <mixed-citation>
          9.
          <string-name>
            <surname>Perez</surname>
            ,
            <given-names>M.</given-names>
          </string-name>
          ,
          <string-name>
            <surname>Perez</surname>
            ,
            <given-names>G.</given-names>
          </string-name>
          ,
          <string-name>
            <surname>Rabal</surname>
            ,
            <given-names>O.</given-names>
          </string-name>
          ,
          <string-name>
            <surname>Vazquez</surname>
            ,
            <given-names>M.</given-names>
          </string-name>
          ,
          <string-name>
            <surname>Oyarzabal</surname>
            ,
            <given-names>J.</given-names>
          </string-name>
          ,
          <string-name>
            <surname>Fernandez</surname>
            ,
            <given-names>F.</given-names>
          </string-name>
          ,
          <string-name>
            <surname>Valencia</surname>
            ,
            <given-names>A.</given-names>
          </string-name>
          ,
          <string-name>
            <surname>Krallinger</surname>
            ,
            <given-names>M.</given-names>
          </string-name>
          ,
          <string-name>
            <surname>Lourenco</surname>
            ,
            <given-names>A.</given-names>
          </string-name>
          :
          <article-title>The Markyt visualisation, prediction and benchmark platform for chemical and gene entity recognition at BioCreative/CHEMDNER challenge</article-title>
          .
          <source>Database</source>
          . (
          <year>2016</year>
          )
        </mixed-citation>
      </ref>
      <ref id="ref10">
        <mixed-citation>
          10.
          <string-name>
            <surname>Schwartz</surname>
            ,
            <given-names>A.S</given-names>
          </string-name>
          &amp;
          <string-name>
            <surname>Hearst</surname>
            ,
            <given-names>M.A.</given-names>
          </string-name>
          :
          <article-title>A simple algorithm for identifying abbreviations de nitions in biomedical text</article-title>
          .
          <source>Paci c Symposium on Biocomputing</source>
          , pp.
          <fpage>451</fpage>
          -
          <lpage>462</lpage>
          . (
          <year>2003</year>
          )
        </mixed-citation>
      </ref>
      <ref id="ref11">
        <mixed-citation>
          11.
          <string-name>
            <surname>SNOMED-CT</surname>
          </string-name>
          ,
          <article-title>Systematized Nomenclature of Medicine-Clinical Terms</article-title>
          .
          <source>International Health Terminology Standards Development Organisation (IHTSDO)</source>
          .
          <year>2016</year>
          . Accessed 2014-
          <volume>04</volume>
          -09.
        </mixed-citation>
      </ref>
    </ref-list>
  </back>
</article>