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  <front>
    <journal-meta />
    <article-meta>
      <title-group>
        <article-title>On stabilizability of the manifold of steady states in a model of the spread of a mutating viruses</article-title>
      </title-group>
      <contrib-group>
        <contrib contrib-type="author">
          <string-name>Ju. Ermoshkina</string-name>
          <xref ref-type="aff" rid="aff0">0</xref>
          <xref ref-type="aff" rid="aff1">1</xref>
        </contrib>
        <aff id="aff0">
          <label>0</label>
          <institution>Continuous functions are chosen as the initial conditions. They have the form:</institution>
        </aff>
        <aff id="aff1">
          <label>1</label>
          <institution>Samara National Research University</institution>
          ,
          <addr-line>34 Moskovskoe Shosse, 443086, Samara</addr-line>
          ,
          <country country="RU">Russia</country>
        </aff>
      </contrib-group>
      <pub-date>
        <year>2017</year>
      </pub-date>
      <fpage>43</fpage>
      <lpage>48</lpage>
      <abstract>
        <p>A system of semilinear parabolic equations with a manifold of steady states is considered and the conditions of stabilizability of this manifold are obtained in the paper. Consider the system of differential equations:</p>
      </abstract>
      <kwd-group>
        <kwd>bifurcation</kwd>
        <kwd>parabolic equation</kwd>
        <kwd>the manifold of equilibrium states</kwd>
        <kwd>the model of interaction of viruses</kwd>
      </kwd-group>
    </article-meta>
  </front>
  <body>
    <sec id="sec-1">
      <title>1. Introduction</title>
      <p>
        = 
=  ( ,  ,  ),
+  ( ,  ,  ),
+  ( ,  ,  ),
where  ,  ∈   ;  ,  ∈   ;  ,  ∈   . Assume that  ( , 0,0)≡ 0,  ( , 0,0)≡ 0,  ( , 0,0)≡ 0. Then the system (
        <xref ref-type="bibr" rid="ref1">1</xref>
        ) has a
manifold of equilibrium states  = {( , 0)| ∈   , 0 ∈   ×   }.
      </p>
      <p>Following [1, 2], let say that the manifold  is stable with respect to variable  = ( ,  ), if for any point  ∈   and any
neighborhood of zero W in phase space   ×   we can specify such a neighborhood of zero  0 ⊂   ×   , that for any
point  0 = ( 0,  0)∈  the corresponding solution  =  ( ,  0,  0),  =  ( ,  0,  0)( (0,  0,  0)=  0,  (0,  0,  0)=  0)
satisfies the ratio  =  ( ,  0,  0)∈  when  ≥ 0.</p>
      <p>Let say that  is asymptotically stable with respect to variable  = ( ,  ), if it is stable with respect to variable  and,
moreover, lim →∞  ( ,  0,  0)= 0 for all  0 ∈  .</p>
      <p>Let say that  is stabilized, if it is asymptotically stable with respect to variable  and when  → ∞ { ( ,  0,  0),
 ( ,  0,  0)} converge to some point of diversity  , if  0 ∈  0.</p>
      <p>M.A. Ayzerman and F.R. Gantmakher established that the state of equilibrium of nonholonomic system is stable, if all roots
of the characteristic equation, except for the zero roots, the number of which equals the number of equations of nonholonomic
connections, have negative real parts [3, 4]. Each perturbed motion, which is close enough to unperturbed motion, is converge to
one of the possible established motions, belong to a given manifold, when  → ∞. [5]</p>
    </sec>
    <sec id="sec-2">
      <title>2. Model description</title>
      <p>Let consider the model of interaction of two populations of microorganisms in one-dimensional case. This system is based on
the equations of Fisher-Kolmogorov-Petrovsky-Piskunov. Let  ( ,  )and  ( ,  )be concentrations of the two sub-types of a
virus at a point  and a time  . Consider the problem on the interval  ∈ [0; 1]. The system has the form:
 ( , )
{ 
 ( , )

=  1  2   (2, )+  1 ( ,  )(1 −  1 ( ,  ))(1 −  ( ,  )−  ( ,  ));
=  2  2   (2, )+  2 ( ,  )(1 −  2 ( ,  ))(1 −  ( ,  )−  ( ,  )),
where a1,a2 - the replacement rates for populations u and v accordingly, D1,D2 – the coefficients of diffusion, q1, q2 − the
coefficients of the interaction between individuals of different populations.</p>
      <p>The condition of impermeability at the ends of the considered interval are considered as the boundary conditions in this
problem. They look like:
  ( , )|</p>
      <p>
        =0
  ( , )|
  =0
=    ( , )| =1
=    ( , )| =1
= 0;
= 0.
(
        <xref ref-type="bibr" rid="ref2">2</xref>
        )
(
        <xref ref-type="bibr" rid="ref3">3</xref>
        )
(
        <xref ref-type="bibr" rid="ref4">4</xref>
        )
Members of the second and higher orders can be neglected since the perturbations are infinitely small. Taking into
Finally, substituting equations determining the perturbations (
        <xref ref-type="bibr" rid="ref7">7</xref>
        ) into the equations defining the model (
        <xref ref-type="bibr" rid="ref2">2</xref>
        ), leads to a set
of equations showing how the perturbance will develop in time:
      </p>
      <p>Let consider the Jacobian matrix for the system (10). The signs of the eigenvalues of this matrix will give the
conditions of stability of the stationary solutions.</p>
    </sec>
    <sec id="sec-3">
      <title>3. Analysis of the model</title>
      <p>
        Let find the conditions of stability for the model (
        <xref ref-type="bibr" rid="ref2">2</xref>
        ). First of all, let find the equilibrium states of the system. These
which defined by the following equations:
stationary solutions are obtained by equating all partial derivatives to zero in equations of model. Introduce functions  1,  2,
 ( ,  )=  ( ,  )−  ;  ( ,  )=  ( ,  )−  .
      </p>
      <p>
        Consider the approximation of functions  1( ,  ),  2( ,  )near any equilibrium states ( ,  ). Multivariable calculus
may be used to obtain the following approximations:
 1( ,  )≈  1( ,  )+
 2( ,  )≈  2( ,  )+
  1
  2
 +
 +
consideration equations (
        <xref ref-type="bibr" rid="ref5">5</xref>
        ), let receive:
+  −1 +  2  (1 −  2  )(1 −   −   ).
(
        <xref ref-type="bibr" rid="ref5">5</xref>
        )
(
        <xref ref-type="bibr" rid="ref6">6</xref>
        )
(
        <xref ref-type="bibr" rid="ref7">7</xref>
        )
(
        <xref ref-type="bibr" rid="ref8">8</xref>
        )
(9)
(10)
(11)
(12)
(13)
(14)
(15)
(16)
4. Numerical modeling
their mesh analogues. Receive:


ℎ
ℎ
 
 +1−  =  1
      </p>
      <p>{  +1−  =  2</p>
      <p>1+1− −+11 = 0;
 1 +1− −+11 = 0.</p>
      <p>The boundary conditions will take the form:
 0 = {
Define the initial conditions as follows:</p>
      <p>0,9(−5(  − 1)2 + 1),  0 &gt; 0,
 0 = {
0,  0 ≤ 0;
0,  0 ≤ 0.</p>
      <p>0,9(−5 2 + 1),  0 &gt; 0,</p>
      <p>Their graphs are presented in figure1.
these functions on variables  ,  . Then, the Jacobian matrix Α takes the form:</p>
      <p>2 ( 2(
Α = ( 1(1 −  1 )(1 − 2 −  )  1 ( 1( + 2 − 1)− 1)
+ 2 − 1)− 1)  2(1 −  2 )(1 −  − 2 )
).
equilibrium ( 3,  3)= (0.5, 0.5).</p>
      <p>Substitute ( 3,  3)= (0.5, 0.5)in (12):
Α = (
−0.5 1(1 − 0.5 1)
−0.5 2(1 − 0.5 2)
−0.5 1(1 − 0.5 1)).
solution is stable. And if  1 1 +  2 2 &gt; 2( 1 +  2), the solution is not stable.</p>
      <p>
        To solve the problem (
        <xref ref-type="bibr" rid="ref2">2</xref>
        )-(
        <xref ref-type="bibr" rid="ref4">4</xref>
        ) let make an explicit finite-difference scheme. To do this, replace the differential operators of
      </p>
      <p>To solve the problem (14)-(16) the program was realised in Matlab, which calculates the values of the grid functions on the
time interval 0 ≤ t ≤ 600.</p>
    </sec>
    <sec id="sec-4">
      <title>5. Different cases</title>
      <p>Consider the case when the coefficients of the first and the second equations are equal, i. e.  1 =  2 = 1,  1 =  2 = 0.001,
q1 = q2 . Separating the variables and solving the task on eigenvalues, find the value of parameters q1 = q2 = 2, in the
transition through which the bifurcation happens in the system. To illustrate this phenomenon, consider the three different cases:
1. q1 = q2 &lt; 2
2. q1 = q2 ≈ 2
3. q1 = q2 &gt; 2</p>
      <p>In the first case, the trajectories of system converge to the equilibrium (0,5;0,5), belonging to the manifold of equilibrium
states of the system. By Ayzerman-Gantmacher`s theorem, the state of equilibrium of system is stable. Thus, manifold is
stabilized. In the second case, there is a soft loss of stability of the system when passing through the critical value, and in the
third case, it is possible to observe a complete loss of stability.
5.1. Case, when q1 = q2 &lt; 2.</p>
      <p>For the first case , when q1 = q2 = 1.5, the dynamics of function u(x,t) is presented in figure 2. The dynamics of function
v(x,t) is presented in figure 3. In figure 4 a solution in a finite time t=600 is presented.
5.2. Case, when q1 = q2 ≈ 2.</p>
      <p>For the second case, when q1 = q2 = 2.05, the dynamics of function u(x,t) is presented in figure 5. The dynamics of
function v(x,t) is presented in figure 6. In figure 7 a solution in a finite time t=600 is presented.
5.3. Case, when q1=q2&gt;2.</p>
      <p>For case 3, when  1 =  2 = 2.5, the dynamics of function u(x,t) is presented in figure 8. The dynamics of function v(x,t) is
presented in figure 9. In figure 10 a solution in a finite time t=600 is presented.</p>
    </sec>
    <sec id="sec-5">
      <title>6. Conclusion</title>
    </sec>
    <sec id="sec-6">
      <title>Acknowledgements</title>
      <p>Hence, it is shown that for q1 = q2 &lt; 2 the manifold of equilibrium states of the system is stabilized, and when passing
through the value of the coefficients of the interaction q1 = q2 = 2 loss of stability occurs in the system.</p>
      <p>The paper was supported by the Russian Foundation for Basic Research and the government of the Samara region in the
framework of a research project № 16-41-630529.</p>
    </sec>
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