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  <front>
    <journal-meta />
    <article-meta>
      <title-group>
        <article-title>Autonomous Comprehensive Geriatric Assessment</article-title>
      </title-group>
      <contrib-group>
        <contrib contrib-type="author">
          <string-name>Luigi Asprino</string-name>
          <xref ref-type="aff" rid="aff0">0</xref>
          <xref ref-type="aff" rid="aff2">2</xref>
        </contrib>
        <contrib contrib-type="author">
          <string-name>Aldo Gangemi</string-name>
          <xref ref-type="aff" rid="aff1">1</xref>
          <xref ref-type="aff" rid="aff2">2</xref>
        </contrib>
        <contrib contrib-type="author">
          <string-name>Andrea Giovanni Nuzzolese</string-name>
          <xref ref-type="aff" rid="aff2">2</xref>
        </contrib>
        <contrib contrib-type="author">
          <string-name>Valentina Presutti</string-name>
          <xref ref-type="aff" rid="aff2">2</xref>
        </contrib>
        <contrib contrib-type="author">
          <string-name>Diego Reforgiato Recupero</string-name>
          <xref ref-type="aff" rid="aff2">2</xref>
        </contrib>
        <contrib contrib-type="author">
          <string-name>Alessandro Russo</string-name>
          <xref ref-type="aff" rid="aff2">2</xref>
        </contrib>
        <aff id="aff0">
          <label>0</label>
          <institution>DISI - Universita` di Bologna</institution>
          ,
          <addr-line>Bologna</addr-line>
          ,
          <country country="IT">Italy</country>
        </aff>
        <aff id="aff1">
          <label>1</label>
          <institution>LIPN, Universite ́ Paris 13, Sorbone Cite ́, UMR CNRS</institution>
          ,
          <addr-line>Paris</addr-line>
          ,
          <country country="FR">France</country>
        </aff>
        <aff id="aff2">
          <label>2</label>
          <institution>STLab, ISTC-CNR</institution>
          ,
          <addr-line>Rome</addr-line>
          ,
          <country country="IT">Italy</country>
        </aff>
      </contrib-group>
      <fpage>41</fpage>
      <lpage>45</lpage>
      <abstract>
        <p>This paper presents the MARIO's CGA (Comprehensive Geriatric Assessment) module for the Kompa¨ı platform that aims at autonomously performing and managing the execution of specific tests required in the CGA process. The application relies on the CGA ontology, which is part of the Mario Ontology Network (MON)4, as a support to the execution of the assessment process and a reference model for storing test information.</p>
      </abstract>
    </article-meta>
  </front>
  <body>
    <sec id="sec-1">
      <title>1 Introduction</title>
      <p>Dementia is a broad category of brain diseases which cause a gradual decrease in the
ability to speak, think and remember thus affecting a person’s daily functioning. These
impairments are often accompanied by loneliness, isolation and depression.
Unfortunately, the number of people with dementia (PWD) is increasing and is expected to
reach 80 million, by 2040. Current health care strategies are insufficient to combat this
phenomena hence, ICT solutions and companion robots are considered key
technologies for mitigating its effect.</p>
      <p>MARIO5 is a companion robot (based on the KOMPAI¨ platform) that contributes to
address this problem. It relies on the Semantic Web for the background knowledge
supporting its understanding and dialoguing capabilities. Among its functionalities,
MARIO assists caregivers and physicians in performing the Comprehensive Geriatric
Assessment (CGA) of PWD, a clinical procedure for assessing the medical,
psychosocial, functional and environmental status of a PWD.</p>
      <p>
        This is not the first attempt to support health professionals in this procedure, in fact
they increasingly use ICT tools and devices during the performance of the CGA for
recording test results and calculate the corresponding scores. Specific software
applications are available for supporting the clinicians in the evaluation and calculation of
the MPI (Multidimensional Prognostic Index) and related scores, such as the
CalculateMPI tool and the iMPI application for iOS-based devices. However, it has been observed
that these devices and the need to interact with them to input information can represent
a “communication barrier” between the caregiver and the patient during clinical
interviews. The lack of visual contact with the caregiver can further increase stress and
anxiety in frail elderly patients undergoing a cognitive evaluation whose results may
potentially impact on their autonomy. MARIO’s solution proposes a completely different
4 http://www.ontologydesignpatterns.org/ont/mario/mario.owl
5 http://www.mario-project.eu/portal/
approach: to make the patient interact with a robot that can autonomously perform the
procedure. In a similar direction, as follow up of the ECHORD++ challenge focused on
Robotics for the CGA6, the ASSESSTRONIC project and the CLARC framework [
        <xref ref-type="bibr" rid="ref1">1</xref>
        ]
are investigating robotic solutions for supporting the CGA process. In the rest of the
paper, we describe the MARIO’s CGA module, its main functionalities, components
and the ontologies it relies on.
      </p>
      <p>The Comprehensive Geriatric Assessment. The CGA is a diagnostic process that
aims to collect and to analyse data to determine the medical, psychosocial, functional
and environmental status and problems of an elderly patient. Its ultimate goal is to
define an overall, personalized plan for treatment and long-term care. The CGA
procedures conceptually include three main phases: (i) Clinical Interview, to gather
preliminary information about patient’s health status, by interacting with the patient and
his/her relatives; (ii) Multidimensional Assessment, to assess the functional mental and
social status of the patient, through multidimensional tests; (iii) Care Plan Definition
and Review, based on the previous phases a patient-specific care plan is defined and
implemented. The multidimensional assessment phase is the core of the CGA process
and represents a critical, time consuming activity for the caregivers. Physicians rely
on a set of assessment tools and standardized rating scales to evaluate patient’s
functional abilities, physical and mental health, and cognitive status. Two main classes of
tests are performed: (i) Questionnaire-based tests: standardized clinical questionnaires
(e.g., about his/her daily life and ability to autonomously perform specific activities).
Depending on the answers, a score is given to the patient and evaluated according to a
reference rating scale. (ii) Observation-based activity performance tests: specific
physical activities (such as getting up and walking for a short path) are observed to rate the
patient as for gait/balance assessment and fall risk assessment.</p>
      <p>The introduction of a robotic solution able of autonomously performing parts of a
CGA is expected to reduce the direct involvement of health professionals in the
timeconsuming data collection tasks, as well as the perceived tiredness resulting from the
performance of repetitive tests. As a result, this will enable them to concentrate their
efforts on the interpretation of the results and the elaboration of personalized care plans.
2</p>
    </sec>
    <sec id="sec-2">
      <title>Application Design</title>
      <p>By exploiting the underlying robotic platform and its sensors and I/O devices, the CGA
module is required to enable MARIO to manage autonomously the execution of some
CGA tests. To this end, the robotic CGA module is required to: (i) initiate and
undertake a dialogue-based interaction with the patient to perform questionnaire-based
selected tests; (ii) monitor patient’s motion behaviour under specific constraints and
execution settings; (iii) complement the natural language interface with a graphical user
interface and touch-based interaction modality to gather patient’s input. Sensorimotor
capabilities are considered as a viable solution for further improving the user
experience during the assessment procedures. This includes the ability of MARIO to orient
itself towards the user, as well as the ability to dynamically approach the patient and
adjust its position and distance depending on the test to be performed.</p>
      <sec id="sec-2-1">
        <title>6 ECHORD++, http://echord.eu/</title>
        <p>Architecture. A diagram sketching the architectural components of the CGA module
is shown in Figure 1 and the main components are described as follows. The Caregiver
Vocal answer</p>
        <p>Kinect device
MARIO(IONNCTLOULDOINGGYCNGEATWMOORDKULAENADNKDNPOPWDLBE-DRGDFE)BASE</p>
        <p>On screen
Q&amp;A
joints/skeleton
tracking</p>
        <p>Interface a Web-based Graphical User Interface, designed to allow the authorized
clinicians to configure patient’s profile and CGA sessions, trigger and monitor their
executions, and access generated health reports and scores resulting from the assessments.
The Session and State Manager manages the overall execution of CGA sessions,
coordinating the scheduling of the configured tests. The MPI Calculator is responsible
for calculating the overall Multidimensional Prognostic Index, taking into account the
scores and rating scales resulting from the execution of the assessment tests.</p>
        <p>The Questionnaire-based Test Executor is in charge of the engaging and the
execution of questionnaire-driven tests that are part of the assessment process. The dialogue
flow is driven by the robot (i.e., the interaction is system-initiated) and unfolds on the
basis of a continuous question-answer interaction pattern. For a specific test, the
corresponding questionnaire script is derived from its description and representation
retrieved from the Knowledge Base. Questions are thus formulated in a way that induces
a restriction on the answers space. The advantages of this approach are twofold: on
one side, providing the user with a limited set of possible answers (typically restricted
to “yes/no” options) aims at reducing the cognitive load for the patient in the
questionanswer process; on the other side, this reduces the interpretation dimensions that have to
be considered when natural language understanding techniques are used. If the system
is not able to understand and interpret the answer, the question is posed again.</p>
        <p>The CGA Answers Understander takes as input the textual representation of
patient’s utterances, as provided by the MARIO Speech-to-Text subsystem. From the
analysis of video and audio recording of CGA-sessions emerged that the usage of a
restricted vocabulary and keyword-spotting techniques can be effective in supporting
predefined dialogues where the interaction is driven by the system for eliciting specific
information from the user through a set of questions. The actual interpretation strategy
directly depends on the question classification and corresponding answer type, namely:
yes-no or Wh -questions. (i) Yes-no questions. The Yes-No questions cover most of
the items in the CGA questionnaires, the patient’s answers are matched against regular
expression patterns that aim at capturing both positive and negative answers. The
patterns were built by exploiting existing linguistic resources, in particular the Paraphrase
Database (PPDB)7, an automatically extracted multilingual database containing
paraphrases in 16 different languages. PPDB has been re-engineered in RDF8 according to
the recently introduced PPDB ontology9. (ii) Wh-Questions. In the case of
Wh-questions, which cover most of the items in the SPMSQ10 (e.g., ”What day of the week is
it today?”, ”Who is the Pope now?”), the understanding process maps to the task of
comparing patient’s answers with known properties of named entities retrieved from
the MARIO’s KB as well as commonsense KBs. The matching process relies on
specialised understanding functions that restrict the recognition and interpretation to
specific domains, such as dates and numbers (used for example when the user is asked to
perform basic math calculations as part of the SPMSQ questionnaire).</p>
        <p>
          CGA ontology module. The contribution of the CGA ontology11 is twofold. On the
one hand, the ontology supports the execution of the assessment by providing a
reference model for storing test information (such as questions, expected answer etc.). On
the other hand, it allows to store the data resulting from the patient’s assessments. To
the best of our knowledge there is no other ontology able to represents the results of an
execution of the CGA. Some ontologies have been proposed for supporting the
(general) medical assessment process [
          <xref ref-type="bibr" rid="ref2 ref3">3, 2</xref>
          ]. These ontologies define high-level concepts for
representing medical assessments. The CGA ontology follows their approach and
specialises the high-level concepts where needed. The requirements of the ontology have
been directly derived from the form template used by physicians during the assessment
of a Physician’s Working Diagnosis. The CGA ontology implements the high-level
conceptual model shared by all the tests included in the CGA process. The peculiarities of
each test are captured in other ontologies which are imported by the CGA ontology.
These models specialise the CGA ontology on the basis of the specific requirements of
the test, e.g. the CGA ontology defines the class cga:GeriatricAssessment and
the ontology addressing ADL and IADL specialises this class with
ca:CapabilityAssessment. The Figure 2 shows a diagram representing the CGA ontology. As
in [
          <xref ref-type="bibr" rid="ref2">2</xref>
          ], a patient assessment (i.e. cga:GeriatricAssessment) is an action having
as participant a healthrole:Patient and an action:Agent12 who makes the
assessment. The agent making the assessment can be either a healthrole:Physician
or another kind of agent (e.g. MARIO). In order to represent the description of how the
        </p>
      </sec>
      <sec id="sec-2-2">
        <title>7 PPDB, http://paraphrase.org/</title>
        <p>8 PPDB-RDF SPARQL endpoint, http://w3id.org/framester/sparql
9 PPDB ontology, http://w3id.org/ppdb/ontology/ppdb.owl
10 SPSMQ stands for Short Portable Mental Status Questionnaire.
11 http://www.ontologydesignpatterns.org/ont/mario/cga.owl
12 Since cga:GeriatricAssessment specialises the class action:Action</p>
        <p>cga:ClinicalTest
clinicalact:hasMember</p>
        <p>cga:GeriatricAssessment clinicalact:hasMember
cga:assessesPatient action:Action
healthrole:Patient cga:CGA time:TempotrimaleE:a1ntTtiimtye
action:Task cga:Question
action:executesTask cga:correctResponse rdfs:Literal
clinicalact:hasMember cga:score rdfs:Literal</p>
        <p>cga:hasText
language:Text
cga:score rdfs:Literal
action:byAgent</p>
        <p>action:Agent
cga:toQuestion cga:anscwgear:rAdnfss:Lwiteerral
assessment is to be executed, we implemented the Ontology Design Pattern Task
Execution. The action cga:GeriatricAssessment executes a cga:ClinicalTest
which provides a “description” of how the assessment has to be executed. A
cga:ClinicalTest can be composed of other clinical tests or some cga:Question.
Furthermore the CGA ontology allows to store information about the answers (i.e.
cga:Answer) provided by a patient to reply to a question.
3</p>
      </sec>
    </sec>
    <sec id="sec-3">
      <title>Conclusions</title>
      <p>The MARIO’s CGA module described in this paper is being validated for acceptability
with patients in two different dementia care settings in Ireland and Italy. It will be
tested and validated with patients in hospital settings and in nursing facility settings.
The outcome and continuous feedback provided by trial activities will further contribute
to the refinement and evolution of the CGA module.</p>
      <p>Acknowledgements. The research leading to these results has received funding from
the European Union Horizons 2020 the Framework Programme for Research and
Innovation (2014-2020) under grant agreement 643808 Project MARIO ”Managing active
and healthy aging with use of caring service robots”.</p>
    </sec>
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