<!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Archiving and Interchange DTD v1.0 20120330//EN" "JATS-archivearticle1.dtd">
<article xmlns:xlink="http://www.w3.org/1999/xlink">
  <front>
    <journal-meta />
    <article-meta>
      <title-group>
        <article-title>Exploiting Natural Language Processing for Improving Health Processes</article-title>
      </title-group>
      <contrib-group>
        <contrib contrib-type="author">
          <string-name>M. van Keulen</string-name>
          <xref ref-type="aff" rid="aff1">1</xref>
        </contrib>
        <contrib contrib-type="author">
          <string-name>J. Geerdink</string-name>
          <xref ref-type="aff" rid="aff0">0</xref>
        </contrib>
        <contrib contrib-type="author">
          <string-name>G. Linssen</string-name>
          <xref ref-type="aff" rid="aff0">0</xref>
        </contrib>
        <contrib contrib-type="author">
          <string-name>R.H.J. Slart</string-name>
          <email>r.h.j.a.slartg@utwente.nl</email>
          <xref ref-type="aff" rid="aff1">1</xref>
        </contrib>
        <contrib contrib-type="author">
          <string-name>O. Vijlbrief</string-name>
          <email>o.vijlbriefg@zgt.nl</email>
          <xref ref-type="aff" rid="aff0">0</xref>
        </contrib>
        <aff id="aff0">
          <label>0</label>
          <institution>Hospital Group Twente</institution>
        </aff>
        <aff id="aff1">
          <label>1</label>
          <institution>University of Twente</institution>
        </aff>
      </contrib-group>
      <fpage>145</fpage>
      <lpage>146</lpage>
      <abstract>
        <p>In the medical world, high quality digital registration in an Electronic Patient Dossier (EPD) of symptoms, diagnoses, treatments, test results, images, interpretations, and outcomes becomes commonplace. Together with a shortage of medical professionals, means that they experience pressure at the expense of actual `hands on the bed'. On the other hand, EPDs contain a wealth of largely unused, unstructured textual information. Clinicians primarily communicate with each other through letters and reports. Our main question is: Can Natural Language Processing (NLP) exploit this wealth? By extracting structured data and using it as features for machine learning, a wide variety of process improvements become possible. Furthermore, it may contribute to the desire of government and health stakeholders to simplify registration and relieve pressure. This paper sketches a few prominent process improvements that we plan to research.</p>
      </abstract>
    </article-meta>
  </front>
  <body>
    <sec id="sec-1">
      <title>-</title>
      <p>Introduction</p>
      <p>Tests</p>
      <p>First Imaging
symptoms Consults</p>
      <p>Long
term
outcome
now
score malignant
Years of letters and reports about the course of a disease of a patient
time
data window
findings
findings</p>
      <p>Co
rrelate
outcome
label
(a) Di erent data windows have di erent prediction performance (b) BIRADS score
model may be unobtrusively incorporated in existing EPD software warning the
clinician of substantial risk for uncommon conditions like GCA.</p>
      <p>
        As another example, chemo and radiation therapy in cancer patients damage
heart and bloodvessels. It is important to identify those patients who are at high
risk for long term complications. They need tailored medical therapy to prevent
cardiovascular diseases. Machine learning may aid in identi cation, avoiding or
suggesting such measures [
        <xref ref-type="bibr" rid="ref2">2</xref>
        ].
      </p>
      <p>
        Dynamic Shortening of Care Processes. Actions like tests, imaging,
treatments, etc. are preceded by consults. Patterns may be discovered between data
in letters and reports from before a consult, that su ciently predict a subsequent
action. In such cases, one may dynamically adapt the process to already plan
this action before the consult, at the limited expense of some cancellations due
to mispredictions, or one may even decide to omit the consult altogether.
Quality assurance. Hospitals often enforce strict protocols as a means for
quality assurance. NLP techniques may aid in checking adherence to protocols
and supporting clinicians in upholding the standards. For example, the
radiology diagnostic reports for breast cancer in the Hospital Group Twente contain
among other things a standard risk classi cation, called \Breast Imaging
Reporting and Data System" (BIRADS; see Figure 1(b)). Whether or not these
risk scores correlate well with actual outcomes is largely unknown. Being able to
check this is important for quality assurance. Moreover, discovering under which
circumstances deviating risk assessments are given, may aid in improving care
processes with better-informed decisions [
        <xref ref-type="bibr" rid="ref3">3</xref>
        ].
      </p>
    </sec>
  </body>
  <back>
    <ref-list>
      <ref id="ref1">
        <mixed-citation>
          1.
          <string-name>
            <surname>Prior</surname>
            ,
            <given-names>J.</given-names>
          </string-name>
          ,
          <string-name>
            <surname>Ranjbar</surname>
            ,
            <given-names>H.</given-names>
          </string-name>
          ,
          <string-name>
            <surname>Belcher</surname>
            ,
            <given-names>J.</given-names>
          </string-name>
          ,
          <string-name>
            <surname>Mackie</surname>
            ,
            <given-names>S.</given-names>
          </string-name>
          ,
          <string-name>
            <surname>Helliwell</surname>
            ,
            <given-names>T.</given-names>
          </string-name>
          ,
          <string-name>
            <surname>Liddle</surname>
            ,
            <given-names>J.</given-names>
          </string-name>
          , CD, C.M.:
          <article-title>Diagnostic delay for giant cell arteritis - a systematic review and meta-analysis</article-title>
          .
          <source>BMC Med</source>
          .
          <volume>15</volume>
          (
          <issue>1</issue>
          ) (
          <year>June 2017</year>
          ) 120
        </mixed-citation>
      </ref>
      <ref id="ref2">
        <mixed-citation>
          2.
          <string-name>
            <surname>Rumsfeld</surname>
            ,
            <given-names>J.</given-names>
          </string-name>
          ,
          <string-name>
            <surname>Joynt</surname>
            ,
            <given-names>K.</given-names>
          </string-name>
          ,
          <string-name>
            <surname>Maddox</surname>
            ,
            <given-names>T.</given-names>
          </string-name>
          :
          <article-title>Big data analytics to improve cardiovascular care: promise and challenges</article-title>
          .
          <source>Nat Rev Cardiol</source>
          .
          <volume>13</volume>
          (
          <year>2016</year>
          )
          <volume>350</volume>
          {
          <fpage>359</fpage>
        </mixed-citation>
      </ref>
      <ref id="ref3">
        <mixed-citation>
          3.
          <string-name>
            <surname>Sippo</surname>
            ,
            <given-names>D.</given-names>
          </string-name>
          ,
          <string-name>
            <surname>Warden</surname>
          </string-name>
          , G.:
          <article-title>Automated extraction of bi-rads nal assessment categories from radiology reports with natural language processing</article-title>
          .
          <source>J Digit Imaging</source>
          <volume>26</volume>
          (
          <issue>5</issue>
          ) (
          <year>October 2013</year>
          )
          <volume>989</volume>
          {
          <fpage>94</fpage>
        </mixed-citation>
      </ref>
    </ref-list>
  </back>
</article>