<!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Archiving and Interchange DTD v1.0 20120330//EN" "JATS-archivearticle1.dtd">
<article xmlns:xlink="http://www.w3.org/1999/xlink">
  <front>
    <journal-meta />
    <article-meta>
      <title-group>
        <article-title>Case-based Interpretation of Best Medical Coding Practices - Application to Data Collection for Cancer Registries</article-title>
      </title-group>
      <contrib-group>
        <contrib contrib-type="author">
          <string-name>Michael Schnell</string-name>
          <email>michael.schnell@lih.lu</email>
          <email>michael.schnell@loria.fr</email>
        </contrib>
        <aff id="aff0">
          <label>0</label>
          <institution>Epidemiology and Public Health Research Unit, Department of Population Health, Luxembourg Institute of Health</institution>
          ,
          <addr-line>1A-B, rue Thomas Edison, L-1445 Strassen</addr-line>
          ,
          <country country="LU">Luxembourg</country>
        </aff>
        <aff id="aff1">
          <label>1</label>
          <institution>UL</institution>
          ,
          <addr-line>CNRS, Inria, Loria, F-54000 Nancy</addr-line>
        </aff>
      </contrib-group>
      <fpage>199</fpage>
      <lpage>203</lpage>
    </article-meta>
  </front>
  <body>
    <sec id="sec-1">
      <title>Introduction</title>
      <p>
        Currently, cancer remains one of the main causes of death. To assist in the
fight against this disease, cancer registries are being used. A cancer registry
is a systematic, continuous, exhaustive and non redundant collection of data
about cancers diagnosed and/or treated in a country or region. The collected
data is defined in international standards with common terminologies (e.g., the
International Classification of Diseases, commonly abbreviated as ICD [
        <xref ref-type="bibr" rid="ref7">7</xref>
        ]) and
associated to best medical coding practices. Unfortunately, these practices and
standards are very complex, making it dicult for operators, i.e. medical sta↵
in charge of collecting and coding the data, and coding experts to apply them
eciently and consistently.
      </p>
      <p>The aim of this research is to tackle this complexity, by assisting both
operators and coding experts in the interpretation of best medical coding practices.</p>
      <p>For the Luxembourg National Cancer Registry (NCR), a ticketing system
has been implemented for operators. When they encounter a dicult coding
problem, they can ask questions through this system and coding experts
provide individual answers. Interesting questions are later presented and discussed
in regular training sessions for operators. Coding experts rely on their medical
knowledge and their understanding of the coding standards and best medical
coding practices to answer the questions. However, it is crucial for cancer
registries to have a consistent coding of the data, meaning that two similar patients
should be coded similarly. Thus, two similar coding questions should have
similar answers. For that reason, the coding experts must also take into account
previous questions to answer new questions.</p>
      <p>Section 2 presents the research plan, followed by a review of the current
progress in section 3. Finally, section 4 outlines the remaining work.</p>
      <p>Copyright © 2017 for this paper by its authors. Copying permitted for private and
academic purpose. In Proceedings of the ICCBR 2017 Workshops. Trondheim, Norway</p>
    </sec>
    <sec id="sec-2">
      <title>Research plan</title>
      <p>The research plan contains the following main work packages: an analysis of
the questions answering approach and design of a coding solving method and a
question management tool, an implementation of the tool and an evaluation of
the impact of the proposed tool.</p>
      <p>The analysis and design package contains the following areas of work:
– a literature review for case-based reasoning and the combination with other
methods, e.g., rule-based reasoning, belief merging or formal argumentation;
– a state of the art for coding assistants and decision support systems;
– a analysis of the questions asked by operators of the NCR and the answers
provided by experts, as well as their solving process;
– functional design of a question management tool and technical choices for
the implementation.</p>
      <p>With the results of the analysis, a implementation of the designed software
will be provided, starting with a prototype for a limited test usage before
transitioning to a more general usage.</p>
      <p>Lastly, an evaluation of the impact of the implemented assistant, notably to
assess the evolution of the expert and operator workloads, is planned.
3</p>
    </sec>
    <sec id="sec-3">
      <title>Current progress</title>
      <p>
        The first step of this research is to analyze the coding process and the question
solving process. Therefore, a dozen tricky questions and several easier questions
have been discussed with the coding experts of the NCR. Given the similarities
in the solving process of the experts and case-based reasoning, the proposed
approach is adapted from the 4-R cycle presented in [
        <xref ref-type="bibr" rid="ref1">1</xref>
        ] and the knowledge
containers presented in [
        <xref ref-type="bibr" rid="ref6">6</xref>
        ]. Other approaches have been considered (e.g., automatic
coding [
        <xref ref-type="bibr" rid="ref5">5</xref>
        ]), but are not being pursued at the moment.
      </p>
      <p>The approach proposed by this research uses arguments for the solving
process. Indeed, when answering a case, experts often point out which arguments
(pros and/or cons) have been identified and which solution they support. This
is very helpful for operators, as it gives them insights into the reasoning
process and allows them to learn more quickly. In order to incorporate this user
guidance and solution explanation into our approach, the retrieval step uses the
arguments of a source case to find the best match for the given target problem.
The approach has been described in more detail in a paper submitted to ICCBR
2017. A prototype developed for the paper (shown in figures 1 and 2) focuses
on structured questions asked by operators and the solutions provided by the
system.</p>
      <p>
        Arguments have already been used in CBR, but not to identify similar cases.
For example, in [
        <xref ref-type="bibr" rid="ref3">3</xref>
        ] and [
        <xref ref-type="bibr" rid="ref4">4</xref>
        ] arguments are generated and used to explain the
inferred solution of the target problem.
      </p>
      <p>To facilitate the handling of the operators’ questions, it was decided to
structure the questions rather than apply natural language processing methods.
Figure 1 shows an example of a structured question. Still, there are plenty of items
that can be relevant for the various questions, making it very dicult to define
every possible data item. Thus, only the most important subject are completely
structured, i.e. the data asked of the operator is almost exhaustively defined.
The assistant proposed by this research project will only handle structured
questions. The remaining unstructured questions, i.e. questions where the operators
describes his problem using free text, will continue to be answered by the coding
experts, with little change to the current situation.
4</p>
    </sec>
    <sec id="sec-4">
      <title>Future work</title>
      <p>Once the prototype has been tested, a first version of the ticketing system for
the coding questions will be developed. By the end of the year, this first version
should be tested by the operators of the NCR. This version will be evaluated,
notably to determine the impact of the system. Several types of criteria can be
measured (e.g., quality of the coded data, workload of the coding experts). The
final list of criteria will be determined during the implementation of the ticketing
system. Alongside, other avenues are considered:</p>
      <p>– increasing the eciency of the solving algorithm (e.g., combining arguments
using logic operators like and, reusing arguments from several source cases);
– adding a conversational approach where the system can ask for additional
information about a given patient (to reduce the amount of information
asked to only relevant data);</p>
      <p>
        The following problems, though interesting, will probably not be researched
in depth during this project:
– adding a confidence indication of the given result to help operators and
coding experts distinguish between tentative solutions and validated solutions;
– taking into account the evolution of the coding standards [
        <xref ref-type="bibr" rid="ref2">2</xref>
        ].
      </p>
    </sec>
  </body>
  <back>
    <ref-list>
      <ref id="ref1">
        <mixed-citation>
          1.
          <string-name>
            <surname>Aamodt</surname>
            ,
            <given-names>A.</given-names>
          </string-name>
          ,
          <string-name>
            <surname>Plaza</surname>
            ,
            <given-names>E.</given-names>
          </string-name>
          :
          <article-title>Case-based reasoning: Foundational issues, methodological variations, and system approaches (</article-title>
          <year>1994</year>
          )
        </mixed-citation>
      </ref>
      <ref id="ref2">
        <mixed-citation>
          2.
          <string-name>
            <surname>Cardoso</surname>
            ,
            <given-names>S.D.</given-names>
          </string-name>
          ,
          <string-name>
            <surname>Pruski</surname>
            ,
            <given-names>C.</given-names>
          </string-name>
          ,
          <string-name>
            <surname>Da</surname>
            <given-names>Silveira</given-names>
          </string-name>
          ,
          <string-name>
            <given-names>M.</given-names>
            ,
            <surname>Lin</surname>
          </string-name>
          ,
          <string-name>
            <given-names>Y.C.</given-names>
            ,
            <surname>Groß</surname>
          </string-name>
          ,
          <string-name>
            <given-names>A.</given-names>
            ,
            <surname>Rahm</surname>
          </string-name>
          ,
          <string-name>
            <given-names>E.</given-names>
            ,
            <surname>ReynaudDelaˆıtre</surname>
          </string-name>
          , C.:
          <article-title>Leveraging the Impact of Ontology Evolution on Semantic Annotations</article-title>
          , pp.
          <fpage>68</fpage>
          -
          <lpage>82</lpage>
          . Springer International Publishing,
          <string-name>
            <surname>Cham</surname>
          </string-name>
          (
          <year>2016</year>
          )
        </mixed-citation>
      </ref>
      <ref id="ref3">
        <mixed-citation>
          3.
          <string-name>
            <surname>McSherry</surname>
            ,
            <given-names>D.</given-names>
          </string-name>
          :
          <article-title>Explaining the Pros and Cons of Conclusions in CBR</article-title>
          .
          <source>In: European Conference on Case-Based Reasoning</source>
          . pp.
          <fpage>317</fpage>
          -
          <lpage>330</lpage>
          . Springer (
          <year>2004</year>
          )
        </mixed-citation>
      </ref>
      <ref id="ref4">
        <mixed-citation>
          4.
          <string-name>
            <surname>Murdock</surname>
            ,
            <given-names>J.W.</given-names>
          </string-name>
          ,
          <string-name>
            <surname>Aha</surname>
            ,
            <given-names>D.W.</given-names>
          </string-name>
          ,
          <string-name>
            <surname>Breslow</surname>
            ,
            <given-names>L.A.</given-names>
          </string-name>
          :
          <article-title>Assessing elaborated hypotheses: An interpretive case-based reasoning approach</article-title>
          .
          <source>In: International Conference on CaseBased Reasoning</source>
          . pp.
          <fpage>332</fpage>
          -
          <lpage>346</lpage>
          . Springer (
          <year>2003</year>
          )
        </mixed-citation>
      </ref>
      <ref id="ref5">
        <mixed-citation>
          5.
          <string-name>
            <surname>Pestian</surname>
            ,
            <given-names>J.P.</given-names>
          </string-name>
          ,
          <string-name>
            <surname>Brew</surname>
            ,
            <given-names>C.</given-names>
          </string-name>
          ,
          <string-name>
            <surname>Matykiewicz</surname>
            ,
            <given-names>P.</given-names>
          </string-name>
          ,
          <string-name>
            <surname>Hovermale</surname>
            ,
            <given-names>D.J.</given-names>
          </string-name>
          , Johnson, N.,
          <string-name>
            <surname>Cohen</surname>
            ,
            <given-names>K.B.</given-names>
          </string-name>
          ,
          <string-name>
            <surname>Duch</surname>
            ,
            <given-names>W.:</given-names>
          </string-name>
          <article-title>A shared task involving multi-label classification of clinical free text</article-title>
          .
          <source>In: Proceedings of the Workshop on BioNLP 2007: Biological, Translational, and Clinical Language Processing</source>
          . pp.
          <fpage>97</fpage>
          -
          <lpage>104</lpage>
          . Association for Computational Linguistics,
          <volume>1572411</volume>
          (
          <year>2007</year>
          )
        </mixed-citation>
      </ref>
      <ref id="ref6">
        <mixed-citation>
          6.
          <string-name>
            <surname>Richter</surname>
            ,
            <given-names>M.M.</given-names>
          </string-name>
          ,
          <string-name>
            <surname>Weber</surname>
            ,
            <given-names>R.O.</given-names>
          </string-name>
          :
          <article-title>Case-based reasoning: a textbook</article-title>
          . Springer Science &amp; Business
          <string-name>
            <surname>Media</surname>
          </string-name>
          (
          <year>2013</year>
          )
        </mixed-citation>
      </ref>
      <ref id="ref7">
        <mixed-citation>
          7. World Health Organisation:
          <article-title>The ICD-10 classification of mental and behavioural disorders</article-title>
          . Geneva: World Health Organisation (
          <year>1992</year>
          ), http://www.who.int/ classifications/icd/en
        </mixed-citation>
      </ref>
    </ref-list>
  </back>
</article>