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  <front>
    <journal-meta />
    <article-meta>
      <title-group>
        <article-title>Evaluation of Sensors' Precision in a Low Cost e-Health Monitoring System</article-title>
      </title-group>
      <contrib-group>
        <contrib contrib-type="author">
          <string-name>Nikos Petrellis</string-name>
          <email>npetrellis@teilar.gr</email>
          <xref ref-type="aff" rid="aff0">0</xref>
        </contrib>
        <contrib contrib-type="author">
          <string-name>Michael Birbas</string-name>
          <email>mbirbas@ece.upatras.gr</email>
          <xref ref-type="aff" rid="aff1">1</xref>
        </contrib>
        <contrib contrib-type="author">
          <string-name>Fotios Gioulekas</string-name>
          <email>gioulekas@uhl.gr</email>
          <xref ref-type="aff" rid="aff2">2</xref>
        </contrib>
        <aff id="aff0">
          <label>0</label>
          <institution>Department of Computer Science and Engineering, Technology Educational Institute of Thessaly</institution>
          ,
          <country country="GR">Greece</country>
        </aff>
        <aff id="aff1">
          <label>1</label>
          <institution>Electrical Engineering and Computer Technology Dept., University of Patras</institution>
          ,
          <addr-line>Greece, and Analogies S.A</addr-line>
        </aff>
        <aff id="aff2">
          <label>2</label>
          <institution>Sub-directorate of Informatics, University General Hospital of Larissa</institution>
        </aff>
      </contrib-group>
      <fpage>377</fpage>
      <lpage>382</lpage>
      <abstract>
        <p>In this paper, a low cost e-health platform is evaluated concerning the precision of the employed sensors. The sensors used by the developed ehealth platform are not medically certified but are compared against medically certified ones. The developed platform exhibits enhanced key characteristics to cover a broad range of medical scenarios in a reliable and flexible way. A lowcost Sensor Controller capable of performing both simple medical tests and more advanced ones communicates with a Gateway and a tablet or smart phone providing instructions to the patient. The employed protocol used for the communication between the Sensor Controller and the Gateway, supports a variety of sensors with different sampling profiles. The platform exhibits high portability due to the power saving modes that have been employed. However, the sensors' accuracy is an important issue that is investigated in this paper in order to highlight the medical cases where the (low-cost) developed e-health platform can be used in a fairly reliable way. Such a platform would be especially useful for the enhancement of the quality of life of residents in distant or isolated rural areas. Moreover, it would be possible to use part of this platform for the continuous monitoring of livestock (e.g., excluding the tablet/phone).</p>
      </abstract>
      <kwd-group>
        <kwd>health monitor</kwd>
        <kwd>sensors</kwd>
        <kwd>accuracy</kwd>
        <kwd>low power</kwd>
      </kwd-group>
    </article-meta>
  </front>
  <body>
    <sec id="sec-1">
      <title>1 Introduction</title>
      <p>
        Experts can remotely monitor aging population using health care systems
        <xref ref-type="bibr" rid="ref10">(Zhang
et al, 2014)</xref>
        . The results of the tests that are performed can be securely stored in a
remote cloud or database. In
        <xref ref-type="bibr" rid="ref4">(Gay and Leijdekkers, 2007)</xref>
        , a monitoring system was
proposed based on wireless sensors and smart phones to monitor high risk cardiac
patients exploiting the usage of a real-time ECG. In
        <xref ref-type="bibr" rid="ref2">(Chan et al. 2008)</xref>
        a similar
monitoring architecture is proposed based on commercial sensors. In
        <xref ref-type="bibr" rid="ref6">(Mukherjee et
al. 2014)</xref>
        a perception layer is introduced, where Bluetooth, Zigbee and WiMAX
protocols are used to connect the patient sensors to the monitoring infrastructure. The
available sensor/communication technology for the implementation of wearable
systems and patient monitoring is reviewed in
        <xref ref-type="bibr" rid="ref7">(Patel et al., 2012)</xref>
        . The importance of
achieving both high precision and low-energy sensors is denoted. Cooking Hacks
ehealth kits are employed in an experimental Body Sensor Network (BSN) platform
suggested in
        <xref ref-type="bibr" rid="ref5">(Khelil et al. 2014)</xref>
        .
      </p>
      <p>
        A versatile framework for home monitoring of wireless sensor networks is
presented in
        <xref ref-type="bibr" rid="ref1">(Antonopoulos et al., 2015)</xref>
        . It consists of an extendible wireless digital
sensor network that transmits data to a Home Gateway (HG). The gathered data are
forwarded to the Service Data Platform (SDP) which performs several tasks like
database transactions, data processing and decision-making. No details are given in
this framework for the connection of analog sensors. There also exist a number of
expensive commercial platforms like e-Shimmer Health BSN
        <xref ref-type="bibr" rid="ref9">(The Shimmer
Platform, 2008)</xref>
        , with proprietary (not open-source) components.
      </p>
      <p>
        The current work is based on the platform initially presented by the authors of this
paper in
        <xref ref-type="bibr" rid="ref8">(Petrellis et al., 2015)</xref>
        and is based on the low-cost e-Health kit by
LibeliumCooking Hacks. A flexible communication protocol capable of supporting a variety
of sensors’ sampling profiles has been defined. Moreover, smart solutions for low
power consumption have been employed for the development of a low cost flexible
and portable e-health sensor platform.
      </p>
      <p>The Libelium-Cooking Hacks e-health platform supports 9 sensors both digital
and analog including: body temperature, airflow, galvanic skin sensor, patient
position, measurement of the oxygen in the blood (SPO2), glucose meter, blood
pressure, ECG and electromyogram (EMG). In this paper we focus on some of these
analog sensors and evaluate their precision, comparing them with commercial,
medically certified devices where necessary.</p>
      <p>In Section 2 a brief overview of the developed e-health system and its key features
is presented. The evaluation results of the sensors mentioned above and their
measurements are given in Section 3.</p>
    </sec>
    <sec id="sec-2">
      <title>2 System Description</title>
      <p>The architecture of the developed heath monitoring system is shown in Fig. 1. The
patient that is monitored by this e-health system reads instructions by a smart phone
or a tablet through a user-friendly interface. The supported medical sensors are listed
at the right of Fig. 1 and are connected to the developed Sensor Controller. The
eHealth kit by Libelium-Cooking Hacks equipped with a Raspberry PI microcontroller
board is used as the Sensor Controller. A Gateway coordinates the communication
between the Sensor Controller and the Tablet as well as the communication with the
cloud or remote database where the sensor values are forwarded. A supervisor doctor
can view the measured values by visiting this cloud. Moreover, the instructions given
by the supervisor doctor to the patient are also retrieved by the Gateway and
downloaded to the Tablet and the Sensor Controller. All sensors are connected in a
wired manner to the Sensor Controller that has to be carried by the monitored person.
For this reason, the Sensor Controller should be characterized by increased
portability. The Sensor Controller and the Tablet communicate with the Gateway in a
wireless way.</p>
      <sec id="sec-2-1">
        <title>Temperature</title>
      </sec>
      <sec id="sec-2-2">
        <title>Airflow EMG ECG</title>
      </sec>
      <sec id="sec-2-3">
        <title>Body Position</title>
      </sec>
      <sec id="sec-2-4">
        <title>Galvanic</title>
      </sec>
      <sec id="sec-2-5">
        <title>Glucose</title>
      </sec>
      <sec id="sec-2-6">
        <title>Blood Pressure</title>
      </sec>
      <sec id="sec-2-7">
        <title>Sensor</title>
      </sec>
      <sec id="sec-2-8">
        <title>Controller</title>
        <p>
          In this section we focus on the behavior of 5 sensors of the Libelium Cooking Hacks
e-Health kit with analog interface: the body temperature sensor, the breathing
airflow, the body position sensor, the EMG and the ECG. Furthermore, we compare
their behavior with commercial medically certified sensors where possible, like the
temperature sensor and the ECG by Shimmer
          <xref ref-type="bibr" rid="ref9">(The Shimmer Platform, 2008)</xref>
          .
Sensors like the breathing airflow and EMG are evaluated by applying breathing or
muscle contraction patterns and see if they are represented well by the digitized
electrical signals generated by the sensors. Of course only draft levels can be
discriminated in this way but this is adequate for several applications.
400
350
300
250
lfow200
ir
A
150
100
50
00
200
180
1600
EMG with 1sec sampling period
        </p>
        <p>Temp with 1sec sampling period</p>
        <p>The body position sensor has only 5 distinct values that show that the patient is in
one of the following positions: a) standing or sitting, b) supine, c) prone, d) left and
e) right. By testing several times this sensor, the experimental results showed that it
produced 100% correct results.</p>
        <p>The airflow sensor was tested by applying breathing patterns (e.g., deep breaths
followed by shallow ones that have certain short durations). Such an example is
shown in Fig. 2. As it can be seen, the sensor output can represent well the depth of a
breath and its duration. It is not possible to measure more accurately the sensor
output but it is feasible for the supervising doctor or an artificial intelligence software
package to draw conclusions about the state of the patient by taking into account the
shape of signals like the ones shown in Fig. 2. The sampling period for this sensor
does not have to be shorter than a few hundreds of milliseconds.</p>
        <p>In the same way, the EMG sensor was evaluated by applying muscle contractions
of different strength as shown in Fig. 3a. The EMG sensor output represents well the
contractions applied and its sampling period can be as high as 1 second. Of course, if
micro-contractions are useful to be captured a smaller sampling period has to be
adopted. More than one EMG sensor can be connected at various muscles on the
body of a handicapped person in order to distinguish several combinations of EMG
sensor signal levels. Each one of these combinations can be used to apply a different
control to prosthetic limbs with high accuracy. The Libelium Cooking Hacks
eHealth kit offers only one EMG channel and can be used for simple experiments
only. It is easy however to either use multiple e-Health kits or develop a new Sensor
Controller board that uses multiple copies of the EMG interface circuit of the
eHealth kit still with very low cost (compared with the usually expensive medically
certified ones) and, as aforementioned, with reliable results.</p>
        <p>The temperature sensor output is displayed in Fig. 3b. The displayed signal was
retrieved after performing the best possible calibration based on the instructions of
the manufacturer. A 1 sec sampling period is adequate and no faster sampling is
necessary for most applications. The temperature of the same patient was measured
at the same time by a commercial temperature sensor and was found 36.5 oC. As can
be shown by Fig. 3b the individual measurements fluctuate between 36.1 and 36.8
degrees Celsius and this fluctuation might seem high for a valid measurement.
However, the first 10 seconds can be assumed to be a transient period before the
sensor temperature is stabilized and gets equal to the temperature of the patient body.
Furthermore, if 10 samples of a moving window are averaged, the estimated patient
temperature would be 36.48 οC, i.e., almost equal to the temperature measured by the
commercial sensor.</p>
        <p>3.5
4
3
2
CG2.5
E
1.5
(a)</p>
        <p>ECG with 50ms sampling period
10 0.5 1 1.5 2 time2.(5sec) 3 3.5 4 4.5 5 0.50 0.5 1 1.5 2 time2.(5sec) 3 3.5 4 4.5 5
(c) (d)
Fig. 4. Reference Cooking Hacks e-Health ECG sensor output (a), real ECG output using a
sampling period of 40ms (b), 50ms (c) and Shimmer ECG output (d).</p>
        <p>The single channel ECG sensor offered by the e-Health kit was compared to the
corresponding sensor offered by Shimmer. The ECG sensor output should have the
form shown in Fig. 4a. The best ECG output retrieved experimentally was the one
shown in Fig. 4b using 40ms sampling period and no averaging. Even in this case it
is difficult to match the peaks shown in Fig. 4a. The ECG shape gets much worse if a
slightly different sampling period is used as shown in Fig. 4c. However it should be
noted that the output of even medically certified ECG sensors may not be better as
shown in Fig. 4d.
3.5
3
2.5
G
C
E
2
1.5
10
3.5
3
2.5
CG 2
E
1.5
1</p>
        <p>ECG with 40ms sampling period
1
2
4
5</p>
        <p>6
time3(sec)</p>
        <p>(b)
ECG / Shimmer
A low-cost platform for remote heath monitoring of patients was used in order to
evaluate how precise measurements can be taken and which sensors are appropriate
for specific applications. Several sensors including temperature, breathing airflow,
body position, etc, that are not medically certified can be used even in professional
applications for monitoring the habits of individuals or every day activity. Some of
the low cost sensors like the electromyogram can also be used in more complicated
and ambitious applications (e.g. for the control of prosthetic limbs). However,
sensors like the electrocardiogram did not prove to be accurate and stable enough and
should be used only for experimentation purposes.</p>
        <p>Acknowledgments. This work was performed as part of ELTAB project (465435).</p>
      </sec>
    </sec>
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