=Paper= {{Paper |id=Vol-2048/paper02 |storemode=property |title=Argumentation Mining in Scientific Discourse |pdfUrl=https://ceur-ws.org/Vol-2048/paper02.pdf |volume=Vol-2048 |authors=Nancy L. Green |dblpUrl=https://dblp.org/rec/conf/icail/Green17 }} ==Argumentation Mining in Scientific Discourse== https://ceur-ws.org/Vol-2048/paper02.pdf
                            Argumentation Mining in Scientific Discourse
                                              Nancy L. Green
                       University of North Carolina Greensboro, Greensboro, NC, USA
                                             nlgreen@uncg.edu


                         Abstract                             audience, as well as constraints of the underlying
                                                              argumentation scheme [Green, 2010].
        The dominant approach to argumentation
        mining has been to treat argumentation                   Although human-level understanding of natural
        scheme detection as a machine learning                language text is currently beyond the state of the art,
        problem based upon superficial text features,         we contend that an inference-based approach is
        and to treat the relationships between                feasible for applications requiring a deeper analysis
        arguments as support or attack. However,              of argumentation. In [Green, 2016] we proposed an
        applications such as accurately representing          approach to mining individual arguments in
        and summarizing argumentation in scientific           biomedical research articles using argumentation
        research articles require a deeper                    schemes implemented as logic programs. The
        understanding of the text and a richer model          schemes are formulated in terms of semantic
        of relationships between arguments. This              predicates that could be obtained from a text by use
        paper presents a semantic rule-based                  of BioNLP (biomedical/biological natural language
        approach to extracting individual arguments,          processing) tools. This semantic approach to mining
        and demonstrates the need for a richer                avoids the various problems faced by purely feature-
        model of inter-argument relationships in              based approaches, e.g., that argument components
        biomedical/biological research articles.              may be conveyed through non-contiguous or
                                                              overlapping text segments of varying granularity, the
                                                              sparcity of discourse cues marking argument
   1    Introduction                                          components, and the occurrence of enthymemes.
   The dominant approach to argumentation (or                    In this paper, we build on our previous proposal by
   argument) mining [e.g., Green et al., 2014; Cardie et      considering the role of discourse structure in mining
   al., 2015; Reed et al., 2016] has been to treat it as a    argumentation in scientific texts. In section 2 we
   machine learning problem based upon superficial text       summarize our previous proposal to mining
   features, enabling researchers to adopt methods that       individual arguments. In section 3 we discuss the
   have been applied successfully to other natural            relationship of the individual arguments to other
   language processing tasks. This approach has been          aspects of discourse structure, and how the arguments
   useful for applications such as identifying reasons        are related to each other, i.e., the argumentation
   given for opinions in social media, or automatic           structure of the discourse.
   assessment of student essay quality. However some
   applications, such as accurately summarizing               2   Mining Arguments
   argumentation in scientific research articles, require a   This section summarizes our proposed approach to
   deeper understanding of the text.                          mining individual arguments described in [Green,
       There are a number of problems with mining             2016], using argumentation schemes implemented as
   arguments in scientific documents at the text level        logic programs written in Prolog [Bratko, 2001].
   rather than at the semantic level [Green, 2015a;           Argumentation schemes are abstract descriptions of
   2015b]. Argument components may not occur in               acceptable, possibly defeasible, arguments used in
   contiguity. In fact, the content of an argument may be     conversation as well as in formal genres such as legal
   widely separated or the content of two arguments           and scientific text [Walton et al., 2008]. To provide
   may be interleaved at the text level. Furthermore          examples of argumentation schemes in open-access
   scientific text often contains enthymemes, i.e.            text, we analyzed arguments in the Results section of
   arguments with implicit premises or an implicit            a biomedical research article [van de Leemput et al.,
   conclusion.     Interpretation of enthymemes may           2007] in the CRAFT corpus [CRAFT]. The CRAFT
   require use of the preceding discourse context             corpus has been annotated by other researchers for
   (including inferred conclusions of other arguments),       purposes of biomedical text mining [Verspoor et al.,
   presumed shared knowledge of the author and                2012; Bada et al., 2012], but not for argument
                                                              mining. The seven argumentation schemes presented



18th Workshop on Computational Models of Natural Argument                                                               7
Floris Bex, Floriana Grasso, Nancy Green (eds)
16th July 2017, London, UK
in [Green, 2016] were implemented in terms of                  To use the implemented rules for argument
domain-specific semantic predicates that could in          mining, i.e., to extract individual arguments, it is
theory be automatically extracted by BioNLP tools.         assumed that, firstly, BioNLP tools would be applied
(Results of a preliminary study of human analysts’         to a source text to create a knowledge base (KB).
ability to apply the argumentation schemes                 Named entity recognition tools such as ABNER
consistently will be reported in the future.) We expect    [Settles, 2005] or MutationFinder [Caporaso et al.,
that these rules, while domain-specific, are applicable    2007] could be used to recognize expressions
to the large body of research articles on genetic          referring to semantic class names such as genes,
variants with effects on human health.                     mutations, proteins, and phenotypes.            Domain-
   To illustrate a few of the schemes, first, the          specific relations in the argumentation schemes such
Method of Agreement scheme can be paraphrased as           as have_phenotype and have_genotype could be
follows.                                                   extracted from the text using relation extraction tools
                                                           such as OpenMutationMinder [Naderi and Witte,
Premises:                                                  2012] and DiMeX [Mahmood et al., 2016]. Also, a
    • A group of individuals G have atypical               certain amount of domain knowledge would be
        phenotype P                                        required, e.g., for the relations similar and difference,
    • All of the individuals in G have atypical            which could be acquired from a domain ontology or
        genotype M.                                        domain experts. After a KB has been created, the
Conclusion: M may be the cause of P (in G).                argument scheme rules would be applied to the KB to
                                                           recognize      the     premises,     conclusion,     and
In the rules, genotype describes a variation (mutation)    argumentation scheme of each argument in the text.
at the level of chromosome, region on the                  The rules were tested by manually creating a KB and
chromosome, or gene that may have a deleterious            then applying the rules to the KB.
effect (or effects), and phenotype describes the             To illustrate, the implementation of the
effect(s). This scheme can be seen as a specialization     argumentation scheme for Method of Agreement is as
of a more general scheme, related to Mill’s Method         follows.
of Agreement [Jenicek and Hitchcock, 2005].
   Another scheme, related to Mill’s Method of             arg(
Difference [Jenicek and Hitchcock, 2005], can be             scheme('Agreement'),
paraphrased as follows.                                      premise(have_phenotype(G, P)),
                                                             premise(have_genotype(G, M)),
Premises:                                                    conclusion(cause(M, P)))
    • A group of individuals G have atypical               :-
        phenotype P                                        group(G),
    • All of the individuals in G have atypical            have_phenotype(G, P),
        genotype M.                                        have_genotype(G, M).
    • A group of individuals Control do not have
        P.                                                 Applying this rule to a KB containing the facts:
    • None of the individuals in Control have M.
Conclusion: M may be the cause of P (in G).                group(mice1).
                                                           have_phenotype(mice1, ataxia).
The following scheme can be seen as a specialization       have_genotype(mice1, ‘Itpr1 opt/opt’).
of Argument by Analogy, e.g. as described in [Walton
et al., 2008].                                             would derive an argument whose scheme is identified
                                                           as Agreement, whose premises are the above listed
Premises:                                                  facts, and whose conclusion is that the Itpr1 opt/opt
    • Phenotype P1 of group G1 is similar to               variant may be the cause of their ataxia. Note that
        phenotype P2 of group G2                           the rules are formulated in such a way that even
    • Genotype M1 of group G1 may be the cause             implicit conclusions of arguments can be recognized,
        of P1.                                             given the premises and an argumentation scheme
    • Genotype M2 of group G2 is similar to                rule. The inferred conclusion itself can be added to
        genotype M1.                                       the KB, enabling it to be used as a premise in
Conclusion: M2 may be the cause of P2 (in G2).             subsequent arguments. Also note that the conclusions
                                                           of the schemes are not asserted with complete
                                                           certainty. The corresponding arguments in the source




8                                                         18th Workshop on Computational Models of Natural Argument
                                                                      Floris Bex, Floriana Grasso, Nancy Green (eds)
                                                                                          16th July 2017, London, UK
   text range in force from ‘plausible hypothesis’ to       of an experiment, e.g. Conclusion, will be
   ‘fairly certain conclusion’. For details of the Prolog   capitalized, and labels of argument components will
   implementation of the seven schemes, see [Green,         be italicized.)
   2016].                                                       In the report of Experiment 1, the conclusion of
      This approach is in contrast to machine-learning      Argument 1 must be inferred to understand the
   approaches to argumentation scheme recognition that      Conclusion of the experiment. Also, it can be seen
   use only superficial text features such as keywords,     that the conclusion of Argument 1 is a premise
   parts of speech, and clause length [Feng and Hirst,      needed in the argument (Argument 2) for the
   2011; Lawrence and Reed, 2016]. In addition, some        Hypothesis of Experiment 2 in the next paragraph.
   of those approaches, e.g. [Feng and Hirst], assume       Note that Experiment 2 contains two arguments, one
   that clauses of a text are labeled as premise or         (Argument 2) for the Hypothesis, and one (Argument
   conclusion before argumentation scheme recognition       3) for the Conclusion. The conclusions of Argument
   begins. On the other hand, similar to our approach,      2 and Argument 3 are not identical, i.e., the
   [Saint-Dizier, 2012] uses manually-derived rules         conclusion of Argument 3 is more specific than that
   encoded in a logic programming language for              of Argument 2. The conclusion of Argument 3 can
   automatic identification of arguments giving reasons     be challenged by a critical question of the Method of
   for a conclusion in instructional texts or opinion       Agreement scheme, i.e., whether the putative cause
   texts. However, the rules are based on syntactic         of the disorder is causally plausible. Experiment 3
   patterns and lexical features.                           contains Argument 4, whose conclusion addresses
                                                            that critical question. Note that, in general, critical
   3    The Results Narrative                               questions associated with argumentation schemes
                                                            provide ways in which arguments may be challenged
   Having proposed an approach to mining individual
                                                            [Walton et al., 2008].
   arguments, the next step of our research is to
                                                               Paragraph 4 states a new Goal: to discover any
   investigate how the arguments are related to other
                                                            related genetic variants causing a similar disorder in
   aspects of discourse structure, and how the arguments
                                                            humans. The article then goes on to describe another
   are related to each other. Previous computation-
                                                            sequence of experiments towards that goal.
   oriented investigations of discourse in the natural
                                                               In Experiment 4, Background Knowledge and the
   sciences have addressed automatic classification of
                                                            conclusion of Argument 4 (in Experiment 3) are used
   text segments, e.g., discourse coherence relations in
                                                            (in Argument 5) to argue for the Hypothesis of the
   corpora such as BioDRB [Prasad et al., 2011] and
                                                            experiment. Based on the Result of Experiment 4,
   BioCause [Mihaila et al., 2013], argumentative zones
                                                            the implicit Conclusion (conclusion of Argument 6)
   [Teufel, 2010], and activities in a scientific
                                                            that a deletion in ITPR1-SUMF1 may be the cause, is
   investigation (CoreSC) [Liakata, 2012]. None of
                                                            broader than the original Hypothesis, that a deletion
   those annotation schemes treat arguments in the sense
                                                            in ITPR1 may be the cause. However, the conclusion
   described in the previous section.
                                                            is also narrower in the sense that it is restricted to
      The Results section of the article whose arguments
                                                            particular individuals in the AUS1 family.
   were analyzed in [Green, 2016] reports on a logical
                                                               In Experiments 5 and 6, the respective conclusions
   and temporal sequence of experiments. Arguments
                                                            of Argument 7 and Argument 8 agree with the
   are given in the context of this narrative, i.e. the
                                                            conclusion of Argument 6. Experiment 7 provides
   report of the scientific investigation. Figure 1 shows
                                                            support (Argument 9) for a related conclusion. The
   our ad hoc analysis of the narrative using descriptive
                                                            conclusions of arguments in Experiments 5-7 are
   terms similar to those of the argumentative zone and
                                                            used as premises to argue for a more general
   CoreSC systems. The relevant content of the article
                                                            conclusion in Argument 10. Then, using results of
   has been paraphrased in the figure.
                                                            Previous Research, the authors argue (Argument 11)
      The Results section begins, in its first paragraph,
                                                            against part of the conclusion of Argument 10. The
   with a description of the fortuitous discovery of an
                                                            conclusion of Argument 11 is a premise of Argument
   inherited disorder in mice bred in the authors’ lab.
                                                            12, whose conclusion is a refinement of the
   Then the authors describe a sequence of three
                                                            conclusion of Argument 10. Finally, the conclusion
   experiments intended to reveal the genetic variant
                                                            of Argument 13 addresses a critical question of
   responsible for that mouse disorder. Figure 1
                                                            Argument 12, a relationship like that of Argument 4
   describes each individual experiment in terms of its
                                                            to Argument 3.
   Goal, (use of) Previous Research or Background
                                                               As for the first of the above research questions
   Knowledge, Hypothesis, Method, Result, and/or
                                                            (how arguments are related to other aspects of
   Conclusion. (To avoid confusion with argument
                                                            discourse structure), the above analysis raises some
   components, the first letter of terms describing parts
                                                            interesting possibilities. It could be that some



18th Workshop on Computational Models of Natural Argument                                                             9
Floris Bex, Floriana Grasso, Nancy Green (eds)
16th July 2017, London, UK
argumentation schemes are more commonly used for           2001] has a key feature in common with the scientific
certain scientific purposes and not others. For            article that we analyzed. In a discovery dialogue, the
example, Argument by Analogy is used only in               goal is not to try to prove or disprove a given claim,
arguments for Hypotheses in the article that was           but to discover something not previously known.
analyzed. This could be verified by statistical
analyses of corpora, and if true, could augment the        4 Discussion
semantic method we have proposed for extracting
individual arguments. Another possibility is that the      Previous argumentation mining research has not
location in the narrative could be used as a constraint    addressed      the    natural   sciences.     However,
on argument scheme recognition. Although it can be         argumentation is an important feature of scientific
seen in Figure 1 that argument content is not in one-      discourse. This paper proposes a semantic approach
to-one correspondence with paragraph or Experiment         to automatic recognition of premises, conclusion, and
boundaries, in cases where multiple rules match, a         argumentation scheme of arguments in scientific text.
heuristic strategy of preferring local content might be    Argumentation schemes are implemented as logic
applied.                                                   programs. The logic programs would be used with a
   As for the second of the above research questions       knowledge base that could be constructed from a text
(how the arguments are related to each other), the         in a large part automatically using existing language
analysis in Figure 1 shows that a richer model is          processing tools (as described in section 2). The logic
needed than support-attack relationships represented       programs can be used, not only to recognize fully
in current argument mining approaches, e.g., [Cabrio       explicit arguments in the text, but also arguments
and Villata, 2012], [Peldszus and Stede 2016], [Stab       with implicit conclusions. This is important because
and Gurevych, 2014]. The relationships between             often the conclusions are implicit and may function
conclusions of the arguments in Figure 1 is                as implicit premises of subsequent arguments in the
summarized in Table 1.                                     text. Although the argumentation schemes have been
                                                           implemented using domain-specific predicates, they
 Table 1. Dialectical structure of Results section.        are specializations of more general schemes
 Conclusion of Relationship to      Conclusion of          applicable to other qualitative causal domains in the
 argument #                         argument #             natural sciences.
 2               Refines            1                         Also, as a step towards automatic recognition of
 3               Refines            2                      the structure of argumentation in scientific discourse,
 4               Responds to CQ 3                          we present a discourse analysis of part of a scientific
                 of                                        text and discuss the relationship of the individual
 5               Analogous to       3                      arguments to other aspects of the discourse structure,
 6               Broadens from 5                           and how the arguments are related to each other, i.e.,
                 del. of ITPR1 to                          the argumentation structure of the discourse. It is
                 ITPR1-SUMF1                               shown that a richer model is needed than support-
                 & restricts from                          attack relationships.
                 humans         to
                 AUS1                                      Acknowledgments
 7               Agrees with        6                      The analysis of argument schemes was done with the
 8               Agrees with        6                      help of graduate students, Michael Branon and
 9               Extends to more 6                         Bishwa Giri, who were supported by a University of
                 individuals                               North Carolina Greenboro 2016 Summer Faculty
 10              Extends            9 and 6                Excellence Research Grant.
 11              Attacks part of 6
                 and extends to                            References
                 humans
                                                           [Bada et al., 2012] M. Bada, M. Eckert, D. Evans, et
 12              Refines            11
                                                           al. Concept Annotation in the CRAFT corpus. BMC
 13              Responds to CQ 12                         Bioinformatics, 13:161, 2012.
                 of
                                                           [Bratko, 2001] Ivan Bratko. Prolog Programming
It would be misleading to reduce these relationships       for Artificial Intelligence. 3rd edition. Addison-
to pro or con some claim. As described in research         Wesley, Harlow, England, 2001.
on formal dialogue games for use by software agents,
the discovery dialogue [McBurney and Parsons,




10                                                        18th Workshop on Computational Models of Natural Argument
                                                                      Floris Bex, Floriana Grasso, Nancy Green (eds)
                                                                                          16th July 2017, London, UK
   [Cabrio and Villata, 2012] Cabrio, E. and Villata, S.    Hitchcock. Logic and Critical Thinking in Medicine.
   2012. Generating Abstract Arguments: A Natural           American Medical Association Press, 2005.
   Language Approach. In Verheij, B., Szeider, S., and
   Woltran, S. (eds.) Computational Models of               [Lawrence and Reed, 2016] Lawrence, J. and Reed,
   Argument: Proceedings of COMMA 2012.                     C. Argument Mining Using Argumentation Scheme
   Amsterdam, IOS Press, 454-61.                            Structures. In Baroni, P. et al. (eds.) Computational
                                                            Models of Argument: Proceedings of COMMA 2016.
   [Caporaso et al. 2007] J. G. Caporaso, W.A.              Amsterdam, IOS Press, 379-90.
   Baumgartner Jr., D. A. Randolph, K. B. Cohen, and
   L. Hunter. MutationFinder: A high-performance            [van de Leemput et al., 2007] J. van de Leemput, J.
   system for extracting point mutation mentions from       Chandran, M. Knight, et al. Deletion at ITPR1
   text. Bioinformatics, 23:1862-1865.                      Underlies Ataxia in Mice and Spinocerebellar Ataxia
                                                            15 in Humans. PLoS Genetics, 3(6) e108:1076-1082,
   [Cardie et al., 2015] C. Cardie et al. (Eds.) Second     2007.
   Workshop on Argumentation Mining. North
   American Conference of the Association for               [Liakata, M. et al., 2012] M. Liakata. Automatic
   Computational Linguistics, Denver, 2015.                 recognition of conceptualization zones in scientific
                                                            articles and two life science applications.
   [CRAFT] http://bionlp-corpora.sourceforge.net/           Bioinformatics 28(7), 2012.
   CRAFT/ index.shtml.
                                                            [Mahmood et. al., 2016] Mahmood A.S., Wu, T.J.,
   [Feng and Hirst, 2011] V.W. Feng and G. Hirst.           Mazumder, R. and Vijay-Shanker, K. (2016)
   Classifying Arguments by Scheme. In Proceedings of       DiMeX: A Text Mining System for Mutation-Disease
   the 49th Annual Meeting of the Association for           Association Extraction. PLoS One.
   Computational Linguistics, pages 987-996, Portland,
   OR, 2011.
                                                            [McBurney and Parsons, 2001] P. McBurney and S.
                                                            Parsons. Chance Discovery Using Dialectical
   [Green, 2010] N. Green. Representation of
                                                            Argumentation. In New Frontiers in Artificial
   Argumentation in Text with Rhetorical Structure
                                                            Intelligence, T. Terano et al. (Eds.). Lecture Notes in
   Theory. Argumentation 24(2): 181-196.
                                                            Artificial Intelligence, v.2253, Berlin, Springer
                                                            Verlag, 414-424.
   [Green, 2015a] N. Green. Identifying Argumentation
   Schemes in Genetics Research Articles. In
                                                            [Naderi and Witte, 2012] N. Naderi and R. Witte.
   Proceedings of the        Second Workshop on
                                                            Automated extraction and semantic analysis of
   Argumentation Mining, North American Conference
                                                            mutation impacts from the biomedical literature.
   of the Association for Computational Linguistics
                                                            BMC Genomics, 13(Suppl 4):510, 2012.
   (NAACL), Denver, CO, 2015.
                                                            [Peldszus and Stede, 2016] A. Peldszus, M. Stede.
   [Green, 2015b] N. Green. Annotating Evidence-
                                                            Rhetorical structure and argumentation structure in
   Based Argumentation in Biomedical Text. In Proc.
                                                            monologue text. In: Proceedings of the 3rd Workshop
   2015 Int. Workshop on Biomedical and Health
                                                            on Argumentation Mining, ACL Berlin, 2016.
   Informatics, IEEE Int. Conf. on Bioinformatics and
   Biomedicine (BIBM 2015), Washington, D.C, Nov. 9-
                                                            [Prasad et al., 2011] R.Prasad, S. McRoy, N. Frid, A.
   12, 2015. IEEE Computer Society Press.
                                                            Joshi, and H. Yu. The Biomedical Discourse Relation
                                                            Bank. BMC Bioinformatics, 12:188, 2011.
   [Green, 2016]          N. Green. Implementing
   Argumentation Schemes as Logic Programs.
                                                            [Reed et al., 2016] C.Reed et al. (Eds.) Third
   Workshop on Computational Models of Natural
                                                            Workshop on Argumentation Mining. Association for
   Argument (CMNA 2016).             International Joint
                                                            Computational Linguistics, Berlin, 2016.
   Conference on Artificial Intelligence, New York.
                                                            [Saint-Dizier, P, 2012] P. Saint-Dizier. Process
   [Green et al., 2014] N. Green, et al. (Eds.) First
                                                            natural language arguments with the 
   Workshop on Argumentation Mining. Association for
                                                            platform. Argument and Computation 3(1), March
   Computational Linguistics, Baltimore, MD., 2014.
                                                            2012, 49-82.
   [Jenicek and Hitchcock, 2005] M. Jenicek and D.



18th Workshop on Computational Models of Natural Argument                                                             11
Floris Bex, Floriana Grasso, Nancy Green (eds)
16th July 2017, London, UK
[Settles, 2005] B. Settles. ABNER: an open source            [Walton et al., 2008] D. Walton, C. Reed, and F.
tool for automatically tagging genes, proteins, and          Macagno. Argumentation Schemes. Cambridge
other entity names in text. Bioinformatics                   University Press, 2008.
21(14):3191-3192, 2005.

[Stab and Gurevych, 2014] C. Stab and I. Gurevych,
Annotating Argument Components and Relations in
Persuasive Essays. In Proc. COLING 2014, pp. 1501-
1510.

[Teufel, 2010] S. Teufel, S. The Structure of
Scientific Articles: Applications to Citation Indexing
and     Summarization.      Stanford,    CA,     CSLI
Publications.

[Verspoor et al., 2012] K. Verspoor, K.B. Cohen, A.
Lanfranchi, et al. A Corpus of Full-text Journal
Articles is a Robust Evaluation Tool for Revealing
Differences in Performance of Biomedical Natural
Language Processing Tools. BMC Bioinformatics
13:207, 2012.

Appendix. Figure 1. Analysis of discourse structure and argumentation.

¶1
Report Observation: Some mice bred in the authors’ lab are affected with an autosomal recessive disorder
resembling a kind of ataxia. (premise, Argument 1)
¶2
Report Experiment 1:
        Method: Linkage analysis
        Result: The affected mice have a lesion on chromosome 6qE1 (premise, Argument 1)
        Conclusion (implicit): A genetic variant on 6qE1 may be the cause of their disorder. (conclusion,
        Argument 1 - Method of Agreement; premise, Argument 2)
¶3
Report Experiment 2:
        Previous Research: A certain deletion on 6qE1 in gene Itpr1, the Itpr1 opt/opt variant, is known
        to cause a similar disorder in mice. (premise, Argument 2)
        Hypothesis: A deletion in Itpr1 may be the cause the disorder in the lab’s mice. (conclusion, Argument 2
        – Analogy)
        Method: Sequence Itpr1
        Result: The lab’s affected mice have a deletion in Itpr1: the Itpr1 Δ18/Δ18 variant. (premise, Argument 3)
        Conclusion: The Itpr1 Δ18/Δ18 variant may be the cause of their disorder. (conclusion, Argument
        3 – Method of Agreement)
Report Experiment 3:
        Previous Research: Cerebellar Purkinjee cells of Itpr1 opt/opt mice, who have ataxia, have decreased Itpr1
        expression (premise, Argument 4)
        Method: Measure expression of Itpr1 in cerebellar Purkinjee cells of mice with the Itpr1 Δ18/Δ18 variant.
        Result: Decreased level of Itrpr1 expression found. (premise, Argument 4)
        Conclusion (implicit): There is a plausible explanation at the molecular level of how deletions in
        Itpr1 may cause ataxia-like disorders in mice. (conclusion, Argument 4 – Consistent Explanation;
        premise, Argument 5)
¶4
Report Goal: Discover cause of cognate human disorders, such as spinocerebellar ataxia 15 (SCA15), where no
        causal mutation has been identified.




12                                                          18th Workshop on Computational Models of Natural Argument
                                                                        Floris Bex, Floriana Grasso, Nancy Green (eds)
                                                                                            16th July 2017, London, UK
   ¶5
   Report Experiment 4:
           Background knowledge (implicit): The ITPR1 gene in humans is functionally similar to Itpr1 in
           mice. (premise, Argument 5)
           Hypothesis: A deletion in ITPR1 is a cause of SCA15 in humans. (conclusion, Argument 5 – Analogy)
           Method: Sequence DNA from three AUS1 family members with SCA15.
           Result: The three family members had a deletion in ITPR1-SUMF1. (premise, Argument 6; premise,
           Argument 7)
           Conclusion (implicit): A deletion in ITPR1-SUMF1 may be the cause of ataxia in the three AUS1
           family members. (conclusion, Argument 6 – Method of Agreement)
   Report Experiment 5:
           Goal: Determine if the ITPR1-SUMF1 deletion is a benign polymorphism.
           Method: Compare to ITPR1 and SUMF1 in two control groups.
           Results: No deletion found in ITPR1 or SUMF1 in the control groups. (premise, Argument 7)
           Conclusion: A deletion in ITPR1-SUMF1 may be the cause of ataxia in the three affected AUS1
           family members. (conclusion, Argument 7 – Method of Difference)
   ¶6
   Report Experiment 6:
           Method: Fine-map the breakpoints of the deletion in the affected AUS1 family members and in the
           controls.
           Result: Deletion of the first three of the nine exons of SUMF1 and the first 10 of the 58 exons of
           ITPR1 in the affected family members only. (premise, Argument 8)
           Conclusion: A deletion in ITPR1-SUMF1 may be the cause of ataxia in the three AUS1 family members.
           (conclusion, Argument 8 – Method of Difference)
   ¶7
   Report Experiment 7:
           Method: Analyzed two additional families (H33 and H27) with an inherited cerebellar ataxia
           similar to that described in the AUS1 family.
           Result: The affected H33 and H27 family members have a deletion at the SCA15 locus from
           SUMF1 through IPTR1; the unaffected family members do not. (premise, Argument 9)
           Conclusion (implicit): A deletion in ITPR1-SUMF1 may be the cause of the ataxia disorder in the
           affected H33 and H27 family members. (conclusion, Argument 9 – Method of Difference)
   Report Conclusion:
           In three families [AUS1, H33, H27] cerebellar ataxia segregated with a deletion in SUMF1-ITPR1, not
           observed in controls. (premise, Argument 10)
           The deletion in ITPR1-SUMF1 is the cause of SCA15 in those families. (conclusion, Argument 10 –
           Method of Difference; premise, Argument 12)
   ¶8
   Report Previous Research:
           Homozygous mutation of SUMF1 results in autosomal recessive multiple sulfatase deficiency…
           No co-occurrence of ataxia has been described in heterozygous parents [i.e. who have one copy of a
           SUMF1 mutation] of patients with multiple sulfatase deficiency (premise Argument 11).
           It is improbable that the deletion of SUMF1 … itself causes or contributes to
           SCA15 (conclusion Argument 11 – Failed Method of Agreement; premise Argument 12).
           [Therefore, deletion in ITPR1 is the likely cause of ataxia in the three families (implicit conclusion,
           Argument 12 – Eliminate Difference)]
           Mutation of ITPR1 is biologically plausible as a cause of ataxia (conclusion, Argument 13 – Consistent
           Explanation




18th Workshop on Computational Models of Natural Argument                                                            13
Floris Bex, Floriana Grasso, Nancy Green (eds)
16th July 2017, London, UK