=Paper= {{Paper |id=Vol-2125/paper_186 |storemode=property |title=Interactive Sampling for Systematic Reviews. IMS Unipd At CLEF 2018 eHealth Task 2 |pdfUrl=https://ceur-ws.org/Vol-2125/paper_186.pdf |volume=Vol-2125 |authors=Giorgio Maria Di Nunzio,Giacomo Ciuffreda,Federica Vezzani |dblpUrl=https://dblp.org/rec/conf/clef/NunzioCV18 }} ==Interactive Sampling for Systematic Reviews. IMS Unipd At CLEF 2018 eHealth Task 2== https://ceur-ws.org/Vol-2125/paper_186.pdf
    Interactive Sampling for Systematic Reviews.
     IMS Unipd At CLEF 2018 eHealth Task 2.

     Giorgio Maria Di Nunzio1 , Giacomo Ciuffreda2 , and Federica Vezzani2
              1
               Dept. of Information Engineering – University of Padua
          2
            Dept. of Linguistic and Literary Studies – University of Padua
    giorgiomaria.dinunzio@unipd.it, giacomo.ciuffreda@studenti.unipd.it,
                         federica.vezzani@phd.unipd.it


       Abstract. This is the second participation of the Information Manage-
       ment Systems (IMS) group at CLEF eHealth Task of Technologically
       Assisted Reviews in Empirical Medicine. This task focuses on the prob-
       lem of medical systematic reviews, a problem which requires a recall close
       (if not equal) to 100%. Semi-Automated approaches are essential to sup-
       port these type of searches when the amount of data exceed the limits
       of users, i.e. in terms of attention or patience. We present a variation
       of the two-dimensional approach which 1) sets the maximum amount of
       documents that the physician is willing to read, 2) takes into account a
       sampling strategy to estimate the 95% confidence interval of the number
       of relevant documents present in the collection.


1    Introduction
In this paper, we describe the participation of the Information Management
Systems (IMS) group at CLEF eHealth 2018 [10] Task [1]. This task focuses on
the problem of systematic reviews, that is the process of collecting articles that
summarise all evidence (if possible) that has been published regarding a certain
medical topic. This task requires long search sessions by experts in the field of
medicine; for this reason, semi-automatic approaches are essential to support
these type of searches when the amount of data exceed the limits of users, i.e.
in terms of attention or patience.
    The objective of our participation to this task was to:
 – include a fixed stopping strategy to simulate the maximum amount of docu-
   ments that a physician is willing to review in the two-dimensional approach
   presented in [4, 5];
 – add a sampling strategy in the interactive process to estimate the 95% con-
   fidence interval of the proportion of relevant documents present in the col-
   lection.

2    Approach
In this paper, we continue to investigate the interaction with the two dimensional
interpretation of the BM25 model applied to the problem of explicit relevance
feedback [8, 2, 7, 4, 6]. In order to explain how the two-dimensional BM25 space
works, in the following sections we present a brief review of the BM25 model.


2.1    BM25

The BM25 is a probabilistic retrieval model where the weight of a term in a
document is equal to [9]:

                                              tf
                 wiBM 25 (tf ) =                   dl
                                                             wiBIM           (1)
                                   k1 (1 − b) + b avdl   + tf

where wi is the weight of the i-th term, k1 and b are two parameters (some
default parameters are3 k1 = 1.2 and b = 0.75), tf is the term frequency in the
document, and wiBIM is the Binary Independence Model weight of the i-th term:

                                          θiR   (1 − θiN R )
                         wiBIM = log                                          (2)
                                       (1 − θi ) θiN R
                                              R


where θiR and θiN R are the parameters of the Bernoulli random variable that
represent the presence (or absence) of the i-th term in the relevant (R) and
non-relevant (N R) documents. The estimate of each parameter is:

                                         ri + αR
                               θiR =                                          (3)
                                       R + αR + β R

                                       ni − ri + αN R
                          θiN R =                                             (4)
                                    N − R + αN R + β N R
where R is the number of relevant documents, ri the number of relevant docu-
ments in which the i-th term appears, N is the total number of documents and
ni is the total number of documents in which the i-th term appears. Parameters
α and β correspond to the hyper-parameter of the conjugate beta prior distribu-
tion of the Bernoulli random variable. For αR = β R = 0.5 and β R =N R = 0.5,
we obtain the definition of the well-known Robertson - Spärck Jones weight
wiRSJ . Given a document d, the probability of the document being relevant is
proportional to:
                                      X
                            P (R|d) ∝    wiBM 25 (tf )                      (5)
                                         i∈d



2.2    Two-Dimensional Model

The two-dimensional representation of probabilities [3, 8] is an intuitive way of
presenting a two-class classification problem on a two-dimensional space. Given
3
    http://terrier.org
two classes, for example relvant R and non-relevant N R, a document d is as-
signed to category R if the following inequality holds:
                            P (d|N R) < m P (d|R) +q                            (6)
                            | {z }        | {z }
                                   y                    x

where P (d|R) and P (d|N R) are the likelihoods of the object d given the two cat-
egories, while m and q are two parameters that can be optimized to compensate
for either the unbalanced class issues or different misclassification costs.
    If we interpret the two likelihoods as two coordinates x and y of a two dimen-
sional space, the problem of classification can be studied on a two-dimensional
plot. The decision of the classification is represented by the line y = mx + q
that splits the plane into two parts: all the points that fall ‘below’ this line are
classified as objects that belong to class R.

Two-dimensional BM25 In order to link the two-dimensional model to the
BM25 model, first we define the BIM weight as a difference of logarithms:
                         θiR              θiN R
        wiBIM = log              − log              = wiBIM,R − wiBIM,N R       (7)
                      (1 − θiR )       (1 − θiN R )
then, we can define the BM25 term weight accordingly
                                  tf               
                                                       BIM,R     BIM,N R
                                                                         
       wiBM 25 (tf ) =                 dl
                                                    w i     − w i              (8)
                       k1 (1 − b) + b avdl   + tf
                       |          {z             }
                                       wtf
                                                           
                    = wtf       wiBIM,R − wiBIM,N R                             (9)

                    = wiBM 25,R (tf ) − wiBM 25,N R (tf )                      (10)
                                                                               (11)
We now have all the elements to define the two coordinates x = P (d|R) and
y = P (d|N R) in the following way:
                                     X BM 25,R
                           P (d|R) =  wi       (tf )                   (12)
                                             i∈d

                                                   wiBM 25,N R (tf )
                                             X
                         P (d|N R) =                                           (13)
                                             i∈d
       P
where i∈d indicates (with an abuse of notation) the sum over all the terms of
document d.
    In Figure 1, we show an example of the visualization of a collection of docu-
ments using the two-dimensional BM25 model. Relevant and non relevant docu-
ments which have already been judged by a user (in our case the physician) are
colored in green and red; documents that have not been judged are greyed. The
two lines represents two possibile decision lines (see Equation 6) to rank/classify
new documents as relevant.
       0




    −50




    −100                                                                   rel
                                                                                 rel
y




                                                                                 not rel
                                                                                 not judged

    −150




    −200




    −250
           −200            −150         −100         −50          0
                                               x


                  Fig. 1: Example of two-dimensional view of the BM25 model.



3     Method

We focused on the following problems:

1. study the effectiveness of a classifier given a fixed amount of documents that
   a physician is willing to review;
2. design a sampling strategy to estimate the 95% confidence interval of the
   number of relevant documents in the collection.

In the experiments, we used the following procedure:

 – we set a number n of documents that the physician is willing to read and
   a number s that tells the algorithm when (every s documents) to randomly
   sample a document from the collection instead of presenting to the physician
   the next most relevant document;
 – for each topic, we run an optimized (hyper-parameters) BM25 retrieval
   model and we obtain the relevance feedback for the first abstract in the
   ranking list;
 – from the second document until n/2−1, we continuously update the relevance
   weights of the terms according to the explicit relevance feedback given by
   the physician (simulated by the qrels available with the test collection);
 – for the last half of the documents n/2 that the physician is willing to read, we
   use a Naı̈ve Bayes classifier continuously updated with the explicit relevance
   feedback [4].


4     Experiments

For all the experiments, we set the values of the BM25 hyper-parameters in the
following way:

 – αR = αN R = 1.0
 – β R = β N R = 0.01

These values are consistent with other experiments and indicate that a beta prior
distribution that discounts the ‘presence’ of a term in favour of its ‘absence’ (high
α and low β) results in a better retrieval performance [5]. The slope m of the
decision line is set m = 1.0 and q = 0 for the first half n/2 of the documents; then,
m and q are continuously updated according to the relevance information [4].


4.1   Official runs

We submitted three runs by varying the number of documents n that the physi-
cian is willing to read per topic: n = 1000, n = 2000, n = 3000. We set the
parameter s = 10, this means that every ten documents we sample a random
document from the collection instead of showing to the physician the next ranked
document. The three official runs are named as follows:

 – ims unipd t500.task2, n = 1000
 – ims unipd t1000.task2, n = 2000
 – ims unipd t1500.task2, n = 3000

    In Figure 2, we show the recall per topic for each official run. We see that there
are two topic in particular that are more difficult than the others: CD009263 and
CD012010 with a recall less (or close to) 0.6 for all the runs. Seven topics can
be considered as medium difficult (recall between 0.6 and 0.6 for at least one
of the experiments): CD008567, CD010213, CD010502, CD012165, CD012179,
CD012281, CD012599.
    in Figure 3, we compare the results of our three runs with the summary of
all the other CLEF 2018 participant. This plot confirms that most of high and
medium difficult topics are also topics that, on average, were difficult for most
of the participants (barplots more stretched and median far from value 1.00).


Confidence intervals of number of relevant documents During the exper-
iments, every 10 documents we sample a random document from the collection
and show the document for relevance assessment in order to estimate the number
of relevant documents in the collection. In Table 1, 2, and 3, we show a breakdown
         1.0




         0.8

                                                                                                                                                                                                                                                                                                                                                          runid
                                                                                                                                                                                                                                                                                                                                                             ims_unipd_t1000.task2
recall




                                                                                                                                                                                                                                                                                                                                                             ims_unipd_t1500.task2
                                                                                                                                                                                                                                                                                                                                                             ims_unipd_t500.task2


         0.6




         0.4
               CD008122
                          CD008587
                                     CD008759
                                                CD008892
                                                           CD009175
                                                                      CD009263
                                                                                 CD009694
                                                                                            CD010213
                                                                                                       CD010296
                                                                                                                  CD010502
                                                                                                                             CD010657
                                                                                                                                        CD010680
                                                                                                                                                   CD010864
                                                                                                                                                              CD011053
                                                                                                                                                                          CD011126
                                                                                                                                                                                     CD011420
                                                                                                                                                                                                CD011431
                                                                                                                                                                                                           CD011515
                                                                                                                                                                                                                      CD011602
                                                                                                                                                                                                                                 CD011686
                                                                                                                                                                                                                                            CD011912
                                                                                                                                                                                                                                                       CD011926
                                                                                                                                                                                                                                                                  CD012009
                                                                                                                                                                                                                                                                             CD012010
                                                                                                                                                                                                                                                                                        CD012083
                                                                                                                                                                                                                                                                                                   CD012165
                                                                                                                                                                                                                                                                                                              CD012179
                                                                                                                                                                                                                                                                                                                         CD012216
                                                                                                                                                                                                                                                                                                                                    CD012281
                                                                                                                                                                                                                                                                                                                                               CD012599
                                                                                                                                                                         topic


                                                                        Fig. 2: Recall per topic of the three official runs.



of the number of documents per topic, how many topics were read (explicit rele-
vance feedback), the number of relevant documents, how many documents were
randomly sampled, the estimate of the number of relevant documents based on
the random sample as well as the 95% confidence interval (minimum and maxi-
mum range), and the number of relevant documents found within the limit of the
threshold. In most cases, the estimate of the number of relevant documents (and
the 95% range) is much larger than the true number of relevant documents. The
analysis of the results shown in these table is still under study since we would
need a more sophisticated cost-benefit model to understand whether we want to
put more effort in the estimate of the number of relevant documents or in the
automatic classifier.

4.2            Unofficial runs
In addition to the three official runs, we prepared two unofficial runs in order to
study the feasibility of the query rewriting approach based on the work of [5]. We
asked two experts in linguistics to rewrite the query, each with a different goal:
the first variant is written with the aim of creating a list of keywords resulting
from the semic analysis (the study of meaning in linguistic units) of the technical
terms contained in the initial query. The second variant is written with the aim
of reformulating the information need into a humanly readable sentence using
         1.00




         0.75




                                                                                                                                                                                                                                                                                                                                                           runid
                                                                                                                                                                                                                                                                                                                                                              ims_unipd_t1000.task2
recall




         0.50
                                                                                                                                                                                                                                                                                                                                                              ims_unipd_t1500.task2
                                                                                                                                                                                                                                                                                                                                                              ims_unipd_t500.task2




         0.25




         0.00
                CD008122
                           CD008587
                                      CD008759
                                                 CD008892
                                                            CD009175
                                                                       CD009263
                                                                                  CD009694
                                                                                             CD010213
                                                                                                        CD010296
                                                                                                                   CD010502
                                                                                                                              CD010657
                                                                                                                                         CD010680
                                                                                                                                                    CD010864
                                                                                                                                                               CD011053
                                                                                                                                                                           CD011126
                                                                                                                                                                                      CD011420
                                                                                                                                                                                                 CD011431
                                                                                                                                                                                                            CD011515
                                                                                                                                                                                                                       CD011602
                                                                                                                                                                                                                                  CD011686
                                                                                                                                                                                                                                             CD011912
                                                                                                                                                                                                                                                        CD011926
                                                                                                                                                                                                                                                                   CD012009
                                                                                                                                                                                                                                                                              CD012010
                                                                                                                                                                                                                                                                                         CD012083
                                                                                                                                                                                                                                                                                                    CD012165
                                                                                                                                                                                                                                                                                                               CD012179
                                                                                                                                                                                                                                                                                                                          CD012216
                                                                                                                                                                                                                                                                                                                                     CD012281
                                                                                                                                                                                                                                                                                                                                                CD012599
                                                                                                                                                                          topic


Fig. 3: Boxplot of recall per topic of all the CLEF 2018 runs subtask 2 overlapped
with our three official runs.



alternative terms such as synonyms, orthographic variants, related forms and/or
acronyms. The two experts worked independently from each other by follow-
ing a structured linguistic methodology and focusing on different terminological
aspects. We name these two experiments with “keyword” and “readable”.


Linguistic Methodology: Terminological Record The methodology ap-
plied for the process of query rewriting is based on a linguistic and terminological
analysis of all the technical terms contained in the information needs provided
in the dataset. The approach is divided into the following steps:

 1. Recognition of technical terms;
 2. Extraction of technical terms;
 3. Linguistic and semantic analysis;
 4. Formulation of terminological records;
 5. Query rewriting.

    The core of our methodology is basically a new model of terminological record
used for the analysis of medical terminology [11]. This tool is a structured set
of terminological data referring to a specific concept and it is used in order to
provide linguistic information about the concept itself and the term used for its
         1.0




         0.9



                                                                               groupid
                                                                                  auth
         0.8                                                                      cnrs
                                                                                  ECNU
recall




                                                                                  ims
                                                                                  sheffield
         0.7                                                                      uci
                                                                                  UW




         0.6




         0.5
               0          50000        100000        150000        200000
                                          shown


Fig. 4: Recall per number of documents shown of all the CLEF 2018 runs subtask
2. Runs have been grouped per participant.



designation both for its lexical and semantic framing. This terminological record
is composed of four general fields, which individually refer to formal features,
semantics, corpus and references. Each field in turn is divided in specific subfields
describing the term according to linguistic and notional criterions.
    Focusing on the first two subfields, the section named “formal feature” con-
tains lexical and morphosyntactic information such as genre, tonic accent, spelling,
etymology (derivation and composition), orthographic variant, acronyms/expansions
and related forms. From the semantic viewpoint, the subfield “semantics” con-
tains the definition of the term, its semic analysis, cases of phraseology (collo-
cations and colligations) and all the possible semantic variants.
    For example for topic CD011602, the information need provided is:
           Ultrasonography for diagnosis of alcoholic cirrhosis in people with alco-
           holic liver disease.
We initially proceeded with the extraction of technical terms (both single-word
and multi-word terms) such as ultrasonography, diagnosis, alcoholic cirrhosis,
cirrhosis, alcoholic liver disease, liver, disease and then we started to formulate
terminological records for each of them. The subfield named “formal feature”
was useful for the human readable reformulation, whereas ‘semantics” subfield
provided the information necessary for the keywords reformulation.
Table 1: Number of documents and relevant documents (true and estimated) per
topic. Experiment with threshold t = 500.
topic    num docs docs read num rel sampled est rel range min range max found rel
CD008122     1911       987    272       76    150         54        246     239
CD008587     9152       993     79      104    722        255       1189      63
CD008759      932       932     60       65     73         27        119      60
CD008892     1499       987     69       74    118         43        193      64
CD009175     5644       992     65      105    445        158        732      55
CD009263    78803       995    124      639 6221         2187     10255       49
CD009694      161       161     16       10     12          6         18      16
CD010213    15198       993    599      114 1199          423       1976     348
CD010296     4602       991     53       88    363        129        597      52
CD010502     2985       990    229       91    235         84        386     144
CD010657     1859       989    139       83    146         53        240     133
CD010680     8405       993     26      100    663        235       1092      25
CD010864     2505       989     44       84    197         71        324      37
CD011053     2235       989     12       90    176         63        288      12
CD011126     6000       994     13      156    473        168        779      13
CD011420      251       251     42       10     19          9         30      42
CD011431     1182       984    297       62     93         34        151     279
CD011515     7244       992    127       95    571        202        940     104
CD011602     6157       994       8     129    486        172        799        8
CD011686     9443       994     55      208    745        263       1227      54
CD011912     1406       989     36       76    111         40        181      36
CD011926     4050       994     40       96    319        114        525      39
CD012009      536       536     37       29     42         16         67      37
CD012010     6830       994    290       99    539        191        887     146
CD012083      322       322     11       16     25         11         39      11
CD012165    10222       993    308      117    807        285       1328     229
CD012179     9832       995    304      119    776        274       1277     205
CD012216      217       217     11       16     17          8         26      11
CD012281     9876       994     23      157    779        275       1283      17
CD012599     8048       994    575      103    635        225       1045     279




First variant: keywords reformulation In particular, semic analysis turns
out to be the most useful process for the keyword reformulation and it aims to
decompose the meaning of the term analyzed. This process consists of breaking
down the sememe (i.e. the meaning) of a word in all its sense components, e.g.
the semes. So for exemple, for the term cirrhosis the process of decomposition
of meaning produced the following list of keywords: /chronic disease/ /liver/
/degeneration/ /cells/ /human body/ /inflammation/ /fibrous/ /thickening/
/tissue/ /alcoholism/ /hepatitis/.
    We repeat this kind of analysis of each technical term in the information need
and considering the above mentioned exemple for topic CD011602, the keyword
reformulation is the following:
Table 2: Number of documents and relevant documents (true and estimated) per
topic. Experiment with threshold t = 1000.
topic    num docs docs read num rel sampled est rel range min range max found rel
CD008122     1911      1911    272      104    150         54        246     272
CD008587     9152      1987     79      190    722        255       1189      75
CD008759      932       932     60       65     73         27        119      60
CD008892     1499      1499     69       90    118         43        193      69
CD009175     5644      1986     65      185    445        158        732      59
CD009263    78803      1994    124      737 6221         2187     10255       50
CD009694      161       161     16       10     12          6         18      16
CD010213    15198      1989    599      209 1199          423       1976     486
CD010296     4602      1981     53      163    363        129        597      53
CD010502     2985      1984    229      136    235         84        386     187
CD010657     1859      1859    139      122    146         53        240     139
CD010680     8405      1990     26      188    663        235       1092      26
CD010864     2505      1971     44      132    197         71        324      39
CD011053     2235      1973     12      126    176         63        288      12
CD011126     6000      1991     13      234    473        168        779      13
CD011420      251       251     42       10     19          9         30      42
CD011431     1182      1182    297       65     93         34        151     297
CD011515     7244      1986    127      169    571        202        940     115
CD011602     6157      1988       8     202    486        172        799        8
CD011686     9443      1990     55      289    745        263       1227      55
CD011912     1406      1406     36       86    111         40        181      36
CD011926     4050      1987     40      160    319        114        525      39
CD012009      536       536     37       29     42         16         67      37
CD012010     6830      1986    290      178    539        191        887     168
CD012083      322       322     11       16     25         11         39      11
CD012165    10222      1988    308      200    807        285       1328     272
CD012179     9832      1991    304      197    776        274       1277     264
CD012216      217       217     11       16     17          8         26      11
CD012281     9876      1992     23      233    779        275       1283      19
CD012599     8048      1988    575      180    635        225       1045     444



   /technique/ /echoes/ /ultrasound pulses/ /ultrasound/ /pulse/ /delin-
   eate/ /areas/ /different density/ /body/ /human being/ /cells/ /exam-
   ination/ /evaluation/ /diagnostic/ /diagnosing/ /diagnose/ /alcohol/
   /chronic/ /disease/ /cirrhosis of the liver/ /liver/ degeneration/ /cells/
   /inflammation/ /fibrous/ /thickening/ /tissue/ /alcoholism/ /hepati-
   tis/ /patient/ /large lobed glandulare organ/ /abdomen/ vertebrates/
   /metabolic processes/ /disorder/ /structure/ /function/ / symptoms/
   /affect/ /location/ /physical injury/.


Second variant: human readable reformulation The second type of query
was written with the aim of reformulating the information need in a humanly
readable sentence. Thanks to terminological records, we have been able to replace
Table 3: Number of documents and relevant documents (true and estimated) per
topic. Experiment with threshold t = 1500.
topic    num docs docs read num rel sampled est rel range min range max found rel
CD008122     1911      1911    272      104    150         54        246     272
CD008587     9152      2984     79      274    722        255       1189      77
CD008759      932       932     60       65     73         27        119      60
CD008892     1499      1499     69       90    118         43        193      69
CD009175     5644      2977     65      238    445        158        732      61
CD009263    79786      2993    124     1811 6298         2214     10383       56
CD009694      161       161     16       10     12          6         18      16
CD010213    15198      2984    599      283 1199          423       1976     523
CD010296     4602      2967     53      210    363        129        597      53
CD010502     2985      2954    229      170    235         84        386     229
CD010657     1859      1859    139      122    146         53        240     139
CD010680     8405      2983     26      270    663        235       1092      26
CD010864     2505      2505     44      142    197         71        324      44
CD011053     2235      2235     12      161    176         63        288      12
CD011126     6000      2979     13      293    473        168        779      13
CD011420      251       251     42       10     19          9         30      42
CD011431     1182      1182    297       65     93         34        151     297
CD011515     7244      2976    127      244    571        202        940     117
CD011602     6157      2982       8     268    486        172        799        8
CD011686     9443      2979     55      370    745        263       1227      55
CD011912     1406      1406     36       86    111         40        181      36
CD011926     4050      2970     40      199    319        114        525      39
CD012009      536       536     37       29     42         16         67      37
CD012010     6830      2977    290      242    539        191        887     177
CD012083      322       322     11       16     25         11         39      11
CD012165    10222      2981    308      282    807        285       1328     292
CD012179     9832      2984    304      269    776        274       1277     278
CD012216      217       217     11       16     17          8         26      11
CD012281     9876      2985     23      321    779        275       1283      20
CD012599     8048      2978    575      246    635        225       1045     503



original terms with validly attested synonyms and use orthographic alternatives
as variants of the medical terms provided in the original information need as
well as to systematically replace acronyms with their expansions and expansions
with their acronyms. Considering the previous topic CD011602, we obtained the
following readable reformulation:


   Diagnostic accuracy of medical ultrasound, known as diagnostic sonogra-
   phy or ultrasonography, for the detection of alcoholic liver disease (ALD)
   as the liver manifestations of alcohol overconsumption, including fatty
   liver, alcoholic hepatitis, and chronic hepatitis with liver fibrosis or cir-
   rhosis.
         Table 4: Recall at documents shown: official vs unofficial results
                       t = 500                  t = 1000                  t = 1500
    topic    original readable keyword original readable keyword original readable keyword
    CD008122   0.879     0.882    0.879  1.000     1.000    1.000  1.000     1.000    1.000
    CD008587   0.797     0.797    0.785  0.949     0.962    0.962  0.975     0.975    0.975
    CD008759   1.000     1.000    1.000  1.000     1.000    1.000  1.000     1.000    1.000
    CD008892   0.928     0.928    0.928  1.000     1.000    1.000  1.000     1.000    1.000
    CD009175   0.846     0.846    0.846  0.923     0.923    0.923  0.938     0.938    0.938
    CD009263   0.403     0.395    0.355  0.411     0.427    0.427  0.452     0.452    0.476
    CD009694   1.000     1.000    1.000  1.000     1.000    1.000  1.000     1.000    1.000
    CD010213   0.581     0.589    0.611  0.811     0.816    0.820  0.873     0.871    0.871
    CD010296   0.981     0.981    0.981  1.000     1.000    1.000  1.000     1.000    1.000
    CD010502   0.633     0.633    0.633  0.817     0.996    1.000  1.000     1.000    1.000
    CD010657   0.964     0.964    0.971  1.000     1.000    1.000  1.000     1.000    1.000
    CD010680   0.962     0.962    0.962  1.000     1.000    1.000  1.000     1.000    1.000
    CD010864   0.841     0.841    0.841  0.886     0.909    0.909  1.000     1.000    1.000
    CD011053   1.000     1.000    1.000  1.000     1.000    1.000  1.000     1.000    1.000
    CD011126   1.000     1.000    0.846  1.000     1.000    1.000  1.000     1.000    1.000
    CD011420   1.000     1.000    1.000  1.000     1.000    1.000  1.000     1.000    1.000
    CD011431   0.939     0.946    0.939  1.000     1.000    1.000  1.000     1.000    1.000
    CD011515   0.819     0.811    0.819  0.906     0.906    0.906  0.921     0.921    0.921
    CD011602   1.000     1.000    1.000  1.000     1.000    1.000  1.000     1.000    1.000
    CD011686   0.982     0.982    0.982  1.000     1.000    1.000  1.000     1.000    1.000
    CD011912   1.000     1.000    1.000  1.000     1.000    1.000  1.000     1.000    1.000
    CD011926   0.975     0.975    0.975  0.975     0.975    0.975  0.975     0.975    0.975
    CD012009   1.000     1.000    1.000  1.000     1.000    1.000  1.000     1.000    1.000
    CD012010   0.507     0.507    0.507  0.579     0.579    0.583  0.614     0.617    0.614
    CD012083   1.000     1.000    1.000  1.000     1.000    1.000  1.000     1.000    1.000
    CD012165   0.747     0.737    0.727  0.886     0.880    0.880  0.948     0.942    0.945
    CD012179   0.674     0.681    0.678  0.868     0.875    0.878  0.914     0.921    0.921
    CD012216   1.000     1.000    1.000  1.000     1.000    1.000  1.000     1.000    1.000
    CD012281   0.739     0.739    0.783  0.826     0.826    0.826  0.870     0.870    0.826
    CD012599   0.485     0.492    0.483  0.772     0.767    0.765  0.877     0.875    0.878
               0.856     0.856    0.851  0.920     0.928    0.928  0.945     0.945    0.945




5    Discussion

We are currently evaluating the results of these reformulation topic by topic,
Table 4, and studying the impact, from a linguistic point of view, of a query
reformulation in the top 10 retrieved documents, Table 5.
    In this phase of the analysis, we noted that there are some topics for which
the two reformulations (“keywords” and/or “readable”) retrieved, in the first
10 positions, more relevant documents than the original query. Table 6 shows
these topics and the number of documents retrieved depending on the type
of reformulation. We then proceed with the manual analysis of such topics by
reading the abstracts of the relevant documents retrieved from the two variants
and we started to analyse from a linguistic viewpoint which terms contained in
the two reformulations allowed the retrieval of such relevant documents.
    As a first and approximate analysis, we noted that the terms that were most
frequently used in the two reformulations are those related to the diagnostic and
evaluative sphere such as diagnosis and related forms as diagnostic, diagnose and
diagnosing as well as evaluation, examination, test and detection. Furthermore,
even the replacement of the full multi-word terms with the acronym such as
DMSA for Dimercaptosuccinic Acid Scan, VUR for Vesicoureteral Reflux and
UTI for Urinary Tract Infection, has turned out to be a good approach because
    Table 5: Precision at 10 documents for each topic for the official runs.
                      topic   original readable keyword
                      CD008122 0.800      0.100    0.200
                      CD008587 0.300      0.000    0.000
                      CD008759 0.700      0.000    0.000
                      CD008892 0.700      0.600    0.300
                      CD009175 0.400      0.200    0.100
                      CD009263 0.500      0.000    0.000
                      CD009694 0.500      0.600    0.300
                      CD010213 0.500      0.400    0.000
                      CD010296 0.600      0.000    0.000
                      CD010502 0.600      0.600    0.500
                      CD010657 0.400      0.600    0.100
                      CD010680 0.100      0.300    0.000
                      CD010864 0.000      0.000    0.000
                      CD011053 0.400      0.200    0.100
                      CD011126 0.100      0.000    0.000
                      CD011420 0.600      0.900    0.800
                      CD011431 0.400      0.000    0.800
                      CD011515 0.100      0.100    0.000
                      CD011602 0.100      0.100    0.100
                      CD011686 0.100      0.700    0.000
                      CD011912 0.400      0.400    0.200
                      CD011926 0.400      0.700    0.600
                      CD012009 0.000      0.200    0.400
                      CD012010 1.000      1.000    0.100
                      CD012083 0.300      0.000    0.300
                      CD012165 0.200      0.100    0.300
                      CD012179 0.600      0.300    0.000
                      CD012216 0.100      0.000    0.100
                      CD012281 0.100      0.100    0.000
                      CD012599 0.400      0.400    0.000



reduced lexical forms are one of the typical feature of medical language and
abbreviations are used in order to rapidly transmit health information.


6   Ongoing and Future Work

In this work, we presented a continuous active learning approach that uses a
fixed stopping strategy to simulate the maximum amount of documents that a
physician is willing to review, and a sampling strategy that is used to estimate
the number of relevant documents in the collection. We are currently performing
a failure analysis to understand the possibile reasons of a recall below 90% and
identify the linguistic aspects of a query rewriting approach that may help to
improve the performance of an interactive system.
         Table 6: Topics and number of relevant documents retrieved
                          topic    readable keywords
                          CD009694    1        0
                          CD010657    5        1
                          CD010680    2        0
                          CD011420    7        7
                          CD011431    0        8
                          CD011686    7        0
                          CD011926    5        4
                          CD012009    2        4
                          CD012165    1        3


References
1. Evangelos Kanoulas, Rene Spijker, Dan Li, and Leif Azzopardi, editors. CLEF 2018
   Technology Assisted Reviews in Empirical Medicine Overview. CLEF 2018 Evalu-
   ation Labs and Workshop: Online Working Notes, CEUR Workshop Proceedings.
   CEUR-WS.org, 2018.
2. Giorgio Maria Di Nunzio. A new decision to take for cost-sensitive naı̈ve bayes
   classifiers. Inf. Process. Manage., 50(5):653–674, 2014.
3. Giorgio Maria Di Nunzio. Interactive text categorisation: The geometry of likeli-
   hood spaces. Studies in Computational Intelligence, 668:13–34, 2017.
4. Giorgio Maria Di Nunzio. A study of an automatic stopping strategy for tech-
   nologically assisted medical reviews. In Advances in Information Retrieval - 40th
   European Conference on IR Research, ECIR 2018, Grenoble, France, March 26-29,
   2018, Proceedings, pages 672–677, 2018.
5. Giorgio Maria Di Nunzio, Federica Beghini, Federica Vezzani, and Geneviève Hen-
   rot. An interactive two-dimensional approach to query aspects rewriting in sys-
   tematic reviews. IMS unipd at CLEF ehealth task 2. In Working Notes of CLEF
   2017 - Conference and Labs of the Evaluation Forum, Dublin, Ireland, September
   11-14, 2017., 2017.
6. Giorgio Maria Di Nunzio, Maria Maistro, and Federica Vezzani. A gamified ap-
   proach to naı̈ve bayes classification: A case study for newswires and systematic
   medical reviews. In Companion of the The Web Conference 2018 on The Web
   Conference 2018, WWW 2018, Lyon , France, April 23-27, 2018, pages 1139–1146,
   2018.
7. Giorgio Maria Di Nunzio, Maria Maistro, and Daniel Zilio. Gamification for ma-
   chine learning: The classification game. In Proceedings of the Third International
   Workshop on Gamification for Information Retrieval co-located with 39th Inter-
   national ACM SIGIR Conference on Research and Development in Information
   Retrieval (SIGIR 2016), Pisa, Italy, July 21, 2016., pages 45–52, 2016.
8. Giorgio Maria Di Nunzio, Maria Maistro, and Daniel Zilio. The university of
   padua (IMS) at TREC 2016 total recall track. In Proceedings of The Twenty-Fifth
   Text REtrieval Conference, TREC 2016, Gaithersburg, Maryland, USA, November
   15-18, 2016, 2016.
9. Stephen E. Robertson and Hugo Zaragoza. The probabilistic relevance framework:
   BM25 and beyond. Foundations and Trends in Information Retrieval, 3(4):333–
   389, 2009.
10. Hanna Suominen, Liadh Kelly, Lorraine Goeuriot, Evangelos Kanoulas, Leif Az-
    zopardi, Rene Spijker, Dan Li, Aurélie Névéol, Lionel Ramadier, Aude Robert,
    Joao Palotti, Jimmy, and Guido Zuccon, editors. Overview of the CLEF eHealth
    Evaluation Lab 2018. CLEF 2018 - 8th Conference and Labs of the Evaluation
    Forum, volume Lecture Notes in Computer Science (LNCS). Springer, September
    2018.
11. Federica Vezzani, Giorgio Maria Di Nunzio, and Geneviève Henrot. Trimed: A
    multilingual terminological database. In Proceedings of the Eleventh International
    Conference on Language Resources and Evaluation, LREC 2018, Miyazaki, Japan,
    May 7-12, 2018., 2018.