Scrutinizing the axiomatic basis of SNOMED CT: How confused is it by the ambiguous terminology paradigm? Jean-Marie Rodrigues1,2* Stefan Schulz3 and Alan Rector4 1 INSERM LIMICS UPMC UP 13 Paris, France 2 University of Saint Etienne, CHU, Department of Public Health and Medical Informatics, Saint Etienne, France 3 3Institute for Medical Informatics, Statistics and Documentation, Medical University of Graz, Austria 4 University of Manchester, UK ABSTRACT rectness of the axiomatic expressions is affected when SNOMED CT, the world’s largest clinical terminology introduces it- SNOMED CT curators are led preferentially by language. self as “a terminological resource which consists of codes representing meanings expressed as terms, with interrelationships between the We first analyse the external inconsistencies between axio- codes to provide enhanced representation of the meanings.” On the matic descriptions and definitions of SNOMED CT con- one hand, concepts are linked to lexical entities (terms), including Fully cepts on the one hand and the ICD11 class. Thereafter, we Specified Names, Preferred Terms, and Synonyms. On the other hand, SNOMED CT concepts are described and defined by expressions follow- investigate inconsistencies within SNOMED CT and their ing a formalism called Compositional Grammar (CG), according to relation to ambiguities in typical clinical interface terms. As which SNOMED CT might be considered a formal ontology. We investi- a conclusion, we recommend that the axiomatic underpin- gate whether or not the ambiguity in the terms, which are formulated ning of SNOMED CT should be developed autonomously according to lexical and linguistic principles, is hampering the quality of the formal concept model using DL semantics and propose a more from the lexical entitites/terms, and that the linkage of terms autonomous development process for formal concept definitions. for concepts to the axiomatic descriptions of those concepts be done after the axiomatic model of the concepts is consol- 1 INTRODUCTION idated. SNOMED CT [1], a clinical terminology standard with about 300,000 representational units, is presented as a ter- 2 MATERIAL AND METHODS minological resource linked to description logics expres- SNOMED CT‘s representational units, called concepts are sions [1]. We can therefore consider SNOMED CT as both linked to clinical terms (so called “descriptions”) in several  A terminology – as constituted by concepts (entities of languages. Terms are of several types including Fully Speci- lexical meaning), related terms of different types (Fully fied Names (FSNs), Preferred Terms (PTs), and Synonyms. Specified Names, Preferred Terms, and Synonyms, SNOMED CT concepts are also formally described by ex- obeying several naming conventions). pressions following a language called Compositional  A formal ontology constituted by classes, individuals Grammar (CG) [3], which can be interpreted according to and formal relations expressed as axioms in “Composi- description logic (DL) semantics. In the following example, tional Grammar” equivalent to EL++/OWL-EL – what Fracture of tibia, is fully defined as being equivalent to SNOMED call the “concept model”. As such, the con- Injury of tibia and Fracture of lower leg, with Associated sistency of the SNOMED CT concept model can be morphology Fracture and Finding site Bone structure of checked by description logics reasoners. tibia. Its rendering in CG and the Description Logics Man- It is critical that the concepts referred to by linguistic ex- chester Syntax is shown below (class symbols are set in pressions used in electronic health records are accurately Italics and relation symbols are in Bold): aligned with the underlying axiomatic representation of those concepts. Recent works on the harmonization between 31978002 |Fracture of tibia(disorder)| a subset of SNOMED CT and a pre-final version of ICD-11 === 428881005 |Injury of tibia (disorder)| + have highlighted significant modelling issues. In more than 414292006 |Fracture of lower leg (disorder)| : one third of cases, the SNOMED CT axiomatic expressions { 363698007 |Finding site (attribute)| = did not align well with the intuitive meaning derived from 12611008 |Bone structure of tibia (body structure)|, their Fully Specified Names or synonyms, when lexically 116676008 |Associated morphology (attribute)| = mapped to ICD-11 classes [2]. 72704001 |Fracture (morphologic abnormality)| } This paper will investigate the hypothesis that in the pro- ‘Fracture of tibia’ equivalentTo cess of building and maintaining SNOMED CT, the cor- ‘Injury of tibia (disorder)’ and ‘Fracture of lower leg (disorder)’ and RoleGroup some * To whom correspondence should be addressed: ((‘Finding site (attribute)’ some rodrigue@univ-st-etienne.fr 1 ‘Bone structure of tibia (body structure)’) and lexically mapped to a single ICD 11 class constituted a fully (‘Associated morphology (attribute)’ some equivalent representation of the ICD11 class. ‘Fracture (morphologic abnormality)’)) The details are developed below and summarized in Figure Table 1. SNOMED CT definitions in Conceptual Grammar 1 and Table 2. (above) and OWL Manchester Syntax (below) We introduce the following symbols for the mapping types: CG supports logic-based compositional expressions in order M (refined by M1 and M2), A (refined by A1 and A2), P to maximise the coverage of utterances in clinical records, and Z. We consider the mapping of a SNOMED CT Con- without requiring the terminology to attend the users’ de- cept SCi, described by terms STi{1…n} to an ICD class ICi, mand by continuous creation of new concepts. The latter is described by a name ITi. known as pre-coordination. An example for a pre- Lexical map coordinated concept is “right hand”, which has the code  The following rules apply for the lexical maps 78791008 |Structure of right hand (body structure). In con-  If there is a full lexical map between the ICD-11 class trast, there is no code for “right thumb”, but the meaning of name ITi and one SNOMED CT description STi{1…n, this is expressible by post-co-ordination, viz. by the CG considered as pre-coordinated in SNOMED CT it is expression 76505004 |Thumb structure (body structure)|: classified as M (for lexical Map) type . 272741003 |Laterality (attribute)| = 24028007 |Right  If there is no lexical map between any ITi and STik , but (qualifier value), corresponding to the OWL expression: if mapping can be achieved to the post-coordination of ‘Thumb structure (body structure)’ and two or more descriptions STi{1…n, of SCk , it is classi- ‘Laterality (attribute)’ some ‘Right (qualifier value)’. fied as A (for Addition map) type.  If only a part of ITi of ICi can be lexically mapped to ICD – the International Classification of Diseases and Re- any STik it is classified as P (for Partial) type. lated Health Problems – is promoted by WHO as “the  Finally, if not even a partial lexical mapping between standard diagnostic tool for causes of death, epidemiology, any ITi o of ICi and STik is possible, it is classified as Z health management and clinical purposes”. However, it is (for Zero) type. particularly focused on the analysis of the health of popula- Match of meaning tion groups, and is used to monitor the incidence and preva- Subsequently, the defining and constraining axioms of one lence of diseases and other health problems. The ongoing or more than one SCi CG expressions were analysed to 11th (ICD-11) revision, named ICD-11-MMS (Mortality, check whether they correspond to the totality of the textual Morbidity and Standard) is planned to be finalized in 2018. definition and to the hierarchy inheritance of ICi . The fol- ICD has recently been characterized as an “aggregation lowing cases are distinguished: terminology” [2]. This terminology genre typically contains  M (lexical map) type: rules that enforce the principle of single hierarchies and 1. This expression fully represents the meaning of ICi, disjoint classes. Partitioning ICD-11 into non-overlapping a complete match meaning is assumed: the classifi- chapters requires exclusion rules at all hierarchical levels. cation is refined to M1. E.g., the chapter “circulatory system” excludes infections, 2. This expression does not fully represent the mean- neoplasms, endocrine and congenital diseases called “devel- ing of ICi, a new expression is produced according opmental”, which have their own chapters. Making ICD to CG: the classification is refined to M2. exhaustive requires residual classes (“other specified”, “oth-  A (addition map) type: er unspecified”), indicated by codes ending in “Y” or “Z”. 1. These expressions fully represent the meaning of named residuals which have no meaning outside the ICD ICi, a complete match meaning is assumed: the hierarchy. classification is refined to A1. The current study is limited to 428 classes from ICD-11, as 2. These expressions do not fully represent the mean- displayed by the WHO browser [5], covering the circulatory ing of ICi, a new expression is produced according system, and 522 classes covering the digestive system. We to CG: the classification is refined to A2. exclude ICD-11 residuals because they are meaningless  P type: outside ICD. The resulting totals are 206 in the circulatory For ICi it is then necessary to create a logical represen- chapter and 250 in the digestive chapter (see Table 4). tation based on one existing CG expression plus an ex- tended de novo CG expression. In a first step, we compared the Compositional Grammar (CG) expressions of lexically mapped ICD11 classes and  Z type: For this ICi it is necessary to create a logical expression SNOMED CT concepts using WHO and in accordance with SNOMED CT CG . IHTSDO/SNOMED Browsers [4][5]. As explained in [6], the lexical map is based on ICD 11 class names and In the following, only M and A types will be analysed. SNOMED CT FSNs or synonyms. In a second step, we checked if the CG expressions of SNOMED CT concepts 2 Erreur ! Il n'y a pas de texte répondant à ce style dans ce document. adapted SNOMED CT concept terms. We were conforming to the assumptions, rules, and standards of the SNOMED CT concept model when we have to extend the representa- tion (Types M2 and A2). Two knowledge engineering mas- ter students did the work, one each for the circulatory and digestive chapters. The same senior ICD-11 and SNOMED CT expert supervised both. Map and meaning ICD11 Rate ICD11 Rate match types Circ. (%) count Digestive (%) Fig. 1. ICD-11 SNOMED CT semantic alignment principle count M1 209 51 251 53 Lexical map M2 123 30 125 26 and meaning Action Compositional grammar A1 17 4 23 5 match A2 15 3 25 5 Lexical map and Take the representation The existing pre- P 44 11 45 9 full meaning expression of the coordinated inferred Z 4 1 9 2 match (M 1). SNOMED CT concept expression of SNOMED Total (M + A + P + Z) 412 68 478 66 CT concept “complete chapter” Lexical map and Take the representation Modify the existing pre- Other and unspecified 197 32 250 34 no full meaning expression of the coordinated inferred number of codes match (M 2) SNOMED CT concept expression of SNOMED Total number of codes 609 100 728 100 CT concept Table 3. Numbers of codes in the Circulatory chapter and Diges- Post-coordinated Take the representation Post-coordination of two tive chapter, from ICD 11 MMS 2017 to SNOMED CT 31 January lexical map of two or more pre- or more pre-coordinated 2017 release by map and meaning match types possible and full coordinated existing existing inferred expres- meaning match representations of sion of SNOMED CT 3 RESULTS (A 1). SNOMED CT concepts concepts Post-coordinated Take the representation Post-coordination and Table 3 provides an overview of the results. The two most lexical map of two or more pre- modification of two or frequent lexical map types are M (M1 plus M2) for full possible but no coordinated existing more pre-coordinated lexical map with a pre-coordinated SNOMED CT concept full meaning representations of existing inferred expres- and A (A1 plus A2) full lexical map with more than one match (A 2). SNOMED CT concepts sion of SNOMED CT post-coordinated SNOMED CT concepts: 78 % for the concepts circulatory chapter and 89% for the digestive chapter. The Partial lexical Take the representation One pre-coordinated most frequent type is M1 for both. The less frequent types map (P) of one pre-coordinated existing inferred expres- are Z for no possible lexical map for the circulatory chapter existing representation sion of a SNOMED CT (1%) and for the digestive chapter (2%). These differences of SNOMED CT con- concept plus an extended can be explained by inter-ratter differences (the work was cept de novo CG expression done by two different knowledge engineering master stu- No lexical map Create a logical CG A new logical CG expres- dents supervised by the same senior terminology expert) or (Z). expression sion quality differences between these two chapters either in Table 2. The lexical maps types and meaning matches between WHO ICD 11 or in SNOMED CT or in both. the ICD-11 MMS classes and SNOMED CT formal expressions Map and ICD11 ICD11 ICD11 ICD11 meaning Circ. Circ. Digestive Digestive We did not consider the current pre-final version of ICD-11 match types system system system system primi- as a gold standard. Therefore, the total or partial omission total primitives total tives of a SNOMED CT concept that seemed necessary to ICD 11 M1 209 44 (21%) 251 58 (23 %) was not considered an issue, and these cases were omitted. Neither did we assess the clinical consistency of ICD 11’s M2 123 112 (91%) 125 105 (84%) textual definitions. We assessed only the existing CG ex- A1 17 6 (35%) 23 11 (47%) pression(s) as to how well they represented the ICD-11 class A2 15 8 (53%) 25 13 (52%) textual definitions when the IC11 class names have been Table 4. Primitive SNOMED CT concepts by map and meaning lexically mapped to SNOMED terms or to a minimally match types 3 To address the quality of the formal descriptions of ‘Sudden onset AND/OR short duration (qualif. value)’) and SNOMED CT, it is interesting to compare the rate of primi- (‘Has definitional manifestation (attribute)’ some tive SNOMED CT concepts in the different Map and Mean- ‘Tachycardia (finding)’) ) ing match types as shown in Table 4. The types with full This representation lacks the localization of the arrhythmia map and meaning match (M1 and A1) have a lower rate of at the atrium and the formalization allows representing it as SNOMED CT primitive concepts (from 21 % to 47%) and the following one. The modification to the original expres- the types with no full match (M2 and A2) have a higher rate sion is underlined. of SNOMED CT primitive concepts (from 52% to 91%). RoleGroup some Nevertheless the primitive concepts rate of full Map and ((‘Finding site (attribute)’ some Meaning match types (M1 and A1) is high when it is con- ‘Preferential interatrial pathway (body structure)’)and sidered that the lexical map was complete between the ICD- (‘Clinical course (attribute))’ some 11 class name and the SNOMED CT FSN or synonym. On ‘Sudden onset AND/OR short duration (qualif. value)’) and the contrary, when the lexical map is incomplete we should (‘Has definitional manifestation (attribute)’ some have expected a rate nearer from 100 % which is nearly ‘Tachycardia (finding)’) ) true for M2 but less for A2. An example for the type A1 is BA04.3 is Secondary hyper- It is necessary to go further by taking some examples of tension associated with renal tubular disorders This ICD-11 mismatches regarding primitive and fully defined SNOMED class has no definition in most recent version (Jan 2017). A CT concepts. full lexical map can be done with the SNOMED CT concept As an example for the type M1, the ICD ICD-11 class DA 31992008, Secondary hypertension(disorder), a primitive 40.4 Perforation of esophagus is defined by: “Perforation of concept, together with 95568003, Renal tubular disorder esophagus is a penetration or hole of the wall of the esoph- (disorder), a fully defined one, using the following post- agus, resulting in luminal contents in esophagus flowing coordinated SNOMED CT inferred expressions, which into the mediastinum and/or thoracic cavity”. The full lexi- introduces the aetiology using the relation DueTo: cal map is with the fully defined SNOMED CT concept Has definitional manifestation (attribute) some 23387001, Finding of increased blood pressure (finding) and Perforation of esophagus (disorder), which is equivalent to RoleGroup some (‘Finding site (attribute)’ some the following (inferred) pre-coordinated SNOMED CT ‘Systemic circulatory system structure (body structure)’) and inferred expression: ‘Due to (attribute)’ some Renal tubular disorder (disorder) RoleGroup some As an example for the type A2, let us analyse the ICD-11 ((‘Finding site (attribute)’ some ‘Esophageal structure (body structure)’) and class DB02.31 Ig-E mediated allergic enteritis of small (‘Associated morphology (attribute)’ some intestine, defined as “Immediate type (IgE-mediated) enter- ‘Perforation (morphologic abnormality)’)) ic hypersensitivity due to exposure to an allergen in individ- uals previously sensitized. The symptoms are acute ab- As an example for the type M2, the ICD-11 class BB67.3 dominal pain and diarrhoea and can be combined to other Macro re-entrant atrial tachycardia is defined as “An atrial symptoms in cases of anaphylaxis”. A full lexical map is arrhythmia in which there is intra-atrial re-entry or circus possible with the fully defined SNOMED CT concepts movement around a fixed or functional central obstacle. The 22231002 Allergic enteritis (disorder) and 422076005 central obstacle may consist normal (e.g. valves) or abnor- Immunoglobulin E-mediated allergic disorder (disorder), mal (e.g., scar) structures. Conduction to the ventricles is constructing the following expression (addition underlined): not necessary for the tachycardia to continue. All that is required is an organised atrial rhythm with a rate typically ‘Pathological process (attribute)’ equivalentTo between 250 and 350 bpm, including tachycardia using a ‘Allergic process (qualifier value)’ and RoleGroup some variety of re-entry circuits that often occupy large areas of ((‘Associated morphology (attribute)’ some the atrium (‘‘macro-re-entrant’’). Here the arrhythmia in- ‘Inflammation (morphologic abnormality)’) and volves the cavo-tricuspid isthmus”. (‘Finding site (attribute)’ some The full lexical map is with the SNOMED CT concept ‘Intestinal structure (body structure)’)) and 233893007 Re-entrant atrial tachycardia (disorder), a prim- ‘Due to (attribute)’ some itive concept with the following pre-coordinated SNOMED ‘Type 1 hypersensitivity response (disorder)’ and ‘Causative agent (attribute)’ some CT inferred expression: ‘Immunoglobulin E (substance)’ RoleGroup some ((‘Finding site (attribute)’ some ‘Cardiac conducting system structure (body structure.)’)and (‘Clinical course (attribute))’ some 4 Erreur ! Il n'y a pas de texte répondant à ce style dans ce document. 4 DISCUSSION 4.2 Misalignment between SNOMED CT concept The study makes the attempt to propose semantically pre- FSN and full definitions cise mappings between two independent representation The ICD-11 class DA52.51 Allergic gastritis due to IgE- artefacts (ICD-11 and SNOMED CT), based on OWL-DL, mediated hypersensitivity can be fully represented by the using the axioms in the SNOMED Composition Grammar SNOMED CT concepts 1824008 Allergic gastritis (disor- “concept model” (and OWL-EL equivalent to from it), der) and 422076005 Immunoglobulin E-mediated allergic which are intended to fine what is universally true in a do- disorder (disorder), both of which are fully defined. The main, [7-8]. role of Immunoglobulin E is not represented in the present The findings are summarised in Table 3: 138 (123 M2 plus version. 15 A2 )out of 364 SNOMED CT concepts (38%) in the circulatory chapter and 150 (125 M2 plus 25 A2) out of 424 4.3 Inconsistencies across SNOMED CT concept SNOMED CT concepts (35%) in the digestive chapter from definitions the Clinical finding hierarchy that were lexically mapped to It is interesting to try to understand why they are so many ICD-11 classes show modelling issues resulting in misa- issues: let us take the example of hypertension. In clinical lignments between the meaning of the ICD-11 MMS classes settings, most healthcare professionals who use “hyperten- (as given by their name, hierarchic context and text defini- sion” in their daily patient monitoring practice this means tion) and formal axioms that characterise SNOMED CT exclusively systemic arterial hypertension, which is a fre- concepts. We equally found misalignments within quent disease. However, the SNOMED CT concept SNOMED CT, i.e. between Fully Specified Names and 59621000 Essential hypertension (disorder) is described by formal axioms. As shown in Table 4, in most of the cases the expression: this is related to the high number of primitives, i.e. not fully defined SNOMED CT concepts but as well with some fully Has definitional manifestation (attribute) some defined concepts. Finding of increased blood pressure (finding) and RoleGroup some (‘Finding site (attribute)’ some 4.1 Misalignment between SNOMED CT concept ‘Systemic circulatory system structure (body structure)’) FSN and primitive representation On the other hand, the SNOMED CT 11399002, Pulmonary There were higher rates of primitive in lexical and meaning hypertensive arterial disease (disorder) is described with match types M2 vs M1, viz. 91% vs 21% in the Circulatory RoleGroup some (‘Finding site (attribute)’ some chapter and 84% vs 23% in the Digestive chapter; and in A2 ‘Pulmonary artery structure (body structure)’) vs A1 53% vs 35% in the Circulatory chapter and 52% vs Both are primitive concepts, and since 24184005. Finding 47% in the Digestive chapter. of increased blood pressure (finding) is clinically under- stood as a finding measuring only for systemic arterial hy- What is challenging is that the OWL axioms allow a fully pertension it cannot be applied to Pulmonary hypertensive defined representation. For example, Essential hypertension arterial disease. (ICD-11 class BA 00), lexically matched to the SNOMED On the other hand, the CG formalism would allow the fol- CT concept 59621000 Essential hypertension (disorder) is lowing representations: the most frequent arterial disease. SNOMED CT does not represent the lack of secondary cause, which is the meaning ‘Pulmonary hypertensive arterial disease (disorder)’ of “essential” or “idiopathic”. SNOMED CT CG provides subclassOf RoleGroup some (‘Finding site (attribute)’ some the possibility to represent the lack of secondary cause by ‘Pulmonary artery structure (body structure)’) and adding the following expression: ‘Has interpretation (attribute)’ some ‘Pathological process (attribute)’ some ‘Abnormally high (qualifier value)’ and ‘spontaneous (qualifier value)’ ‘Interprets (attribute)’ some ‘Blood pressure (observable entity)’ Apart from some other cases of SNOMED CT concepts with the wording “of unknown etiology” there are numer- ‘Essential hypertension (disorder)’ ous cases of “real” qualifying adjectives that are not reflect- subclassOf ed in the definition, such as 85598007, Constrictive peri- RoleGroup some (‘Finding site (attribute)’ some carditis (disorder) with no representation of “constrictive”, ‘Systemic circulatory system structure (body structure)’) and 373945007 Pericardial effusion (disorder) with no repre- ‘Has interpretation (attribute)’ some sentation of “effusion” and 706882009 Hypertensive crisis ‘Abnormally high (qualifier value)’ and ‘Interprets (attribute)’ some (disorder) with no representation of “crisis”. ‘Blood pressure (observable entity)’ and ‘Pathological process (attribute)’ some ‘Spontaneous (origin) (qualifier value)’ 5 If the clinical vocabulary (interface terminology) and the omatized expression minus the representations (codes) or logic-based descriptions were defined independently, this “traumatic tears of meniscus” as recommended in [8]. would reduce the problem. However, there would still be issues where the full meaning of the natural language ex- 5 CONCLUSION pression would not be captured in the formal logical expres- To answer the main question of this paper, viz. whether the sion. logic based expressions in SNOMED CT are blurred by a The difference between flexible human language and ma- primarily language-driven modelling approach, we can state chine-required logic is apparent in the SNOMED CT Edito- the following points as a route to an answer: rial guide [1]. What is an inappropriate synonym when a SNOMED CT currently integrates two aspects, a reference synonym is defined by SNOMED as “a term other than the clinical terminology and a formal ontology. FSN that is an acceptable way to express the meaning of a SNOMED CT concept in a particular language”? This syn- It is necessary to distinguish clearly the part of SNOMED onym is anchored to a FSN which shall be aligned on the CT natural language definition to be used as the basis of a FSN concept model instance. An inappropriate synonym formal representation in the Composition Gram- must therefore be “an acceptable (or unacceptable) way to mar/Description Logic from the part used for the manage- express the meaning of a SNOMED CT concept” and ment of the clinical interface vocabularies used by clinicians aligned or not aligned on the FSN concept model instance. in electronic health records. Clinical language is character- ised by lexical ambiguities due to brevity and assumed con- The dimension of this issue is summarized by 24,782 shared text. The words used by clinicians often hide widely under- terms between pairs of active concepts either in one hierar- stood conventions that, if taken literally, give rise to incor- chy or across hierarchies. In the Clinical findings disorder rect formal representations. hierarchy there are 1394 instances of duplicate terms (around 3%). Across hierarchies, most of duplicate terms Given the conflict between clinical usage and formal repre- are between Product and Substance, e.g. 53009005 Analge- sentation, errors in the axiomatized formal content arise sic (product) and 373265006 Analgesic (substance). Such easily. External validation of the axiomatic content in definitions (a drug name replaced by the name of the active SNOMED CT is critical to reach validated DL-based (or ingredient) are acceptable for interface terminologies but any other logic-based) model medical knowledge and con- inappropriate for ontological standards. This therefore sug- cept descriptions. The harmonization of SNOMED CT with gests a principled reworking of the relations between FSN, ICD-11 provides one example of such an external valida- concept model instances and synonyms. tion. Another example is related to negation as in Non traumatic tear of meniscus. The formal SNOMED CT expression is REFERENCES 1. SNOMED CT® Editorial Guide January 2017 International Release based on their Compositional Grammar (equivalent to (US English) chapter 2.1. snomed.org/eg last access 15 may 2017 OWL-EL and EL++ without disjointness), which does not 2. Rodrigues JM, Robinson D, Della Mea V, Campbell J, Rector A, support any form of negation. Here the question arises Schulz S, Brear H, Üstün B, Spackman K , Chute CG , Millar J, Sol- whether the negative expression might be rather restricted to brig H, Brand Persson K. Semantic Alignment between ICD-11 and SNOMED CT. Studies in health technology and informatics. 2015; a common interface term feature or represented in CG. Such 216:790-794. an interface term, in our example, could point to a fully 3. SNOMED CT Compositional Grammar. Version 2.3.1 may 2015. specified name Degenerative tear of meniscus. 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