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  <front>
    <journal-meta />
    <article-meta>
      <title-group>
        <article-title>The Consolidated Information Web-Resource about Pharmacy Networks in City</article-title>
      </title-group>
      <fpage>0000</fpage>
      <lpage>0001</lpage>
      <abstract>
        <p>The main objective of this work was the development of the information system for support of pharmacy customers. This system provides information about required medicines and their analogues, medicine availability and prices. The main functions of the system and detailed workflow diagrams are described. The developed consolidated information resource allows to find the right medicine, sort pharmacies according to medicine location and price, give the necessary information about pharmacies and medicines, search for alternative medicines with the same chemical agent, view usage instructions for selected medications without internet connection.</p>
      </abstract>
      <kwd-group>
        <kwd />
        <kwd>consolidated resource</kwd>
        <kwd>Android</kwd>
        <kwd>classification</kwd>
        <kwd>clustering</kwd>
        <kwd>contentanalysis</kwd>
        <kwd>geolocation</kwd>
        <kwd>information search</kwd>
        <kwd>ontology</kwd>
      </kwd-group>
    </article-meta>
  </front>
  <body>
    <sec id="sec-1">
      <title>-</title>
      <p>
        Our free time is an incredibly valuable resource [
        <xref ref-type="bibr" rid="ref1">1</xref>
        ]. All our efforts to rationalize
and optimize its usage, only lead to the more pronounced feeling of the time deficit
[
        <xref ref-type="bibr" rid="ref2">2</xref>
        ]. Typically we allocate only a scant amount of time for such an important subject
as caring for our health, so visiting a doctor for consultation or the prescription of
medicine is often avoided and performed only in dire need [
        <xref ref-type="bibr" rid="ref3">3</xref>
        ].
      </p>
      <p>
        According to statistics, only a third of pharmacy customers actually know what
medicine they have come for. Among them approximately 10% heard about medicine
from advertisement, for 40% it was prescribed by doctor, and the rest used
recommendation of pharmacist or acquaintance [
        <xref ref-type="bibr" rid="ref4">4</xref>
        ]. Thus, an average customer of pharmacy
needs information resources to support his decision for medicine purchase in a timely
and objective manner, taking also in consideration customer location and his means.
      </p>
      <p>
        People often need a medicine without prior planning, at need [
        <xref ref-type="bibr" rid="ref5">5</xref>
        ]. Often they
cannot use the full version of pharmacy network website. Such websites typically don’t
provide the service of recommending purchase from other network or from pharmacy
located near the customer [
        <xref ref-type="bibr" rid="ref6">6</xref>
        ]. Nowadays customers are accessing commercial
services using smartphones more often than stationary computers [
        <xref ref-type="bibr" rid="ref7">7</xref>
        ]. The adaptation of
web-application to mobile platform interface along with storing and analyzing
information about prior searches simplifies the process of information consolidation taking
in consideration the customer’s needs [
        <xref ref-type="bibr" rid="ref8">8</xref>
        ]. This trend should be also followed by
pharmaceutical market in our country, which is still based on antiquated solutions and
needs innovations [
        <xref ref-type="bibr" rid="ref9">9</xref>
        ]. Our work aims to create a general architecture of intellectual
system for customer support in Lviv pharmacy networks, which will allow to obtain
the sufficient information about availability and purchase of medical medicines. This
system will be able to provide such services:
1. Perform an extensive search for required medicine.
2. Produce the lists of pharmacies according to customer’s location, price and
comments of other customers.
3. Review the obtained information in convenient form.
4. Search for alternative prescriptions.
5. Obtain information about selected medicine.
6. Create recommendations according to customer’s needs and history of his requests.
      </p>
      <p>
        The sale of medicinal drugs by pharmacies is performed with doctor’s
prescriptions or without them. Medicines, which are sold without prescriptions or subsidies
are sold using the rules developed for other retail goods [
        <xref ref-type="bibr" rid="ref10">10</xref>
        ].
      </p>
      <p>
        However in average people are still not educated enough about health care and
pharmaceutics [
        <xref ref-type="bibr" rid="ref11">11</xref>
        ]. The pharmacy networks have difficulties when introducing new
medicines or replacing not efficient medicines [
        <xref ref-type="bibr" rid="ref12 ref13 ref14 ref15">12-15</xref>
        ]. This problem can be resolved
by usage of the consolidated information resources which can provide the customer
with the extensive information about pharmacies, their location and pricing, available
medicines and discounts on them.
2
      </p>
      <p>The current status and research perspectives</p>
      <p>
        The activities of pharmaceutical networks reflect the general trends in the market
of health protection services: providing information for medicinal medicines,
controlling the medicine’s quality and cost of services, catering to customer needs [
        <xref ref-type="bibr" rid="ref13">13</xref>
        ].
Pharmacists as a part of healthcare industry are involved in support of their customers. In
some European countries, hospital based pharmacies control the safety, efficacy and
profitability of medicine consumption within the hospital [
        <xref ref-type="bibr" rid="ref14">14</xref>
        ]. This started with
creation of variety of therapeutic medicines usage committees co-opting different
specialists with a purpose of development of the medicine consumption polices which
reduces the costs while providing the acceptable level of safety and efficacy. The next
step in many hospitals lead to creation of hospital reference books. Thanks to hospital
based pharmacies the patient stay in hospital was reduced, medicinal medicines were
used optimally and under control. Also possible errors in prescriptions were found.
      </p>
      <p>
        The development of pharmaceutical services lead to creation of information
services providing information about medicines [
        <xref ref-type="bibr" rid="ref15">15</xref>
        ]. They were initially created within
hospitals, but were subsequently enlarged to municipal and national levels [
        <xref ref-type="bibr" rid="ref16">16</xref>
        ]. The
providers of those services compile information into databases and collaborate with
governmental and industrial organizations [
        <xref ref-type="bibr" rid="ref17">17</xref>
        ].
      </p>
      <p>
        Ukrainian pharmaceutical market is continuing to grow [
        <xref ref-type="bibr" rid="ref18">18</xref>
        ]. According to 2017
year results, the amount of packed medicine consumption was restored to pre-war
level [
        <xref ref-type="bibr" rid="ref19">19</xref>
        ]. The growth of market measured in dollars was 16,5% [
        <xref ref-type="bibr" rid="ref20">20</xref>
        ]. Lastly the
number of pharmacies has stabilized [
        <xref ref-type="bibr" rid="ref21">21</xref>
        ]. The process of retail sector consolidation is
continuing [
        <xref ref-type="bibr" rid="ref22">22</xref>
        ]. The leading pharmacies are pharmacies-discounters [
        <xref ref-type="bibr" rid="ref23">23</xref>
        ]. The
number of such pharmacies will continue to grow [
        <xref ref-type="bibr" rid="ref24">24</xref>
        ]. However, it would be erroneous to
think that only such pharmacies will remain in the market [
        <xref ref-type="bibr" rid="ref25">25</xref>
        ]. Among key factor
influencing the market are the introduction of reimbursement system, medical reform,
electronic prescriptions, licensing imported medicines and change of VAT rate for
medicines [
        <xref ref-type="bibr" rid="ref26">26</xref>
        ]. The structure of medicine consumption will change [
        <xref ref-type="bibr" rid="ref27">27</xref>
        ]. It is
predicted that part of medicines sold on prescriptions, generic medicines, medicines
produced in Ukraine, and medicines supported by reimbursement system will grow [
        <xref ref-type="bibr" rid="ref28">28</xref>
        ].
In the same time the reduction of sales is expected for medicines with arguable
efficacy such as homeopathic, functions enhancers, probiotics, prophylactic medicines
Later the amount of sold antibiotics also will be reduced [
        <xref ref-type="bibr" rid="ref29">29</xref>
        ]. Among the actively
discussed topics is the introduction of e-pharmacies. The retailers and consumers are
ready to use this tool and Ukraine has all infrastructure available for it, but as of now
this issue is not supported legally. There are risks of erroneous medicine
consumption, the difficulties of controlling fakes, and fiscal accounting. Discussion are going
only around selling medicines through Internet. However, cosmetics and dietary
supplements are already successfully sold there. Thus, distribution of medicinal
medicines through Internet using modern information technologies (IT) is only question of
time, so we need to legally resolve all problems related to it.
3
      </p>
      <p>The model of consolidated information web-resource for the
networks of pharmacies in a city</p>
      <p>The analysis of principles governing the functioning of pharmacy networks leads
to conclusion that it is rather hard to implement a convenient for the customer system
for exchange of information about relevant medicines and their availability in
pharmaceutical network. The user often does not understand which medicine should or
should not be consumed taking in consideration probable symptoms or doctor’s
diagnosis, whether there are similar medicines – analogues which are cheaper, but have
the different efficacy. Our formal model S of consolidated information web-resource
for network of pharmacies can be represented by tuple:</p>
      <p>S  InpDt, RqHr,OtpDt, StItCmt, StSm, CntOnt, ExtPtm,
TmTrz, CndOpSt, fid , f rh , f frs , f st , f fr , f col , fod , fep , faep ,
OtpDt  fod (InpDt, RqHr, StItCmt, StSm, CntOnt, ExtPtm,</p>
    </sec>
    <sec id="sec-2">
      <title>TmTrz, CndOpSt, fid , f rh , f frs , f st , f fr , fcol , fep , f aep ),</title>
      <p>(1)</p>
      <p>InpDt  {InpDtus , InpDt pr , InpDtvr , InpDtmd , InpDt pn , InpDtad , InpDtdr }
(3)
–
the input date from pharmacy InpDt pr , user InpDtus , visitor InpDtvr , moderator
InpDtmd , network of pharmacies InpDt pn , administrator InpDtad , doctor</p>
    </sec>
    <sec id="sec-3">
      <title>InpDtdr ;</title>
      <p>RqHr  {RqHrus , RqHrpr , RqHrvr , RqHrmd , RqHrpn , RqHrad , RqHrdr }
– the request
from pharmacy RqHrpr , user RqHrus , visitor RqHrtvr , moderator RqHrmd ,
pharmacy network RqHrpn , administrator RqHrad , doctor RqHrdr ;
OtpDt  {RptDtsh , RptDtas , RptDt fr , RptDtrd } – output data as result of search
requests RptDtsh , extended search</p>
      <sec id="sec-3-1">
        <title>RptDtas (the name of pharmacy, network,</title>
        <p>medicine, symptoms, geolocation, price, discount), search filters applied RptDt fr ,
the recommendations about filters RptDtrd (taking in consideration the history of
requests, comments of other users, frequency of requests, statistics of usage,
applicability to different groups of consumers);
StItCmt  {StItCmt ft , StItCmtrs } – the internal parts of resource – facts StItCmt ft
and rules StItCmtrs , which are used in system’s learning. This learning is based
on classification and clustering. Machine learning is used for the definition of
better content and ultimately for gaining new customers. In process of classification
input data is grouped in two or more classes and learning system should generate
the model which assign the new inputs to one of those classes. This learning as a
rule assisted. The example of such classification is provided by extended search
filters (popular content, last seen content), where input is the content and requests
to system and classes are represented by relevant and not relevant content.
In clustering the set of inputs is divided in groups. Contrarily to classification, the
groups are not known beforehand, which makes this a subject for non-assisted
learning. We use also the estimates for density of pharmacies distribution in space
for better location definition. The reduction of dimension number simplifies inputs
by mapping them into space with less dimensions. The similar task is thematic
modeling where the software obtains the list of prescriptions/symptoms for
identification of similar medicines if demanded medicines are not available.
StSm  StSmgl , StSmqp , StSmcs , StSmcc , StSmds , StSmar , StSmwr  – the tuple of
states including location</p>
      </sec>
      <sec id="sec-3-2">
        <title>StSmgl , request processing</title>
      </sec>
      <sec id="sec-3-3">
        <title>StSmqp , cache lookup</title>
        <p>
          StSmcs , if not found – search in cloud StSmcc and later – in data store StSmds , if
not found – search in resources of other pharmacies StSmar and other
webresources StSmwr ;
CntOnt  C, R, F  С – the content of system represented as ontology (the
references for medicines, symptoms, pharmacy networks, and pharmacies, addresses of
pharmacies,….), where C – is the finite set of concepts of subject area described
by ontology O ; R : C  C the finite set of mappings between concepts from
selected subject area; F – the finite set of interpretation functions (axioms or
constraints), defined on concepts and relations of ontology O . The natural constraints
imposed on set C , is its finiteness and non-emptiness, F and R should also be
the finite sets;
ExtPtm  Enrc , Eqrc , Encm , Eqcm , Entr , Eqtr , Enfp , Eqfp , Enfw , Eqfw 
– the tuple of
external parameters used in creation of statistics describing system functioning
(the quantity and quality of relevant content Enrc , Eqrc correspondingly,
comments Encm , Eqcm , page access time Entr , Eqtr , time spent on pharmacy page
Enfp , Eqfp , time spent on pharmacy network pages Enfw , Eqfw );
TmTrz – transaction time (search, comments analysis, evaluating rating, sorting,
symptom analysis);
CndOpSt – the condition of creation of new rules and facts for machine learning;
f id – the operator of analysis inputs from different sources [
          <xref ref-type="bibr" rid="ref14">14</xref>
          ];
f rh – the operator of requests analysis from different sources [
          <xref ref-type="bibr" rid="ref15">15</xref>
          ];
f aep – the operator of external parameters analysis for forming new facts and rules
for machine learning;
f ep – the operator for external parameters selection and sorting according to rating
for creation of statistical data reflecting system operation (if those parameters are
selected correctly system will be able to create relevant results for customers);
f frs – the operator of machine learning of the system according to consolidated
resource performance statistics. Statistical results are obtained from cloud, the
results of last requests are stored in the cache. The cache also contains the web
pages accessed recently, statistics from current period (day, or couple of hours
depending on time of the year or resource load);
f st – the operator of changing system into the state of data processing;
f col – the operator of moderation and updating of ontology for consolidated
webresource for network of pharmacies;
f fr – the operator for facts creation and rules generation for recommendation;
fod – the operator for formation of reports according to analysis of requests from
different sources.
        </p>
        <p>The user of consolidate resource should obtain the information about the price of
the medicine, possible replacements, main chemical agent, the availability of the
medicine in a pharmacy, the prescription requirement, and pharmacy contact data. For
pharmacy customers it important to read the medicine usage instruction before a visit
to pharmacy. The main goal for our created information system is providing the
support for pharmacy customers. This goal can be further divided in three sub-goals:
“System design”, “Data acquisition”, “Customer support” (fig.1). For more
information on fig.1 further subgoals are shown. Thus, “System design” goal is split into
“Database design” (the elucidation of entities used), “The usage of modern technologies”
(will allow in future to upgrade functionality and performance, new learning rules
included), “Coding modules”. The subgoals “The design of server and client
components, their interactions” corresponds to the main client-server design pattern used in
the system. The next major goal describing the data acquisition is split in two
subgoals: “Gathering data about pharmacies and networks of pharmacies” and
“Gathering data about medicines”. The “Customer support” goal emphasizes the importance
of the usability for customer factor in system design. The implementation of this goal
will allow pharmacy customers to use search functions with additional criteria, such
as the price and location, medicine’s chemical agent, discounts, whether prescription
is required, popularity, comments, ratings, similar medicines) and also see previously
selected information offline.</p>
        <p>Creating an information system for providing the support for pharmacy customers</p>
        <p>System design</p>
        <p>Data acquisition</p>
        <p>Customer support
Reliability</p>
        <p>Request
processing
time</p>
        <p>Functional
interface</p>
        <p>The relevance
and fullness of
information</p>
        <p>Access
flexibility</p>
        <p>Usability</p>
        <p>Access
time
Control information system</p>
        <p>Search information system</p>
        <p>Customer interaction system</p>
        <p>The goal tree also list criteria attached to corresponding nodes. “Reliability”
criterion stresses system stability in face of errors, “Request processing time” focuses on
server side solutions for quick transaction processing; “Functional interface”
implements the functional interactions between client and server parts; “The relevance and
fullness of information” is necessary for correct execution of requests; “Access
flexibility” – the ability of system to change functions in a way imperceptible for user;
“Usability” – the correspondence to user needs; “Access time” – reduces the access
time by storing information in customer’s device.</p>
        <p>There’s also a view of our system having three parts: “Control information system”
implements such functions as making decisions, distribution of information. “Search
information system” realizes the storage and access of information in databases;
”Customer interaction system” implements customer-oriented interface functionality.
4</p>
        <p>Detailed view of system’s functions</p>
        <p>Contextual diagram (fig. 2) shows the interaction of system with a customer
represented as an external entity. Customer creates a new session, supplies the search
parameters and his location in order to provide information for better service. System if
needed, interacts with customer via dialog windows. When required data from
customer is obtained, server processed it and sends back results. Fig.3 shows the
decomposition of this process into two intermediary processes and local data store. On
session’s start main page is shown with the list of medicines, stored locally.
The decomposition of process “Find medicines” contains the most of data flows of
our designed system (fig. 4.):</p>
        <p>Search parameters
Search results</p>
        <p>The data about
found medicines</p>
        <p>Location
Previously</p>
        <p>stored
information</p>
        <p>1.2.1
Process received
data</p>
        <p>The list of pharmacies
having the medicine</p>
        <p>Medicine parameters
Data about
the medicine</p>
        <p>Search results</p>
        <p>1.2.3
Add to favorites</p>
        <p>Pharmacies data</p>
        <p>The data about
analogues
1.2.2</p>
        <p>Find analogue</p>
        <p>Medicines selected
─ “Process received data”. This process receives data about the required medicines
and pharmacies from data store “Pharmacies data” and shows them to customer.</p>
        <p>This data can be also passed to process “Add to favorites” or “Find analogue”.
─ The process “Add to favorites” – passes data about the selected medicine to local
storage.
─ “Find analogue” process upon receiving the data about selected medicine, requests
data store for the list of medicines having the same main chemical agent. This list
is forwarded to process “Process received data” or, if there are no analogues, the
system creates a dialog window with a message about no analogues available.</p>
        <p>The decomposition of process «Process received data» (fig. 5):
─ The process “Form a list for output” obtains from the remote data store the list of
medicines found, checks it and transform into the format suitable for transmission
between client and server subsystems.
─ The process “Sort the list of pharmacies” upon receiving the information about the
medicine required and location data, sorts the list of pharmacies where this
medicine is available.
─ The process “Check for availability in favorites” checks whether requested
medicine is in the local favorites list and allows to customer to add this medicine to
favorites if it is not there.
─ The process “Distribute and output data” upon receiving the information for
output, distribute it into corresponding fields and outputs the result in the
userconvenient form.</p>
        <p>1.2.1.1
Form a list for
output</p>
        <p>Search parameters</p>
        <p>Data about the
availability
of medicine
in pharmacy
Data about the
found medicines</p>
        <p>Location
The list of
pharmacies</p>
        <p>having
the medicine</p>
        <p>The list of
found medicines
Search
results</p>
        <p>Data about
the medicine</p>
        <p>1.2.1.4
Distribute and
output data</p>
        <p>Pharmacy
information for output</p>
        <p>Previously stored</p>
        <p>information
The possibility
to add to favorites</p>
        <p>1.2.1.2
Sort the list of
pharmacies
The sorted data
The medicine id
1.2.1.3</p>
        <p>Check for
availability in
favorites</p>
        <p>The decomposition of process “Find analogue” (fig. 6):
─ The process “Find the main chemical agent” receives as input the information
about medicine, identifies its main chemical agent and passes this data to further
search operation;
─ The process “Compile parameters for the search of analogues” obtains the list of
analogues having the same chemical agent and excludes from it previously found
medicines.</p>
        <p>1.2.2.1
Find the main
chemical agent</p>
        <p>Medicine id
Medicine’s parameters</p>
        <p>The data about chemical agent</p>
        <p>Search data</p>
        <p>Pharmacy data
The data about analogues
The hierarchy of processes for designed system is shown on fig. 7.</p>
        <p>The developed system uses PostgreSQL database management system. The schema
of database is shown on fig.8. The entity spatial_ref_sys is necessary for quick search
based on geolocation and is created automatically by PostGIS.</p>
        <p>The software created was built using client-server design pattern (fig. 9). The
server is represented as an abstract network service able to accept HTTP-request,
process it and return the response in JSON format. The client is an android – based
application able to form and send a valid HTTP request. REST interface is used for
data manipulation, creating requests and corresponding reports in selected form. The
structure of software is shown in further detail on fig. 10. The template, using the
framework Spring MVC, defines following modules in the system: Controller,
Service, DAO and their implementations. The controller analysis the user’s request,
creates a corresponding model, and works as a service requesting DAO module. This
module performs request to database, obtains data and passes it for output.</p>
        <p>The information resource created caters for people who need to know about a
specific medicine, where it is sold and analogues, helping to save time and money. The
client and server parts of software are written in Java. The application works on any
mobile platform with OS Android version 5.0 or higher. The Internet access is
required. The application performs the search of medicines in Lviv pharmacies. The
user types the name of required medicine and program provides the list of pharmacies
sorted according to prices or distance from user’s current location. On request the
application provides the information about analogues available and their prices. User
can also add medicine to the list of favorites, which will grant him the access to
information about this medicine offline. Differently from similar applications, the
developed resource contains the information about all pharmacies and their networks in
Lviv.
5</p>
        <p>Consolidated information resource interface and functioning
The examples of real world search for medicines using our developed information
resource are shown on fig. 14- 19. Each page of the application contains an
advertisement banner from Google AdMob which provides advertisement service in the
context of user search history. The main application window is shown on fig. 14. It
contains fields for up to four medicines and controls allowing to search the medicine
in pharmacies, remove the medicine from search or show the medicine’s usage
instruction. Also, in the upper part of the page there are the field for the search of the
medicine by its full or partial name. The user types a part of the medicine name and
presses “Search” button. The application loads the search screen where the field with
the name of required medicine is still present. This allows user to change the medicine
name and search for the medicine again. Below the search field is a scrollable list of
medicine names, which contain the text from search field. For example, if user typed
“Loratadyn” in search field, the application will show the medicine names with this
word. For every item displayed the application provide the search for analogues
medicines or read the user instruction (fig.15).</p>
        <p>The search for analogues is performed based on main chemical agents (fig. 16-17).
The initial medicine is excluded from the list of analogues. After the selection of
required medicines, application makes a search based on the list of pharmacies sorted
by price and shows the results to user. In case if medicine is not yet included on
“favorites”, and this list is not full, application provides a possibility to add medicine to
“favorites’, and shows a corresponding button.</p>
        <p>The slider is shown on the screen allowing for user to switch the list of pharmacies
taking into account the current user location. Moreover, when user taps on the
pharmacy network logo, the application shows additional information about the pharmacy
network in the dialog window. Application also shows buttons allowing for a user to
see the pharmacy location on Google Maps or close the application. (fig. 19).</p>
        <p>Additionally, the application can show the medicine usage instruction in offline
mode (fig. 19). This information comes from the local storage, although in this mode
the advertisement banner is not shown.</p>
        <p>Our research was targeting the introduction of new mobile services in
pharmaceutical market with a purpose of improving the communications between pharmacies
and their customers. We address the problem of customer need for additional
knowledge about available medicines and their analogues which are often cheaper than
initially proposed medicine. Our developed consolidated information resource provide
relevant information about medicines available in pharmacies in Lviv.</p>
        <p>The general goal was decomposed into the tree of subgoals. The dataflow diagrams
specifying processes and operations were developed. Based on them functional
elements of the system, and required data transformations were defined. The software
application, based on mobile platform Android and Java programming language, was
created. Client and server side code was implemented and tested. In order to obtain
the correct location data the technology PostGIS (part of PostgreSQL product) was
used. This technology uses the system Google Geocoding to translate the coordinates
of pharmacy into required format. This design solution greatly influenced the
system’s performance. The customers of developed service can view the information
about medicines in offline mode. This service is based on using the local database,
which stores data about previously selected medicines, their images and usage
instructions. The developed software was built using the client-server architecture and
MVC design pattern. Data from database to the mobile application are returned in
JSON format. In order to have access to full set of the application’s functions, the user
needs a smartphone based on Android OS (with version 5.0 or later), and to have
access to Internet and active geolocation service.</p>
      </sec>
    </sec>
  </body>
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          <fpage>195</fpage>
          -
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          (
          <year>2016</year>
          )
        </mixed-citation>
      </ref>
    </ref-list>
  </back>
</article>