=Paper=
{{Paper
|id=Vol-2507/276-279-paper-49
|storemode=property
|title=Implementation of the «Digital Lab» Platform for the Processing and Analysis Heterogeneous Neurobiological Data in the NRC «Kurchatov Institute»
|pdfUrl=https://ceur-ws.org/Vol-2507/276-279-paper-49.pdf
|volume=Vol-2507
|authors=Andrey Polyakov,Irina Enyagina,Dmitry Kokovin,Maria Kalmikova
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==Implementation of the «Digital Lab» Platform for the Processing and Analysis Heterogeneous Neurobiological Data in the NRC «Kurchatov Institute»==
https://ceur-ws.org/Vol-2507/276-279-paper-49.pdf
Proceedings of the 27th International Symposium Nuclear Electronics and Computing (NEC’2019)
Budva, Becici, Montenegro, September 30 – October 4, 2019
IMPLEMENTATION OF THE «DIGITAL LAB» PLATFORM
FOR THE PROCESSING AND ANALYSIS
HETEROGENEOUS NEUROBIOLOGICAL DATA IN THE
NRC «KURCHATOV INSTITUTE»
A.N. Polyakov1, I.M. Enyagina1, D.S. Kokovin1, M.V. Kalmikova1
1
NRC “Kurchatov Institute”, 1 Akademika Kurchatova sq., Moscow, 123182, Russia
E-mail: irina_enyagina@mail.ru
This paper presented the project of «Digital Lab» Platform implementation for organize storage,
processing and analysis of heterogeneous neurobiological data (MRI, fMRI, EEG). The «Digital Lab»
Platform is an information system for intensive work with metadata in heterogeneous data store with
the function of the dynamic modification by user of both the data and the metadata models. There is
growing interest in combining EEG, MRI and fMRI experimental data for study of human brain
functional connectivity. To implement this methodology was developed the new Module of «Digital
Lab» Platform for automatic processing, analysis and storage of heterogeneous neurobiological data
(MRI, fMRI, EEG), obtained at NRC «Kurchatov Institute. The creation of this Module allows
organizing interaction between the Resource Center «Cognimed», the Computer Center Complex for
Simulation and Data Processing and the scientists at the Kurchatov Institute (Moscow). The Module
uses the cluster HPC4 of the KI Supercomputer as a computing resource. The implementation of this
Module allowed scientists to combine experimental EEG, MRI and fMRI data to study the functional
connectivity of the human brain.
Keywords: Data analysis, Digital Lab, neuroimaging, MRI, fMRI, EEG
Andrey Polyakov, Irina Enyagina, Dmitry Kokovin, Maria Kalmikova
Copyright © 2019 for this paper by its authors.
Use permitted under Creative Commons License Attribution 4.0 International (CC BY 4.0).
276
Proceedings of the 27th International Symposium Nuclear Electronics and Computing (NEC’2019)
Budva, Becici, Montenegro, September 30 – October 4, 2019
1. Introduction
Integration and analysis of heterogeneous (obtained at disparate equipment) experimental data
is very actual question today, because it allows to get of higher-level scientific results [1], [2], [3].
Kurchatov Institute Resource Centers have more than 400 units of modern experimental devices and
installations, what allows to obtain a various kind of scientific data. Kurchatov Institute Computing
Center includes a Complex for Simulation and Data Processing for Mega-science Facilities providing
of high-performance computing for Big Scientific Data analytics. There is a general task is to
organize of better collaboration between the KI Computing Center and KI Resources Centers for
improving of processing and analysis experimental scientific data. Another important task is to
integration of heterogeneous (obtained on various equipment) experimental data for getting of higher
level scientific results. The third task is are creating of a centralized unified data storage, which will
allows use heterogeneous experimental data many times for various scientific studies. To solve these
tasks we are propose apply the «Digital Lab» Platform, which allows to organize the interaction
between the Resource Centers, Computing Center and scientists at the Kurchatov Institute (Figure 1).
Figure 1. Implementation of the «Digital Lab» Platform for the processing and analysis
heterogeneous neurobiological data in the NRC «Kurchatov Institute»
2. «Digital Lab» Platform
The «Digital Lab» Platform [4] is the information system for intensive work with metadata in
heterogeneous data store with a function of the dynamic modification by user of both the data and the
metadata models. «Digital Lab» Platform performs a role of data flows manager for organizing the
conversion and transfer of data between separate elements of System for data processing and analysis.
Based on the «Digital Lab» Platform it is possible to create as the simple modules for processing and
analysis homogeneous data, and complex modules for processing and analysis heterogeneous data.
Key functions:
Design of new data and metadata models with function of their dynamical
modification;
Registration of input data with extraction of initial metadata;
Multi-criteria search on metadata attributes;
Easy integration of external applications and services by users;
Ingesting, restructuring and data processing jobs and workflows;
Data share and access permissions to the toolkit resources;
Collaborative work for multiple users.
277
Proceedings of the 27th International Symposium Nuclear Electronics and Computing (NEC’2019)
Budva, Becici, Montenegro, September 30 – October 4, 2019
3. «Digital Lab» Architecture
Key component is Metadata Storage, main elements of this storage are data and metadata
models. Interface to these models have standardized format and will be provided by services. Services
are at of three groups system, application and user’s. One of the basic functions for system services
are extracting initial set of metadata from input data as well creation of further metadata during the
user work. System services are provide also the job loading on computing resources, processing
inquires to the storage (file) system etc (Figure 2).
Figure 2. «Digital Lab» Platform Architecture
4. Module «Neuroimaging» for processing and analysis of heterogeneous
neurobiological data
Understanding of the human brain architecture and its neuronal functional connectivity is an
important neuroscience goal. There are two areas of research: anatomical structure (MRI) and
functional connectivity (fMRI, EEG). Results of these researchers are used in machine intelligence
and bioinformatics scientific studies (brain-computer interface, thought recognition, polygraph, etc.),
and in clinical practice (neuropsychology, neurology, neuroradiology, neurosurgery, psychiatry,
rehabilitation). There is growing interest in combining EEG, MRI and fMRI experimental data for
study of human brain functional connectivity [1], [2], [3]. To implement this methodology the new
Module «Neuroimaging» of Digital Lab Platform was developed for automatic processing, analysis
and storage of heterogeneous neurobiological data (MRI, fMRI, EEG) of the Kurchatov Institute
Resource Center of Nuclear Physical Research Methods "Cognimed" (Figure 3).
The Module «Neuroimaging» has the following structure:
Data Storage: Unified storage of data and results of their processing and analysis.
Computing Module: Data processing and analysis using specialized software (standard tools
and own developed by Kurchatov Institute researchers tools, unique methods for rest-fMRI,
etc.). Parallelization of calculations on supercomputer’s nodes {5}.
Analytics and Statistic Module: Data group’s formation by set of parameters; analytics and
statistic reports generated.
Data Visualization Module: Creating the models of data neuroimaging with Viewer Editors.
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Proceedings of the 27th International Symposium Nuclear Electronics and Computing (NEC’2019)
Budva, Becici, Montenegro, September 30 – October 4, 2019
Figure 3. Automatic processing, analysis and storage of heterogeneous neurobiological data
5. Conclusion
To improving of MRI/fMRI/EEG data analysis process, we develop a Module for the
processing and analysis of a MRI/fMRI/EEG experimental data, based on Kurchatov Institute «Digital
Lab» Platform [4], with involvement the Kurchatov Institute Supercomputer [5]. Benefits of Module
implementation: centralized data storage, with the possibility of searching on a set of parameters,
what make possible in the future to reuse this data for various scientific studies; many time speed up of
processing and analysis data due to parallelization of computations on supercomputer’s nodes;
improving of data analysis by implementing of mathematical methods developed by scientists of the
Kurchatov Institute. The implementation of this Module allowed scientists to combine experimental
EEG, MRI and fMRI data to study the functional connectivity of the human brain.
Acknowledgement
The work was supported by the NRC Kurchatov Institute (№1359) as research activities on the
project «Creation of a distributed modular research and development platform «Digital laboratory».
References
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