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  <front>
    <journal-meta />
    <article-meta>
      <title-group>
        <article-title>The development of a mindfulness-based mobile application to learn emotional self-regulation</article-title>
      </title-group>
      <contrib-group>
        <contrib contrib-type="author">
          <string-name>Diano</string-name>
          <email>fdrdiano@gmail.com</email>
        </contrib>
        <contrib contrib-type="author">
          <string-name>Federico</string-name>
          <xref ref-type="aff" rid="aff1">1</xref>
        </contrib>
        <contrib contrib-type="author">
          <string-name>Ferrara</string-name>
        </contrib>
        <contrib contrib-type="author">
          <string-name>Fabrizio</string-name>
          <xref ref-type="aff" rid="aff0">0</xref>
        </contrib>
        <contrib contrib-type="author">
          <string-name>Calabretta</string-name>
        </contrib>
        <contrib contrib-type="author">
          <string-name>Raffaele</string-name>
          <xref ref-type="aff" rid="aff0">0</xref>
        </contrib>
        <aff id="aff0">
          <label>0</label>
          <institution>Institute of Cognitive Sciences and Technologies (ISTC) - National Research Council (CNR)</institution>
          ,
          <addr-line>Rome</addr-line>
          ,
          <country country="IT">Italy</country>
        </aff>
        <aff id="aff1">
          <label>1</label>
          <institution>Italian School of Clinical Cognitivism (SICC)</institution>
          ,
          <addr-line>Rome</addr-line>
          ,
          <country country="IT">Italy</country>
        </aff>
      </contrib-group>
      <abstract>
        <p>The growing interest for mindfulness practices and the development of mobile applications market have ran together during the last decade, resulting in a large number of mindfulness-based applications, emotional help assistants, mood trackers and self-care/self-help mobile applications that have spread on the app stores. If the validity of mindfulness practices has been proved repeatedly in the last decades, there is also an emerging literature about mental health mobile applications' efficacy. Since smartphones are already everyday life common devices, taking advantage of these tools and implement their usage in clinical practice can be a challenging opportunity for mental health improvement among people. This paper starts with an overview of the state of the art of mental health mobile applications, highlighting some possible guidelines to follow during the design of a mental health app. In the second part of this paper, it is described the design and development process of a mindfulness-based app that could provide helpful features to develop emotional self-regulation, in particular for people who have just concluded a mindfulness-based program (MBSR). In this second part of the paper are so described the emotional regulation theory which the app is based on, an overview of the several indicators of physical and psychological health to which mindfulness practices are significantly related to, and finally the way these concepts and guidelines have shaped the design of this mindfulnessbased application.</p>
      </abstract>
      <kwd-group>
        <kwd>mindfulness</kwd>
        <kwd>mobile application</kwd>
        <kwd>emotional regulation</kwd>
      </kwd-group>
    </article-meta>
  </front>
  <body>
    <sec id="sec-1">
      <title>-</title>
      <p>The rise of the smartphones we witnessed in the last decade has completely changed
the way people seek and access health-related content, self-help material and, more
generally, people’s everyday routines, giving access to a continuously growing amount
of mobile applications that nowadays can nearly give an answer to every possible health
question and need from the user. In this scenery, mHealt apps (mobile health
applications) have spread, and in Apple’s App Store and Google’s Play Store it is possible to
count thousands of app covering any possible health area, and so do mental health apps
that are a great part of this number. It is estimated that by 2020, the greatest part of
Copyright © 2019 for this paper by its authors. Use permitted under</p>
      <p>
        Creative Commons License Attribution 4.0 International (CC BY 4.0).
internet usage will come from mobile devices [
        <xref ref-type="bibr" rid="ref9">9</xref>
        ], and for adolescents and young adults
smartphones already are the most used platform for accessing the internet through apps.
      </p>
      <p>
        The proliferation and the pervasiveness of smartphone usage to access health
informations and their usage for health management are a matter of fact for health
professionals. Although the number of mental health mobile applications is growing fast, it is
not possible to tell the same about research supporting its efficacy and mechanisms,
still leaving unanswered many questions about opportunities and risks linked to the use
of smartphones as mental health support devices [
        <xref ref-type="bibr" rid="ref23">23</xref>
        ]. Since smartphones have been
and are part of a technology revolution that has deeply changed people’s daily life, it
seems reasonable that mental health professionals have to deal with these tools, taking
advantage of the potentialities offered by technology applied to mental health and being
conscious about the risks and limitations that comes every time a new technology
becomes part of the professional’s toolbox.
      </p>
      <p>Considering this premise, this paper aims at first describing the state of the art of
this phenomenon, and then to describe the design and development process of a
mindfulness-based mobile application currently in development in the Natural and Artificial
Cognition Lab (NAC) of University of Naples Federico II.</p>
      <p>In the next paragraph we are going to firstly describe the main categories of mental
health applications found by searching in the Apple App Store and in the Google Play
Store, as well as a description of their main features.
1.1</p>
    </sec>
    <sec id="sec-2">
      <title>Emotional help assistants, mood trackers and mindfulness-based mobile applications: the state of the art</title>
      <p>From analyses conducted among scientific literature about this topic and a direct search
in the main mobile applications marketplace, it seems reasonable to suggest to describe
four main categories in which it is possible to discriminate mental health apps,
considering the main target for the category, the content, the user experience and the main
purpose for each category, described as it follows.</p>
    </sec>
    <sec id="sec-3">
      <title>Emotional help assistants</title>
      <p>
        This category includes apps that present as core feature the presence of a chatbot for
psychological assistance, like “WoeBot” [
        <xref ref-type="bibr" rid="ref31">31</xref>
        ], “Wysa” [
        <xref ref-type="bibr" rid="ref32">32</xref>
        ]and “Youper” [
        <xref ref-type="bibr" rid="ref33">33</xref>
        ]. This
kind of applications allows to start a conversation with a bot through the classical chat
interface known to anyone uses a mobile messaging app. The chat is used to “talk” to
the bot and explain what feelings or thoughts the user is experiencing, and to receive
help from the bot that can help the user to reflect and to decenter from difficult thoughts
or reframing a specific situation. For example, “WoeBot” describes to the user some
basic cognitive psychotherapy concepts, like cognitive distortion, and then tries to help
the user to identify if there are any in the formulation used to describe e stressful or
difficult situation. Some of these app integrates even some short questionnaires, like in
“Youper”, or scales to identify the mood tone. Another common feature of these apps
is the possibility to setup a reminder that helps the user to daily track his/her mood.
      </p>
      <p>
        Among these apps, “Wysa” seemed to be the most complete [
        <xref ref-type="bibr" rid="ref14">14</xref>
        ], since it integrates
many different features that go beyond the presence of the chatbot and questionnaires,
giving the possibility to access, after subscribing to a monthly/annual plan, sections of
the app where the user can learn, as an example, to plan a difficult conversation, start
the day with yoga postures, mindfulness exercises, emotion-management, grounding
exercises and problem solving strategies.
      </p>
      <p>All of these emotional help assistants also allow the user to get in contact with real
psychologists suggested by the app, if it is the user to request it. Another common
aspect of emotional help assistant apps is that they all are only available in English
language. This may surely be a barrier to non-English speakers and even for users who are
not native English speakers as well, highlighting the importance of developing different
language versions of these apps or new apps which target other non-English speaking
populations.</p>
      <p>
        These apps are all based on a common cognitive-behavioral framework, which is
surely more suitable, comparing to other psychotherapy models, to be schematized and
proposed through this format and has shown to be, even if the literature about this topic
is still poor, some evidence of efficacy [
        <xref ref-type="bibr" rid="ref19 ref28 ref5">5,19, 28</xref>
        ].
      </p>
    </sec>
    <sec id="sec-4">
      <title>Self-care apps</title>
      <p>
        A second category of apps includes those applications that help the user to build up
positive habits, allowing the user to setup personal goals in a specific area. Some of the
most famous apps in this category are “Fabulous - Self Care” [
        <xref ref-type="bibr" rid="ref4">4</xref>
        ], “Shine - Self-Care &amp;
Meditation” [
        <xref ref-type="bibr" rid="ref26">26</xref>
        ] and “Ten Percent Happier” [
        <xref ref-type="bibr" rid="ref27">27</xref>
        ]. These apps can help the user to track
their progress other than practice with different kinds of exercises, like guided
meditations and mindfulness practices. Also in this case the user have to submit to a
monthly/annual plan in order to access the greatest part of the provided material and
exercises. This kind of apps have their main goal on setting up positive habits and to
help maintain them through the cultivation of mental health developing awareness,
calmness and motivation to build a healthier lifestyle without directly focusing on
specific distresses or difficult situations like the emotional help assistants applications.
      </p>
    </sec>
    <sec id="sec-5">
      <title>Mood trackers</title>
      <p>
        A very crowded category is the “Mood trackers” one. Apps like “Daylio” [
        <xref ref-type="bibr" rid="ref3">3</xref>
        ] allows
the user to keep track of his/her mood through a diary that can include not just the mood,
expressed for example with a label and/or an emoticon, but also a written journal and
some pre-registered activities to tag to that specific mood log, like for example “Hard
work” or “Running”. These apps use all the collected data through the user logs to build
graphics that can show his/her mood trends compared to the different activities
previously tagged. This can be useful for some users that may discover recurring occurrences
of a certain mood linked to a certain activity or situation experienced. These mood
trackers usually don’t provide exercises or tasks to complete, they only record and
elaborate data to show trends, without giving any other information about how to deal with
distress, except for some short advices, like in “MindCare: mental well-being analytics
made easy” [
        <xref ref-type="bibr" rid="ref22">22</xref>
        ], where the app suggests to keep a journal or to write letters to express
one’s emotions and feelings. Moreover, some mood trackers are specifically designed
for bipolar patients that can use these apps to keep track of mood swings and prevent
dangerous mood shifts. Apps in this specific sub-category include often also sleep and
diet tracking features.
      </p>
    </sec>
    <sec id="sec-6">
      <title>Mindfulness-based apps</title>
      <p>
        The last category we considered is also the closest to the kind of mobile application we
latterly approached to design and develop. Applications in this category, despite the
different features included in each case, have their common core on mindfulness
practices. Leaving a deeper examination of mindfulness practice related to emotional
regulation to the second part of this paper, meantime we can describe mindfulness as “The
awareness that arises from paying attention, on purpose, in the present moment and
non-judgmentally” [
        <xref ref-type="bibr" rid="ref16">16</xref>
        ], as mindfulness practices are meditations or exercises that
involve this particular kind of awareness. Mindfulness-based apps so are based on the
principles that comes from mindfulness and promote this mental ability through
different content. Many of these apps have rapidly spread in the last few years due to the
fame the word “mindfulness” has achieved, partly to decades of scientific research on
clinical usage of mindfulness-based practices [
        <xref ref-type="bibr" rid="ref16 ref18 ref25">16, 18, 25</xref>
        ], and partly thanks to mediatic
claim. These apps offer guided meditations, lectures, stories, breathing exercises and
guided reflections on specific themes, like “Calm” [
        <xref ref-type="bibr" rid="ref1">1</xref>
        ] and “Headspace” [
        <xref ref-type="bibr" rid="ref12">12</xref>
        ]. These
apps offer just some features for free, leaving many of them reserved for paid users that
can subscribe to a plan.
      </p>
      <p>
        A little different app is “Insight Timer” [
        <xref ref-type="bibr" rid="ref15">15</xref>
        ], which main features are the presence
of a timer for meditation practices and a social network structure where users can add
friends to meditation groups, take lessons or guided meditation from teachers or even
buy courses and classes.
1.2
      </p>
    </sec>
    <sec id="sec-7">
      <title>Mental health mobile applications: some emerging guidelines</title>
      <p>As already noted about emotional help assistant apps, at the moment, even in the other
app categories the content is often limited to be experienced in English language,
limiting the usability of their contents, especially in mindfulness-based apps that often use
audio tracks to guide meditations. Another critical point can be stressed about
emotional help assistant apps since the AI involved in the chatbot is still quite rigid and
always tries to bring back the user to scripted dialogues, breaking down the sensation
to talk to a human being and turning the conversation quite soon to a repetitive sequence
of questions. Moreover these apps require the user to have achieved an average ability
to describe and decenter from thoughts to be effective that is not so obvious for many
people, even less for people struggling with distressful health situations that may be
very entangled in negative patterns of behaviors, emotions and thoughts.</p>
      <p>
        Even if CBT(Cognitive-Behavioral Therapy)-based and MBI(Mindfulness-Based
Interventions)-based mobile applications have been demonstrated to be effective in
some studies [
        <xref ref-type="bibr" rid="ref23 ref28">23, 28</xref>
        ], their extent of efficacy has been measured only at a maximum
of 3 months follow-ups, and the few research on this topic has shown that some areas
of interventions (e.g. “quality of social relationships”) [
        <xref ref-type="bibr" rid="ref30">30</xref>
        ] were not different compared
to the control group. An emerging guideline that could be highlighted from these
considerations is that this kind of apps may be more effective for people that already are
under treatment or when they have completed a psychotherapeutic intervention to
maintain and to manage the effects of a treatment. On the other hand, emotional help
assistant apps take advantage of a user interface that almost any user is already familiar with,
since it is shared with the most common messaging app, encouraging the user to start
the chat as a common mobile conversation with a human agent.
      </p>
      <p>Mindfulness apps present a different problem that can be highlighted from this
review, and it is the lack of interaction with real instructors and fellows, which is an
important feature of every mindfulness-based practice course or intervention. Without
a point of reference during mindfulness practice is easy to misunderstand the purpose
of exercises or to experience frustration and disengagement. A partial exception in this
sense seems to be “Insight Timer”, which allows the user to stay in contact with other
people practicing meditation and with teachers. Considering this critical point, a second
possible guideline for the development of mental health apps could be to introduce as
a feature the possibility to directly keep in touch with a psychologist, mindfulness
instructor and so on, giving the possibility for the professional to propose new material
to students/patients and to directly give instructions and updates to targeted material
tailored on the patient/student needs. One final critical point emerging seems to be the
metrics used to assess user’s progresses. All mental health applications evaluated for
this paper used explicit measurements, such as questionnaires, scales and labels to
describe one’s experience and progress. This methodology exposes the measurement to
different systematic errors that are typical of self-report assessment tools, but without
the warranty that a mental health professional can integrate these reports with other
clinical practices. So, we conclude this paragraph with one last possible guideline, that
is to use (or to integrate) implicit measurements to assess the progresses of the user,
using for example performance tasks together with questionnaires. These features have
been included in apps designed especially for research intents and still seems to lack in
public mobile apps.
2</p>
      <sec id="sec-7-1">
        <title>The design of a mindfulness mobile application to help emotional self-regulation in people suffering stressful situations</title>
        <p>Considering the preliminary review of the state of the art of mobile applications for
mental health, we tried to propose a coherent project for a mobile app that could give
some helpful features for the development of emotional self-regulation among people
who were dealing with stressful situations. In this second part of the paper are described
the theorical framework which underlies to the development of the app as well as the
design and development process for a mindfulness-based mobile application that could
take count of the guidelines highlighted in the previous section.
2.1</p>
      </sec>
    </sec>
    <sec id="sec-8">
      <title>Emotional regulation and mindfulness-based practices</title>
      <p>
        By emotional regulation it is intended the set of processes through which individuals
regulate their affective states [
        <xref ref-type="bibr" rid="ref10">10</xref>
        ]. Emotions have a fundamental role for survival,
however if not regulated in their duration, intensity or coherence with the situation, they
can trigger maladaptive behaviors that have a deep negative impact on health. The
aspect of the emotional processes in which individuals have control are mainly the
emergence, duration, content and quality of the experience. As the main theorical framework
for the development of this app we considered James Gross’ work and theory on
emotion regulation strategies, which directly derives from cognitive appraisal theories from
authors such as Lazarus and Folkman [
        <xref ref-type="bibr" rid="ref6">6</xref>
        ].
      </p>
      <p>The theorical model adopted for this purpose describes emotions as a dynamic,
flexible, multi-componential process, defining three main aspect. The first is that the
generative process of emotions is a dynamic mechanism of multiple feedback loops that
influence every stage of the emotional processing as well as the final emotional
responses.</p>
      <p>The second aspect deals with the timing of the regulation strategies, that can be
focused on the antecedent (Antecedent-Focused Regulation) or on the response
(Response-Focused Regulation). A third option is a mix of the two described strategies that
occur as parallel processes at different timing levels of the emotional process. Starting
from this distinction, Gross’ model proposes five different strategies of emotional
regulation as it follows:
• Situation Selection;
• Situation Modification;
• Attentional Deployment;
• Cognitive Change;
• Response Modulation.</p>
      <p>
        The first four are antecedent-focused strategies, since they occur before the
emotional response, while the last one is response-focused, since it occurs after that the
response has been generated [
        <xref ref-type="bibr" rid="ref10">10</xref>
        ].
      </p>
      <p>
        Considering this general model of emotional regulation, there are many situations
where the emotional regulation strategy used by the individual is efficient in the short
period, like avoidance for example, but on the long period it can increase stress, rigidity
and ultimately suffering and stress. Avoidance is considered by many authors as a core
element, together with rigidity and cognitive fusion, for the development of stress and
as high-risk factors for psychopathological outcomes, as described for example by
Hayes and colleagues [
        <xref ref-type="bibr" rid="ref11">11</xref>
        ]. By avoidance it is intended every behavior that takes as a
goal the systematic reduction of a nocuous stimulus, including sensations, thoughts,
feelings and situations. By rigidity it is intended every automatic behavior that is not
sensible to change and adaptability to the environmental changes, and by cognitive
fusion is considered the identification of an individual with his/her own mental content,
such as thoughts, without decentering and metacognition.
      </p>
      <p>
        On the opposite side of this kind of emotional regulation, we find the decentering,
one of the core elements of mindfulness practices [
        <xref ref-type="bibr" rid="ref13">13</xref>
        ]. The construct of decentering
can be described as a reframing process, a distancing that allows to experiment a
different prospective upon an event without being entangled with feelings and thoughts
about it as the only possible ones and not considering them automatically true, giving
the possibility to experiment mental content, like pain, difficult emotions and thoughts
as purely mental content, being present to them without avoidance.
      </p>
      <p>
        Shapiro and colleagues [
        <xref ref-type="bibr" rid="ref25">25</xref>
        ] highlight this as the core element of mindfulness
practices, actually calling it reperceiving, to stress even more the process of radically
perceiving differently a situation by a decentered point of view that allows people to be
more flexible, to deal more efficiently with stressful situations by enhancing the ability
to accept things that actually can not be changed, and to bring more focus on more
adaptive behaviors. Mindfulness-based clinical practices aim at reducing automatic
maladaptive behaviors, empowering the ability of the mind to be present to just what is
present, and to act with awareness toward what needs to be changed, and this clearly
explain why it can be a tremendous help for many different situations when people
struggle with emotions, recurring and intrusive thoughts and difficult situations [
        <xref ref-type="bibr" rid="ref16 ref18 ref8">8, 16,
18</xref>
        ].
      </p>
      <p>
        According to the current literature, mindfulness meditation has shown to be effective
on many different aspects. Meta-analyses such as the one by Sedlmeier and colleagues
[
        <xref ref-type="bibr" rid="ref24">24</xref>
        ], conducted on 163 studies that met strict methodological criteria, have highlighted
that meditation practices have strong effects on emotional and relational issues,
attentional and other cognitive measures, revealing that experience in meditation does not
impact so strongly the positive effect of practicing. The same meta-analysis has also
shown in particular that mindfulness meditation has a great effect on the following
domains: negative personality traits, stress, anxiety state, perception, anxiety trait, positive
emotions, well-being, negative emotions and emotion regulation. Other meta-analysis,
such as the one from Chen and colleagues [
        <xref ref-type="bibr" rid="ref2">2</xref>
        ], have focused on the impact of meditation
on anxiety issues, finding that this practices are effective on reducing anxiety
symptoms, suggesting that meditation practices could affect emotional regulation as training
to control mind abilities, developing more efficient coping mechanisms and more
adaptive responses to stressors, affecting the individuals’ biological, behavioral and
cognitive regulation abilities, which of course affect in turn emotional regulation.
      </p>
      <p>
        From a cognitive point of view, all of this processes can be called defusion, as it
involves the cognitive ability to de-fuse and let go a rigid ego-centered perspective on
mental content that causes suffering, and to see mind contents as what they are, surely
involving a strong development of metacognitive abilities in this process of exploring
one’s own mind and processes occurring by a moment to moment awareness [
        <xref ref-type="bibr" rid="ref11">11</xref>
        ].
Mindfulness practices then not just allow individuals to develop a new perspective from
which looking at things in their life, but also enable people to have more space between
the stimulus and their response, and there is a great amount of research that agrees on
the tremendous help mindfulness-based practices can be to emotional self-regulation
[
        <xref ref-type="bibr" rid="ref8">8</xref>
        ].
2.2
      </p>
    </sec>
    <sec id="sec-9">
      <title>The mobile application design process</title>
      <p>Taking account of the concepts described in the previous paragraphs, the research team
at NAC started working to develop a mobile application to help people to improve
emotional regulation through mindfulness exercises. The mindfulness app has been
designed as a part of the “Emotion.exe” (Emotional Mediated Online Training for
Introspection, Observation, Novelization</p>
      <p>
        and Expression) research project by the ISTC (Institute of Cognitive Sciences and
Technologies – National Research Council) of Rome. The project aims at developing a
suite of training tools for the development of emotional intelligence and self-regulation.
Which this app is a part of. From an early overview of the state of the art of actual
mobile applications that provide mental health support tools, reported in the first part
of this paper, emerged the three guidelines described before. The first is that it seems
reasonable to consider that, according to the literature, mental health apps can be more
effective on people who already are, or have been, in treatment [
        <xref ref-type="bibr" rid="ref23">23</xref>
        ]. Other than being
an evidence supported by some studies, it seemed reasonable for two reasons, that are:
the risk for the people to take the mobile app as an obstacle for searching for real help
from mental health professionals, and on the other hand the opportunity for well trained
individuals to take real advantage of exercises and tools which people can correctly
understand and that can give real support even for ongoing or terminated treatments.
These are the reasons why we decided to focus on developing a mobile app that could
be a support tool for people who have just concluded a MBSR (Mindfulness Based
Stress Reduction program) [
        <xref ref-type="bibr" rid="ref16 ref7 ref8">7, 8, 16</xref>
        ], one of the most diffuse and evidence-based and
mindfulness-based 8 weeks protocol, focusing on providing content that could help
users to maintain a certain mindfulness practice achieved through the participation to a
mindfulness-based program.
      </p>
      <p>
        As we can assume from large reviews such as the one conducted by Keng and
colleagues [
        <xref ref-type="bibr" rid="ref17">17</xref>
        ], a large number of RCT seems to confirm that MBSR is strongly effective
for many clinical and non-clinical populations on reducing self-reported levels of
axiety, depression, anger, rumination, general psychological distress, including perceived
stress, cognitive disorganization, post-traumatic avoidance symptoms and medical
symptoms; the same way, MBSR seems to improve positive affect, sense of spirituality,
empathy, sense of cohesion, mindfulness, forgiveness, self-compassion, satisfaction
with life and quality of life.
      </p>
      <p>The second guideline that has been considered in the design process was the
opportunity to create a direct intervention from teachers/health professionals within the
materials provided by the app. The idea is to develop a simple account-based network that
can easily allow mindfulness teachers to provide new content (e.g. guided meditations,
short readings, suggestions) to a virtual class that corresponds to the participants who
had already attended an MBSR. This could give the opportunity to rise the engagement
of users within the app and to maintain a sense of connectiveness to the class, other
than allowing teachers to provide new interesting content to students/patients.</p>
      <p>
        One last guideline we assumed has been the focus on implicit measurements for
user’s progress. Instead of just providing questionnaires, we thought that it could have
been more efficient to provide short exercises or minigames at the end of each
mindfulness exercise to test implicit parameters. Some possible tasks could include, for
example, short Stroop tests to assess maintained attention, which is considered one of the
most affected cognitive process by mindfulness-based practice [
        <xref ref-type="bibr" rid="ref20 ref29">20, 29</xref>
        ].Through these
measurements, it could be possible to record scores related to cognitive processes
involved and enhanced in mindfulness practices, according to the literature, without the
use of other implicit measurements like psychophysiological values obtained through
biofeedback and neurofeedback sensors that would have reduced the number of people
and made more complicated the user experience of the app.
      </p>
      <p>Although a greater focus on implicit psychological measurements has been put in
the development process of the app, we thought that questionnaires could be still useful
to log mood states, like in mood trackers apps, and to elaborate scores not by just
administrating a dimensional scale (e.g. “How calm do you feel now from 0 to 10?”), but
to integrate scales’ scores to produce measurements. For example, the score on a scale
that measures self-reported “feeling of calmness” could be used, together with the score
of a scale that reports the presence of “intrusive/disturbing thoughts” to produce a
“defusion score” that could be, according on the most recent theories on mindfulness
practices described in the previous paragraph, a very important value to take count to
establish if the user is improving his/her skills or not, and maybe investigate if something is
going wrong for him/her.</p>
      <p>
        These were the main aspect we considered for the design of the app, which is still in
development at this moment. From a technical point of view the app is currently
developed using the STELT (Smart Technologies to Enhance Learning and Teaching)
platform [
        <xref ref-type="bibr" rid="ref21">21</xref>
        ], which is an engine, developed at NAC, that focuses on an agent-based
modeling process that enable the developer to design the software as a natural interaction
between a “Tutor” behavior and a “Player” behavior, allowing to naturally design
possible interactions between user’s choices and preferences and Tutor’s responses as a
powerful and yet easy-to-use development platform for agent-based apps and games.
3
      </p>
      <sec id="sec-9-1">
        <title>Conclusions and future directions</title>
        <p>To conclude this short paper that has described an overview of the state of the art and
the resulting guidelines for the development of mental health mobile applications, it is
possible to point out some aspects that indicate the future directions for research on this
topic. The first is that, if it is true that there are more than a thousand different mental
health apps on the most important marketplaces, scientific literature about the usage,
implications and outcomes of these health applied technologies is still very poor,
especially compared to the growing number of smartphone users and the pervasiveness of
mobile technology.</p>
        <p>A second important aspect to highlight seems to be the lack of localization for many
of the contents currently available in the applications stores, that puts a limit even to
research to some selected countries.</p>
        <p>Furthermore, it is very important to involve mental health professionals into the
development of this kind of software, to reduce risks and to guarantee an average level of
theorical and methodological validity.</p>
        <p>The three main guidelines emerged by the overview of current mental health apps
could be a starting point, to be integrated in the future, to give hints about important
aspects to consider in the development process, and by describing the process of design
of a currently developing mindfulness-based app by the NAC Laboratory, this paper
tried to show a possible way to determine what seem to be important points to focus on
the development of a mental health mobile application, which if scientifically
evaluated, may be a great support tool for mental health professionals.</p>
      </sec>
      <sec id="sec-9-2">
        <title>Acknowledgment</title>
        <p>The Emotion.exe project (Emotional Mediated Online Training for Introspection,
Observation, Novelization and Expression) is funded by Regione Lazio in the framework
of Regional Law LR 13/2008 art. 7 “Progetti per gruppi di Ricerca” call, CUP
B56C18000590002.</p>
      </sec>
    </sec>
  </body>
  <back>
    <ref-list>
      <ref id="ref1">
        <mixed-citation>
          1.
          <string-name>
            <given-names>CALM</given-names>
            <surname>Homepage</surname>
          </string-name>
          , https://www.calm.com/.
        </mixed-citation>
      </ref>
      <ref id="ref2">
        <mixed-citation>
          2.
          <string-name>
            <surname>Chen</surname>
            ,
            <given-names>K. W.</given-names>
          </string-name>
          ,
          <string-name>
            <surname>Berger</surname>
            ,
            <given-names>C. C.</given-names>
          </string-name>
          ,
          <string-name>
            <surname>Manheimer</surname>
            ,
            <given-names>E.</given-names>
          </string-name>
          ,
          <string-name>
            <surname>Forde</surname>
            ,
            <given-names>D.</given-names>
          </string-name>
          ,
          <string-name>
            <surname>Magidson</surname>
            ,
            <given-names>J.</given-names>
          </string-name>
          ,
          <string-name>
            <surname>Dachman</surname>
            ,
            <given-names>L.</given-names>
          </string-name>
          , &amp;
          <string-name>
            <surname>Lejuez</surname>
            ,
            <given-names>C. W.</given-names>
          </string-name>
          :
          <article-title>Meditative therapies for reducing anxiety: A systematic review and meta‐analysis of randomized controlled trials</article-title>
          .
          <source>Depression and anxiety</source>
          ,
          <volume>29</volume>
          (
          <issue>7</issue>
          ),
          <fpage>545</fpage>
          -
          <lpage>562</lpage>
          (
          <year>2012</year>
          ). https://doi.org/10.1002/da.21964
        </mixed-citation>
      </ref>
      <ref id="ref3">
        <mixed-citation>
          3.
          <string-name>
            <given-names>DAYLIO</given-names>
            <surname>Homepage</surname>
          </string-name>
          , https://daylio.webflow.io/.
        </mixed-citation>
      </ref>
      <ref id="ref4">
        <mixed-citation>
          4.
          <string-name>
            <given-names>FABULOUS</given-names>
            <surname>Homepage</surname>
          </string-name>
          , https://www.thefabulous.co/.
        </mixed-citation>
      </ref>
      <ref id="ref5">
        <mixed-citation>
          5.
          <string-name>
            <surname>Fitzpatrick</surname>
            ,
            <given-names>K. K.</given-names>
          </string-name>
          ,
          <string-name>
            <surname>Darcy</surname>
            ,
            <given-names>A.</given-names>
          </string-name>
          , &amp;
          <string-name>
            <surname>Vierhile</surname>
            ,
            <given-names>M.</given-names>
          </string-name>
          :
          <article-title>Delivering cognitive behavior therapy to young adults with symptoms of depression and anxiety using a fully automated conversational agent (Woebot): a randomized controlled trial</article-title>
          .
          <source>JMIR mental health</source>
          ,
          <volume>4</volume>
          (
          <issue>2</issue>
          ),
          <year>e19</year>
          (
          <year>2017</year>
          ). doi:
          <volume>10</volume>
          .2196/mental.7785
        </mixed-citation>
      </ref>
      <ref id="ref6">
        <mixed-citation>
          6.
          <string-name>
            <surname>Folkman</surname>
            ,
            <given-names>S.</given-names>
          </string-name>
          ,
          <string-name>
            <surname>Lazarus</surname>
            ,
            <given-names>R. S.</given-names>
          </string-name>
          ,
          <string-name>
            <surname>Dunkel-Schetter</surname>
            ,
            <given-names>C.</given-names>
          </string-name>
          ,
          <string-name>
            <surname>DeLongis</surname>
            ,
            <given-names>A.</given-names>
          </string-name>
          , &amp;
          <string-name>
            <surname>Gruen</surname>
            ,
            <given-names>R. J.:</given-names>
          </string-name>
          <article-title>Dynamics of a stressful encounter: cognitive appraisal, coping, and encounter outcomes</article-title>
          .
          <source>Journal of personality and social psychology</source>
          ,
          <volume>50</volume>
          (
          <issue>5</issue>
          ),
          <volume>992</volume>
          (
          <year>1986</year>
          ).
        </mixed-citation>
      </ref>
      <ref id="ref7">
        <mixed-citation>
          7.
          <string-name>
            <surname>Giommi</surname>
            ,
            <given-names>F.</given-names>
          </string-name>
          :
          <string-name>
            <surname>Introduzione</surname>
          </string-name>
          .
          <article-title>Al di là del pensiero, attraverso il pensiero</article-title>
          . In
          <string-name>
            <surname>Segal</surname>
            ,
            <given-names>Z. V.</given-names>
          </string-name>
          ,
          <string-name>
            <surname>Williams</surname>
            ,
            <given-names>J. M. G.</given-names>
          </string-name>
          , &amp;
          <string-name>
            <surname>Teasdale</surname>
            ,
            <given-names>J. D.</given-names>
          </string-name>
          <string-name>
            <surname>Mindfulness</surname>
          </string-name>
          <article-title>: al di là del pensiero, attraverso il pensiero (pp. XIII-LXXIX)</article-title>
          .
          <source>Bollati Boringhieri</source>
          ,
          <string-name>
            <surname>Milano</surname>
          </string-name>
          (
          <year>2014</year>
          ).
        </mixed-citation>
      </ref>
      <ref id="ref8">
        <mixed-citation>
          8.
          <string-name>
            <surname>Goldin</surname>
            ,
            <given-names>P. R.</given-names>
          </string-name>
          , &amp;
          <string-name>
            <surname>Gross</surname>
            ,
            <given-names>J. J.:</given-names>
          </string-name>
          <article-title>Effects of mindfulness-based stress reduction (MBSR) on emotion regulation in social anxiety disorder</article-title>
          .
          <source>Emotion</source>
          ,
          <volume>10</volume>
          (
          <issue>1</issue>
          ),
          <volume>83</volume>
          (
          <year>2010</year>
          ). http://dx.doi.org/10.1037/a0018441
        </mixed-citation>
      </ref>
      <ref id="ref9">
        <mixed-citation>
          9.
          <string-name>
            <surname>Grist</surname>
            ,
            <given-names>R.</given-names>
          </string-name>
          ,
          <string-name>
            <surname>Porter</surname>
            ,
            <given-names>J.</given-names>
          </string-name>
          , &amp;
          <string-name>
            <surname>Stallard</surname>
            ,
            <given-names>P.</given-names>
          </string-name>
          :
          <article-title>Mental health mobile apps for preadolescents and adolescents: a systematic review</article-title>
          .
          <source>Journal of medical internet research</source>
          ,
          <volume>19</volume>
          (
          <issue>5</issue>
          ),
          <year>e176</year>
          (
          <year>2017</year>
          ). doi:
          <volume>10</volume>
          .2196/jmir.7332
        </mixed-citation>
      </ref>
      <ref id="ref10">
        <mixed-citation>
          10.
          <string-name>
            <surname>Gross</surname>
            ,
            <given-names>J. J.:</given-names>
          </string-name>
          <article-title>Emotion regulation: Affective, cognitive, and social consequences</article-title>
          .
          <source>Psychophysiology</source>
          ,
          <volume>39</volume>
          (
          <issue>3</issue>
          ),
          <fpage>281</fpage>
          -
          <lpage>291</lpage>
          (
          <year>2002</year>
          ). https://doi.org/10.1017/S0048577201393198
        </mixed-citation>
      </ref>
      <ref id="ref11">
        <mixed-citation>
          11.
          <string-name>
            <surname>Hayes</surname>
            ,
            <given-names>S. C.</given-names>
          </string-name>
          ,
          <string-name>
            <surname>Strosahl</surname>
            ,
            <given-names>K. D.</given-names>
          </string-name>
          , &amp; Wilson, K. G.:
          <article-title>Acceptance and commitment therapy (p. 6)</article-title>
          . New York, Guilford Press (
          <year>1999</year>
          ).
        </mixed-citation>
      </ref>
      <ref id="ref12">
        <mixed-citation>12. HEADSPACE Homepage, https://www.headspace.com/.</mixed-citation>
      </ref>
      <ref id="ref13">
        <mixed-citation>
          13.
          <string-name>
            <surname>Hölzel</surname>
            ,
            <given-names>B. K.</given-names>
          </string-name>
          ,
          <string-name>
            <surname>Lazar</surname>
            ,
            <given-names>S. W.</given-names>
          </string-name>
          ,
          <string-name>
            <surname>Gard</surname>
            ,
            <given-names>T.</given-names>
          </string-name>
          ,
          <string-name>
            <surname>Schuman-Olivier</surname>
            ,
            <given-names>Z.</given-names>
          </string-name>
          ,
          <string-name>
            <surname>Vago</surname>
            ,
            <given-names>D. R.</given-names>
          </string-name>
          , &amp;
          <string-name>
            <surname>Ott</surname>
            ,
            <given-names>U.</given-names>
          </string-name>
          :
          <article-title>How does mindfulness meditation work? Proposing mechanisms of action from a conceptual and neural perspective</article-title>
          .
          <source>Perspectives on psychological science</source>
          ,
          <volume>6</volume>
          (
          <issue>6</issue>
          ),
          <fpage>537</fpage>
          -
          <lpage>559</lpage>
          (
          <year>2011</year>
          ). https://doi.org/10.1177/1745691611419671
        </mixed-citation>
      </ref>
      <ref id="ref14">
        <mixed-citation>
          14.
          <string-name>
            <surname>Inkster</surname>
            ,
            <given-names>B.</given-names>
          </string-name>
          ,
          <string-name>
            <surname>Sarda</surname>
            ,
            <given-names>S.</given-names>
          </string-name>
          , &amp;
          <string-name>
            <surname>Subramanian</surname>
            ,
            <given-names>V.</given-names>
          </string-name>
          :
          <article-title>An empathy-driven, conversational artificial intelligence agent (Wysa) for digital mental well-being: real-world data evaluation mixedmethods study</article-title>
          .
          <source>JMIR mHealth and uHealth</source>
          ,
          <volume>6</volume>
          (
          <issue>11</issue>
          ),
          <year>e12106</year>
          (
          <year>2018</year>
          ).
          <source>doi:10.2196/12106</source>
        </mixed-citation>
      </ref>
      <ref id="ref15">
        <mixed-citation>15. INSIGHT TIMER Homepage, https://insighttimer.com/.</mixed-citation>
      </ref>
      <ref id="ref16">
        <mixed-citation>
          16.
          <string-name>
            <surname>Kabat-Zinn</surname>
            ,
            <given-names>J.</given-names>
          </string-name>
          , &amp;
          <string-name>
            <surname>Hanh</surname>
            ,
            <given-names>T. N.</given-names>
          </string-name>
          :
          <article-title>Full catastrophe living: Using the wisdom of your body and mind to face stress, pain, and illness</article-title>
          . Random House Publishing Group, New York (
          <year>2009</year>
          ).
        </mixed-citation>
      </ref>
      <ref id="ref17">
        <mixed-citation>
          17.
          <string-name>
            <surname>Keng</surname>
            ,
            <given-names>S. L.</given-names>
          </string-name>
          ,
          <string-name>
            <surname>Smoski</surname>
            ,
            <given-names>M. J.</given-names>
          </string-name>
          , &amp;
          <string-name>
            <surname>Robins</surname>
            ,
            <given-names>C. J.:</given-names>
          </string-name>
          <article-title>Effects of mindfulness on psychological health: A review of empirical studies</article-title>
          .
          <source>Clinical psychology review</source>
          ,
          <volume>31</volume>
          (
          <issue>6</issue>
          ),
          <fpage>1041</fpage>
          -
          <lpage>1056</lpage>
          (
          <year>2011</year>
          ). https://doi.org/10.1016/j.cpr.
          <year>2011</year>
          .
          <volume>04</volume>
          .006
        </mixed-citation>
      </ref>
      <ref id="ref18">
        <mixed-citation>
          18.
          <string-name>
            <surname>Lutz</surname>
            ,
            <given-names>J.</given-names>
          </string-name>
          ,
          <string-name>
            <surname>Herwig</surname>
            ,
            <given-names>U.</given-names>
          </string-name>
          ,
          <string-name>
            <surname>Opialla</surname>
            ,
            <given-names>S.</given-names>
          </string-name>
          ,
          <string-name>
            <surname>Hittmeyer</surname>
            ,
            <given-names>A.</given-names>
          </string-name>
          ,
          <string-name>
            <surname>Jäncke</surname>
            ,
            <given-names>L.</given-names>
          </string-name>
          ,
          <string-name>
            <surname>Rufer</surname>
            ,
            <given-names>M.</given-names>
          </string-name>
          , ... &amp;
          <string-name>
            <surname>Brühl</surname>
            ,
            <given-names>A. B.</given-names>
          </string-name>
          :
          <article-title>Mindfulness and emotion regulation-an fMRI study</article-title>
          .
          <source>Social cognitive and affective neuroscience</source>
          ,
          <volume>9</volume>
          (
          <issue>6</issue>
          ),
          <fpage>776</fpage>
          -
          <lpage>785</lpage>
          (
          <year>2013</year>
          ). https://doi.org/10.1093/scan/nst043
        </mixed-citation>
      </ref>
      <ref id="ref19">
        <mixed-citation>
          19.
          <string-name>
            <surname>Mak</surname>
            ,
            <given-names>W. W.</given-names>
          </string-name>
          ,
          <string-name>
            <surname>Tong</surname>
            ,
            <given-names>A. C.</given-names>
          </string-name>
          ,
          <string-name>
            <surname>Yip</surname>
            ,
            <given-names>S. Y.</given-names>
          </string-name>
          ,
          <string-name>
            <surname>Lui</surname>
            ,
            <given-names>W. W.</given-names>
          </string-name>
          ,
          <string-name>
            <surname>Chio</surname>
            ,
            <given-names>F. H.</given-names>
          </string-name>
          ,
          <string-name>
            <surname>Chan</surname>
            ,
            <given-names>A. T.</given-names>
          </string-name>
          , &amp;
          <string-name>
            <surname>Wong</surname>
            ,
            <given-names>C. C.</given-names>
          </string-name>
          :
          <article-title>Efficacy and moderation of mobile app-based programs for mindfulness-based training, self-compassion training, and cognitive behavioral psychoeducation on mental health: Randomized controlled noninferiority trial</article-title>
          .
          <source>JMIR mental health</source>
          ,
          <volume>5</volume>
          (
          <issue>4</issue>
          ),
          <year>e60</year>
          (
          <year>2018</year>
          ). doi:
          <volume>10</volume>
          .2196/mental.8597
        </mixed-citation>
      </ref>
      <ref id="ref20">
        <mixed-citation>
          20.
          <string-name>
            <surname>Malinowski</surname>
            ,
            <given-names>P.</given-names>
          </string-name>
          <article-title>Neural mechanisms of attentional control in mindfulness meditation</article-title>
          .
          <source>Frontiers in neuroscience, 7</source>
          ,
          <issue>8</issue>
          (
          <year>2013</year>
          ). https://doi.org/10.3389/fnins.
          <year>2013</year>
          .00008
        </mixed-citation>
      </ref>
      <ref id="ref21">
        <mixed-citation>
          21.
          <string-name>
            <surname>Miglino</surname>
            ,
            <given-names>O.</given-names>
          </string-name>
          ,
          <string-name>
            <surname>Di</surname>
            <given-names>Ferdinando</given-names>
          </string-name>
          ,
          <string-name>
            <given-names>A.</given-names>
            ,
            <surname>Schembri</surname>
          </string-name>
          ,
          <string-name>
            <given-names>M.</given-names>
            ,
            <surname>Caretti</surname>
          </string-name>
          ,
          <string-name>
            <given-names>M.</given-names>
            ,
            <surname>Rega</surname>
          </string-name>
          ,
          <string-name>
            <given-names>A.</given-names>
            , &amp;
            <surname>Ricci</surname>
          </string-name>
          ,
          <string-name>
            <surname>C.</surname>
          </string-name>
          :
          <article-title>STELT (Smart Technologies to Enhance Learning and Teaching): una piattaforma per realizzare ambienti di realtà aumentata per apprendere, insegnare e giocare</article-title>
          .
          <source>Sistemi intelligenti</source>
          ,
          <volume>25</volume>
          (
          <issue>2</issue>
          ),
          <fpage>397</fpage>
          -
          <lpage>404</lpage>
          (
          <year>2013</year>
          ).
          <source>doi:10.1422/75364</source>
        </mixed-citation>
      </ref>
      <ref id="ref22">
        <mixed-citation>22. MINDCARE Homepage, https://mindcare-app.com/en/.</mixed-citation>
      </ref>
      <ref id="ref23">
        <mixed-citation>
          23.
          <string-name>
            <surname>Price</surname>
            ,
            <given-names>M.</given-names>
          </string-name>
          ,
          <string-name>
            <surname>Yuen</surname>
            ,
            <given-names>E. K.</given-names>
          </string-name>
          ,
          <string-name>
            <surname>Goetter</surname>
            ,
            <given-names>E. M.</given-names>
          </string-name>
          ,
          <string-name>
            <surname>Herbert</surname>
            ,
            <given-names>J. D.</given-names>
          </string-name>
          ,
          <string-name>
            <surname>Forman</surname>
            ,
            <given-names>E. M.</given-names>
          </string-name>
          ,
          <string-name>
            <surname>Acierno</surname>
            ,
            <given-names>R.</given-names>
          </string-name>
          , &amp;
          <string-name>
            <surname>Ruggiero</surname>
            ,
            <given-names>K. J.:</given-names>
          </string-name>
          <article-title>mHealth: a mechanism to deliver more accessible, more effective mental health care</article-title>
          .
          <source>Clinical psychology &amp; psychotherapy</source>
          ,
          <volume>21</volume>
          (
          <issue>5</issue>
          ),
          <fpage>427</fpage>
          -
          <lpage>436</lpage>
          (
          <year>2014</year>
          ). https://doi.org/10.1002/cpp.1855
        </mixed-citation>
      </ref>
      <ref id="ref24">
        <mixed-citation>
          24.
          <string-name>
            <surname>Sedlmeier</surname>
            ,
            <given-names>P.</given-names>
          </string-name>
          ,
          <string-name>
            <surname>Eberth</surname>
            ,
            <given-names>J.</given-names>
          </string-name>
          ,
          <string-name>
            <surname>Schwarz</surname>
            ,
            <given-names>M.</given-names>
          </string-name>
          ,
          <string-name>
            <surname>Zimmermann</surname>
            ,
            <given-names>D.</given-names>
          </string-name>
          ,
          <string-name>
            <surname>Haarig</surname>
            ,
            <given-names>F.</given-names>
          </string-name>
          ,
          <string-name>
            <surname>Jaeger</surname>
            ,
            <given-names>S.</given-names>
          </string-name>
          , &amp;
          <string-name>
            <surname>Kunze</surname>
            ,
            <given-names>S.:</given-names>
          </string-name>
          <article-title>The psychological effects of meditation: A meta-analysis</article-title>
          .
          <source>Psychological Bulletin</source>
          ,
          <volume>138</volume>
          (
          <issue>6</issue>
          ),
          <fpage>1139</fpage>
          -
          <lpage>1171</lpage>
          (
          <year>2012</year>
          ). http://dx.doi.org/10.1037/a0028168
        </mixed-citation>
      </ref>
      <ref id="ref25">
        <mixed-citation>
          25.
          <string-name>
            <surname>Shapiro</surname>
            ,
            <given-names>S. L.</given-names>
          </string-name>
          ,
          <string-name>
            <surname>Carlson</surname>
            ,
            <given-names>L. E.</given-names>
          </string-name>
          ,
          <string-name>
            <surname>Astin</surname>
            ,
            <given-names>J. A.</given-names>
          </string-name>
          , &amp;
          <string-name>
            <surname>Freedman</surname>
            ,
            <given-names>B.</given-names>
          </string-name>
          :
          <article-title>Mechanisms of mindfulness</article-title>
          .
          <source>Journal of clinical psychology</source>
          ,
          <volume>62</volume>
          (
          <issue>3</issue>
          ),
          <fpage>373</fpage>
          -
          <lpage>386</lpage>
          (
          <year>2006</year>
          ). https://doi.org/10.1002/jclp.20237
        </mixed-citation>
      </ref>
      <ref id="ref26">
        <mixed-citation>
          26.
          <string-name>
            <surname>SHINE - SELF</surname>
            <given-names>CARE</given-names>
          </string-name>
          &amp; MEDITATION Homepage, https://advice.shinetext.com/tags/selfcare/.
        </mixed-citation>
      </ref>
      <ref id="ref27">
        <mixed-citation>
          27.
          <string-name>
            <surname>TEN PERCENT HAPPIER Homepage</surname>
          </string-name>
          , https://www.tenpercent.com/.
        </mixed-citation>
      </ref>
      <ref id="ref28">
        <mixed-citation>
          28.
          <string-name>
            <surname>Torous</surname>
            ,
            <given-names>J.</given-names>
          </string-name>
          ,
          <string-name>
            <surname>Levin</surname>
            ,
            <given-names>M. E.</given-names>
          </string-name>
          ,
          <string-name>
            <surname>Ahern</surname>
            ,
            <given-names>D. K.</given-names>
          </string-name>
          , &amp;
          <string-name>
            <surname>Oser</surname>
            ,
            <given-names>M. L.</given-names>
          </string-name>
          :
          <article-title>Cognitive behavioral mobile applications: clinical studies, marketplace overview</article-title>
          , and research agenda.
          <source>Cognitive and Behavioral Practice</source>
          ,
          <volume>24</volume>
          (
          <issue>2</issue>
          ),
          <fpage>215</fpage>
          -
          <lpage>225</lpage>
          (
          <year>2017</year>
          ). https://doi.org/10.1016/j.cbpra.
          <year>2016</year>
          .
          <volume>05</volume>
          .007
        </mixed-citation>
      </ref>
      <ref id="ref29">
        <mixed-citation>
          29. van den Hurk, P. A.,
          <string-name>
            <surname>Giommi</surname>
            ,
            <given-names>F.</given-names>
          </string-name>
          ,
          <string-name>
            <surname>Gielen</surname>
            ,
            <given-names>S. C.</given-names>
          </string-name>
          ,
          <string-name>
            <surname>Speckens</surname>
            ,
            <given-names>A. E.</given-names>
          </string-name>
          , &amp;
          <string-name>
            <surname>Barendregt</surname>
            ,
            <given-names>H. P.</given-names>
          </string-name>
          :
          <article-title>Greater efficiency in attentional processing related to mindfulness meditation</article-title>
          .
          <source>Quarterly Journal of Experimental Psychology</source>
          ,
          <volume>63</volume>
          (
          <issue>6</issue>
          ),
          <fpage>1168</fpage>
          -
          <lpage>1180</lpage>
          (
          <year>2010</year>
          ). https://doi.org/10.1080/17470210903249365
        </mixed-citation>
      </ref>
      <ref id="ref30">
        <mixed-citation>
          30.
          <string-name>
            <surname>van Emmerik</surname>
            ,
            <given-names>A. A.</given-names>
          </string-name>
          ,
          <string-name>
            <surname>Berings</surname>
            ,
            <given-names>F.</given-names>
          </string-name>
          , &amp;
          <string-name>
            <surname>Lancee</surname>
          </string-name>
          , J.:
          <article-title>Efficacy of a mindfulness-based mobile application: a randomized waiting-list controlled trial</article-title>
          .
          <source>Mindfulness</source>
          ,
          <volume>9</volume>
          (
          <issue>1</issue>
          ),
          <fpage>187</fpage>
          -
          <lpage>198</lpage>
          (
          <year>2018</year>
          ).
          <source>doi: 10.1007/s12671-017-0761-7</source>
        </mixed-citation>
      </ref>
      <ref id="ref31">
        <mixed-citation>31. WOEBOT Homepage, https://woebot.io/.</mixed-citation>
      </ref>
      <ref id="ref32">
        <mixed-citation>32. WYSA Homepage, https://www.wysa.io/.</mixed-citation>
      </ref>
      <ref id="ref33">
        <mixed-citation>33. YOUPER Homepage, https://www.youper.ai/https://www.youper.ai/.</mixed-citation>
      </ref>
    </ref-list>
  </back>
</article>