=Paper=
{{Paper
|id=Vol-2544/shortpaper10
|storemode=property
|title=Phytochimic Study And Biological Activities Of The Hydro-Alcoholic Extract Of Leaves Of Bridelia Ferruginea Benth And Its Fractions
|pdfUrl=https://ceur-ws.org/Vol-2544/shortpaper10.pdf
|volume=Vol-2544
|authors=B. Bakoma,K. S. Sanvee,K. Metowogo,K. Eklu-Gadegkeku,K. Aklikokou,M. Gbeassor
|dblpUrl=https://dblp.org/rec/conf/irehi/BakomaSMEAG18
}}
==Phytochimic Study And Biological Activities Of The Hydro-Alcoholic Extract Of Leaves Of Bridelia Ferruginea Benth And Its Fractions==
<pdf width="1500px">https://ceur-ws.org/Vol-2544/shortpaper10.pdf</pdf>
<pre>
               Phytochimic Study And Biological Activities Of The
                 Hydro-Alcoholic Extract Of Leaves Of Bridelia
                      Ferruginea Benth And Its Fractions

                     B. Bakomab, K. S. Sanveea, K. Metowogoa, K. Eklu-Gadegkekua,
                                  K. Aklikokoua, M. Gbeassora

                  a Department of Animal Physiology, Faculty of Sciences, University of
                                         Lome, Togo.

                   b Departement of Pharmacy, Faculty of Health Sciences University of
                                      Lome, Togo BP 1515



                  Background and purpose: Bridelia ferruginea is a plant with antihyperglyce-
                  mic properties. The roots are most used parts of the plant in traditional medicine
                  against diabetes, this poses a problem of preservation of the species. Studies
                  have shown that leaves have low antihyperglycaemic power. The aim of this
                  study is to improve the antihyperglycemic using fractions of the leaf extract.
                  Methods: The effect of Leaf extract on Oral Glucose Tolerance Test (OGTT)
                  was tested in healthy mice, phytochemical screening and antioxidant activity
                  were achieved (in vitro: DPPH and ex vivo: AAPH ); the fractions resulting
                  from the fractionation were subjected to an OGTT test on mice, a phytochemi-
                  cal screening and antioxidant activity tests (in vitro: DPPH and ex vivo:
                  AAPH).
                  Results: The extract showed an antihyperglycemic activity at 750 mg / kg at the
                  30th minute after administration of glucose to the mice. Phytochemical screen-
                  ing of the extract showed the presence of phenols, flavonoids and condensed
                  tannins. The extract also showed antioxidant activity. The supernatant showed
                  antihyperglycemic activity at 100 mg / kg in the 30th and 60th after glucose
                  administration. Phytochemical screening of the supernatant revealed the pres-
                  ence of phenols, flavonoids and condensed tannins. The supernatant showed
                  more pronounced antioxidant activity than the total extract. The other fraction
                  of the pellet showed no antihyperglycemic activity at 100 mg / kg and the phy-
                  tochemical screening revealed the presence of phenols, flavonoids. The pellet
                  also showed less pronounced antioxidant activity than the supernatant.
                  Conclusion: In view of the results, the most active fraction obtained by frac-
                  tionation technique is the supernatant.

                  Keywords: Bridelia ferruginea, diabetes, HPVO, antioxidant, fraction.




Copyright © 2019 for this paper by its authors. Use permitted under Creative Commons License Attribution 4.0
International (CC BY 4.0) IREHI 2018 : 2nd IEEE International Rural and Elderly Health Informatics Conference

</pre>