<!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Archiving and Interchange DTD v1.0 20120330//EN" "JATS-archivearticle1.dtd">
<article xmlns:xlink="http://www.w3.org/1999/xlink">
  <front>
    <journal-meta />
    <article-meta>
      <title-group>
        <article-title>Improving Sleeping Habits: Preliminary Experiments in Barcelona and Lleida</article-title>
      </title-group>
      <contrib-group>
        <aff id="aff0">
          <label>0</label>
          <institution>CIBERES</institution>
          ,
          <addr-line>Madrid</addr-line>
          ,
          <country country="ES">Spain</country>
        </aff>
        <aff id="aff1">
          <label>1</label>
          <institution>Eurecat, Centre Tecnlogic, eHealth Unit</institution>
          ,
          <addr-line>Barcelona</addr-line>
          ,
          <country country="ES">Spain</country>
        </aff>
        <aff id="aff2">
          <label>2</label>
          <institution>Institut de Recerca Biomedica (IRBlleida)</institution>
          ,
          <addr-line>Lleida</addr-line>
        </aff>
      </contrib-group>
      <pub-date>
        <year>1900</year>
      </pub-date>
      <abstract>
        <p>Due to intrinsic (e.g., daily-life habits) and extrinsic (e.g., environmental change) factors, people are far to have a healthy life and, thus, there is an increase of chronic diseases, mental disorders, and premature death. In this paper, we propose a solution to improve lifestyle habits in terms of sleeping activity through an intelligent system that monitors the sleeping and further habits together with environmental data and provides personalized recommendations and nudges. Our solution aims to study how to improve sleeping habits of citizens, investigating if and how the environment impacts the sleeping activity, as well as how it may be in uenced by bad lifestyle habits. To perform a feasibility study of the proposed solution, on May we started recruiting volunteers in Barcelona (from Eurecat) and in Lleida (from IRBLleida). Volunteers were asked to wear their activity tracker 24/7, to weight once a week, and to answer the selected questionnaires at the end of the week. The day of the inclusion, we also took note of the comfort of the bed of each volunteer, as well as her/his address to take into consideration the environmental factors. Preliminary experiments clearly show the need for improving sleeping habits in the population and, thus, of intelligent solutions like the one presented in this paper.</p>
      </abstract>
      <kwd-group>
        <kwd>Sleeping activity ronmental monitoring</kwd>
      </kwd-group>
    </article-meta>
  </front>
  <body>
    <sec id="sec-1">
      <title>-</title>
      <p>Life-style</p>
      <p>Activity monitoring</p>
      <p>EnviTo live longer, healthier and more active, people at any age must follow
simple and clear suggestions that cover the 3 main pillars of health: nutrition,
physical-, and sleeping-activity. Unfortunately, due to the intrinsic (e.g.,
dailylife habits) and extrinsic (e.g., environmental change) factors, people are far to
have a healthy life and, thus, there is an increase of chronic diseases, mental
disorders, and premature death. While a lot of e ort has been done to support
good habits on nutrition providing personalized diet and continuous follow-up
and to encourage and monitor physical activity, sleeping activity is still an
untaught and unconsidered problem. In this paper, we propose a solution aimed at
improving sleeping habits through an intelligent system that monitors the
sleeping activity together with environmental data and lifestyle habits and provides
personalized recommendations and nudges. In particular, the proposed system
focuses on the following research questions:</p>
    </sec>
    <sec id="sec-2">
      <title>Q1 How we may improve sleeping habits of citizens? Q2 How the environment in uences and impacts the sleeping activity of citizens? Q3 How bad lifestyle habits in uence and impact the sleeping activity of citizens?</title>
      <p>The work presented in this paper is part of the CarpeDiem project
(Collaborative and Adaptive Recommender for PErsonalized DIEt Management), aimed
at providing intelligent and automatic support to people who want to follow a
diet to lose weight, or to maintain a healthy lifestyle (in a comprehensive way,
taking into account nutrition, physical activity, and sleep). CarpeDiem target
users are elderly people who need to follow healthy habits, including sleeping
better.</p>
      <p>To study the feasibility of the solution and to start creating the
machinelearning models that will allow to send personalized recommendations to the nal
users, on May we started collecting data from volunteers in Barcelona and Lleida
(Spain). Accordingly, in this paper we present the overall idea of the solution,
currently under development, and the preliminary experiments performed to
study its feasibility.</p>
      <p>The rest of the paper is organized as follow. Section 2 illustrates the
underlying problem and its relevance for the population. In Section 3, we describe the
overall solution for monitoring sleeping activity, environmental data, and lifestyle
habits. Section 4 presents the preliminary experiments we made in Barcelona and
Lleida with volunteers. Finally, Section 5 ends the paper with conclusions and
future directions.
2</p>
      <sec id="sec-2-1">
        <title>The Problem</title>
        <p>
          The Center for Disease Control and Prevention (CDC) in the United States,
within the Healthy People 2020 policy, has considered that sleeping little is a
public health problem. In fact, according to a recent CDC study, more than a
third of adult Americans do not get enough sleep on a regular basis [
          <xref ref-type="bibr" rid="ref7">7</xref>
          ].
Insufcient sleep is not exclusively a problem of the United States, it also a ects
other industrialized countries such as the United Kingdom, Japan, Germany, or
Canada [
          <xref ref-type="bibr" rid="ref1">1</xref>
          ]. Regarding Catalonia, the average number of hours of the overall
population is 7.1 hours at night, very close to the lower limit recommended by
clinicians (i.e., 7 hours at night). At Catalan level, a survey made in 2015 [
          <xref ref-type="bibr" rid="ref3">3</xref>
          ]
performed using the SATED questionnaire [
          <xref ref-type="bibr" rid="ref2">2</xref>
          ] con rms that sleeping duration is
age dependent. Moreover, they found that the SATED score is lower for elderly
people than citizens of other age groups, meaning that their sleep is worse.
        </p>
        <p>
          According to recent studies, the proportion of people who sleep less than
the recommended hours (i.e., between 7 and 9) continuously increases and it is
associated to lifestyle factors related to a modern society, such as psycho-social
stress, unbalanced diet, lack of physical activity, and excessive use of electronic
media, among others [
          <xref ref-type="bibr" rid="ref8">8</xref>
          ]. This is alarming since it has been found that lack of
sleep is associated with negative social and health outcomes.
        </p>
        <p>
          The association of lack of sleep with a series of negative social and health
outcomes is becoming worrisome. Insu cient sleep duration has been linked to
seven of the fteen leading causes of death in the United States. The existing
evidence suggests that the relationship between sleep time and health, outside
of the normal window (7-9 hours), both below and above, is associated with a
high risk of stroke, coronary heart disease, hypertension, obesity, type 2 diabetes
and mortality [
          <xref ref-type="bibr" rid="ref11">11</xref>
          ] [
          <xref ref-type="bibr" rid="ref12">12</xref>
          ]. For instance, Gallicchio and Kalesan [
          <xref ref-type="bibr" rid="ref5">5</xref>
          ] report that the
combined relative risk (RR) for all-cause mortality for sleep insu ciency is 1.10
(95% CI = [1.06, 1.15]).
        </p>
        <p>The link between sleep duration and mortality represents that a citizen who
sleeps on average less than 6 hours per night has a mortality risk 13% higher
than an individual who sleeps between 7 and 9 hours, which is the window that
is considered as the healthy amount of sleep. Furthermore, a person who sleeps
between 6 and 7 hours per night has a 7% increased risk of death, including
all causes of death such as fatal car accidents, strokes, cancer, or cardiovascular
disease.</p>
        <p>
          Finally, sleeping insu cient time reduces productivity in the workplace:
workers who sleep less than 6 hours per day have an average productivity loss of more
than 2.4 percentage points due to absenteeism, calculated on those workers who
sleep between 7 and 9 per day. Those who sleep on average between 6 and 7
hours continue to generate a loss of productivity greater than 1.5 percentage
points compared to those of seven to nine hours. To put these numbers in
perspective, assuming that there are 250 business days in a given year, this means
that a worker who sleeps less than 6 hours loses about 6 business days per year
more than a worker who sleeps 7 to 9 hours. A person sleeping for 6 to 7 hours
loses an average of 3.7 more business days per year [
          <xref ref-type="bibr" rid="ref9">9</xref>
          ].
3
        </p>
      </sec>
      <sec id="sec-2-2">
        <title>The Proposed Solution</title>
        <p>The aim of this work is improving sleeping habits in the population. Thus,
we propose an automatic and intelligent system that empowers and supports
the citizens giving them personalized recommendations and nudges. In order to
ensure a clinical relevance, the actual set of recommendations and nudges will
be de ned by the clinical personnel. Personalization will be then reached by
monitoring the citizens and studying their usual behavior.</p>
        <p>Three main categories of factors that impact sleeping habits will be
considered:</p>
      </sec>
    </sec>
    <sec id="sec-3">
      <title>1. number of hours;</title>
      <p>2. sleep e ciency, calculated as the ratio between the number of slept hours
and the total number of hours in bed per night;
3. the satisfaction of the citizen about her/his sleep calculated through the
standard questionnaire SATED.</p>
      <p>The proposed solution, sketched in Figure 1, works with a set of data coming
from di erent sources:
{ The citizen wears a wristband 24/7 and the sleep activity is monitored in
terms of: total number of sleeping hours, number of sleeping hours during
the night, number of the sleeping hours during the day, number of naps,
time when going to sleep, wake-up time, and sleep e ciency. Moreover, the
data regarding the physical activity in terms of total number of steps and
vigorous activity before going to sleep are constantly monitored.
{ The citizen is asked to monitor her/his weight once a week in order to take
under control her/his Body Mass Index (BMI) and to avoid reaching obesity.
{ To build the user's pro les, the day of the inclusion, the citizen is asked
to answer to some questionnaires regarding her/his life-style habits. The
following questionnaires will be used: SATED, about the satisfaction of the
citizen regarding her/his sleep; Ca eine, regarding the number of cups of
co ee or teas drunk on average during the week; Smoke, on the number
of cigarettes smoked on average during the week; and Use of technology,
concerning the number of minutes spent on average using the smartphone
or a tablet before going to sleep.
{ The smartphone of the citizen is used to detect the luminosity of the bedroom
during the sleeping time.
{ The citizen will be asked regarding the comfort of the bed, since especially
vulnerable or at risk citizens often sleep on truly old or uncomfortable beds.
{ To be aware regarding seasonality, daylight hours, and further environmental
data, we will rely to the Dark Sky API4. It allows to look up the weather
anywhere on the globe, returning (where available): weather conditions,
minuteby-minute forecasts out to one hour, hour-by-hour and day-by-day forecasts
out to seven days, hour-by-hour and day-by-day observations going back
decades, weather alerts, and humidity.
{ To monitor the data about the air quality and noise pollution in Barcelona,
the Open Data service by the Barcelona Municipality (Open Data BCN)
will be used5.</p>
      <p>The system will collect and fuse the heterogeneous data coming from all the
data sources and, through machine learning techniques, will build the models to
cluster and classify citizens according to their habits.</p>
      <p>
        First, the pro le of the citizen is calculated adopting data mining and
machine learning approaches relying on Knowledge Data Discovery (KDD) models
[
        <xref ref-type="bibr" rid="ref4">4</xref>
        ] as well as User Data Discovery (UDD) models [
        <xref ref-type="bibr" rid="ref6">6</xref>
        ]. A static pro le will be
created considering gender and age together with data coming from the
questionnaires. That pro le will be dynamically and continuously updated by
considering the data gathered from the wristband, the changes in the BMI, if any,
and the environmental data.
      </p>
      <p>Once built the pro le, the citizen will be automatically clustered according
to xed groups of habits de ned considering the intersections among the three
categories: number of sleeping hours (less than 7 hours, between 7 and 9 hours,
more than 9 hours), sleep e ciency (less than 50%, between 50% and 95%, more
than 95%), and satisfaction about the sleep (by using the 5 levels of the SATED
questionnaire: 1 = Never, 2 = Rarely, 3 = Sometimes, 4 = Usually, 5 = Always).
For each cluster, the clinicians will de ne a suitable set of recommendations and
nudges with the nal goal of moving all the citizens in the healthiest cluster,
corresponding to a number of hours between 7 and 9, a sleep e ciency higher
than 95%, and a satisfaction of 5 (i.e., always satis ed). In the case a citizen
does not belong to that cluster because s/he is not compliant with one or more
4 https://darksky.net/dev
5 https://opendata-ajuntament.barcelona.cat/en/
of the categories, the system asks to choose the category s/he wants to improve
(monthly goal).</p>
      <p>
        Recommendations and nudges will be sent to the citizen on daily
(shortterm), weekly (medium-term), and monthly (long-term) basis.
Recommendations and nudges on daily basis will be based on the number of slept hours, the
e ciency, the performed physical activity, and will take into account anomalies
in environmental factors speci c of the considered day (e.g., high temperatures).
Taking particular reference to the category the citizen wants to improve, on
weekly basis the system will send speci c questions or request of lling a
questionnaire in case of anomalies (e.g., in case of a decrease of the number of hours,
the Ca eine questionnaire may be sent to be lled). Finally, monthly based ones
will take into account the changes in habits during the month, the change from
a cluster to another, if any, and will consider similarities among citizens in order
to send recommendations and nudges according to a collaborative ltering
approach [
        <xref ref-type="bibr" rid="ref10">10</xref>
        ]. At monthly basis the citizen will be also asked to con rm or change
the category s/he want to improve, depending on the results of the past month.
      </p>
      <p>From a technological point of view, the citizen will interact with the system
through a simple and user-friendly app installed in her/his smartphone and
that will automatically send recommendations and nudges as push noti cations.
Through the app, the citizen will be also able to set-up her/his pro le, answer
questionnaires, pair her/his smartphone and smart-scale (if any), or to manually
input the weight (e.g., after weighting at the pharmacy). The app will also allow
to capture the luminosity of the bedroom during the sleeping hours.
4</p>
      <sec id="sec-3-1">
        <title>Preliminary Experiments</title>
        <p>The success of the proposed solution strictly depends on the gathered data.
In fact, pro ling, recommendations and nudges de nition, clustering, and
personalization cannot be achieved without a preliminary phase in which data are
collected and used to build all the models. Thus, we started on May recruiting
volunteers in Barcelona (from Eurecat) and in Lleida (from IRBLleida) to pro le
the users and to study the feasibility of the proposed solution.
4.1</p>
        <sec id="sec-3-1-1">
          <title>The Collected Dataset</title>
          <p>A total of 30 volunteers has been recruited in Barcelona and Lleida. Volunteers
were asked to wear their activity tracker 24/7, to weight once a week, and to
answer the selected questionnaires at the end of the week. The day of the
inclusion, we also took note of the comfort of the bed of each volunteer, as well as
her/his address to take into consideration the environmental factors.</p>
          <p>Due to technical problems and adherence issues, 6 of the 30 volunteers
dropped-out before nishing the rst month of the study. Thus, the analysis
of the data have been done using the data of 24 volunteers (38:43 11:46 years
old; 15 females; and 23:09 3:66 BMI). The preliminary study started on May
and will nish in December.</p>
          <p>At inclusion time, we rst analysed the distribution of our population among
the three categories:</p>
          <p>Figure 2 shows the percentage of volunteers in each group for the three
categories. As shown, all the volunteers slept less than 7 hours, which, as stated
above, is risky for their health. Regarding the e ciency, the 70% of the volunteers
are in the healthiest group, whereas the 30% are in the group between 50% and
95%. As for the satisfaction, the majority of the volunteers answered sometimes
or normally with about 40% of the answers in each. The rest of the volunteers are
in the Always group (about 8%) and in the Rarely one (only a 4%). It is worth
noting that nobody belongs to the Never group. This rst analysis performed
at inclusion time shows the need of the proposed solution to improve sleeping
habits with the nal goal to move the volunteers to the healthiest group of each
category, specially in case of Sleeping Hours and Satisfaction.</p>
          <p>As a second step, for each category, we computed the percentage of weeks
that each volunteer belonged to the healthiest group. To better visualise the
distribution, for each category we considered four sets (see Figure 3): less than
25% of the weeks, between 25% and 50% of the weeks, between 50% and 75% of the
weeks, and more than 75% of the weeks. As shown, the majority of the volunteers
are in the set less than 25% of the weeks for all the categories: about 58% for
Sleeping Hours, 41% for E ciency, and 91% for Satisfactions. Results clearly
show that there is a urgent need for a solution to improve sleeping activity of
citizens considering all the three categories. In fact, at least in our population,
the percentage of people that sleeps the right number of hours, with a high
e ciency, and is satis ed of their sleep is very low (about 16%, 20%, and 4% for
Sleeping Hours, E ciency, and Satisfactions, respectively).</p>
          <p>Finally, we analysed the dynamics of the changes among groups in a monthly
basis. To visualize it a Sankey Diagram is used: the left column display the groups
from which the volunteer moved and the right column the groups to which the
volunteer moved. The links between them are represented with arcs that have a
width proportional to the number of times this transition occurred.</p>
          <p>Figure 4 shows the dynamics of the Sleeping Hours category. As shown, all
the volunteers are in the groups less than 7h and between 7h and 9h, being the
majority of them in the rst group (about 72%). The volunteers tend to stay in
the same group. Only a small percentage changed from less than 7h to between
7h and 9h (about 11%), and vice versa (about 27%). In this case, the proposed
solution will give support to move all the volunteers from the less than 7h to the
between 7h and 9h group. It is worth noting that, once a volunteer reaches the
healthiest group, the system will give support to do not change the group.</p>
          <p>Figure 5 shows the dynamics of the E ciency category. As shown, all the
volunteers are in the groups between 50% and 95% and more than 95%, and
they are balanced (about 51% and 49%, respectively). In this case, the tendency
is either stay in the same group (about 60%) or change to the other one (about
40%). Seemly to the Sleeping hours category, our system will work to change
this dynamic and move all the volunteers from between 50% and 95% group to
the more than 95% one. Once a volunteer reaches the healthiest group, s/he will
be supported by the system to stay in it.</p>
          <p>Figure 6 shows the dynamics of the Satisfaction category. As shown, the
majority of the volunteers are in the groups Sometimes and Normally (about
the same number in each, i.e. 43% and 49%, respectively), and a small percentage
in the group Rarely (about 8%). The volunteers from the Rarely group used to
stay in the same group (about 67%) or to move to the Normally one (about
33%). On the contrary, volunteers belonging to Sometimes and Normally groups
move to their consecutive groups: Rarely, Sometimes, and Normally (about 12%,
47% and 41%, respectively) and Sometimes, Normally and Always (about 26%,
68% and 5%, respectively), respectively. Let us note that, only volunteers from
the Normally group moves to the Always one (about 5%)6.
4.2</p>
        </sec>
        <sec id="sec-3-1-2">
          <title>Daily Monitoring</title>
          <p>Recommendations and nudges on daily basis will be based on the number of
slept hours, the e ciency, the performed physical activity, and will take into
account anomalies in environmental factors speci c of the considered day (e.g.,
high temperatures).</p>
          <p>The aim of our system is to encourage the user to Keep going if s/he is
improving with respect to \yesterday" or suggests to Keep following the
recommendation to improve in case of worsening. Recommendations could be provided
with respect to the sleeping habits (e.g., You should go to sleep every night at the
same hour and before 12 am) and/or the performed physical activity (e.g., Do
not perform high-intensity exercises 2 hours before going to sleep). Regarding the
environmental factors, the system informs: when the city is su ering from high
temperature and suggests to the user to keep the bedroom temperature to the
recommended one (between 16-18 C); when the air quality is low and suggests
the user to not perform vigorous activity outdoors; and when the noise level of
her/his street is too high and suggests to keep closed the windows during night.
6 The group Always appears only in the right column because the month which a
volunteer was in the group Always was the last one of the study</p>
          <p>Figure 7 shows an example of collected data of a volunteer (52 years old; male
and who lives in Barcelona) and potential messages that the proposed system
should send to the nal user. Let us note that during the selected days (the week
from June 24th to June, 30th) a high temperature was measured in Barcelona.
4.3</p>
        </sec>
        <sec id="sec-3-1-3">
          <title>Weekly Check-Up</title>
          <p>In order to support the user in changing her/his sleeping habits, the proposed
system will compute a summary, weekly. Based on it, nudges and
recommendations will be provided. In case a change greater than 2 hours, 5% in e ciency,
and/or 3 points in satisfaction is detected, the system will send a requests to ll
the questionnaires in order to recalculate the pro le and nd potential anomalies
that could have a ected the sleeping activity. Figure 8 shows an example of 3
consecutive weeks of a volunteer (26 years old; female): her evolution in terms
of the three categories and the suggested messages to give her support.
4.4</p>
        </sec>
        <sec id="sec-3-1-4">
          <title>Monthly Clustering</title>
          <p>At the beginning of a new month, the system analyses all the collected data to
cluster the users considering the three selected categories. In so doing, the system
veri es if the user changed the cluster s/he belongs to, or not. In case of a positive
change, the system sends an awards to the user and suggests the new goal to be
followed during then next month. In case of a negative change or not changing,
the system recommends to still work on the same goal during the next month.
In both cases, the users can accept or reject the received suggestion and choose
the goal to be achieved. Figure 9 shows an example of 2 consecutive months for
a volunteer (26 years old; female) in which e ciency has been improved while
the satisfaction still needs to be enhanced.
5</p>
        </sec>
      </sec>
      <sec id="sec-3-2">
        <title>Conclusions and Future Work</title>
        <p>In this paper, we presented a novel solution aimed at improving sleeping
activities. Although the research and development is at its early stage, the feasibility
study performed right now shows how the research questions listed in the
Introduction will be addressed.</p>
        <sec id="sec-3-2-1">
          <title>Q1. How we may improve sleeping habits of citizens? The proposed</title>
          <p>solution is a recommender system that will be built according to clinical
evidence and with the supervision of the clinical team of the Sleep Unit at the IRB
in Lleida. The overall set of recommendations and nudges will be de ned by
clinicians of that Unit and will be fully personalized according to the typology
of the nal user. The system will automatically send the recommendations and
nudges to the citizens on daily base (short-term recommendations), on weekly
base (medium-term recommendations), and on monthly base (long-term
recommendations).</p>
        </sec>
        <sec id="sec-3-2-2">
          <title>Q2: How the environment in uences and impacts the sleeping ac</title>
          <p>tivity of citizens? It has been shown in the literature that the main
environmental factors that in uence and impact the sleeping activity are: daylight
hours, seasonality, luminosity, humidity, pollution, noise, and comfort of the bed.
The proposed solution will consider all these factors, their in uence on sleeping,
and will de ne recommendations taking into account the peculiarities of each
citizen according to the environment in which s/he lives.</p>
          <p>Q3: How bad lifestyle habits in uence and impact the sleeping
activity of citizens? Having bad lifestyle habits has an impact on the overall
sleeping activity. In particular, clinicians recommend to not perform the
following tasks just before going to bed: take a co ee, smoke, eat, perform vigorous
physical activity, and use the smartphone or a tablet. In addition, citizens have
to control their weight, in order to avoid obesity which could cause sleeping
problems. The nal system will send recommendations and nudges on this kind
of tasks to improve citizens behavior and will sporadically monitor co ee
intake, smoking, eating, and smartphone usage, in case of detected anomalies with
respect to the usual sleeping behavior. Moreover, physical activity will be
continuously monitored and suitable suggestions given accordingly.</p>
          <p>As for the future work, as soon as 6 months of data will be collected from all
the volunteers, we will build the models for sending daily, weekly, and monthly
recommendations and nudges. Clinicians in IRBLleida are currently working
on the de nition of them. At the beginning of next year, the system will be
integrated in the CarpeDiem app and the pilot will start with new volunteers
from both Barcelona and Lleida, as well as further towns in the Catalonia Region.
6</p>
        </sec>
      </sec>
      <sec id="sec-3-3">
        <title>Acknowledgments</title>
        <p>This work was nancially supported by the Catalan Government through the
funding grant ACCI-Eurecat (CarpeDiem project).</p>
      </sec>
    </sec>
  </body>
  <back>
    <ref-list>
      <ref id="ref1">
        <mixed-citation>
          1.
          <string-name>
            <surname>Buman</surname>
            ,
            <given-names>M.P.</given-names>
          </string-name>
          ,
          <string-name>
            <surname>Phillips</surname>
            ,
            <given-names>B.A.</given-names>
          </string-name>
          ,
          <string-name>
            <surname>Youngstedt</surname>
            ,
            <given-names>S.D.</given-names>
          </string-name>
          ,
          <string-name>
            <surname>Kline</surname>
            ,
            <given-names>C.E.</given-names>
          </string-name>
          ,
          <string-name>
            <surname>Hirshkowitz</surname>
            ,
            <given-names>M.</given-names>
          </string-name>
          :
          <article-title>Does nighttime exercise really disturb sleep? results from the 2013 national sleep foundation sleep in america poll</article-title>
          .
          <source>Sleep Medicine</source>
          <volume>15</volume>
          (
          <issue>7</issue>
          ),
          <volume>755</volume>
          {
          <fpage>761</fpage>
          (
          <year>2014</year>
          )
        </mixed-citation>
      </ref>
      <ref id="ref2">
        <mixed-citation>
          2.
          <string-name>
            <surname>Buysse</surname>
            ,
            <given-names>D.J.</given-names>
          </string-name>
          : Sleep health: can we de ne it? does it matter?
          <source>Sleep</source>
          <volume>37</volume>
          (
          <issue>1</issue>
          ),
          <volume>9</volume>
          {
          <fpage>17</fpage>
          (
          <year>2014</year>
          )
        </mixed-citation>
      </ref>
      <ref id="ref3">
        <mixed-citation>
          3.
          <string-name>
            <surname>Dalmases</surname>
            ,
            <given-names>M.</given-names>
          </string-name>
          ,
          <string-name>
            <surname>Ben</surname>
            <given-names>tez</given-names>
          </string-name>
          , I.D.,
          <string-name>
            <surname>Mas</surname>
            ,
            <given-names>A.</given-names>
          </string-name>
          ,
          <string-name>
            <surname>Garcia-Codina</surname>
            ,
            <given-names>O.</given-names>
          </string-name>
          ,
          <string-name>
            <surname>Medina-Bustos</surname>
            ,
            <given-names>A.</given-names>
          </string-name>
          ,
          <string-name>
            <surname>Escarrabill</surname>
            ,
            <given-names>J.</given-names>
          </string-name>
          ,
          <string-name>
            <surname>Salto</surname>
            ,
            <given-names>E.</given-names>
          </string-name>
          ,
          <string-name>
            <surname>Buysse</surname>
            ,
            <given-names>D.J.</given-names>
          </string-name>
          ,
          <string-name>
            <surname>Roure</surname>
            ,
            <given-names>N.</given-names>
          </string-name>
          ,
          <string-name>
            <surname>Sanchez-</surname>
          </string-name>
          de-la
          <string-name>
            <surname>Torre</surname>
            ,
            <given-names>M.</given-names>
          </string-name>
          , et al.:
          <article-title>Assessing sleep health in a european population: Results of the catalan health survey 2015</article-title>
          .
          <article-title>PloS one 13(4</article-title>
          ),
          <year>e0194495</year>
          (
          <year>2018</year>
          )
        </mixed-citation>
      </ref>
      <ref id="ref4">
        <mixed-citation>
          4.
          <string-name>
            <surname>Fawcett</surname>
            ,
            <given-names>T.</given-names>
          </string-name>
          ,
          <string-name>
            <surname>Provost</surname>
            ,
            <given-names>F.J.:</given-names>
          </string-name>
          <article-title>Combining data mining and machine learning for e ective user pro ling</article-title>
          .
          <source>In: KDD</source>
          . pp.
          <volume>8</volume>
          {
          <issue>13</issue>
          (
          <year>1996</year>
          )
        </mixed-citation>
      </ref>
      <ref id="ref5">
        <mixed-citation>
          5.
          <string-name>
            <surname>Gallicchio</surname>
            ,
            <given-names>L.</given-names>
          </string-name>
          ,
          <string-name>
            <surname>Kalesan</surname>
            ,
            <given-names>B.</given-names>
          </string-name>
          :
          <article-title>Sleep duration and mortality: a systematic review and meta-analysis</article-title>
          .
          <source>Journal of sleep research 18(2)</source>
          ,
          <volume>148</volume>
          {
          <fpage>158</fpage>
          (
          <year>2009</year>
          )
        </mixed-citation>
      </ref>
      <ref id="ref6">
        <mixed-citation>
          6.
          <string-name>
            <surname>Kanoje</surname>
            ,
            <given-names>S.</given-names>
          </string-name>
          ,
          <string-name>
            <surname>Girase</surname>
            ,
            <given-names>S.</given-names>
          </string-name>
          ,
          <string-name>
            <surname>Mukhopadhyay</surname>
            ,
            <given-names>D.:</given-names>
          </string-name>
          <article-title>User pro ling trends, techniques and applications</article-title>
          .
          <source>arXiv preprint arXiv:1503.07474</source>
          (
          <year>2015</year>
          )
        </mixed-citation>
      </ref>
      <ref id="ref7">
        <mixed-citation>
          7.
          <string-name>
            <surname>Liu</surname>
            ,
            <given-names>S.</given-names>
          </string-name>
          ,
          <string-name>
            <surname>Lamaze</surname>
            ,
            <given-names>A.</given-names>
          </string-name>
          ,
          <string-name>
            <surname>Liu</surname>
            ,
            <given-names>Q.</given-names>
          </string-name>
          ,
          <string-name>
            <surname>Tabuchi</surname>
            ,
            <given-names>M.</given-names>
          </string-name>
          ,
          <string-name>
            <surname>Yang</surname>
            ,
            <given-names>Y.</given-names>
          </string-name>
          ,
          <string-name>
            <surname>Fowler</surname>
            ,
            <given-names>M.</given-names>
          </string-name>
          ,
          <string-name>
            <surname>Bharadwaj</surname>
            ,
            <given-names>R.</given-names>
          </string-name>
          , Zhang, J.,
          <string-name>
            <surname>Bedont</surname>
            ,
            <given-names>J.</given-names>
          </string-name>
          ,
          <string-name>
            <surname>Blackshaw</surname>
            ,
            <given-names>S.</given-names>
          </string-name>
          , et al.:
          <article-title>Wide awake mediates the circadian timing of sleep onset</article-title>
          .
          <source>Neuron</source>
          <volume>82</volume>
          (
          <issue>1</issue>
          ),
          <volume>151</volume>
          {
          <fpage>166</fpage>
          (
          <year>2014</year>
          )
        </mixed-citation>
      </ref>
      <ref id="ref8">
        <mixed-citation>
          8.
          <string-name>
            <surname>Roenneberg</surname>
            ,
            <given-names>T.</given-names>
          </string-name>
          :
          <article-title>Chronobiology: the human sleep project</article-title>
          .
          <source>Nature</source>
          <volume>498</volume>
          (
          <issue>7455</issue>
          ),
          <volume>427</volume>
          (
          <year>2013</year>
          )
        </mixed-citation>
      </ref>
      <ref id="ref9">
        <mixed-citation>
          9.
          <string-name>
            <surname>Rosekind</surname>
            ,
            <given-names>M.R.</given-names>
          </string-name>
          ,
          <string-name>
            <surname>Gregory</surname>
            ,
            <given-names>K.B.</given-names>
          </string-name>
          ,
          <string-name>
            <surname>Mallis</surname>
            ,
            <given-names>M.M.</given-names>
          </string-name>
          ,
          <string-name>
            <surname>Brandt</surname>
            ,
            <given-names>S.L.</given-names>
          </string-name>
          ,
          <string-name>
            <surname>Seal</surname>
            ,
            <given-names>B.</given-names>
          </string-name>
          ,
          <string-name>
            <surname>Lerner</surname>
            ,
            <given-names>D.</given-names>
          </string-name>
          :
          <article-title>The cost of poor sleep: workplace productivity loss and associated costs</article-title>
          .
          <source>Journal of Occupational and Environmental Medicine</source>
          <volume>52</volume>
          (
          <issue>1</issue>
          ),
          <volume>91</volume>
          {
          <fpage>98</fpage>
          (
          <year>2010</year>
          )
        </mixed-citation>
      </ref>
      <ref id="ref10">
        <mixed-citation>
          10.
          <string-name>
            <surname>Schafer</surname>
            ,
            <given-names>J.B.</given-names>
          </string-name>
          ,
          <string-name>
            <surname>Frankowski</surname>
            ,
            <given-names>D.</given-names>
          </string-name>
          ,
          <string-name>
            <surname>Herlocker</surname>
            ,
            <given-names>J.</given-names>
          </string-name>
          ,
          <string-name>
            <surname>Sen</surname>
            ,
            <given-names>S.:</given-names>
          </string-name>
          <article-title>Collaborative ltering recommender systems</article-title>
          .
          <source>In: The adaptive web</source>
          , pp.
          <volume>291</volume>
          {
          <fpage>324</fpage>
          . Springer (
          <year>2007</year>
          )
        </mixed-citation>
      </ref>
      <ref id="ref11">
        <mixed-citation>
          11.
          <string-name>
            <surname>Sperry</surname>
            ,
            <given-names>S.D.</given-names>
          </string-name>
          ,
          <string-name>
            <surname>Scully</surname>
            ,
            <given-names>I.D.</given-names>
          </string-name>
          ,
          <string-name>
            <surname>Gramzow</surname>
            ,
            <given-names>R.H.</given-names>
          </string-name>
          ,
          <string-name>
            <surname>Jorgensen</surname>
            ,
            <given-names>R.S.:</given-names>
          </string-name>
          <article-title>Sleep duration and waist circumference in adults: a meta-analysis</article-title>
          .
          <source>Sleep</source>
          <volume>38</volume>
          (
          <issue>8</issue>
          ),
          <volume>1269</volume>
          {
          <fpage>1276</fpage>
          (
          <year>2015</year>
          )
        </mixed-citation>
      </ref>
      <ref id="ref12">
        <mixed-citation>
          12.
          <string-name>
            <surname>Wang</surname>
            ,
            <given-names>Q.</given-names>
          </string-name>
          ,
          <string-name>
            <surname>Xi</surname>
            ,
            <given-names>B.</given-names>
          </string-name>
          ,
          <string-name>
            <surname>Liu</surname>
            ,
            <given-names>M.</given-names>
          </string-name>
          ,
          <string-name>
            <surname>Zhang</surname>
            ,
            <given-names>Y.</given-names>
          </string-name>
          ,
          <string-name>
            <surname>Fu</surname>
            ,
            <given-names>M.</given-names>
          </string-name>
          :
          <article-title>Short sleep duration is associated with hypertension risk among adults: a systematic review and meta-analysis</article-title>
          .
          <source>Hypertension Research</source>
          <volume>35</volume>
          (
          <issue>10</issue>
          ),
          <volume>1012</volume>
          (
          <year>2012</year>
          )
        </mixed-citation>
      </ref>
    </ref-list>
  </back>
</article>