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  <front>
    <journal-meta />
    <article-meta>
      <title-group>
        <article-title>Towards a multilingual corpus for Named Entity Linking evaluation in the clinical domain ?</article-title>
      </title-group>
      <contrib-group>
        <aff id="aff0">
          <label>0</label>
          <institution>LASIGE, Faculdade de Ciˆencias, Universidade de Lisboa</institution>
          ,
          <addr-line>Lisbon 1749-016</addr-line>
          ,
          <country>Portugal ps</country>
        </aff>
      </contrib-group>
      <pub-date>
        <year>2020</year>
      </pub-date>
      <abstract>
        <p>We propose a new multilingual, parallel corpus for Named Entity Linking benchmarking which comprises English, Portuguese and Spanish clinical case reports1. The medical diagnostic entities in the reports were annotated with the respective code of the International Classification of Diseases 10 - Clinical Modification (ICD10-CM) terminology and its Portuguese and Spanish versions. The result is a preliminary annotation set, which will be further validated and expanded by humans. Additionally, the ICD10-CM codes in the annotations will be mapped to the respective Medical Subject Headings (MeSH) identifiers when possible.</p>
      </abstract>
      <kwd-group>
        <kwd>Text Mining</kwd>
        <kwd>Multilingual clinical case reports</kwd>
        <kwd>Named Entity Linking</kwd>
        <kwd>Information retrieval</kwd>
        <kwd>Named Entity Recognition</kwd>
      </kwd-group>
    </article-meta>
  </front>
  <body>
    <sec id="sec-1">
      <title>Introduction</title>
    </sec>
    <sec id="sec-2">
      <title>Building the corpus</title>
      <p>2.1
SciELO2 is a digital library for scientific articles, its majority written in Spanish,
Portuguese and English. One of the main advantages is that many articles have
versions in different languages. We extracted the abstract of clinical case reports
(search filters: *AND subject area:(”Health Sciences”) AND type:(”case-report”)
AND la:(”es” OR ”pt” OR ”en”)), and only considered those with the three
versions simultaneously available (English, Portuguese and Spanish). We obtained
1917 abstracts in the three languages, corresponding to 639 clinical case reports,
which we considered enough to test the annotation approach described below.
2.2</p>
      <p>
        Annotation of medical diagnostic entities using NER and NEL
We used the python interface of MER [
        <xref ref-type="bibr" rid="ref1">1</xref>
        ], which recognises entity mentions in the
text according to a given lexicon, i.e., a list of terms that represent the concepts
of a vocabulary or a KB. In this work, we used as target KB the International
Classification of Diseases 10th Revision - Clinical Modification (ICD10-CM),
since it is available in several languages. This vocabulary contains codes
relative to medical diagnostics and an hierarchy defining subsumption relations
between them. For each language, we used the most recent available edition:
the 2020 edition for the English ICD10-CM provided by the Center for Disease
Control and Prevention (CDC)3; the 2020 edition for the Spanish Classificaci´on
Internacional de Enfermedades - 10a Revisi´on - Modificaci´on Cl´ınica
(CIE10CM), provided by the Spanish Ministry of Health4; the 2017 edition for the
Portuguese Classifica¸c˜ao Internacional de Doen¸cas - 10a Revis˜ao - Modificac¸˜ao
Cl´ınica (CID10-CM), provided by the Portuguese Ministry of Health5. MER
recognised the entity mentions related with medical diagnostics in the
clinical case reports, and then linked each mention to the respective code in the
ICD10-CM (or the respective language version). The resulting annotations were
converted to the brat Standoff format.
3
      </p>
    </sec>
    <sec id="sec-3">
      <title>Discussion</title>
      <p>The overall statistics pertaining the annotation process are available in Table 1.
MER was able to recognise entity mentions in the text expressed in the three
languages, but its NER performance was slightly higher in English text than in
other languages as expected. Surprisingly, the NEL performance was higher in
Portuguese text. As example, a sentence from a retrieved abstract is expressed in
the three languages: (1 - English) “Among the identified nursing diagnosis was
2 https://scielo.org/
3 www.cdc.gov/nchs/icd/icd10cm.htm
4 www.mscbs.gob.es/estadEstudios/estadisticas/normalizacion/home.htm
5 www.ctc.min-saude.pt/category/catalogos/</p>
      <p>Multilingual corpus for clinical Named Entity Linking evaluation
included: acute confusion, constipation and knowledge deficit.”; (2 - Portuguese)
“Entre os diagn´osticos de enfermagem identificados inclu´ıram-se confusa˜o aguda,
constipa¸c˜ao e conhecimento deficiente.”; (3 - Spanish) “Los resultados del
estudio permitieron identificar los seguientes diagn´osticos de enfermer´ıa: confusi´on
aguda, constipaci´on e conocimiento deficiente.”. MER was able to identify the
italicised entity “constipation” in the English sentence (1) because there is a
ICD10-CM term with the same designation: “Constipation” (code K59.0).
However, the Portuguese and Spanish equivalents “constipa¸c˜ao” (sentence 2) and
“constipaci´on” (sentence 3) were not recognised nor linked because the
respective terms in the ICD10-CM have a different designation: “Obstipa¸c˜ao” and
“Estren˜imiento” (code K59.0).</p>
      <p>English Portuguese Spanish</p>
      <p>Abstracts retrieved 639 639 639
Abstracts with annotations 217 197 199
Ratio of annotated abstracts 0.340 0.308 0.314</p>
      <p>Entity mentions 533 432 465
Entity mentions per annotated abstract 2.456 2.193 2.340</p>
      <p>Linked entity mentions 463 432 389
Linked entity mentions per annotated abstract 2.134 2.193 1.955</p>
      <p>Ratio of linked entity mentions 0.867 1.000 0.837</p>
      <p>
        The resulting corpus is available at https://github.com/lasigeBioTM/
MultiNEL-corpus. The future work consists in the human validation of the
annotation set, as well as its expansion with new annotations. This validation will
be performed either by expert analysis or by crowd-sourcing, a less expensive
approach that has shown comparable results to the expert analysis [
        <xref ref-type="bibr" rid="ref2">2</xref>
        ].
Additionally, the ICD10-CM codes present in the annotations will be further mapped
to the respective Medical Subject Headings (MeSH) concepts using the
MeSDiCon subset for CodiEsp [
        <xref ref-type="bibr" rid="ref3">3</xref>
        ], which will improve the cross-linking evaluation
capability.
      </p>
    </sec>
  </body>
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</article>