This volume represents the proceedings of the selected papers of the 1th International Conference Intellectual System and Information Technologies (ISIT 2019), held in Odessa, Ukraine, on August 19-24, 2019. It comprises 17 papers dedicated to the information technologies, systems and artificial intelligence techniques, networks and their components, cybernetic and information security, automation of control system and processes, project management that were carefully peer-reviewed and selected from 71 submissions. Copyright © 2019 for the individual papers by the papers’ authors. Copying permitted for private and academic purposes. This volume is published and copyrighted by its editors.