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  <front>
    <journal-meta />
    <article-meta>
      <title-group>
        <article-title>Overview of the ImageCLEFmed 2020 Concept Prediction Task: Medical Image Understanding</article-title>
      </title-group>
      <contrib-group>
        <contrib contrib-type="author">
          <string-name>Christoph M. Fri</string-name>
          <email>christoph.friedrichg@fh-dortmund.de</email>
        </contrib>
        <aff id="aff0">
          <label>0</label>
          <institution>Department of Computer Science, University of Applied Sciences and Arts Dortmund</institution>
          ,
          <country country="DE">Germany</country>
        </aff>
        <aff id="aff1">
          <label>1</label>
          <institution>Department of Diagnostic and Interventional Radiology and Neuroradiology, University Hospital Essen</institution>
          ,
          <country country="DE">Germany</country>
        </aff>
        <aff id="aff2">
          <label>2</label>
          <institution>Institute for Medical Informatics, Biometry and Epidemiology (IMIBE), University Hospital Essen</institution>
          ,
          <country country="DE">Germany</country>
        </aff>
        <aff id="aff3">
          <label>3</label>
          <institution>University of Applied Sciences Western Switzerland (HES-SO)</institution>
          ,
          <country country="CH">Switzerland</country>
        </aff>
        <aff id="aff4">
          <label>4</label>
          <institution>University of Essex</institution>
          ,
          <country country="UK">UK</country>
        </aff>
        <aff id="aff5">
          <label>5</label>
          <institution>University of Geneva</institution>
          ,
          <country country="CH">Switzerland</country>
        </aff>
      </contrib-group>
      <abstract>
        <p>This paper describes the ImageCLEFmed 2020 Concept Detection Task. After rst being proposed at ImageCLEF 2017, the medical task is in its 4th edition this year, as the automatic detection from medical images still remains a challenging task. In 2020, the format remained the same as in 2019, with a single sub-task. The concept detection task is part of the medical tasks, alongside the tuberculosis and visual question and answering tasks. Similar to the 2019 edition, the data set focuses on radiology images rather than biomedical images, however with an increased number of images. The distributed images were extracted from the biomedical open access literature (PubMed Central). The development data consists of 65,753 training and 15,970 validation images. Each image has corresponding Uni ed Medical Language System (UMLS R ) concepts, that were extracted from the original article image captions. In this edition, additional imaging acquisition technique labels were included in the distributed data, which were adopted for pre- ltering steps, concept selection and ensemble algorithms. Most applied approaches for the automatic detection of concepts were deep learning based architectures. Long short-term memory (LSTM) recurrent neural networks (RNN), adversarial auto-encoder, convolutional neural networks (CNN) image encoders and transfer learning-based multi-label classi cation models were adopted. The performances of the submitted models (best score 0.3940) were evaluated using F1-scores computed per image and averaged across all 3,534 test images.</p>
      </abstract>
    </article-meta>
  </front>
  <body>
    <sec id="sec-1">
      <title>-</title>
      <p>1</p>
    </sec>
    <sec id="sec-2">
      <title>Introduction</title>
      <p>
        In this paper, the approaches for the detection of Uni ed Medical Language
System (UMLS R ) concepts present in radiology images are presented. The task is
part of the ImageCLEF1 bench-marking campaign, that is part of the Cross
Language Evaluation Forum2 (CLEF). Since 2003, the ImageCLEF bench-marking
campaign has been proposing several image understanding tasks from di erent
domains every year [
        <xref ref-type="bibr" rid="ref4">4, 15, 11</xref>
        ]. Detailed information on other proposed tasks at
the ImageCLEF 2020 can be found in Ionescu et al. [9].
      </p>
      <p>
        The concept detection task in this year is the fourth edition. At
ImageCLEFmed Caption 2017 [
        <xref ref-type="bibr" rid="ref3">3</xref>
        ] and ImageCLEFmed Caption 2018 [7], the task was
comprised of two (2) sub-tasks: concept detection and caption prediction. The
format changed in ImageCLEFmed Caption 2019 [16] with the single task of
concept detection and remained that way this year at ImageCLEFmed Caption
2020. New in this edition is that the imaging modality is given for each image
both in the development and evaluation sets.
      </p>
      <p>As there is an increasing number of medical images available without
metadata, for example in the scienti c literature, there is an essential need to create
systems that can automatically generate such information, hence making the
content of these data sets more useful. The purpose of the ImageCLEFmed
2020 concept detection task was to create a platform for the evaluation of
systems capable of automatically creating UMLS R concepts of a given radiology
image. These predicted information is applicable for data sets that either not
labeled or structured, but also for medical data sets lacking textual metadata, as
multi-modal approaches prove to obtain better results regarding several image
classi cation tasks [18, 19].</p>
      <p>The manual interpretation and generation of knowledge from medical images
is not only time-consuming and prone to error, but also impractical. Therefore,
the modeling systems that can automatically map visual content present in the
images to concise textual representations is a necessity, in regards to e cient
information retrieval and image classi cation.</p>
      <p>For development data, both the development and test sets from the
ImageCLEFmed Caption 2019 [16] was distributed. This data set is a subset of the
Radiology Object in COntext data set (ROCO) [17] and contains solely radiology
images that originate from the PubMed Central (PMC) Open Access Subset3
[20]. Several UMLS R Concept Unique Identi ers (CUIs) are included to each
image. The test set used for o cial evaluation was created in the same manner
as proposed in Pelka et al. [17], for generalization purposes.
1 http://imageclef.org/ [last accessed: 28.07.2020]
2 http://www.clef-initiative.eu/ [last accessed: 28.07.2020]
3 https://www.ncbi.nlm.nih.gov/pmc/tools/openftlist/[last accessed: 28.07.2020]</p>
      <p>This paper presents an overview of the ImageCLEFmed 2020 Concept
Detection Task. Section 2 contains the task description and lists the participating
teams. An explorative analysis computed on the distributed development and
test data sets is described in Section 3. The framework used to evaluate the
submission runs is explained in Section 4. Section 5 displays the modeling
approaches applied by the participating teams and the obtained scores, and is
followed by discussion and conclusions in Section 6.
2</p>
    </sec>
    <sec id="sec-3">
      <title>Task and Participation</title>
      <p>Similar to the ImageCLEF caption task in 2019 [16], in ImageCLEF Caption
2020 the focus is on the automatic detection of concepts in a large corpus of
radiology images. The proposed task aims to interpret and summarise insights gained
from medical images and therefore provide tools for radiology image
understanding. The distributed images in both development and evaluation data sets
originate from biomedical articles extracted from the PubMed Central (PMC)
Open Access Subset[20]. To each radiology image in the distributed data sets,
UMLS R CUIs are included. These concepts are generated from the the original
image captions found in the articles. Figure 1 displays an example of an image
in the distributed data sets. In comparison to the previous tasks, the following
improvements were made:
{ The imaging modality was included.
{ The focus remained on radiology images as in ImageCLEF 2019 .
{ The number of concepts was decreased by preprocessing the captions prior
to concept extraction.
The automatic detection of concepts present in images is a fundamental step
towards scene understanding and hence image captioning, as the presence of
applicable biomedical concepts can be detected and located. As the usage of
multi-modal representations (visual and textual) for image classi cation tasks
helps to achieve good performance [19], the automatically generated concepts
can be adopted for this purpose. In addition, the concepts can also be used
for context-based image analysis, as well as for information retrieval. The
detected concepts are evaluated image-wise with precision and recall scores from
the ground truth, which is described in Section 4.</p>
      <p>In the ImageCLEF 2020 concept detection task a total of 23 unique teams
registered in AICrowd and downloaded the End-User-Agreement. This license
is needed to obtain access to both development and evaluation data. 57 graded
runs were submitted for evaluation by 7 teams from the following countries:
Germany, United Kingdom, India, Greece and United States of America, which
is listed in Table 2. Each of the groups was allowed 10 graded runs and 5 faulty
runs altogether. 10 of the submitted runs were faulty and were not used for the
o cial evaluation.
3</p>
    </sec>
    <sec id="sec-4">
      <title>Data Set</title>
      <p>As in previous editions, the data set distributed for the task originates from
biomedical articles of the PMC Open Access subset [20]. The development data
set contains training and validation sets with 65,753 and 15,970 images,
respectively. These images are subsets of the multi-modal image data set Radiology
Objects in COntext (ROCO), which is presented in Pelka et al. [17]. ROCO
has two classes: Radiology and Out-Of-Class. The rst contains 81,825
radiology images and was adopted for the proposed task. It includes several medical
imaging modalities such as, Computed Tomography (CT), Ultrasound, X-Ray,
Fluoroscopy, Positron Emission Tomography (PET), Mammography, Magnetic
Resonance Imaging (MRI), Angiography and PET-CT.</p>
      <p>The development data of the 2020 task includes the ImageCLEF caption
2019 development data set (archiving date: until 31.01.2018) and the o cial
evaluation set (archiving date: 01.02.2018 - 01.02.2019). To avoid an overlap
with images distributed in previous ImageCLEF medical tasks, the test set for
ImageCLEF 2020 was created with a subset of PMC Open Access (archiving
date: 01.02.2019 - 01.02.2020). The same procedures applied for the creation of
the ROCO data set were applied for the test set as well. An analysis of the
distributed data can be seen in Table 2.</p>
      <p>Imaging Technique Train Validation Test Sum
DRAN: Angiography 4,713 1,132 325 6,170
DRCO: Combined modalities in one image 487 73 49 609
DRCT: Computerized Tomography 20,031 4,992 1,140 26,163
DRMR: Magnetic Resonance 11,447 2,848 562 14,857
DRPE: Positron emission tomography 502 74 38 614
DRUS: Ultrasound 8,629 2,134 502 11,265
DRXR: X-Ray, 2D radiography 18,944 4,717 918 24,579
Sum 65,753 15,970 3534 84,257
From the PMC Open Access subset [20], a total of 6,031,814 image - caption
pairs were extracted in January 2018. Compound gures, which are images with
more than one sub gure, were removed using deep learning as proposed in Koitka
et al. [13]. The non-compound images were further split into radiology and
nonradiology, as the focus was on radiology. Semantic knowledge of object interplay
present in the images were extracted in the form of UMLS R Concepts using the
QuickUMLS library [23]. The image captions from the biomedical articles served
as basis for the extraction of the concepts. The text pre-processing steps applied
are described in Pelka et al. [17]. Using deep learning systems as proposed in
Koitka et al. [13], the radiology images were further split into seven (7) imaging
modality classes. This information can be used for ltering steps prior to model
training, as well as for model ne-tuning.</p>
      <p>
        An additional UMLS R CUI denoting the imaging technique modality was
added to each image. Figure 2 shows example images from the development
data set, according to image modality and additional UMLS R CUI. Similarly to
the caption task in 2019 [16], concepts with very high frequency (&gt;13,000), as
well as redundant synonyms were removed. This lead to a reduction of concepts
per image in comparison to the previous years, from 5,528 in 2019 [16] to 3,047
in 2020. Not all concepts in the ground truth can be visually seen, for example
the concept 'Hole Finding' in Fig. 2 can not be detected from the image. Images
in the training, validation and test sets have [
        <xref ref-type="bibr" rid="ref1 ref2 ref3 ref4 ref5">1-140</xref>
        ], [
        <xref ref-type="bibr" rid="ref1 ref2 ref3 ref4 ref5">1-142</xref>
        ] and [
        <xref ref-type="bibr" rid="ref1 ref2 ref3 ref4 ref5">1-95</xref>
        ] concepts,
respectively. All concepts in the validation and test sets also exist in the training
set.
For all 3,534 radiology images distributed in the test set, UMLS R CUIs have to
be predicted by the participating teams automatically. As in the previous years
[
        <xref ref-type="bibr" rid="ref3">3, 7, 16</xref>
        ], the model performance was measured using the balanced precision and
recall trade-o in terms of F1-score. The default implementation of the Python
scikit-learn (v0.17.1-2) library was applied to compute the F-scores per image
and average them across all test images.
      </p>
      <p>The maximum number of concepts allowed per image was set to 150. This
limitation was chosen as the training, validation and test set contain a maximum
of 140, 142 and 95 concepts per image. Each group could have a maximum of 15
submission, with 10 valid and 5 faulty. Faulty submissions may include:
{ Same image id more than once
{ Wrong image id
{ Too many concepts
{ Same concept more than once
{ Not all test images included</p>
      <p>All submission runs were uploaded by the participating teams and
evaluated with AICrowd4. The source code of the evaluation tool is available on the
ImageCLEF web page5.
5</p>
    </sec>
    <sec id="sec-5">
      <title>Results</title>
      <p>
        The overall performance achieved by the concepts detection models submitted
by the 7 participating teams are listed and discussed in this section. In Table 4,
the submission run with best performance per team is shown. An additional
evaluation regarding the imaging modality was done internally, after the o cial
concept detection evaluation process. The accuracy (%) across all images in the
test set was computed and is listed in Table 6. Compared to the previous
editions, there is an improvement regarding the F1-Score of the submitted concept
detection models, from 0.1583 in ImageCLEF 2017 [
        <xref ref-type="bibr" rid="ref3">3</xref>
        ], 0.1108 in ImageCLEF
2018 [7] and 0.2823 in ImageCLEF 2019 [16] to 0.3940 in 2020.
      </p>
      <p>The AUEB NLP Group [12] from the Athens University of Economics achieved
the overall highest F1-Score of 0.3940 for the detection of concepts for the
images in the o cial evaluation test set. Their three (3) submission runs ranked
1st, 2nd and 6th of all 47 submitted runs. The submitted systems are a
variation of CheXNet [26] with DenseNet-121 [8] and followed by a feed-forward
Neural Network (FFNN), which acts as the classi er layer on the top [12]. The
system was rst pre-trained on the ImageNet data set [21] and then ne-tuned
using the ImageCLEF 2020 concept detection development data set. Several
ensemble methods such as the intersection and union of predicted concepts were
experimented. The system with the intersection of concepts achieved the overall
highest F1-Score.</p>
      <p>The overall 2nd ranked participating team is PwC Healthcare group from
PricewaterhouseCoopers with a total number of nine (9) submitted runs. The
adopted approaches range from Convolutional Neural Network (CNN)
architectures, to Natural Language Processing techniques, as well as clustering
algorithms [24]. The group's three (3) best systems ranked 3rd, 4th and 5th.
Several pre-processing approaches such as range and intensity normalization and
4 https://www.aicrowd.com/challenges/imageclef-2020-caption-concept-detection
[last accessed: 26.07.2020]
5 https://www.imageclef.org/system/
les/ImageCLEF-ConceptDetection</p>
      <p>Evaluation.zip [last accessed: 26.07.2020]
data augmentation were adopted prior to training the models [24]. Multi-modal
approaches were experimented to incorporate the concept imbalanced
distribution and a novel approach of band classi cation was applied. This classi cation
method rst clusters the vocabulary of concepts into bands and then creates for
each band a classi cation architecture [24].</p>
      <p>The third best participating team was from the University of Essex, with an
overall F1-Score of 0.381. The proposed approach adopts pre-trained DenseNet
models [8] for the extraction of relevant features. The additional information
on the imaging modality was used for ne-tuning by adding a fully connected
layer to the DenseNet-121 model and thereby transforming it into a multi-label
classi cation model [6]. Several concept selection strategies, such as distance and
ranked based methods, were applied to a given query image from the test set.
The group's ve best runs of the nine submitted runs ranked 6th to 10th among
all submissions.</p>
      <p>
        Five runs were submitted by the IML group from the German Research
Center for Arti cial Intelligence, with the best F1-Score of 0.3745, and the 4th
best team. Multiple deep learning systems such as VGG16 [22], ResNet50 [
        <xref ref-type="bibr" rid="ref5">5</xref>
        ]
and DenseNet169 [8], which were pre-trained on the ImageNet data set, were
applied for modeling the concept detection systems. The task was addressed as a
multi one-hot encoding with a nal prediction layer of 3,047 sigmoidal activation
units and several ne-tuning steps, such as data augmentation, hyper-parameter
settings, were undertaken [10].
      </p>
      <p>
        TUC MC, a media computing group from the Chemnitz University of
Technology ranked 5th best participating team. The highest F1-Score from the ten
submitted runs was 0.3745. The adopted deep learning model was based on the
Xception architecture [
        <xref ref-type="bibr" rid="ref1">1</xref>
        ] with weights pre-trained on ImageNet. The submitted
runs use the same model base structure, however the hyper-parameters are varied
in regards to last layer threshold and max-pooling in the highest layers [25].
      </p>
      <p>Ten runs were submitted by Morgan CS, a group from the computer science
department at the Morgan State University. The best achieved F1-Score was
0.1673, by approaching the concept detection task as a multi-label classi cation
problem [14]. Classi ers were trained with deep features extracted with the deep
learning system DenseNet169 and ResNet50 and pre-trained on ImageNet. Other
methods experimented include a recurrent concept sequence generator that was
modelled using a multimodal technique of fusing text and image features for
recurrent sequence prediction.</p>
      <p>
        CSE SSN from the department of computer science of the SSN College of
Engineering Chennai submitted one (1) run for o cial evaluation and achieved the
average F1-Score of 0.1347 on all images in the test set. Similar to several
participating teams, the concept detection task was addressed as a convolution neural
network multi-label classi cation problem [
        <xref ref-type="bibr" rid="ref2">2</xref>
        ]. The imaging modality distributed
was applied for pre-processing and model ne-tuning steps.
      </p>
      <p>An ex-post evaluation was computed on all submitted runs. The aim was
to compute the performance on correctly predicting the imaging modality. All
images in the development and test set were assigned concepts that denote the
acquisition technique, as shown in Figure 2. The images belonging to the imaging
modality 'DRCO: Combined modalities in one image' were not considered for
evaluation. For all images in the test set, we computed the presence of these
concepts in the submission runs using this additional information. The best
performance grouped per team is listed in Table 6 and the complete evaluation
in Table 7.</p>
      <p>Institution
PricewaterhouseCoopers US Advisory,
Mumbai, India
Department of Informatics, Athens University
of Economics and Business, Athens, Greece
School of computer Science and Electronic
Engineering, University of Essex,
Essex, United Kingdom
Technische Unversitat Chemnitz,
Chemnitz, Germany
Interactive Machine Learning Group,
German Research Center for Arti cial
Intelligence (DFKI), Saarbrucken, Germany
Computer Science Department,
Morgan State University, Baltimore,
Maryland, United States of America
Department of Computer Science and
Engineering, SSN College of Engineering,
Chennai, India
This paper presents an overview of applied approaches and their performance,
as well as the task description, participation and distributed data set for the
ImageCLEF 2020 concept detection task. Similar to the 2019 edition, the results
this year show that there is an improvement in the achieved F1-scores (best
score 0.3940). In this edition, not only does the dataset contain an increased
number of images, the number of concepts were reduced to be more precise
and additional modality information was distributed. In the previous editions,
the overall best F1-Scores were 0.2823 in Image-med Caption 2019, 0.1108 in
ImageCLEFmed Caption 2018 and 0.1583 in ImageCLEFmed Caption 2017.
Almost all participating groups were new to the task, with only one team that
participated in ImageCLEF caption 2019. The seven participating teams are
a liated to institutions from 5 countries, which shows the continuing research
interest to this challenging task.</p>
      <p>Most of the submitted runs are based on deep learning architectures. The
pre-trained models DenseNet-121, ResNet50 and VGG16 on the ImageNet and
CheXNet were used to extract relevant visual representation for the images.
Multiple pre-processing steps such as concept ltering, data augmentation and
image enhancement were applied to optimize the input for the predicting systems.
Long short-term memory (LSTM) recurrent neural networks (RNN),
adversarial auto-encoders, CNN image encoders and transfer learning-based multi-label
classi cation models were the frequently used approaches.</p>
      <p>As the focus in the caption task 2019 was reduced from biomedical images
to solely radiology images, a reduction of the extracted concepts from 111,155
to 5,528 was observed. We added this year an additional label denoting the
imaging modality of the images. This extra information was used by several
teams for pre- ltering steps prior to training the models, concept selection and
for ensemble algorithms. The class imbalance in the distributed data set proved
to be challenging for several teams. However, medical data and diseases are also
usually unbalanced with a few conditions happening very frequently and most
being very rare.</p>
      <p>In future work, an extensive review of the clinical relevance for the concepts
in the development data should be explored. As the concepts originate from the
natural language captions, not all concepts have high clinical utility. Medical
journals also have very di erent policies in terms of checking gure captions. We
believe this will assist in creating more e cient systems for automated medical
data analysis.
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