Preface The First International “AAI4H – Advances in Artificial Intelligence for Healthcare” Workshop was held in conjunction with the 24th European Confer- ence on Artificial Intelligence (ECAI), Virtual Conference, on September 4, 2020. The workshop comprises papers from the International “HELPLINE – Artificial Intelligence for HEaLth, PersonaLized MedIcine aNd WEllbeing” workshop and papers from the “SP4HC – Singular Problems for Healthcare” Workshop. AAI4H was conceived to provide a new venue in the field cross-cutting infor- mation management and medical informatics to discuss innovative data manage- ment and analytics technologies highlighting end-to-end applications, systems, and methods to address problems in healthcare, public health, and everyday wellness, with clinical, physiological, imaging, behavioral, environmental, and omic data, and data from social media and the Web. A major goal was devoted to advances in Artificial Intelligence applied to Healthcare and Well-Being, with an active interest in frontier-of-knowledge Machine Learning subjects. Namely the so-called singular problems: In particular, imbalanced classification, which is pervasive in important practical problems in healthcare. Artificial intelligence and machine learning are changing the landscape of healthcare and modern personalized precision medicine. The increasing avail- ability of health data together with the rapid progress of machine learning algo- rithms and analysis techniques, are gradually enabling doctors for better diagno- sis, improve disease surveillance, facilitating early disease detection, uncovering novel treatments and drug-interaction, detect false alarms and over-diagnosis, and creating an era of truly personalized medicine. A great challenge is build better modeling tools for integrating human expertise and artificial intelligence techniques to exploit big data in healthcare, and formulate hypothesis about how the human organisms act in health and illness. A major goal of this work- shop was to discuss theoretical as well as application-oriented research studies on relevant topics in the realm of healthcare and health informatics along with applications to real life situations. The programme of the first edition of the AAI4H Workshop included oral presentations of 18 papers accepted at the end of a peer-reviewed process. Out of these, 14 are included in this volume. We would like to thank all the contributing speakers, the members of our Program Committee for timely providing their reviews despite the difficulties arisen in these times of Covid-19 global emergency, and, last but not least, the ECAI-2020 Workshops chairs, Magdalena Ortiz and Amparo Alonso, for their trust and support. September 2020, Ester Zumpano, Andrea Tagarelli, Carmela Comito, Sergio Greco, Pierangelo Veltri, Agusti Solanas, Inmaculada Mora-Jiménez, Miquel Sànchez-Marrè Workshop Organizers Ester Zumpano Department of Computer Engineering, Modeling, Electronics, and Systems Engineering (DIMES), University of Calabria, Rende, Italy. Andrea Tagarelli Department of Computer Engineering, Modeling, Electronics, and Systems Engineering (DIMES), University of Calabria, Rende, Italy. Carmela Comito Institute of High Performance Computing and Networking of the Italian National Research Council (ICAR-CNR), Rende, Italy. Sergio Greco Department of Computer Engineering, Modeling, Electronics, and Systems Engineering (DIMES), University of Calabria, Rende (CS), Italy. Pierangelo Veltri Department of Medical and Surgery Science (DMSC), University Magna Graecia of Catanzaro, Catanzaro, Italy. Agusti Solanas Department of Computer Engineering and Mathematics (DEIM), Universitat Rovira i Virgili, Catalonia, Spain. Inmaculada Mora-Jiménez Department of Signal Theory and Communications, Telematics and Computing Systems Universidad Rey Juan Carlos, Madrid, Spain. Miquel Sànchez-Marrè Department of Computer Science (CS), Universitat Politècnica de Catalunya, Catalonia, Spain. Preface Technical Program Committee – Andrea Calı̀, Birkbeck University of London (UK) – Sergio Flesca, University of Calabria (Italy) – Francesco Gullo, Unicredit R&D Dept. (Italy) – Roberto Interdonato, CIRAD, UMR Tetis, Montpellier (France) – Elio Masciari, Università degli Studi di Napoli Federico II (Italy) – Luigi Pontieri, ICAR-CNR (Italy) – Agostino Forestiero, ICAR-CNR (Italy) – Domenico Ursino, Università Politecnica delle Marche, (Italy) – Roberto Bravo, Persei vivarium (Spain) – Mercedes del Valle, Visual TEAF (Spain) – Andries Engelbrecht, Stellenbosch University (South Africa) – Mohsen Farid, University of Derby (United Kingdom) – Óscar Garcı́a-Algar, Hospital Clı̀nic de Barcelona-Maternitat (Spain) – Adriàn Garcı́a-Romero, Hospital Universitario del Sureste (Spain) – Karina Gibert, Universitat Politècnica de Catalunya (Spain) – Julio Hernández-Castro, University of Kent (UK) – Robert Jenssen, University of Tromso (Norway) – José Marı́a Lillo-Castellano, Centro Nacional de Investigaciones Cardiovas- culares Carlos III (Spain) – Juan Luis Navarro, Universidad de Las Palmas de Gran Canaria (Spain) – Norberto Malpica-González, Universidad Rey Juan Carlos (Spain) – Constantinos Patsakis, University of Piraeus (Greece) – Cristina Soguero-Ruiz, Universidad Rey Juan Carlos (Spain) – Zdenko Sonicki, University of Zagreb (Croatia) – Leif Sörnmo, Lund University (Sweden) – Vanesa Soto-León, Hospital Nacional de Parapléjicos de Toledo (Spain) – Emmanuel Wey, University College London (United Kingdom) Workshop Websites Further information can be found at: – http://events.dimes.unical.it/helpline/ . – http://www.smarttechresearch.com/SP4HC2020/ .