<!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Archiving and Interchange DTD v1.0 20120330//EN" "JATS-archivearticle1.dtd">
<article xmlns:xlink="http://www.w3.org/1999/xlink">
  <front>
    <journal-meta>
      <journal-title-group>
        <journal-title>Vitali M. Comparative Indoor
Pollution from Glo, Iqos, and Juul,
Using Traditional Combustion
Cigarettes as Benchmark: Evidence
from the Randomized SUR-VAPES
AIR Trial. Int. J. Environ. Res. Public
Health</journal-title>
      </journal-title-group>
      <issn pub-type="ppub">1350-4533</issn>
    </journal-meta>
    <article-meta>
      <article-id pub-id-type="doi">10.3390/ijerph17176029</article-id>
      <title-group>
        <article-title>Effects of Using Innovative Technology Heat Not Burn on Indoor Air Quality.</article-title>
      </title-group>
      <contrib-group>
        <contrib contrib-type="author">
          <string-name>Prof.Asoc.Dr. Etleva Muça (Dashi)</string-name>
          <xref ref-type="aff" rid="aff0">0</xref>
          <xref ref-type="aff" rid="aff1">1</xref>
        </contrib>
        <aff id="aff0">
          <label>0</label>
          <institution>Agricultural University of Tirana. Faculty of Economy and Agribusiness. Dep. of Economy &amp;Rural Development Policies. TR. AL</institution>
          ,
          <country country="US">USA</country>
        </aff>
        <aff id="aff1">
          <label>1</label>
          <institution>Proccedings of RTA-CSIT 2021</institution>
        </aff>
      </contrib-group>
      <pub-date>
        <year>2018</year>
      </pub-date>
      <volume>17</volume>
      <issue>6029</issue>
      <fpage>231</fpage>
      <lpage>235</lpage>
      <abstract>
        <p>Today the indoor air quality is considered one of the main concerns of many international institutions related to environmental and health issues and polluted air is considered dangerous for human health. WHO (World Health Organization) has estimated that approximately 3.8 million people die every year prematurely from illness attributable to household air pollution [1]. Science and technology are combined together to create innovative smoking techniques in order to reduce the harm of smoking. As a result, Heat Not Burn revolutionary technology is introduced. This review study is focused on evaluating the smoking effects on indoor air quality comparing traditional smoking with new technologies and smoking techniques. Actually, the use of new techniques such as THS (Tobacco Heating System) or electronic device IQOS (I Quit Ordinary Smoking) has lower pollution effects compared to the traditional type of smoking. The use of new techniques results in the lowest concentrations of formaldehyde, benzene, toluene, PM2.5, among the majority researched pollution sources. So, this paper is based on a literature review approach analyzing the newest debates on the topic with the aim to give conclusion and recommendations on the long-term period on the use of new smoking technologies and future expectations.</p>
      </abstract>
      <kwd-group>
        <kwd>1 Indoor smoking</kwd>
        <kwd>New smoking technology</kwd>
        <kwd>THS</kwd>
        <kwd>IQOS</kwd>
      </kwd-group>
    </article-meta>
  </front>
  <body>
    <sec id="sec-1">
      <title>1. Introduction</title>
      <p>
        Today more and more people are being
sensitive to health problems in general and they
caused by smoking. Many efforts are made to
reduce the harm of smoking. Heat Not Burn
technology is one of the results of these efforts
and researches. People in developed and
developing countries spent the majority of their
living time indoors. [
        <xref ref-type="bibr" rid="ref2">2</xref>
        ],[
        <xref ref-type="bibr" rid="ref3">3</xref>
        ]. Spending most of
their time indoors people are the main
contributor with their style of living on
environmental pollution. Actually, through
several studies it is proven that most hazardous
compounds in tobacco smoke are formed
between 200 and 700 °C, lower temperatures
would limit formation of noxious compounds
(Levels of selected analytes in the emissions of
“heat-not-burn” tobacco products that are
relevant to assess human health risks [
        <xref ref-type="bibr" rid="ref4">4</xref>
        ]
      </p>
      <p>Under this optic, it is important to
understand which are the tobacco types that
have negative effects in indoor areas. This
paper is based on a literature review approach.</p>
      <p>
        According to WHO 2000 [
        <xref ref-type="bibr" rid="ref5">5</xref>
        ] smoking is
considered one of the sources of indoor air
pollution together with other emissions caused
by cooking or solid fuels. WHO (2000) has
evaluated eighteen indoor air constituents
(respirable suspended particles (RSP) &lt; 2.5 mm
in diameter), ultraviolet particulate matter
(UVPM), fluorescent particulate matter (FPM),
solanesol, 3-ethenylpyridine, nicotine,
1,3butadiene, acrylonitrile, benzene, isoprene,
toluene, acetaldehyde, acrolein,
crotonaldehyde, formaldehyde, carbon
monoxide, nitrogen oxide, and combined
oxides of nitrogen) which are determined for
the quality of indoor air pollution.
      </p>
    </sec>
    <sec id="sec-2">
      <title>2. Method</title>
      <p>
        This paper was focused on reviewing
several scientific articles and conference papers
on the main effects in indoor air quality
smoking and to direct future research in this
field. This review permitted to make a
comparative analysis on different scientists’
opinions and research on indoor smoking
effects. So, the analysis was focused on a
systematic review of published papers on
indoor smoking. “A systematic review attempts
to collate all empirical evidence that fits the
pre-specified eligibility criteria in order to
answer a specific research question. It uses
explicit, systematic methods that are selected
with a view to minimizing bias, thus providing
more reliable findings from which conclusions
can be drawn and decisions made”[
        <xref ref-type="bibr" rid="ref6">6</xref>
        ].
      </p>
      <p>
        The first step of the analysis was the paper’s
identification [
        <xref ref-type="bibr" rid="ref7">7</xref>
        ]. The papers selection was
conducted by internet research and manual
reading of published papers related to the
relevant topic. Then I prepared a preliminary
list with the potential journals I had to include
in the analyze. The systematic review is linked
with the use of strict criteria with the aim to
produce best-quality analysis [
        <xref ref-type="bibr" rid="ref8">8</xref>
        ]. The main
condition was the inclusion of peer-reviewed
journals with papers written in English [
        <xref ref-type="bibr" rid="ref7">7</xref>
        ]. The
second condition was paper experiment basis
since it is important to have conclusions only
from primary data. The third condition of the
paper selection was based on WHO priority
pollutants criteria for indoor areas.
      </p>
      <p>As well it was eliminated duplicate titles,
and titles which were clearly not related to our
scope. The selected papers were 19 out of 57
relevant studies, which were considered the
most appropriated corresponding to the goal of
the paper.</p>
      <p>The tobacco industry’s most recent response
to the documented harms of cigarette smoking
was to launch new heat-not-burn (HNB)
tobacco cigarettes [9]. Heat Not Burn
technology is the answer of many researches
and efforts to reduce the harm of smoking. One
of the electronic devices that use heat not burn
revolutionary technology is IQOS (I Quit
Ordinary Smoking). The Heat Stick that
contains the tobacco, a holder and a charger are
parts of the IQOS. Tobacco Heating System
IQOS heats tobacco and not burn it
compared to traditional cigarettes.</p>
    </sec>
    <sec id="sec-3">
      <title>4. Discussion</title>
      <p>For many years indoor smoking cigarettes
was not considered a major problem and only
after 2007 EU adopted a Recommendation on
Smoke-free Environments "provide effective
protection from exposure to tobacco smoke in
indoor workplaces, indoor public places, public
transport and, as appropriate, other public
places”[10].</p>
      <p>A major source of indoor air pollution is
considered second-hand smoke [11]. Normally,
the smoking of tobacco products (especially
second-hand tobacco) leads to a massive
increase of particular matter (PM) in enclosed
spaces [12]. Studies has demonstrated that
long-term exposure to PM correlates with
cardio-vascular and respiratory diseases, lung
cancer, and cardiopulmonary mortality [13]</p>
      <p>But, it is observed that environmental
tobacco smoke (ETS) is one of the many
sources of airborne PM in the indoor
environment [14]. On the other hand, ETS is a
combination of exhaled mainstream smoke
(MS) and side stream smoke (SS) released from
the smoldering tobacco product, and a complex
mixture of chemical constituents that remains
in surfaces fixed in building materials, carpets,
upholstery, and furniture (third-hand smoke).
[11],[15].</p>
      <p>
        Indoor pollutants mainly contain organic or
inorganic chemicals, biological aerosols
(bioaerosols), and particles but the list is a wide
range [
        <xref ref-type="bibr" rid="ref2">2</xref>
        ]. Regarding the impact of both ETS
and PM on human health, only a few data are
published about the concentration of PM in
ETS [11]. But we have to say that the third-hand
smoking does not produce any side-stream
smoke emissions, thus the potential impacts to
indoor air quality from the usage of THS may
come from the only exhaled aerosol [16].
Actually, it is estimated than 10% of
nonsmokers’ homes with smoking bans have
nicotine levels higher than the average level in
homes of smokers without smoking bans (&gt;/=
30mg /m2) [15]
      </p>
      <p>On the other hand, we have to analyze
smoking indoor effects of the new smoking
technologies such as the Tobacco Heating
System (THS).</p>
      <p>Use of THS was reported not to increase
indoor concentrations of carbon monoxide and
nitrogen oxides [17], which are listed as WHO
priority pollutants. Generally, the usage of THS
has been associated with lower or comparable
indoor air pollutant concentrations compared
against other conventional indoor sources or
environments, in most cases distinguishable
above background, thus potentially being
associated with health effects at prolonged
exposure as any other artificial air pollution
source [16].</p>
      <p>On the other hand [18] found that IQOS
have an impact on airways function, exhaled
CO, and SaO2% of both smokers and
nonsmokers immediately after use, but at the same
time they admit their effects on pulmonary
function, short- and long-term, have not been
adequately studied yet.</p>
      <p>
        [19] studied that the levels of pollutants
emitted by e-cigarettes and HNBT are
substantially lower compared to those from
TCs, the new smoking devices are still a source
of indoor air pollutants. As well the nicotine
yield is comparable to typical combustible
cigarettes and observe substantially reduced
levels of aldehydes (approximately 80–95%)
and VOCs (approximately 97–99%) [
        <xref ref-type="bibr" rid="ref4">4</xref>
        ].
      </p>
      <p>On the other hand, according to [20] iQOS
emissions seem to be fairly clean in terms of
metal emissions compared to both
Conventional Cigarettes and Electronic
Cigarettes. So, the concentration levels of
hazardous compounds in the mainstream smoke
of iQOS are much lower than those in
conventional combustion cigarettes [21].</p>
      <p>Recent studies are confirming that iQOS
have a significantly lower burden of emissions
for all classes of PM, including total PM
emissions (all p &lt; 0.05) [22], or at least
modified risk in indoor smoking [23].</p>
      <p>Results for tar and nicotine yield released
from THS 2.2 has shown similar results with
Conventional Cigarette, but there is found more
water in THS 2.2. There are some reasons for
presence of higher water in THS 2.2 compared
to Conventional Cigarettes, and one of the is
linked with due to the additional of glycerol and
propylene glycol in the THS 2.2 heating sticks.
Although most mainstream constituents of THS
2.2 are reduced compared to Conventional
Cigarettes standards or 3R4F. Regulators have
to pay more attention of smoking topography as
a smoking machine according to the
HCI-toISO ratio [24].</p>
    </sec>
    <sec id="sec-4">
      <title>5. Future Work: IoT Based</title>
    </sec>
    <sec id="sec-5">
      <title>Monitoring System for Indoor</title>
    </sec>
    <sec id="sec-6">
      <title>Air Quality</title>
      <p>It is very important to continuously monitor
indoor air quality as the negative effects of
smoking using Heat Not Burn technology and
the impact on indoor environments have not yet
been studied at an adequate level. Real-time
monitoring of indoor air quality can reveal
harmful health situations that can be resolved
with human intervention. Many studies, have
been conceived or designed sensor-based
networks to monitor indoor air quality in real
time [25, 26, 27, 28, 29]. Advances in
networking, sensors, and embedded devices
have made monitoring and supply of assistance
possible to people in their homes [27], but not
only. Based on the systematic review for indoor
air quality monitoring systems based on
internet of things [30] the general architecture
of IoT based monitoring system presented in
figure 1 provide real time monitoring of indoor
air quality.</p>
      <p>Further studies will be needed to find the
best solution in terms of cost and real time
monitoring of indoor air quality when people
smoke with devices that use Heat Not Burn
technology.</p>
    </sec>
    <sec id="sec-7">
      <title>6. Conclusions</title>
      <p>Tobacco smoke and THS are considered as
artificial air pollution source in indoor areas.
Several studies admit that the use of THS
produce insignificant emissions of hazardous
compound in indoor smoking. THS technology
has contributed to reduce the level of the indoor
smoking pollutants.</p>
      <p>Long term health effects by THS indoor
smoking have not been studied properly. On the
other hand, the negative effects of THS and the
impact on indoor smoking is not studied yet in
an adequate level.</p>
      <p>The toxic compounds (nicotine tar and
tobacco specific nitrosamines) are not
completely removed from the mainstream
smoke of iQOS, making it necessary to
consider the health effects and regulation of
second-hand smoke widely recognized as a
common issue by WHO [31].</p>
      <p>On the other hand, scientists are suggesting
that it is better to enable a smoke free
environment to avoid the differences between
main and passive smokers and as well to protect
human health even the negative effects of
heatnot-burn tobacco are not yet verified [32].</p>
    </sec>
    <sec id="sec-8">
      <title>7. References</title>
      <p>[10]
[11]
[12]
[13]
[14]
[15]
[18]
[19]
[20]
[21]
[22]</p>
      <p>Bekki K., Inaba Y., Uchiyama
Sh. Kunugita N., Comparison of
Chemicals in Mainstream Smoke in
Heat-not-burn Tobacco and
Combustion Cigarettes. J UOEH 39
(3): 201-207 (2017)</p>
      <p>M. AL-Harbi. Impact
of tobacco smoke on the elemental
composition of indoor different
particles sizes. International Journal of
Environmental Science and
Technology (2018)
https://doi.org/10.1007/s13762-0181973-7</p>
    </sec>
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