<!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Archiving and Interchange DTD v1.0 20120330//EN" "JATS-archivearticle1.dtd">
<article xmlns:xlink="http://www.w3.org/1999/xlink">
  <front>
    <journal-meta />
    <article-meta>
      <title-group>
        <article-title>Obesity: Patients A Playful Smartphone-based Self-regulation Training for the Prevention and Treatment of Child and Adolescent Technical Feasibility and Perceptions of Young</article-title>
      </title-group>
      <contrib-group>
        <contrib contrib-type="author">
          <string-name>Tobias Kowatsch</string-name>
          <email>tkowatsch@ethz.ch</email>
          <xref ref-type="aff" rid="aff1">1</xref>
          <xref ref-type="aff" rid="aff2">2</xref>
          <xref ref-type="aff" rid="aff4">4</xref>
          <xref ref-type="aff" rid="aff5">5</xref>
        </contrib>
        <contrib contrib-type="author">
          <string-name>Chen-Hsuan (Iris) Shih</string-name>
          <xref ref-type="aff" rid="aff1">1</xref>
          <xref ref-type="aff" rid="aff4">4</xref>
        </contrib>
        <contrib contrib-type="author">
          <string-name>Yanick X. Lukic</string-name>
          <xref ref-type="aff" rid="aff1">1</xref>
          <xref ref-type="aff" rid="aff4">4</xref>
        </contrib>
        <contrib contrib-type="author">
          <string-name>Olivia C. Keller</string-name>
          <xref ref-type="aff" rid="aff1">1</xref>
          <xref ref-type="aff" rid="aff4">4</xref>
        </contrib>
        <contrib contrib-type="author">
          <string-name>Nathalie Farpour-Lambert</string-name>
          <xref ref-type="aff" rid="aff4">4</xref>
          <xref ref-type="aff" rid="aff6">6</xref>
        </contrib>
        <contrib contrib-type="editor">
          <string-name>Geneva, Switzerland</string-name>
        </contrib>
        <aff id="aff0">
          <label>0</label>
          <institution>Adolescent Medicine, Children's Hospital of Eastern Switzerland</institution>
          ,
          <addr-line>St.Gallen</addr-line>
          ,
          <country country="CH">Switzerland</country>
        </aff>
        <aff id="aff1">
          <label>1</label>
          <institution>Centre for Digital Health Interventions, Department of Management, Technology and Economics, ETH Zurich</institution>
          ,
          <addr-line>Zurich</addr-line>
          ,
          <country country="CH">Switzerland</country>
        </aff>
        <aff id="aff2">
          <label>2</label>
          <institution>Centre for Digital Health Interventions, Institute of Technology Management, University of St.Gallen</institution>
          ,
          <addr-line>St.Gallen</addr-line>
          ,
          <country country="CH">Switzerland</country>
        </aff>
        <aff id="aff3">
          <label>3</label>
          <institution>Child and Youth School Health Service, Department of Education and Youth</institution>
          ,
          <addr-line>Vevey</addr-line>
          ,
          <country country="CH">Switzerland</country>
        </aff>
        <aff id="aff4">
          <label>4</label>
          <institution>Katrin Heldt</institution>
        </aff>
        <aff id="aff5">
          <label>5</label>
          <institution>Saw Swee Hock School of Public Health, National University of Singapore</institution>
          ,
          <country country="SG">Singapore</country>
        </aff>
        <aff id="aff6">
          <label>6</label>
          <institution>Service of Endocrinology, Diabetology, Nutrition and Therapeutic Patient Education, Department of Medicine, University Hospitals of Geneva</institution>
        </aff>
      </contrib-group>
      <abstract>
        <p>Efective interventions for the prevention and treatment of child and adolescent obesity play an important role in reducing the global health and economic burden of non-communicable diseases. Although multi-component interventions targeting various health behaviors are deemed promising, evidence for their efectiveness is still limited. Self-regulation seems to be a relevant working mechanism in this regard. Therefore, we propose a playful, smartphone-based self-regulation training that also utilizes the health benefits of a slow-paced breathing exercise. The mobile app uses the microphone of the smartphone to detect breathing sounds (e.g. inhalation, exhalation) and translates these sounds into a visual biofeedback on the smartphone screen. The design and evaluation of a very first prototype is described in this interdisciplinary work of obesity experts, clinical psychologists, young patients, and computer scientists. The apps' breathing detection module uses a random forest tree for quasi real-time classification of the incoming audio samples and biofeedback generation. A study with 11 children and adolescents with obesity was conducted to assess the prototype. Results indicate overall positive evaluations and suggestions for improvement. Implications and limitations are discussed, and an outlook on future work is provided. human-computer interaction, self-regulation, digital health intervention, biofeedback, breathing training, breathing detection CEUR Workshop Proce dings</p>
      </abstract>
      <kwd-group>
        <kwd>Adolescent</kwd>
        <kwd>Perceptions</kwd>
      </kwd-group>
    </article-meta>
  </front>
  <body>
    <sec id="sec-1">
      <title>1. Introduction</title>
      <sec id="sec-1-1">
        <title>Non-communicable diseases (NCDs), such as cardiovas</title>
        <p>cular diseases or mental disorders, are the leading cause
of death worldwide, contributing to 73% of deaths [1].</p>
      </sec>
      <sec id="sec-1-2">
        <title>NCDs also lead to a significant financial burden [ 2, 3], for example, up to 90% of all health care spending in the U.S. [4].</title>
      </sec>
      <sec id="sec-1-3">
        <title>To address this important problem, health interventions must target adverse health behaviors such as mal</title>
        <p>0000-0001-5939-4145 (T. Kowatsch); 0000-0002-2576-6569
(Y. X. Lukic); 0000-0001-8761-8214 (O. C. Keller);
0000-0001-6478-7269 (N. Farpour-Lambert); 0000-0003-3144-3907
(D. l’Allemand-Jander)
of emotional, motivational, and cognitive arousal that
are conducive to positive adjustment and adaptation, as
reflected in positive social relationships, productivity,
achievement, and a positive sense of self.” [12, p. 900] For
instance, obese children, require self-regulation skills to
resist the urge to eat unhealthy food. In this context, it
was demonstrated that children who have experienced
loss of control eating report a higher use of maladaptive
strategies for the regulation of emotions than children
without a history of loss of control eating [13]. Similarly,
another study identifies emotional regulation as the
moderator for the relationship between perceived stress and
emotional eating [14].</p>
        <p>Furthermore, a systematic review indicates that
selfregulation skills are among the best predictors of
outcomes in obesity interventions in adults [15]. Another
study with a representative sample of U.S. children not
only found a link between self-regulation and the risk of
obesity, but further identified that this link is stronger
between boys and girls [16]. Moreover, a recent
systematic review found that interventions with self-regulation
interventions can be efective in children and
adolescents, with possible health benefits [ 17]. All in all,
selfregulation skills represent a relevant target in
multicomponent interventions for the prevention and
treatment of child and adolescent obesity.</p>
        <p>To this end, we propose a playful self-regulation
training for children and adolescents. The training is delivered
via a mobile app and focuses on a breathing exercise. The
app uses the microphone of a smartphone to detect
inhalation, exhalation, silence and noisy sounds to then
visually guide the user to perform a slow-paced
breathing training. With the help of the visual biofeedback,
breathing can be adjusted with the overall goal to
improve self-regulation skills. A conceptual overview of
the training is depicted in Fig. 1.</p>
        <p>After a brief overview of related work in the next
section, we describe the design of a very first prototype and
the evaluation procedure targeting obese children and
adolescents. We then present and discuss the results and
conclude with a summary and outlook on future work.</p>
      </sec>
    </sec>
    <sec id="sec-2">
      <title>2. Related Work</title>
      <sec id="sec-2-1">
        <title>Slow-paced breathing was chosen in this investigation</title>
        <p>because it is not only a common self-regulation tool [e.g.,
18, 19, 20, 21, 22] but also shows positive ”side” efects on
cardiac functioning and mental well-being [23, 24, 25].</p>
        <p>The work of Carlier et al. [26] is similar to our training
as they implemented a mobile game that uses the
microphone of a smartphone to detect an ”ommm”-sound to
then visually guide children through a breathing exercise.
They tested their prototype with three children
sufering from autism spectrum disorder. However, results
indicated no efects on stress reduction or technology
adaptation of breathing based
on biofeedback visualization</p>
        <sec id="sec-2-1-1">
          <title>User</title>
          <p>Goal</p>
          <p>Improving
self-regulation
skills
Slow-paced breathing</p>
        </sec>
        <sec id="sec-2-1-2">
          <title>Smartphone</title>
        </sec>
        <sec id="sec-2-1-3">
          <title>Playful</title>
        </sec>
        <sec id="sec-2-1-4">
          <title>Biofeedback</title>
        </sec>
        <sec id="sec-2-1-5">
          <title>Visualization</title>
        </sec>
        <sec id="sec-2-1-6">
          <title>Breathing</title>
        </sec>
        <sec id="sec-2-1-7">
          <title>Detection</title>
          <p>(inhalation, exhalation,
silence, and noise)</p>
        </sec>
        <sec id="sec-2-1-8">
          <title>Microphone</title>
          <p>acceptance.</p>
          <p>Empirical results of another related work by Shih et
al. [27] were more promising. They implemented a
similar self-regulation training and found positive
effects on physiological outcomes and technology
acceptance. However, the authors tested their prototype with
19 healthy university students and thus, these findings
may not translate to children and adolescents. Another
limitation of this study is that the authors employed a
breathing detection model based on an attention-based
long short-term memory model in conjunction with a
preceding convolutional neural network which may not
run on older smartphones with limited computational
power.</p>
          <p>Another study by Hunter et al. [28] investigated whether
a slow-paced breathing training with a mobile app that
features heart rate variability biofeedback afects the
recovery from an artificial stressor. They found that the
app had a significant efect on salivary alpha amylase
recovery while not showing a significant efect on cortisol
recovery or self-reported stress recovery. Technically, the
app does not detect breathing but the heartbeat from the
smartphone’s rear camera in conjunction with the
flashlight. Thus, the app can present the breathing exercise’s
impact on the user’s heart rate variability. However, the
heart rate variability is not consciously controlled and its
measurement is time-delayed. Consequently, the
breathing training does not allow responsive user interaction.</p>
        </sec>
      </sec>
    </sec>
    <sec id="sec-3">
      <title>3. Methods</title>
      <p>The design and evaluation of the smartphone-based
selfregulation training was collaboratively carried out by
an interdisciplinary team of computer scientists, obese
children and adolescents as well as several obesity
experts including physicians, psychotherapists, and diet
and sport experts from a children’s hospital. The project
described in this work was also approved by the local
ethics board. The specifics of the design and evaluation
phases are outlined in the following sections.
3.1. Design of the Mobile App
3.1.1. User Interface
A focus group discussion with 11 young patients,
moderated by obesity experts, was conducted as a first step to
gather design requirements for the self-regulation
training. In response to that discussion, a first conceptual
draft of the user interface was developed. The overall
goal of the self-regulation training was to ”move” a boat
sailing on an ocean towards an isle, far far away, with
the help of slow-paced breathing. Specifically, exhalation
should imitate wind that blows the boat forward while
inhalation should imitate the collection of wind energy for
the next breathing cycle. A draft of this idea is depicted
in Fig. 2 which also shows a distance-to-destination
indicator on the bottom and speech bubbles with additional
breathing instructions.</p>
      <p>Based on feedback from the obesity experts and young
patients, several elements were dropped and revised to
further streamline the user interface. For example, the
distance indicator at the bottom and the wind energy
indicator on the right-hand side were removed so that users
could better focus better on the sailboat and its
movements toward the destination isle. Further, the speech
bubbles were replaced by a digital coach at the top of
the screen who had the role to ”guide” users through Figure 2: Draft of the App’s User Interface
the training. Moreover, moving clouds were introduced
to support the boat movements towards the destination
isle and to provide also a visual feedback for inhalation To match the style of the user interface of the app, the
sounds. In the latter ”inhalation” case, clouds gathered video clip employs a comic-like character and elements
together at the center of the screen while they moved of the mobile user interface (e.g. ocean, sailboat and
apart when inhaling. The high-level biofeedback logic clouds). The resulting instructional video clip was shown
was also defined collaboratively among young patients, to four young patients who were then asked to perform
obesity experts and computer scientists. It is outlined in the communicated slow-paced breathing. The breathing
Algorithm 1. A prototype of the graphical user interface technique was assessed by the obesity experts according
was then implemented for the Android operating system. to the guidelines communicated through the video clip
Fig. 3 shows a screenshot of that interface. and deemed appropriate.
3.1.2. Instructional Video Clip
3.1.3. Breathing Detection
To ensure consistent and evidence-based instructions on The overall goal of the breathing detection module of
how to perform a slow-paced breathing training, an in- the self-regulation training is to process audio signals
structional video clip was produced with the help of the in quasi real time to distinguish between inhalation,
exinvolved obesity experts. This video clip would be pre- halation, silence, and noise captured by a smartphone’s
sented to the user before she or he would perform the microphone.
self-regulation training with the app for the very first In a first step, we aimed at assessing the technical
featime. The clip explains in ca. 30s how a deep abdominal sibility of this approach and built a database of audio
breathing is conducted and instructs the audience to in- samples. Due to limited access to young patients and to
hale through the nose and to exhale through the mouth reduce the burden of them as patients, as well as due to
while performing circa six breath cycles per minute [25]. the feasibility character of this investigation, we decided
You are doing great.</p>
      <p>Keep it up!
124s
digital coach
messages
destination
clouds
sailboat
sailing route
to collect audio samples from four doctoral students (2
females; all between 25 and 27 years old). We asked the
doctoral students to sit comfortably in a chair in their
ofice and perform a slow-paced breathing exercise for
three minutes according to the instructions of the video
clip described in Section 3.1.2. The audio was recorded
with a Samsung Galaxy S6 Edge through a customized
app that uses the Android AudioRecord API (PCM, 16bit,
44.1 kHz). The distance to the smartphone for these
recordings was about 20cm, a distance we found optimal
for the breathing exercise, too. One co-author listened to
the resulting recordings and manually cut them into
separate audio files labeling them as inhalation, exhalation,
or silence. To collect additional samples for silence and
noise, the same smartphone was used to record sounds
in an ofice. This resulted in audio samples of passing
cars and streetcars or the speech of ofice workers, which
were manually marked as noise. Silent audio samples
were manually labeled as silence. The data collection
resulted in around 28,000 audio samples of 80ms length.</p>
      <p>This length was chosen as it represented the minimum
bufer size that could be acquired through the Android
audio engine at the time of implementation.</p>
      <p>In a second step, we calculated for each sample the
ifrst 13 Mel-frequency cepstral coeficients [ 29] with a
window size of 25ms and a 50% overlap. The coeficients</p>
      <sec id="sec-3-1">
        <title>Algorithm 1: Biofeedback Logic</title>
        <p>Input: detection = {inhalation, exhalation, silence,
noise}
Output: biofeedback = {clouds, sailboat, and</p>
        <p>digital coach message}
1 while destination not reached do
2 switch detection do
3 case inhalation do
4 clouds gather together
5 case exhalation do
6 clouds expand
7 sailboat moves towards destination
8 digital coach provides positive</p>
        <p>feedback
case silence do</p>
        <p>digital coach motivates user to inhale
case noise do
digital coach recommends to reduce
surrounding noise
13
14 end</p>
        <p>end
were supplemented with four descriptive statistical
measures. From the time-domain we used the mean, variance,
and maximum of the raw audio amplitude and from the
frequency-domain the peak frequency amplitude.</p>
        <p>Third, and consistent with prior work that was
successful in detecting breathing patterns [30], a Random
Forest model was used with 100 trees, which was
empirically found to result in the best prediction performance
for our data set.</p>
        <p>Since our audio database was relatively small
compared to related work [e.g., 27] and to prevent our model
from over-fitting, we applied k-fold cross-validation for
training and validation. We trained the random forest
model using the WEKA library. First, we applied a 80/20
training to test split over all four participants. Second,
we conducted 10-fold cross-validation on the training
data. Third, we tested the best model on the test set. The
performance of the model on the test set is reported in
Table 1. The results indicate that the trained model is able
to appropriately diferentiate between the four classes
for the breathing of known individuals.</p>
        <p>Finally, the trained random forest model was
integrated into the mobile app using the WEKA Android
API. The feature extraction in the app was reproduced
using Java in conjunction with the audio processing
library OpenIMAJ 1.3.9. The resulting predictions of the
incoming data would then trigger the animations of the
user interface outlined in Algorithm 1.
3.2. Evaluation Procedure</p>
      </sec>
    </sec>
    <sec id="sec-4">
      <title>4. Results</title>
      <p>A study with obese children and adolescents was con- Overall, 8 female and 3 male young 9-16 year-old (M
ducted in the children’s hospital of the participating obe- = 12.6, SD = 2.4) children and adolescents with obesity
sity experts to assess the technical feasibility and percep- participated in the study. All patients were able to reach
tions of the self-regulation training. The procedure was the goal set by the training app in 40 to 120 seconds.
as follows. However, obesity experts observed that due to the playful</p>
      <p>First, patients were instructed to watch the educational character of the app, three subjects started to perform
breathing video clip and to perform the breathing exer- an adverse breathing pattern (e.g. hyperventilation or
cise without the app. Obesity experts provided feedback extensive and long exhalation), motivated by the goal to
on their breathing to assure a correct technique. bring the sailboat as quickly as possible to its destination,</p>
      <p>In a second step, obesity experts handed over the An- despite being instructed otherwise.
droid smartphone, the same model used for data collec- The descriptive statistics of the patients’ self-reported
tion (i.e. the Samsung S6 Edge), with the self-regulation perceptions of the participating patients are listed in
Tatraining app to the patients. The experts then explained ble 2 and corresponding boxplots with raw responses are
the purpose of the app and its visual feedback logic. shown in Fig. 4. The high average mean values for all</p>
      <p>Finally, obesity experts asked the patients to perform constructs indicate that the patients found the training
the app’s slow-paced breathing exercise. The patients’ app easy to use and conducive to relaxation at home.
Adgoal was to ”sail” the sailboat to the destination. Dur- ditionally, the patients reported enjoying its actual usage
ing the exercise and for safety purposes, obesity experts and indicated that they could even imagine using the
observed the patients and intervened in case of any ad- app-based training every day. Finally, patients shared
verse breathing activity. Moreover, they noted down that they were able to relax using the app. One-sample
whether the goal was achieved and the sailboat reached sign tests confirmed these results as the self-reported
the destination, and how long it took the patients to get scores all lie significantly above the neutral scale value
there. of zero.</p>
      <p>Afterwards, the patients received a questionnaire that The qualitative feedback indicated that the digital coach
allowed them to assess the app. Constructs of inter- moderating the self-regulation exercise should be
cusest were adopted from technology acceptance research tomizable, for example, regarding their outfit. Moreover,
[31, 32] and included perceived ease of use, perceived en- the training session was perceived as too short and thus,
joyment, expected usefulness at home, intention to use it was suggested to extend the journey with the sailboat.
and perceived relaxation after use. Consistent with prior It was also suggested to add further elements to the ocean
work [33, 34], a single item per construct was used to scene, for example, additional milestones such as smaller
reduce the burden of the young patients. All items were isles or surface marker buoys as sub-ordinate targets that
anchored on 7-point Likert scales ranging from strongly would trigger points when passing by with the sailboat.
disagree (-3) to strongly agree (3). All constructs and Interestingly, there were some enquiries into whether
item wordings are listed in Table 2. Finally, patients were the training app was available on Apple’s iOS platform,
asked to write down any suggestions they may have to which indicated further interest in the training app.
improve the app. Overall, the qualitative feedback confirmed the
positive quantitative results presented above.
strongly
agree
3
self-regulation training might be smartphone addiction
[35, 36]. Limiting the number of exercises per day could
2 be a solution in this regard. Finally, adding additional
1 playful elements as suggested by the young patients
raises the question to which degree the experiential efect
neither 0 of the app can potentially cancel out the development of
−1 self-regulation skills and other health benefits of
slowpaced breathing such as calming down or strengthening
−2 the cardiac system. Related work provides first evidence
−3 that both experiential and instrumental efects can
coexdsistraognrgeley ePaesreceoifvuesde ePnejrocyemiveendt uEsaxetpfhueolcnmteeesds eInvttoeernuytsdioeany Preelarcxeaitvioend lfiisnteT[2hp7ies,r3fwo7ro]m.rkanhcaes oalfsothseevdeertaelctliiomnitmatoiodnesl.
isFibrsats,etdheonofa small sample of only four doctoral students and not
Figure 4: Boxplots and Answers of Self-reported Perceptions on breathing data from the target population. Both
asof 11 Young Children and Adolescents with Obesity pects, the small sample size resulting in low variance of
breathing sounds and the mismatch of model
development with population A and assessment by population
5. Discussion B, limit the generalizability of the findings. Second, the
training and test sets were collected in the same context,
The current work presented a playful, smartphone-based i.e. the same recording environment and smartphone
self-regulation training that was collaboratively devel- model, and contain breathing sounds from the same
inoped by an interdisciplinary team of obesity experts, clin- dividuals. Consequently, the detection performance for
ical psychologists, children and adolescents with obesity, unknown individuals, other devices, or diferent
envias well as computer scientists. The evaluation of the train- ronments remains unknown. Third, the data collection
ing with 11 young obesity patients showed the technical with respect to noisy environments was limited to only
feasibility, as all patients were able to bring the sailboat one specific environment (the ofice). Fourth, only one
to its destination. Moreover, self-reports of the partici- specific biofeedback theme was evaluated, i.e. the
”oceanpating patients resulted in overall positive technology and-sailboat” theme, and thus, it is open to which degree
assessments and various suggestions for improvement visual elements may have an impact on the efects of
were provided. the self-regulation training. Third, the cross-sectional</p>
      <p>However, the evaluation also resulted in relevant in- study setting in the children’s hospital does not allow to
sights regarding potential side efects. First, the playful draw any conclusions on long-term engagement with the
biofeedback visualization motivated patients to adopt app. Finally, the evaluation procedure did not contain
a breathing technique that could lead to dizziness due any validated instrument to assess self-regulation and
to hyperventilation or prolonged periods of exhalation. thus, no conclusions can be drawn in this regard, too.
A biofeedback visualization that ofers time-restricted
inhalation and exhalation windows may overcome this
problem. That is, the sailboat could only be moved for- 6. Summary and Future Work
ward during a pre-defined time window that promotes
a ”healthy” slow-paced breathing [27]. Another
potential side efect promoted by the playful nature of the</p>
      <sec id="sec-4-1">
        <title>We highlighted the relevance of self-regulation mechanisms in interventions targeting the prevention and treatment of obesity in children and adolescents. We</title>
      </sec>
    </sec>
    <sec id="sec-5">
      <title>Acknowledgments</title>
      <sec id="sec-5-1">
        <title>We would like to thank the CSS Insurance and the Swiss</title>
        <p>National Science Foundation for their support through
grants 159289 and 162724.
proposed, implemented and evaluated a breathing-based
self-regulation training with young patients afected by
obesity.</p>
        <p>However, the current work also points towards
opportunities for upcoming research. First and foremost, future
work may focus on environment-agnostic breathing
detection that generalizes among individuals, smartphones,
headsets, and various ”distracting” soundscapes. Second,
micro-randomized trials may be conducted to assess an
optimal balance of experiential vs instrumental interface
designs. Third, guided-biofeedback interfaces may limit
cheating in breathing, which, in turn, could reduce any
adverse breathing patterns. And finally, the impact of
self-regulation training on self-regulation skills and
relevant lifestyle behavior should be assessed in longitudinal
ifeld studies that target the prevention and treatment of
child and adolescents obesity.
self-regulation with obesity in boys vs girls in a PervasiveHealth’19, Association for Computing
us national sample, JAMA Pediatrics 172 (2018) Machinery, New York, NY, USA, 2019, p. 452–461.
842–850. doi:1 0 . 1 0 0 1 / j a m a p e d i a t r i c s . 2 0 1 8 . 1 4 1 3 . doi:1 0 . 1 1 4 5 / 3 3 2 9 1 8 9 . 3 3 2 9 2 3 7 .
[17] A. Pandey, D. Hale, S. Das, A.-L. Goddings, S.-J. [27] C.-H. Shih, N. Tomita, Y. X. Lukic, A. H. Reguera,
Blakemore, R. M. Viner, Efectiveness of univer- E. Fleisch, T. Kowatsch, Breeze: Smartphone-based
sal self-regulation–based interventions in children acoustic real-time detection of breathing phases for
and adolescents: A systematic review and meta- a gamified biofeedback breathing training, Proc.
analysis, JAMA Pediatrics 172 (2018) 566–575. ACM Interact. Mob. Wearable Ubiquitous Technol.
doi:1 0 . 1 0 0 1 / j a m a p e d i a t r i c s . 2 0 1 8 . 0 2 3 2 . 3 (2019) Article 152. doi:1 0 . 1 1 4 5 / 3 3 6 9 8 3 5 .
[18] M. Martin, M. Seppa, P. Lehtinen, T. Toro, [28] J. F. Hunter, M. S. Olah, A. L. Williams, A. C. Parks,
Breathing as a Tool for Self-Regulation and Self- S. D. Pressman, Efect of brief biofeedback via a
Reflection, Routledge, London, UK, 2016. doi: 1 0 . smartphone app on stress recovery: Randomized
4 3 2 4 / 9 7 8 0 4 2 9 4 7 2 5 7 2 . experimental study, JMIR Serious Games 7 (2019)
[19] Y.-Y. Tang, Y. Ma, J. Wang, Y. Fan, S. Feng, Q. Lu, e15974. doi:1 0 . 2 1 9 6 / 1 5 9 7 4 .</p>
        <p>Q. Yu, D. Sui, M. K. Rothbart, M. Fan, M. I. Pos- [29] S. B. Davis, P. Mermelstein, Comparison of
parametner, Short-term meditation training improves at- ric representations for monosyllabic word
recogtention and self-regulation, Proceedings of the Na- nition in continuously spoken sentences, IEEE
tional Academy of Sciences 104 (2007) 17152–17156. Transactions on Acoustics, Speech, and Signal
Prodoi:1 0 . 1 0 7 3 / p n a s . 0 7 0 7 6 7 8 1 0 4 . cessing 28 (1980) 357–366. doi:1 0 . 1 1 0 9 / T A S S P . 1 9 8 0 .
[20] N. Harvey, Mindful little yogis: self-regulation tools 1 1 6 3 4 2 0 .</p>
        <p>to empower kids with special needs to breath and [30] T. Rosenwein, E. Dafna, A. Tarasiuk, Y. Zigel,
Derelax, Singing Dragon, London, UK, 2018. tection of breathing sounds during sleep using
non[21] Z. Wang, A. Parnandi, R. Gutierrez-Osuna, Biopad: contact audio recordings, in: 36th Annual
InterLeveraging of-the-shelf video games for stress self- national Conference of the IEEE Engineering in
regulation, IEEE Journal of Biomedical and Health Medicine and Biology Society, 2014, pp. 1489–1492.
Informatics 22 (2018) 47–55. doi:1 0 . 1 1 0 9 / J B H I . 2 0 1 7 . doi:1 0 . 1 1 0 9 / E M B C . 2 0 1 4 . 6 9 4 3 8 8 3 .</p>
        <p>2 6 7 1 7 8 8 . [31] A. Kamis, M. Koufaris, T. Stern, Using an
attribute[22] A. L. Eva, N. M. Thayer, Learning to breathe: A based decision support system for user-customized
pilot study of a mindfulness-based intervention to products online: An experimental investigation,
support marginalized youth, Journal of Evidence- MIS Quarterly 32 (2008) 159–177. doi:1 0 . 2 3 0 7 /
Based Complementary &amp; Alternative Medicine 22 2 5 1 4 8 8 3 2 .</p>
        <p>(2017) 580–591. doi:1 0 . 1 1 7 7 / 2 1 5 6 5 8 7 2 1 7 6 9 6 9 2 8 . [32] F. D. Davis, Perceived usefulness, perceived ease
[23] M. C. Schumer, E. K. Lindsay, J. D. Creswell, Brief of use, and user acceptance of information
technolmindfulness training for negative afectivity: A sys- ogy, MIS Quarterly 13 (1989) 319–339. doi:1 0 . 2 3 0 7 /
tematic review and meta-analysis, Journal of Con- 2 4 9 0 0 8 .
sulting and Clinical Psychology 86 (2018) 569–583. [33] T. Kowatsch, D. Volland, I. Shih, D. Rüegger, F.
Kündoi:1 0 . 1 0 3 7 / c c p 0 0 0 0 3 2 4 . zler, F. Barata, A. Filler, D. Büchter, B. Brogle,
[24] A. Zaccaro, A. Piarulli, M. Laurino, E. Garbella, K. Heldt, P. Gindrat, N. Farpour-Lambert, D.
l’AlleD. Menicucci, B. Neri, A. Gemignani, How breath- mand, Design and Evaluation of a Mobile Chat App
control can change your life: A systematic review for the Open Source Behavioral Health Intervention
on psycho-physiological correlates of slow breath- Platform MobileCoach, Springer, Berlin; Germany,
ing, Frontiers in Human Neuroscience 12 (2018). 2017, pp. 485–489. doi:1 0 . 1 0 0 7 / 9 7 8 - 3 - 3 1 9 - 5 9 1 4 4 - 5 _
doi:1 0 . 3 3 8 9 / f n h u m . 2 0 1 8 . 0 0 3 5 3 . 3 6 .
[25] M. E. B. Russell, A. B. Scott, I. A. Boggero, C. R. [34] T. Kowatsch, W. Maass, I. P. Cvijikj, D. Büchter,
Carlson, Inclusion of a rest period in diaphragmatic B. Brogle, A. Dintheer, D. Wiegand, D. Durrer, R. Xu,
breathing increases high frequency heart rate vari- Y. Schutz, D. l. Dagmar, Design of a health
informaability: Implications for behavioral therapy, Psy- tion system enhancing the performance of obesity
chophysiology 54 (2017) 358–365. doi:1 0 . 1 1 1 1 / p s y p . expert and children teams, in: Proc 22nd
Euro1 2 7 9 1 . pean Conference on Information Systems (ECIS),
[26] S. Carlier, S. Van der Paelt, F. Ongenae, Tel Aviv, Israel, 2014.</p>
        <p>F. De Backere, F. De Turck, Using a serious [35] S. Haug, R. P. Castro, M. Kwon, A. Filler,
game to reduce stress and anxiety in children T. Kowatsch, M. P. Schaub, Smartphone use and
with autism spectrum disorder, in: Proceedings smartphone addiction among young people in
of the 13th EAI International Conference on switzerland, Journal of Behavioral Addictions 4
Pervasive Computing Technologies for Healthcare, (2015) 299–307. doi:1 0 . 1 5 5 6 / 2 0 0 6 . 4 . 2 0 1 5 . 0 3 7 .
[36] M. Kwon, D.-J. Kim, H. Cho, S. Yang, The
smartphone addiction scale: Development and validation
of a short version for adolescents, PLOS ONE 8
(2014) e83558. doi:1 0 . 1 3 7 1 / j o u r n a l . p o n e . 0 0 8 3 5 5 8 .
[37] Y. X. Lukic, C.-H. I. Shih, A. H. Reguera, A. Cotti,</p>
        <p>E. Fleisch, T. Kowatsch, Physiological responses
and user feedback on a gameful breathing
training app: Within-subject experiment, JMIR Serious
Games 9 (2021). doi:1 0 . 2 1 9 6 / 2 2 8 0 2 .</p>
      </sec>
    </sec>
  </body>
  <back>
    <ref-list />
  </back>
</article>