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  <front>
    <journal-meta />
    <article-meta>
      <title-group>
        <article-title>Application of Data-Driven Measures for Impeding COVID-19 Spread at an Academic Institution</article-title>
      </title-group>
      <contrib-group>
        <contrib contrib-type="author">
          <string-name>Minhao Zhang</string-name>
          <xref ref-type="aff" rid="aff0">0</xref>
        </contrib>
        <contrib contrib-type="author">
          <string-name>Geng Zhang</string-name>
          <xref ref-type="aff" rid="aff0">0</xref>
        </contrib>
        <contrib contrib-type="author">
          <string-name>Shengxi Zhang</string-name>
          <xref ref-type="aff" rid="aff0">0</xref>
        </contrib>
        <contrib contrib-type="author">
          <string-name>Zian Liu</string-name>
          <email>zliu@arcadia.edu</email>
          <xref ref-type="aff" rid="aff0">0</xref>
        </contrib>
        <contrib contrib-type="author">
          <string-name>Vitaly Ford</string-name>
          <email>fordv@arcadia.edu</email>
          <xref ref-type="aff" rid="aff0">0</xref>
        </contrib>
        <contrib contrib-type="author">
          <string-name>Victoria Turygina</string-name>
          <xref ref-type="aff" rid="aff1">1</xref>
        </contrib>
        <aff id="aff0">
          <label>0</label>
          <institution>Arcadia University</institution>
          ,
          <addr-line>450 S Easton Rd, Glenside, PA 19038</addr-line>
          ,
          <country country="US">U.S.A</country>
        </aff>
        <aff id="aff1">
          <label>1</label>
          <institution>Ural Federal University</institution>
          ,
          <addr-line>Prospekt Lenina, 51, Yekaterinburg, Sverdlovskaya oblast', Russia, 620075</addr-line>
        </aff>
      </contrib-group>
      <abstract>
        <p>Many U.S. universities are embracing the hybrid teaching modality thanks to the start of the COVID19 vaccinations and availability of online teaching tools. This work presents a continuation of our previous research, in which we analyzed and developed a methodology to inhibit COVID-19 spread on a university campus. We simulate the virus spread on campus, comparing   and   models, and examine how diferent course policies can afect the number of infected students. We demonstrate that we can achieve a safer environment on campus by moving a certain number of courses with the highest centrality values. Additionally, we analyze how the student flow rate can help reduce the  0 value representing the metric of how many other people an infected individual could infect. This work also presents the simulation analysis of the opened public places on campus and the application of the sensitivity analysis to develop the most eficient approach determining the exact courses that need to be moved online. We conclude with the recommendations and analysis results.</p>
      </abstract>
      <kwd-group>
        <kwd>eol&gt;COVID-19</kwd>
        <kwd>simulation</kwd>
        <kwd>university campus</kwd>
        <kwd>centrality parameter</kwd>
        <kwd>hybrid teaching</kwd>
      </kwd-group>
    </article-meta>
  </front>
  <body>
    <sec id="sec-1">
      <title>1. Introduction</title>
      <p>and develop the procedures that help us make policies that provide a valuable input on which
courses should be moved online, what to do with the public places like dining halls, and what
the most important parameters are (through the sensitivity analysis in section 3) that afect the
virus spread on campus.</p>
    </sec>
    <sec id="sec-2">
      <title>2. Simulation</title>
      <sec id="sec-2-1">
        <title>2.1. Model definition</title>
        <p>
          We compared two diferent simulation methods and selected the   model [
          <xref ref-type="bibr" rid="ref4">4</xref>
          ] according to
the characteristics of COVID-19. The advantage of the   model is that the incubation factor
is taken into account in the simulation process. In figure 1, we present the comparison of the
simulation results of   and   [
          <xref ref-type="bibr" rid="ref3">3</xref>
          ] models with  0 [
          <xref ref-type="bibr" rid="ref6">6</xref>
          ] set to 3.2. By using   , we can
obtain more useful information by the end of the simulated semester (specifically, the number
of students exposed) compared to the   model.
        </p>
      </sec>
      <sec id="sec-2-2">
        <title>2.2. Control group simulation</title>
        <p>
          Our control group represents the number of students being infected, assuming that the semester
is fully online. The data we use come from the CDC [
          <xref ref-type="bibr" rid="ref7">7</xref>
          ], and we apply the local region’s rate
of infection in the simulation of the control group (figure 2).
        </p>
        <p>The control group simulation results demonstrate that after 15 weeks in the fully online fall
semester, the total number of infected students could be 374. In the following section, we are
going to compare the control group’s results with the face-to-face semester under our proposed
measures to move only certain courses online.</p>
      </sec>
      <sec id="sec-2-3">
        <title>2.3. Simulation scenarios and outcomes</title>
        <p>In this section, we simulate the virus spread in the pessimistic, normal, and optimistic scenarios
(public places like the dining hall are assumed to be closed). To match our simulation as close
as possible with the complexities of the real situation on campus, we focus on the pessimistic
configuration as it describes the worst-case scenario. The following diagrams are built based on
the pessimistic scenario with the initial  0 set to 3.2. The results of the normal and optimistic
scenarios are also shown in table 1.</p>
        <p>We performed several simulation experiments and would like to share the results under 3
diferent policies presented in figures 3, 4, and 5.</p>
        <p>1. Policy #1: none of the courses are moved online and all students meet face-to-face.
2. Policy #2: five courses with the highest centrality are moved online.</p>
        <p>3. Policy #3: ten courses with the highest centrality are moved online.</p>
        <p>It can be seen that even under the most pessimistic circumstances, the number of infected
people can be reduced by moving five courses with the highest sensitivity online compared
with the control group. After moving 10 high sensitivity courses online, the number of infected
students decreased by 15.5%, from 374 to 316.</p>
        <p>Figure 1 demonstrates the diferent outcomes of moving a certain number of courses online
in a pessimistic scenario relative to the control group (fully online semester).</p>
        <p>We also simulated a special situation by closing certain classrooms every day with the
highest student flow rate (figure 6). The expected  0 value decreased by 38.63%, from 3.2 (default)
to 1.96, and the total number of infected students reduced to 115. We propose to move such
classes to other available classrooms, resulting in the lowest infection rate with the number of
infected students to be in the range from 115 to 374, depending on how many of those classes
can be relocated.</p>
      </sec>
      <sec id="sec-2-4">
        <title>2.4. Simulation analysis of opened public places</title>
        <p>One of the issues that are not addressed in the social network graph is the issue of students’
dining options. Considering that there are only a few places at Arcadia that could provide food
for students, their closure could become an inconvenience for everyone. However, opening
those buildings may bring students together again and speed up the spread of the virus, which
does not conform to the notion of reducing the number of face-to-face courses to protect the
health of students. Consequently, we also simulated the spread of the virus in the school if
we did not close public places like the dining hall (assuming all possible students have lunch).
For example, we studied each student’s schedule to determine if they could have lunch in the
canteen at noon (there are around 650 such students), and then we added it as a “lunch course”
in the social network to simulate the place where students may eat together. The expected
value of  0 increased by 2,769% (from 3.2 (default) to 88.63), meaning that almost all the students
would be infected. Figure 7 presents the simulation of opening dinning halls without moving
any courses online.</p>
        <p>To solve the dining problem, meals can be delivered to each student’s room or takeout meals
without contact could be arranged. Also, while processing the data, we were able to
determine the number of students that would possibly dine on campus at a given time because, for
instance, they had a break between the morning and afternoon classes. Based on this
information, Arcadia could estimate the outdoor seating needs at a given time and provide a suficient
number of tables and chairs on campus, taking into consideration that not all students dine in
public places on campus.</p>
        <p>Additionally, other public places like gyms can set up isolation zones for each part of the
equipment and limit the number of people using the gym at a time.</p>
      </sec>
    </sec>
    <sec id="sec-3">
      <title>3. Sensitivity Analysis</title>
      <p>The purpose of this project is to reduce the number of infected students in a face-to-face
semester as much as possible and make sure that the risk of being infected on campus is lower
than the one in the local region, making it a safer educational environment. At the same time,
we hope to change the curriculum (shift a certain number of courses online) as little as
possible. Therefore, we focus on developing the most eficient approach to determine the courses
that need to be moved online. To better understand our results from section 2, we performed a
sensitivity analysis to determine the changes and correlations in our model depending on the
input variables simulating the virus transmission.
3.1. Sensitivity results for parameters in  0 simulation
We compared the efects of each parameter on the results with parameter changes of -30%,
-10%, 10%, and 30%, and presented them on figure 8, in which:
•  is the speed rate at which students change from being “susceptible” to being
“infectious” (i.e., the infection rate). Its value can be roughly calculated by the product of  0
and the recovery rate.
•  is the speed rate at which students change from being “exposed” to being “infectious”
(i.e., the incubation rate). Its function is defined as 1/   .
•  is the speed rate at which students change from being “infectious” to being “recovered”
(i.e., the recovery rate). Its function is defined as 1/    .</p>
      <p>The  parameter can be simply understood as the number of days that a student can
continuously infect others before being tested (and later quarantined) or beginning to show
symptoms. Therefore, it is particularly important to detect asymptomatic or latent patients as early
as possible, directly reducing the average number of infections per patient. Therefore, it is
necessary for the schools to conduct regular tests when possible. With enough testing equipment,
smaller campuses like Arcadia could eficiently conduct virus tests, reflecting an advantage of
school opening because students can be constantly organized and tested. Regular testing is
comparatively more dificult to implement in the wider community, often leading to family
and community clustering infections.</p>
    </sec>
    <sec id="sec-4">
      <title>4. Discussion and Conclusion</title>
      <p>
        Based on the simulation results, sensitivity analysis, and rectified centrality formula, we can
answer the following questions that we defined in the previous work [
        <xref ref-type="bibr" rid="ref2">2</xref>
        ].
      </p>
      <p>Question #1: “would schools be able to stay open during COVID-19 by moving high
sensitivity classes and students online?” The simulation results demonstrate that it is possible, as long
as the school follows the policies we proposed and all assumptions we made are true. Even
under a pessimistic  0 set to 3.2, the number of infected students at Arcadia could be 316 after
moving 10 classes with the highest centrality online, which is still lower than 374 (the predicted
value of infected students made if the semester is fully online). But this result is based on the
assumption that students would follow safety practices, reduce other forms of contact as much
as possible in addition to basic academic activities, and all students, faculty, and staf could
be tested before returning to and while being on campus. We found that even if all students
take classes online, they will still be exposed to an environment where  0 equals 3 and 374
students could get infected at the end of the semester. Therefore, returning to school based on the
proposed policies can achieve a lower infection rate and provide better protection to students
compared with the fully online semester. However, it should be noted that the school’s dining
places and gyms should be closed, otherwise almost all students would be infected.</p>
      <p>Question #2: “How many students would be infected compared to the model without
converting classes to an online format?” If we do not convert any courses to the online format, the
number of infected students in the optimistic scenario would be 120, in the normal scenario it
would be 217, and in the worst-case pessimistic scenario it would be 456.</p>
      <sec id="sec-4-1">
        <title>4.1. Supplemental statistical data evaluation</title>
        <p>
          Some of the notable characteristics of the data that we worked with are presented below.
• The average and maximum numbers of students that one student may be exposed to
while taking classes on campus throughout a week are:  = 175;  = 66.
• Courses with the respective values of diferent degrees of centrality were shown in a
table in [
          <xref ref-type="bibr" rid="ref2">2</xref>
          ]. We used these data to decide which courses to move online, reducing the
connections among all students based on the values of rectified centrality in section 2.
• The average number of students per class is 12 which is lower than usual.
• Based on the flow rate analysis, we identified several high flow rate classrooms for every
day of the week.
        </p>
        <p>• There are a total of 61,186 pairs of students who are directly connected.</p>
      </sec>
      <sec id="sec-4-2">
        <title>4.2. Recommendations</title>
        <p>
          Our final recommendations based on the simulation results and analysis are presented below.
• It is possible to reduce the  0 value by moving high sensitivity courses online.
• The dining places should be closed. We proposed alternative options in section 2.4.
• Temperature-measuring devices [
          <xref ref-type="bibr" rid="ref8">8</xref>
          ] that can remotely determine body temperature are
needed in every room. As schools plan to reopen during the pandemic, non-contact
temperature assessment devices will play an important role in every classroom. As part
of the first check to identify people who have an elevated body temperature, these devices
can help students, faculty, and staf conduct preliminary self-examinations every day,
ensuring that patients with symptoms can be isolated in time.
• Instructors should avoid running multiple classes one after another in the same
classroom to prevent a potential virus accumulation over time. In section 2.3, the data showed
that  0 could decrease from 3.2 to 1.96 by determining the classrooms with a high flow
rate and moving some of those courses into the classrooms with a low flow rate.
• Student gatherings (clubs, events) should only be allowed in masks outside of buildings.
• All faculty and staf meetings should be moved online.
• Weekly virus testing should be conducted. If it is not feasible to conduct it for everyone,
a random sampling of students from diferent departments could be a viable option.
        </p>
      </sec>
    </sec>
    <sec id="sec-5">
      <title>Acknowledgements</title>
      <p>We would like to thank the Computer Science and Math Department, Arcadia University, for
providing support and help during this research.</p>
    </sec>
  </body>
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