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  <front>
    <journal-meta />
    <article-meta>
      <title-group>
        <article-title>Roles and Their Siblings in Basic Formal Ontology</article-title>
      </title-group>
      <contrib-group>
        <contrib contrib-type="author">
          <string-name>Fumiaki Toyoshima</string-name>
          <email>fumiakit@buffalo.edu</email>
          <xref ref-type="aff" rid="aff0">0</xref>
        </contrib>
        <aff id="aff0">
          <label>0</label>
          <institution>Graduate School of Advanced Science and Technology, Japan Advanced Institute of Science and Technology</institution>
          ,
          <addr-line>Nomi</addr-line>
          ,
          <country country="JP">Japan</country>
        </aff>
      </contrib-group>
      <fpage>2</fpage>
      <lpage>10</lpage>
      <abstract>
        <p>Roles are entities that pervade our everyday life as well as biologists' and medical specialists' actual practice. Their nature nonetheless remains nebulous in spite of a large amount of recent research on it in various disciplines. This paper aims to provide an in-depth study of the term 'role' in alignment with an upper ontology Basic Formal Ontology (BFO). Closer examination reveals that the meanings of the term 'role' can be well disambiguated in terms of five BFO categories: a generically dependent continuant, a site, a role, a disposition, and a function. We also discuss the BFO characterization of role and its practical utility in the biomedical field with a focus on its relation with the BFO methodological principle of ontological realism and other BFO realizable entities: dispositions and functions.</p>
      </abstract>
      <kwd-group>
        <kwd>role</kwd>
        <kwd>Basic Formal Ontology (BFO)</kwd>
        <kwd>ontological realism</kwd>
      </kwd-group>
    </article-meta>
  </front>
  <body>
    <sec id="sec-1">
      <title>-</title>
      <p>
        Talk of roles is ubiquitous in our ordinary life and in a number
of different academic fields, ranging from knowledge
representation [
        <xref ref-type="bibr" rid="ref1">1</xref>
        ] and conceptual modeling [
        <xref ref-type="bibr" rid="ref2">2</xref>
        ] to cognitive
science and linguistics. Several examples of expressions
comprising the term ‘role’ are listed below:
      </p>
    </sec>
    <sec id="sec-2">
      <title>A passenger plays the role of a pilot on a commercial plane in an emergency. [3, p. 58]</title>
    </sec>
    <sec id="sec-3">
      <title>Jane’s being the seventh person to fill the role of director of this institute [4, p. 100]</title>
    </sec>
    <sec id="sec-4">
      <title>Joe’s being the third person to play a particular role in a play [4, p. 101]</title>
    </sec>
    <sec id="sec-5">
      <title>A pyramidal neuron plays the role occupied by a damaged stellar neuron in the brain. [3, p. 58]</title>
    </sec>
    <sec id="sec-6">
      <title>Jim has the role of a nurse. [4, p. 100]</title>
      <p>the role of a stone in marking a boundary [4, p. 100]
the role of a magnet to attract iron objects
the role of the heart to pump blood
Roles are vital to biomedical ontologies at least in two respects.</p>
      <p>
        First, the term ‘role’ is frequently used in the biomedical
literature: e.g., “the specific role of calcium in preventing
disease.” Second, healthcare systems would not be completely
accounted for unless their organizational structure is
wellspecified in terms of roles, or especially so-called ‘social roles’
[
        <xref ref-type="bibr" rid="ref5 ref6">5,6</xref>
        ]. Examples of those medical roles include healthcare
providers (e.g., doctors and pharmacists), receivers (e.g.,
patients), and policy makers (e.g., members of the World Health
Organization). Therefore, a deeper understanding of roles will
contribute to a robust construction and an effective utilization of
biomedical ontologies.
      </p>
      <p>
        Roles nevertheless remain nebulous entities, although they have
been extensively researched in foundational ontology research
for the last few decades [
        <xref ref-type="bibr" rid="ref7">7</xref>
        ]. For instance, it is a long-standing
issue whether there is any single definition of role, some prior
attempts [
        <xref ref-type="bibr" rid="ref2 ref8">2,8</xref>
        ] to offer it notwithstanding. Moreover, it is still a
worthwhile challenge to provide a generic characterization of
multiple meanings of role within a single theoretical framework.
      </p>
      <p>
        Despite some endeavors to meet it [
        <xref ref-type="bibr" rid="ref10 ref9">9,10</xref>
        ], little careful
consideration has been given to a general ontology of roles
visà-vis the biomedical domain.
      </p>
      <p>
        In this paper we provide a close ontological investigation into
the meanings of the term ‘role’ with an emphasis its usage of the
term ‘role’. To do so, we exploit Basic Formal Ontology (BFO)
[
        <xref ref-type="bibr" rid="ref3 ref4">3,4</xref>
        ] as an upper ontology (aka foundational ontology), namely
an ontology to furnish the most general categories (e.g., space
and time) and relations (e.g., identity and parthood) to serve as a
useful guideline for building domain ontologies of high semantic
interoperability. The BFO-based exploration of the term ‘role’
would be of great value for biomedical ontologies because the
practical utility of BFO to them is shown by the achievement of
the Open Biomedical Ontologies (OBO) Foundry [
        <xref ref-type="bibr" rid="ref11">11</xref>
        ]: a
collaborative project to coordinate ontologies to support
biomedical data integration such that BFO can provide a
common semantic basis for all the OBO ontologies.
      </p>
      <p>In the most basic BFO framework, entities fall into two kinds:
universals (aka types, classes) and particulars (aka tokens,
instances). Particulars (e.g., Mary) bear the instance-of relation
to universals (e.g., Human). Particulars, on which we place a
primary focus in this paper, fall into two categories: continuants
and occurrents. Characteristically, continuants can persist, that is
to say, they can exist at one time and also exist at another
different time; whereas occurrents (including processes) extend
through time. Continuants can be further divided into
independent continuants (including objects) and dependent
continuants (intuitively: properties). Independent continuants, or
especially objects (e.g., stones) can be bearers of dependent</p>
      <p>Copyright © 2019 for this paper by its author. Use permitted under Creative Commons License Attribution 4.0 International (CC BY 4.0).
continuants (e.g., hardness) and they can also participate in
occurrents (e.g., a fall of the stone).</p>
      <p>
        For this purpose, we draw upon Toyoshima’s [
        <xref ref-type="bibr" rid="ref12">12</xref>
        ] thesis that,
based on a detailed analysis of upper ontologies, there are (at
least) three closely intertwined notions of role at a foundational
level: a role specification, a role position, and a role potential. It
is found on closer examination that those three facets of roles
(and other meanings of the term ‘role’) can be well-defined in
terms of some existing BFO categories. This would also testify
to the explanatory force of BFO (with regard to roles) as
compared to its relative smallness among upper ontologies.
      </p>
      <p>
        The paper is structured as follows. Section II presents
Toyoshima’s [
        <xref ref-type="bibr" rid="ref12">12</xref>
        ] argument for three roles. Section III analyzes
from the BFO viewpoint those three aspects of role and other
possible meanings of the term ‘role’. Section IV discusses the
BFO notion of role, its connections with the BFO principle of
ontological realism as well as the BFO categories of disposition
and function, and its practical utility in the biomedical domain.
      </p>
      <p>Section V concludes the paper with some brief remarks on
future possible directions of research.</p>
      <p>II.</p>
      <sec id="sec-6-1">
        <title>Three Facets of Roles</title>
        <p>
          Toyoshima [
          <xref ref-type="bibr" rid="ref12">12</xref>
          ] examines some preceding accounts of role,
being motivated to know which ontological conception of role is
suitable for which type of conceptual modeling. He then
hypothesizes that different theories of role might depend on
different ‘role choices’ made by the theories: choices as to
which is most fundamental among ‘three facets’ of role (which
he calls the ‘role triad’), or its three main ontological
interpretations: namely, a role specification, a role position, and
a role potential. On his view, the role triad would defy explicit
analysis, but it can be elucidated by analogy and illustrated with
the question of what it is supposed to mean to say, e.g., that
Mary is a student of University at Buffalo (UB), given the fact
that a student is taken to be a paradigmatic example of role and
Mary bears a student role, or simply Mary is a role-bearer.
One approach to Mary’s studentness focuses on the deontic or
normative dimension of her student role. Mary must gain
admission to UB in order to become a UB student. To enjoy a
full-time student status, she needs to register for a certain
number of credit hours per semester. She is also required to
defend her dissertation to obtain a doctoral degree from UB.
Mary’s studentness is thus explicable in terms of the satisfaction
of the constraints or conditions that are, so to speak, ‘embedded’
in her student role.
        </p>
        <p>
          This observation would lead to an analogy between a role and a
specification. The ontological nature of a specification remains
obscure, but Turner [
          <xref ref-type="bibr" rid="ref13">13</xref>
          ] maintains insightfully that a
specification is something that has “correctness jurisdiction over
an artefact” [13, p. 147]. By ‘correctness jurisdiction’ he means
that the specification places “empirical demands on the physical
device” [13, p. 144]. If an artifact is not built to a certain
specification, the artifact is defective with respect to that
specification. Duncan [
          <xref ref-type="bibr" rid="ref14">14</xref>
          ] illustrates this point as follows: “For
example, if I build a physical implementation of a stack and the
device does not allow me to add and remove items from the top
of the device, my device is defective relative to the specification
of a stack” [14, pp. 16-17]. Quite importantly, Turner considers
specifications as intentional: “Our intentional stance determines
what we take to be the specification: something is a specification
if we give it normal force over the construction of an artefact”
[13, p. 147].
        </p>
        <p>
          A role specification refers to a role that is understood by analogy
with a specification and role-bearing is interpreted as meeting a
role specification. On this specification view of role, a
rolebearer is to its role what an artifact is to its specification. In this
respect, roles and artifacts are closely linked from a modeling
perspective [
          <xref ref-type="bibr" rid="ref15">15</xref>
          ]. In the U.S., for instance, an aircraft has to meet
the strict specification laid down by the Federal Aviation
Administration (FAA). This means that an aircraft-like
aggregate of mechanical parts is not an aircraft unless it is
constructed exactly to the FAA specification. Likewise, UB has
drawn up intentionally its ‘student role specification’ (e.g.,
admission requirements), and Mary fails to be a student (in other
words: to bear a student role) unless she satisfies the UB-student
role specification.
        </p>
        <p>
          Despite their striking similarity, a role specification and a
specification (resp. a role-bearer and an artifact) differ greatly
from each other at least in two points. First, they are temporally
different: a role specification and a role-bearer are temporary
(time-relative) but a specification and an artifact are permanent
(time-insensitive). For instance, an American aircraft emerges
when it is built to the FAA specification and it continues to exist
until it is physically destroyed; whereas, Mary is a UB student as
long as she meets a UB-student role specification and she can
survive even after ceasing to be a student. Second and
connectedly, they are modally contrary: the former are
contingent (accidental) but the latter are necessary (essential).
(Note that, pace Fine [
          <xref ref-type="bibr" rid="ref16">16</xref>
          ], we lightly assume throughout this
paper a conceptual overlap between modality and essentiality
merely for a practical purpose.) While artifactness (e.g.,
FAAaircraftness) constitutes the essence of an American aircraft, for
example, roleness (e.g., UB-studentness) is inessential to Mary.
It must be emphasized that temporality and
contingency/accidentality are key characteristics of a general
notion of role irrespective of which role choice is taken.
B)
        </p>
        <sec id="sec-6-1-1">
          <title>Role Position</title>
          <p>Another possibility for understanding Mary’s studentness is
based on the kind of situation in which Mary bears a student
role. As a UB student, Mary can use various facilities and enjoy
educational opportunities (e.g., taking classes). Mary’s
studenteness may then consist in the fact that she locates herself
in a specific ‘sphere’ or ‘position’ where she can do something
role-related.</p>
          <p>
            A role as conceptualized this way is analogous with a relative
place [
            <xref ref-type="bibr" rid="ref17">17</xref>
            ]. Given the Newtonian conception of absolute space,
both absolute places and relative places persist and may be
occupied by various (material) objects at various times. Unlike
absolute places (which are parts of absolute space that are
independent of objects), relative places stand in fixed spatial
relations with one or more objects (reference objects [
            <xref ref-type="bibr" rid="ref17">17</xref>
            ]).
Examples include places in and around a ship whose reference
object is the ship.
          </p>
          <p>
            A role position means a role that is figured out by analogy to a
relative place and role-bearing is construed as occupying a role
position. Seen from this positional perspective, roles stand in
fixed ‘conceptual’ relations towards one or more entities, which
may be sometimes called ‘context’ in the relevant literature
[
            <xref ref-type="bibr" rid="ref10 ref18">10,18</xref>
            ]. (Note that, despite Smith’s [
            <xref ref-type="bibr" rid="ref19">19</xref>
            ] warning against
concepts in ontology research, we are using the term
‘conceptual’ in its broad sense as a kind of placeholder. Its
precise meaning should be further clarified in the future
investigation.) In bearing a UB-student role, for example, Mary
occupies the student role position that exists relative to UB.
The analogy between role positions and relative places would
shed light on the alleged relational nature of roles [
            <xref ref-type="bibr" rid="ref20 ref7 ref8">7,8,20</xref>
            ]. One
salient feature of relative places is that they may move relative
to one another when their reference objects move relative to one
another. Using Donnelly’s [
            <xref ref-type="bibr" rid="ref17">17</xref>
            ] example, when a ship moves
relative to the earth, places with the ship as their reference object
(e.g. the ship’s hold) move relative to places with the earth as
their reference object. In a similar vein, role positions may
‘conceptually move’ relative to one another when their contexts
‘conceptually move’ relative to one another. For instance, when
a human resource department changes its importance with
respect to its company, personnel director role positions (whose
context is the human resource department) change their
relationship with executive role positions (whose context is the
company).
          </p>
        </sec>
      </sec>
      <sec id="sec-6-2">
        <title>III. Roles and Their Siblings in BFO</title>
        <p>
          In this section we delineate into which BFO category falls each
of the role triad (a role specification, a role position, and a role
performance) and other ontological accounts of the term ‘role’.
We also illustrate them with the examples (1)-(8) listed in
Section I. Note that this section draws partially upon Toyoshima
[
          <xref ref-type="bibr" rid="ref12">12</xref>
          ] (especially its Section 4.3).
        </p>
        <p>We introduce a fine-grained classification of dependent
continuants for the sake of future argument. In BFO, there are
two kinds of dependent continuants. One is a specifically
dependent continuant: “A continuant entity that depends on
precisely one independent continuant for its existence. The
former is dependent on the latter in the sense that, if the latter
ceases to exist, then the former will as a matter of necessity
cease to exist also” [4, p. 185]. Examples include the mass of a
kidney and the shape of a hand.</p>
        <p>The other is a generically dependent continuant: “A continuant
that is dependent on one or other independent continuants and
can migrate from one bearer to another through a process of
copying. We can think of generically dependent continuants as
complex continuant patterns either of the sort created by authors
or designers or (in the case of DNA sequences) brought into
being through the processes of evolution” [4, p. 179]. Examples
include the pdf file on Mary’s laptop and the pdf file that is a
copy thereof on John’s laptop. Characteristically, a generically
dependent continuants exists only if it is concretized in some
counterpart specifically dependent continuant. To take one
example, a paragraph of a novel in concretized in each pattern
(quality) of ink on the pages of the printed novel.</p>
        <p>One subtype of specifically dependent continuant is a realizable
entity (subtypes of which are to be discussed in detail below):
“A specifically dependent continuant entity that has at least one
independent continuant as its bearer, and whose instances can be
realized (manifested, actualized, executed) in associated
processes of specific correlated types in which the bearer
participates” [4, p. 183]. Examples include the role of being a
doctor, the disposition of a fragile glass to break, and the
function of a hammer to hit nails.</p>
        <p>A)</p>
        <sec id="sec-6-2-1">
          <title>Role Specification as a BFO-generically Dependent</title>
        </sec>
        <sec id="sec-6-2-2">
          <title>Continuant</title>
          <p>
            A role specification would be most reasonably classified as a
generically dependent continuant. For one thing, a specification
is plausibly taken to be a generically dependent continuant.
Duncan [
            <xref ref-type="bibr" rid="ref14">14</xref>
            ] analyzes Turner’s [
            <xref ref-type="bibr" rid="ref13">13</xref>
            ] conception of specification
on the basis of BFO and contends that it is a kind of information.
To our eyes, information is naturally seen as a generically
dependent continuant because it obeys the ‘rule of migration’.
For another, an ontological theory of role that endorses
explicitly a role specification can be construed in the BFO
fashion as a commitment to the view that a role is a generically
dependent continuant. Masolo et al. [
            <xref ref-type="bibr" rid="ref8">8</xref>
            ] propose a general
framework for social roles in compliance with an upper ontology
the Descriptive Ontology for Linguistic and Cognitive
Engineering (DOLCE) [
            <xref ref-type="bibr" rid="ref21">21</xref>
            ]. At the nub of their argument is that
social roles are fundamentally characterized by the DOLCE
entity of description. As Toyoshima [
            <xref ref-type="bibr" rid="ref12">12</xref>
            ] argues, they take a
specification approach to role and a DOLCE-description could
be well conceived as a generically dependent continuant that is
connected to agents’ intentionality.
          </p>
          <p>Examples (1)-(3) are explicable in terms of a role specification
as a generically dependent continuant (see [5, p. 101] concerning
Examples (2)-(3)). In Example (1), a pilot role of a passenger
means a generically dependent continuant whose bearers are
passengers, or especially those who know well about the
operation of the plane. In Example (2), the role of director of the
institute depends generically on people (including Jane) with
some qualifications (e.g., age and career). In Example (3), the
particular role in the play can migrate among actors (such as
Joe), e.g., with a certain level of acting proficiency.</p>
          <p>B)</p>
        </sec>
        <sec id="sec-6-2-3">
          <title>Role Position as a BFO-site</title>
          <p>The BFO categorization of a role position would be more
controversial than that of a role specification owing to the still
unclear character of the former. A role position is however
arguably most persuasively regarded as a site. A site is “a
threedimensional immaterial entity that either (1) is (partially or
wholly) bounded by a material entity or (2) is a
threedimensional immaterial part of an entity satisfying (1)” [4, p.
112], where a material entity is an “independent continuant that
has some portion of matter as part, is spatially extended in three
dimensions, and that continues to exist through some interval of
time, however short” [4, p. 180] and an immaterial entity is an
“independent continuant that contains no material entities as
parts” [ibid.]. Examples of sites include a rabbit hole, Mary’s
nasal cavity, and a kangaroo pouch.</p>
          <p>
            A site-based perspective on a role position has its advantages
and disadvantages. A site obviously represents the BFO way of
incorporating a relative place (see e.g., [
            <xref ref-type="bibr" rid="ref22 ref23">22,23</xref>
            ]), and it would be
straightforward to label a role position as a site. On the other
hand, a role position would be considerably different from a site
in the sense of not being explicitly bound or demarcated in
relation to material entities. In the Mary-student example, it
might be possible to think that Mary’s role position is the kind
of site that is formed with respect to physical buildings
possessed by UB, but only with a worry over a somewhat
arbitrary reification of role positions. It is nonetheless equally
true that there is no other promising BFO-categorical candidate
for a role position. Finally, Example (4) can be well explained
from the viewpoint of a role position as a site: the role of the
damaged stellar neuron refers to a site that is identified relative
to the brain (context) and it is now ‘occupied’ by the pyramidal
neuron.
          </p>
          <p>C)</p>
        </sec>
        <sec id="sec-6-2-4">
          <title>Role Potential as a BFO-role</title>
          <p>It is not hard to see that a role potential accords well with the
BFO category of role: “A realizable entity that (1) exists because
the bearer is in some special physical, social, or institutional set
of circumstances in which the bearer does not have to be, and (2)
is not such that, if this realizable entity ceases to exist, then the
physical make-up of the bearer is thereby changed. A role is thus
always optional” [4, p. 184]. Given the BFO conception of role,
for instance, Mary is a UB student in virtue of her student role
that can be realized in, e.g., a process of her using a student
discount. This would mean that a BFO-role is closely akin to a
circumstantial ability, which underlies the idea of a role
potential.</p>
          <p>As said above, the potential view of role would require
elucidation of roles and other comparable entities such as
dispositions and functions. This issue is to be addressed in
Section IV. In addition, it will be also discussed there the
question of why BFO takes a potential-centered approach to
role. Examples (5)-(6) are interpretable in terms of a role
performance as a role. In Example (5), Jim’s nurse role is a role
that can be realized in processes of his taking care of sick or
injured people. In Example (6), the stone in question bears a role
that can be realized in a process of boundary demarcation.</p>
          <p>‘Role’ as a BFO-disposition
We have above pondered three facets of role and their BFO
categories, but the term ‘role’ may be too polysemous to be
understood in terms of the ontological notion of role alone.
Consider Example (7): ‘the role of a magnet to attract iron
objects’. None of the role triad captures the meaning of the term
‘role’ of this example. In particular, a magnet attracts iron
objects permanently and essentially rather than temporally and
accidentally. We submit that, contrary to its linguistic surface,
the term ‘role’ thereof refers to the BFO entity of disposition. A
disposition is: “A realizable entity (a power, potential, or
tendency) that exists because of certain features of the physical
makeup [material basis] of the independent continuant that is its
bearer” [4, p. 178, with our supplementary explanation]. A
classical example of a disposition is fragility: the disposition to
break when pressed with a certain force. More specifically,
fragility of a glass is the disposition of the glass (bearer) to break
(realization) that depends on a particular physical molecule
structure (material basis) of the glass.</p>
          <p>In BFO, dispositions sharply contrast with roles in terms of
‘groundedness’. Dispositions are internally grounded: if a
disposition ceases to exist, then its bearer is physically changed.
Roles are externally grounded in the sense that this is not the
case; see the item (2) of the BFO definition of role. The BFO
grounding differentiation between dispositions and roles would
mesh with our temporal and modal one between artifactness and
role. When a bearer (whether natural or artifactual) of a
disposition fails to have the disposition, the bearer may
sometimes (if not always) lose its essence. An aircraft would be
no longer an aircraft when it loses a disposition to fly, for
example. In that case, the disposition of a bearer determines the
essence of the bearer (or at least serves to do so). In Example
(7), a magnet has a disposition to attract iron objects and this
disposition embodies the essence of the magnet. However, a
bearer of a role is always the same physically even when the
bearer loses that role, and a role is a mere accidental feature of
its bearer. Mary remains physically unchanged when she is
admitted to UB, and her studentness is (ontologically) irrelevant
to her essential nature (which may be extremely difficult to
define explicitly, though).</p>
          <p>E)</p>
          <p>
            ‘Role’ as a BFO-function
The dispositional clarification of the term ‘role’ extends to the
BFO category of function because BFO, or precisely the latest
version of BFO (BFO 2.0) conceives function dispositionally
[
            <xref ref-type="bibr" rid="ref24">24</xref>
            ] (see [
            <xref ref-type="bibr" rid="ref25 ref26">25,26</xref>
            ] for criticism): “A function is a special kind of
disposition. It is a realizable entity whose realization is an
enddirected activity of its bearer that occurs because this bearer is
(a) of a specific kind and (b) in the kind or kinds of contexts that
it is made or selected for. Thus a function is a disposition that
exists in virtue of the bearer’s physical make-up, and this
physical make-up is something the bearer possesses because of
how it came into being --- either through natural selection (in the
case of biological entities) or through intentional design (in the
case of artifacts)” [4, pp. 102-103].
          </p>
          <p>To illustrate this, consider Example (8): ‘the role of the heart to
pump blood’. First of all, the heart has a disposition to pump
blood: it depends on a certain organic structure of the heart and
the heart would undergo physical change when it loses this
disposition. Analyzed more meticulously, the disposition of the
heart to pump blood is a function of the heart because it has
emerged through evolutionary processes of the organism. To
take another example, consider the phrase ‘the role of an aircraft
to carry goods or passengers’. In ontological parlance, an aircraft
has a function (but not a role) to carry good or passengers
because the aircraft has been designed and produced to do so. A
relationship between role and function is however further
complicated by the issue of ‘use function’ to be addressed in
Section IV.</p>
        </sec>
      </sec>
      <sec id="sec-6-3">
        <title>IV. Discussion</title>
        <p>A)</p>
        <sec id="sec-6-3-1">
          <title>The Role Triad in BFO and Ontological Realism</title>
          <p>
            Although we have identified the five BFO meanings of the term
‘role’, questions remain about a detailed description of the BFO
conception of the role triad. Here three of them will be brought
up for discussion. First, why does BFO put a premium on a role
potential, as is supported by the finding that it is classified as a
role in BFO? Toyoshima [
            <xref ref-type="bibr" rid="ref12">12</xref>
            ] holds that there is a strong
correlation between role choices of upper ontologies and their
meta-ontological choices [
            <xref ref-type="bibr" rid="ref27">27</xref>
            ]: roughly, choices that are
fundamental enough to determine ontological choices [
            <xref ref-type="bibr" rid="ref21">21</xref>
            ],
namely choices as to whether and how a certain ontological
category or relation is adopted. The DOLCE theory of role
focuses on a role specification, for instance, because DOLCE
aims to represent categories with a clear cognitive bias that are
associated with e.g., human cognition and socio-cultural artifacts
(which is a DOLCE meta-ontological choice), and a role
specification is arguably the most cognitive and/or linguistic
way of understanding roles in the sense of emphasizing their
intentional aspect.
          </p>
          <p>
            Toyoshima [
            <xref ref-type="bibr" rid="ref12">12</xref>
            ] attributes the BFO role choice of a role
potential to the BFO meta-ontological adoption of ontological
realism [
            <xref ref-type="bibr" rid="ref28">28</xref>
            ] (see [
            <xref ref-type="bibr" rid="ref29 ref30">29,30</xref>
            ] for criticism): “The realist
methodology is based on the idea that the most effective way to
ensure mutual consistency of ontologies over time and to ensure
that ontologies are maintained in such a way as to keep pace
with advances in empirical research is to view ontologies as
representations of the reality that is described by science. This is
the fundamental principle of ontological realism” [28, p. 139]. It
is a rather complicated matter to assess exactly what ontological
realism entails (see e.g., [
            <xref ref-type="bibr" rid="ref31">31</xref>
            ]), but one plausible corollary of this
policy would be that BFO-based ontologies should maximize
symbiosis with empirically scientific inquiry, which would
imply in turn that the BFO notion of role should be consistent
with scientific activities. This results reasonably in the BFO
choice of a role potential because scientists typically focus on
the structure and behavior of the natural world. To investigate
the human mind, for instance, contemporary cognitive scientists
and psychologists tend to highlight the importance of people’s
behaviors such as their facial expressions and actions. Taken
with a scientific attitude, roles (e.g., Mary’s student role) would
be preferably ontologized in terms of externally observable
performances of role-bearers (e.g., Mary’s using a student
discount).
          </p>
          <p>
            Second, how can a role specification and a role position be
described or defined given the BFO performance-oriented view
of role? This amounts to the problem of what kind of generically
dependent continuant (resp. site) is a role specification (resp. a
role position), assuming the ontology-design method of the
Aristotelian definition [
            <xref ref-type="bibr" rid="ref32">32</xref>
            ] where a term can be defined by dint
of a genus (as a species with a differentia). The identity of a
generically dependent continuant is a highly debatable topic (see
e.g., [
            <xref ref-type="bibr" rid="ref33 ref34 ref6">6,33,34</xref>
            ]); and so is a site (but see [
            <xref ref-type="bibr" rid="ref17">17</xref>
            ] for some thoughts).
We can safely say however that both of the definitions of a role
specification and a role position should comprise the BFO term
‘role’ since it is so paramount as to ground all other role-related
notions in BFO; and that a role specification needs to be
constrained at least by its bearer and its concretization, and a
role position at least by which material entity bounds or
demarcates it.
          </p>
          <p>Taking all this into consideration, first of all, it is reasonable to
think that a role specification has as its bearer a bearer of a role
and it is also concretized in the role of the bearer. Suppose for
instance that, in Example (2), Bob was the sixth director of the
institute. In this scenario, Jane’s director role differs from Bob’s,
but they both concretize the same role specification to the effect
that, e.g., a director of the institute is in charge of activities of
the members of the institute. Next, informally speaking, a role
position would be plausibly relativized to the context in which a
certain independent continuant can have some role. It could be
further added that a role position can be occupied by the
rolebearer under discussion. In Example (4), a role position exists in
relation with the brain and it was at first occupied by a healthy
stellar neuron, but later it is by the pyramidal neuron. Finally,
preliminary definitions of a role specification and a role position
are provided as follows:
•</p>
          <p>BFO-role specification =def. a generically dependent
continuant (i) whose bearer has a role and (ii) that is
concretized in the role of the bearer.
• BFO-role position =def. a site that (i) exists relative to
the special physical, social, or institutional set of
circumstances in virtue of which an independent
continuant can have a role and (ii) can be occupied by
the role-bearer.</p>
          <p>It should be noted that the item (i) of the definition of a role
position depends on part of the BFO existing definition of a role;
and that a role position does not always need to be occupied by
some role-bearer and it can be occupied by different role-bearers
at different times. We intend to leave room for the flexibility of
role positions so that they could help to solve some existing
problems with a BFO-role (see below for details).</p>
          <p>
            Third and lastly, why does BFO specify only the role-having
relation (has_role) but not the role-playing one [3, p. 58]? As is
indicated by Examples (1), (3), and (4), talk of role-playing is
quite commonplace in our everyday life. It is however
contentious whether and how the phrase ‘plays a role’ should be
taken with ontological seriousness (see e.g., [
            <xref ref-type="bibr" rid="ref35">35</xref>
            ]). One tenable
idea would be that role-playing conveys the level of achievement
of role-related goals. Mary’s behavior is evaluable by a criterion
(e.g., obtained credits) for being a student, for instance. Different
role choices would yield different understandings of role-playing,
namely as meeting a role specification, as occupying a role
position, or as having a role potential. Characteristic of the BFO
construal of role is to reduce the alleged role-playing to
realization. Mary’s student actions are explicable in terms of
realizations of her student role. Accordingly, BFO only needs the
standard property-having relation (one subtype of which is the
has_role relation), instead of a new primitive role-playing one.
          </p>
        </sec>
        <sec id="sec-6-3-2">
          <title>Roles, Dispositions, and Functions</title>
          <p>
            There is a broad consensus on the high utility for ontologizing a
wide array of entities that is possessed by realizable entities,
ranging from the BFO subtypes of realizables [
            <xref ref-type="bibr" rid="ref36">36</xref>
            ] (i.e.,
dispositions, functions, and roles) to other kinds of realizables
(e.g., tendencies [
            <xref ref-type="bibr" rid="ref37">37</xref>
            ]). It is nevertheless a highly controversial
subject how BFO-realizables are to be individuated. It would be
indeed valuable to elaborate on a comparatively revisionary
classification of BFO-realizables (see e.g., [
            <xref ref-type="bibr" rid="ref25">25</xref>
            ]). To simplify the
matter, however, we will confine ourselves to two topics
regarding the interrelationships between roles and other two
realizable entities while retaining the present, BFO 2.0
characterization of them.
          </p>
          <p>First, a cloud of suspicion may hang over the ‘grounding
distinction’ between roles and dispositions. Guarino [38, p. 17]
asserts, for example: “I think that, especially for social roles, the
corresponding attitudes/commitments/dispositions are not
independent from the physical make-up of their bearer. For
instance, the commitment to realize a student role of course
requires some changes in the brain’s “make-up” of its bearer. I
would say that, in general, active role-properties (being the lover
of Mary) presuppose some (non-essential) change in the physical
make-up of their role bearers, while this is not required for
passive roles (being loved by John).” Paraphrased using the
Mary-student example, the core of his argument is that Mary’s
student role should not be a BFO-role (an externally grounded
realizable entity) because there must be some physical change
involved in Mary’s entering UB.</p>
          <p>Although it may be a misinterpretation of a BFO-role, Guarino’s
criticism would help to elucidate the difference between roles
and dispositions. Quite important is the observation that the
change (including emergence and disappearance) of roles are
frequently concurrent with that of dispositions. To see this point,
let us stipulate that Mary became more diligent after graduation
from UB. It would appear that Mary’s assiduity was caused by
her neural transformation, which was in turn by her student role.
Actually, however, Mary’s diligence should be ascribed to the
fact that Mary’s disposition to work hard was strengthened by
realizations (e.g., taking classes at UB) of her student role which
she no longer bears after graduation. On the other hand, Mary’s
disposition to go to UB may have been greatly weakened when
she lost her UB-student role.</p>
          <p>
            Second, we have seen the cases in which the term ‘role’ refers to
a disposition or a function. One may wonder about their
opposite: the term ‘disposition’ or ‘function’ means a role when
coming under scrutiny. To the best of our knowledge, the term
‘disposition’ rarely, if ever, refers to a role; whereas greater care
may be needed to ensure that the term ‘function’ does not
designate a role. To illustrate the latter, consider the issue of ‘use
function’: roughly, the kind of functions that agents attribute to
objects in actually using them for their use purpose (see e.g.,
[
            <xref ref-type="bibr" rid="ref39">39</xref>
            ] for more details). If Mary uses a screw driver to open her
paint cans, for instance, it has the use function to open paint cans
[
            <xref ref-type="bibr" rid="ref25">25</xref>
            ]. In spite of an ongoing discussion about BFO-functions, the
disputants generally acknowledge that use functions should be
categorized as roles because they are ‘accidental functions’: they
have nothing to do with the essence of their bearers [
            <xref ref-type="bibr" rid="ref24 ref25">24,25</xref>
            ].
          </p>
        </sec>
        <sec id="sec-6-3-3">
          <title>Roles in Biomedical Ontologies</title>
          <p>
            As was alluded to in Section I, roles are crucial for biomedical
ontologies, partly because of the widespread usage of the term
‘role’ in the biomedical literature, partly because of a growing
importance of social roles in ontologies of healthcare systems.
As for the former, we have explicated the term ‘role’ by
leveraging some existing BFO categories. This will help
biologists and medical specialists to understand correctly the
term ‘role’ and represent accurately its meaning on a
case-bycase basis when they build and/or ameliorate OBO ontologies.
We have also shown that the BFO potential-centered conception
of role is well-suitable for scientific ontologies in general. This
is all the more the case with biomedical ontologies for several
reasons. First, ontological realism is currently one of the most
prevailing approaches to biomedical ontologies [
            <xref ref-type="bibr" rid="ref40">40</xref>
            ]. Second,
BFO-roles are relatively understandable for biomedical experts
because they are closely akin to dispositions, which are central
to biomedicine [
            <xref ref-type="bibr" rid="ref37">37</xref>
            ] and serve as a useful conceptual tool for an
ontological analysis of the explanatory practice in biomedicine
from both theoretical [
            <xref ref-type="bibr" rid="ref41">41</xref>
            ] and practical [
            <xref ref-type="bibr" rid="ref42 ref43 ref44">42,43,44</xref>
            ] points of
view. Third, it has been pointed out that “many so-called
functions in biomedical ontologies are, strictly speaking, roles”
[25, p. 11].
          </p>
          <p>
            As for the latter, our work will have implications for the
construction of social ontologies in the biomedical domain. For
one thing, there is general agreement among researchers in
social ontologies aligned with BFO that deontic entities (e.g.,
claims, obligations, and rights) are most appropriately classified
as generically dependent continuants that are concretized in
(social) roles, regardless of whether they are, more concretely,
socio-legal generically dependent continuants [
            <xref ref-type="bibr" rid="ref45">45</xref>
            ] or directive
information entities [
            <xref ref-type="bibr" rid="ref46">46</xref>
            ] or others. Deontic entities as construed
this way can be viewed as a subtype of role specifications; and
in this regard, we might have discussed in some way a
theoretical foundation for deontic entities in social ontology.
For another, it is nowadays fairly popular to model organizations
(totally or partially) upon interrelations among roles in various
disciplines, including multiagent systems [
            <xref ref-type="bibr" rid="ref47 ref48">47,48</xref>
            ] and
foundational ontology research [
            <xref ref-type="bibr" rid="ref49 ref50 ref51">49,50,51</xref>
            ]. It is sometimes
claimed however that the BFO conception of role fits badly with
this approach because it faces what may be called the ‘problem
of non-transferability’ [
            <xref ref-type="bibr" rid="ref46">46</xref>
            ] or especially the ‘problem of vacant
(empty) role’. Being postulated to be represented by a
configuration of roles, an organization should remain the same
even when there exists a ‘vacant role’: a role to be beard by
nobody. Recall an extensive story of Example (2) in Section
IVA: the structure of the institute has not changed itself since Bob
resigned as the sixth director until Jane is newly elected as the
seventh director. BFO-roles would nonetheless seem to embrace
the discrepancy between the real structure of an organization and
its ‘role structure’ because they have to depend specifically on
individual agents (such as Bob and Jane) and they are thus
nontransferable. The issue of vacant role is still unresolved, but one
possible answer to this question may be to ground an
organizational structure upon a constellation of role positions
(rather than roles) of the organization because role positions
thereof, by definition, exist even in the case of vacant roles,
insofar as does the organization. Our complete solution to the
general problem of non-transferability will require not only
clearer delineation of the idea of a role position but also careful
ontological consideration of the identity of organizations (see
e.g., [
            <xref ref-type="bibr" rid="ref52">52</xref>
            ]).
To summarize, we examined within the BFO framework the
meanings of the term ‘role’. We also discussed the BFO
potential-oriented conception of role as an externally grounded
realizable entity with a focus on its connections with ontological
realism, dispositions, and functions as well as its usefulness for
an ontological modeling in the biomedical field. We ended up
with the following BFO-based disambiguation of the term ‘role’
in the aforementioned examples (1)-(8):
          </p>
        </sec>
      </sec>
    </sec>
    <sec id="sec-7">
      <title>A passenger plays the role of a pilot on a commercial plane in an emergency.</title>
      <sec id="sec-7-1">
        <title>Generically dependent continuant (role specification)</title>
      </sec>
    </sec>
    <sec id="sec-8">
      <title>Jane’s being the seventh person to fill the role of director of this institute</title>
      <sec id="sec-8-1">
        <title>Generically dependent continuant (role specification)</title>
      </sec>
    </sec>
    <sec id="sec-9">
      <title>Joe’s being the third person to play a particular role in a play</title>
      <sec id="sec-9-1">
        <title>Generically dependent continuant (role specification)</title>
      </sec>
    </sec>
    <sec id="sec-10">
      <title>A pyramidal neuron plays the role occupied by a damaged stellar neuron in the brain. Site (role position)</title>
    </sec>
    <sec id="sec-11">
      <title>Site (role position)</title>
    </sec>
    <sec id="sec-12">
      <title>Jim has the role of a nurse.</title>
    </sec>
    <sec id="sec-13">
      <title>Site (role position)</title>
      <p>the role of a stone in marking a boundary</p>
    </sec>
    <sec id="sec-14">
      <title>Role (role potential; an externally grounded realizable entity) the role of a magnet to attract iron objects</title>
    </sec>
    <sec id="sec-15">
      <title>Disposition (an internally grounded realizable entity) the role of the heart to pump blood</title>
    </sec>
    <sec id="sec-16">
      <title>Function (a subtype of disposition)</title>
      <p>
        In the future we will be able to proceed along two main
directions of research. On the theoretical side, further
development is warranted of the BFO characterization of a role
specification and a role position, which will require in turn a
deeper understanding of a generically dependent continuant and a
site. Besides, further clarification should be given to complex
relationships between roles, dispositions, and function. On the
practical side, the utility of the BFO specification hitherto of the
term ‘role’ needs to be verified through its application to the
building and enhancement of biomedical ontologies, e.g., of
healthcare systems [
        <xref ref-type="bibr" rid="ref5 ref6">5,6</xref>
        ]. In addition, since ontological realism
prescribes that ontologies should represent, above all, universals
[
        <xref ref-type="bibr" rid="ref28">28</xref>
        ], this necessitates the extension of our work on the role triad
to the sphere of universals and their formal representation
specified in e.g., Web Ontology Language (OWL) [
        <xref ref-type="bibr" rid="ref53">53</xref>
        ]. Finally,
among BFO-realizables, roles have been less carefully
investigated than dispositions and functions. This may raise
doubts about the BFO characterization of role. For instance,
Guarino [38, p. 14] states that it “reflects a very peculiar
understanding of the role notion which, although useful, would
require a broader framework”. We hope that our argument over
BFO-roles and their sibling entities will dispel this kind of worry.
      </p>
      <sec id="sec-16-1">
        <title>Address for correspondence</title>
      </sec>
    </sec>
  </body>
  <back>
    <ref-list>
      <ref id="ref1">
        <mixed-citation>
          1.
          <string-name>
            <given-names>J.</given-names>
            <surname>Fan</surname>
          </string-name>
          ,
          <string-name>
            <given-names>K.</given-names>
            <surname>Barker</surname>
          </string-name>
          ,
          <string-name>
            <given-names>B.</given-names>
            <surname>Porter</surname>
          </string-name>
          and
          <string-name>
            <given-names>P.</given-names>
            <surname>Clark</surname>
          </string-name>
          .
          <article-title>Representing Roles and Purpose</article-title>
          .
          <source>In Proceedings of the 1st International Conference on Knowledge Capture (K-CAP'01)</source>
          , Victoria, British Columbia, Canada,
          <source>October 22-23</source>
          ,
          <year>2001</year>
          , ACM Press,
          <fpage>38</fpage>
          -
          <lpage>43</lpage>
          .
        </mixed-citation>
      </ref>
      <ref id="ref2">
        <mixed-citation>
          2.
          <string-name>
            <given-names>F.</given-names>
            <surname>Steimann</surname>
          </string-name>
          .
          <article-title>On the representation of roles in objectoriented and conceptual modelling</article-title>
          .
          <source>Data &amp; Knowledge Engineering</source>
          ,
          <volume>35</volume>
          (
          <issue>1</issue>
          ),
          <fpage>83</fpage>
          -
          <lpage>106</lpage>
          ,
          <year>2000</year>
          .
        </mixed-citation>
      </ref>
      <ref id="ref3">
        <mixed-citation>
          3.
          <string-name>
            <given-names>B.</given-names>
            <surname>Smith</surname>
          </string-name>
          et al.
          <source>Basic Formal Ontology 2.0 - Specification and User's Guide</source>
          ,
          <year>2015</year>
          . Available online at: https://github.com/BFO-ontology/
          <source>BFO (Last accessed on July 14</source>
          ,
          <year>2019</year>
          ).
        </mixed-citation>
      </ref>
      <ref id="ref4">
        <mixed-citation>
          4.
          <string-name>
            <given-names>R.</given-names>
            <surname>Arp</surname>
          </string-name>
          ,
          <string-name>
            <given-names>B.</given-names>
            <surname>Smith</surname>
          </string-name>
          and
          <string-name>
            <given-names>A. D.</given-names>
            <surname>Spear</surname>
          </string-name>
          .
          <article-title>Building Ontologies with Basic Formal Ontology</article-title>
          . Cambridge, MA: The MIT Press,
          <year>2015</year>
          .
        </mixed-citation>
      </ref>
      <ref id="ref5">
        <mixed-citation>
          5.
          <string-name>
            <given-names>A.</given-names>
            <surname>Hicks</surname>
          </string-name>
          ,
          <string-name>
            <given-names>J.</given-names>
            <surname>Hanna</surname>
          </string-name>
          ,
          <string-name>
            <given-names>D.</given-names>
            <surname>Welch</surname>
          </string-name>
          ,
          <string-name>
            <given-names>M.</given-names>
            <surname>Brochhausen</surname>
          </string-name>
          and
          <string-name>
            <given-names>W. R.</given-names>
            <surname>Hogan</surname>
          </string-name>
          .
          <article-title>The ontology of medically related social entities: recent developments</article-title>
          .
          <source>Journal of Biomedical Semantics</source>
          ,
          <volume>7</volume>
          :
          <fpage>47</fpage>
          ,
          <year>2016</year>
          .
        </mixed-citation>
      </ref>
      <ref id="ref6">
        <mixed-citation>
          6.
          <string-name>
            <surname>J.-F. Ethier</surname>
            ,
            <given-names>A.</given-names>
          </string-name>
          <string-name>
            <surname>Barton</surname>
            and
            <given-names>R.</given-names>
          </string-name>
          <string-name>
            <surname>Taseen</surname>
          </string-name>
          .
          <article-title>An ontological analysis of drug prescriptions</article-title>
          .
          <source>Applied Ontology</source>
          ,
          <volume>13</volume>
          (
          <issue>4</issue>
          ),
          <fpage>273</fpage>
          -
          <lpage>294</lpage>
          ,
          <year>2018</year>
          .
        </mixed-citation>
      </ref>
      <ref id="ref7">
        <mixed-citation>
          7.
          <string-name>
            <given-names>G.</given-names>
            <surname>Boella</surname>
          </string-name>
          ,
          <string-name>
            <given-names>L. van der Torre and H.</given-names>
            <surname>Verhagen</surname>
          </string-name>
          .
          <article-title>Roles, an interdisciplinary perspective</article-title>
          .
          <source>Applied Ontology</source>
          ,
          <volume>2</volume>
          (
          <issue>2</issue>
          ),
          <fpage>81</fpage>
          -
          <lpage>88</lpage>
          ,
          <year>2007</year>
          .
        </mixed-citation>
      </ref>
      <ref id="ref8">
        <mixed-citation>
          8.
          <string-name>
            <given-names>C.</given-names>
            <surname>Masolo</surname>
          </string-name>
          ,
          <string-name>
            <given-names>L.</given-names>
            <surname>Vieu</surname>
          </string-name>
          ,
          <string-name>
            <given-names>E.</given-names>
            <surname>Bottazzi</surname>
          </string-name>
          ,
          <string-name>
            <given-names>C.</given-names>
            <surname>Catenacci</surname>
          </string-name>
          ,
          <string-name>
            <given-names>R.</given-names>
            <surname>Ferrario</surname>
          </string-name>
          ,
          <string-name>
            <given-names>A.</given-names>
            <surname>Gangemi</surname>
          </string-name>
          and
          <string-name>
            <given-names>N.</given-names>
            <surname>Guarino</surname>
          </string-name>
          .
          <article-title>Social Roles and Their Descriptions</article-title>
          . In D. Dubois,
          <string-name>
            <given-names>C.</given-names>
            <surname>Welty</surname>
          </string-name>
          and
          <string-name>
            <given-names>M. A.</given-names>
            <surname>Williams</surname>
          </string-name>
          (Eds.),
          <source>Principles of Knowledge Representation and Reasoning: Proceedings of the 9th International Conference (KR</source>
          <year>2004</year>
          ), Whistler British Columbia, Canada, June 2-5,
          <year>2004</year>
          ,
          <fpage>267</fpage>
          -
          <lpage>277</lpage>
          .
        </mixed-citation>
      </ref>
      <ref id="ref9">
        <mixed-citation>
          9.
          <string-name>
            <given-names>V.</given-names>
            <surname>Genovese</surname>
          </string-name>
          .
          <article-title>Towards a General Framework for Modelling Roles</article-title>
          . In G. Boella, L. van der Torre and H.
          <string-name>
            <surname>Verhagen</surname>
          </string-name>
          (Eds.),
          <source>Normative Multiagent Systems, number 07122 in Dagstuhl Seminar Proceedings. Internationales Begegnungs- und Forschungszentrum für Informatik (IBFI)</source>
          , Schloss Dagstuhl, Germany,
          <year>2007</year>
          .
        </mixed-citation>
      </ref>
      <ref id="ref10">
        <mixed-citation>
          10.
          <string-name>
            <given-names>F.</given-names>
            <surname>Loebe</surname>
          </string-name>
          .
          <article-title>Abstract vs. social roles: Towards a general theoretical account of roles</article-title>
          .
          <source>Applied Ontology</source>
          ,
          <volume>2</volume>
          (
          <issue>2</issue>
          ),
          <fpage>127</fpage>
          -
          <lpage>158</lpage>
          ,
          <year>2007</year>
          .
        </mixed-citation>
      </ref>
      <ref id="ref11">
        <mixed-citation>
          11.
          <string-name>
            <given-names>B.</given-names>
            <surname>Smith</surname>
          </string-name>
          et al.
          <article-title>The OBO Foundry: coordinated evolution of ontologies to support biomedical data integration</article-title>
          .
          <source>Nature Biotechnology</source>
          ,
          <volume>25</volume>
          ,
          <fpage>1251</fpage>
          -
          <lpage>1255</lpage>
          ,
          <year>2007</year>
          .
        </mixed-citation>
      </ref>
      <ref id="ref12">
        <mixed-citation>
          12.
          <string-name>
            <given-names>F.</given-names>
            <surname>Toyoshima</surname>
          </string-name>
          .
          <article-title>Three Facets of Roles in Foundational Ontologies</article-title>
          . In L. Jansen,
          <string-name>
            <given-names>D. P.</given-names>
            <surname>Radicioni</surname>
          </string-name>
          and
          <string-name>
            <given-names>D.</given-names>
            <surname>Gromann</surname>
          </string-name>
          (Eds.),
          <source>Proceedings of the Joint Ontology Workshops</source>
          <year>2018</year>
          (
          <article-title>JOWO 2018)</article-title>
          , Cape Town, South Africa,
          <source>September 17- 18</source>
          ,
          <year>2018</year>
          , CEUR Workshop Proceedings, vol.
          <volume>2205</volume>
          .
        </mixed-citation>
      </ref>
      <ref id="ref13">
        <mixed-citation>
          13.
          <string-name>
            <given-names>R.</given-names>
            <surname>Turner</surname>
          </string-name>
          . Specification.
          <source>Minds &amp; Machines</source>
          ,
          <volume>21</volume>
          (
          <issue>2</issue>
          ),
          <fpage>135</fpage>
          -
          <lpage>152</lpage>
          ,
          <year>2011</year>
          .
        </mixed-citation>
      </ref>
      <ref id="ref14">
        <mixed-citation>
          14. W. D. Duncan.
          <article-title>Ontological distinctions between hardware and software</article-title>
          .
          <source>Applied Ontology</source>
          ,
          <volume>12</volume>
          (
          <issue>1</issue>
          ),
          <fpage>5</fpage>
          -
          <lpage>32</lpage>
          ,
          <year>2017</year>
          .
        </mixed-citation>
      </ref>
      <ref id="ref15">
        <mixed-citation>
          15. L.
          <string-name>
            <surname>Vieu</surname>
            ,
            <given-names>S.</given-names>
          </string-name>
          <string-name>
            <surname>Borgo</surname>
            and
            <given-names>C.</given-names>
          </string-name>
          <string-name>
            <surname>Masolo</surname>
          </string-name>
          .
          <article-title>Artefacts and Roles: Modelling Strategies in a Multiplicative Ontology</article-title>
          . In C. Eschenbach and
          <string-name>
            <given-names>M.</given-names>
            <surname>Grüninger</surname>
          </string-name>
          (Eds.),
          <source>Proceedings of the 5th International Conference (FOIS</source>
          <year>2008</year>
          ), Saarbrücken, Germany,
          <source>October 31 - November 3</source>
          ,
          <year>2008</year>
          , Amsterdam: IOS Press,
          <fpage>121</fpage>
          -
          <lpage>134</lpage>
          .
        </mixed-citation>
      </ref>
      <ref id="ref16">
        <mixed-citation>
          16.
          <string-name>
            <given-names>K.</given-names>
            <surname>Fine</surname>
          </string-name>
          . Essence and Modality.
          <source>Philosophical Perspectives</source>
          ,
          <volume>8</volume>
          ,
          <fpage>1</fpage>
          -
          <lpage>16</lpage>
          ,
          <year>1994</year>
          .
        </mixed-citation>
      </ref>
      <ref id="ref17">
        <mixed-citation>
          17.
          <string-name>
            <given-names>M.</given-names>
            <surname>Donnelly</surname>
          </string-name>
          .
          <source>Relative Places. Applied Ontology</source>
          ,
          <volume>1</volume>
          (
          <issue>1</issue>
          ),
          <fpage>55</fpage>
          -
          <lpage>75</lpage>
          ,
          <year>2005</year>
          .
        </mixed-citation>
      </ref>
      <ref id="ref18">
        <mixed-citation>
          18.
          <string-name>
            <given-names>R.</given-names>
            <surname>Mizoguchi</surname>
          </string-name>
          ,
          <string-name>
            <given-names>E.</given-names>
            <surname>Sunagawa</surname>
          </string-name>
          ,
          <string-name>
            <given-names>K.</given-names>
            <surname>Kozaki</surname>
          </string-name>
          and
          <string-name>
            <given-names>Y.</given-names>
            <surname>Kitamura</surname>
          </string-name>
          .
          <article-title>A Model of Roles within an Ontology Development Tool</article-title>
          : Hozo. Applied Ontology,
          <volume>2</volume>
          (
          <issue>2</issue>
          ),
          <fpage>159</fpage>
          -
          <lpage>179</lpage>
          ,
          <year>2007</year>
          .
        </mixed-citation>
      </ref>
      <ref id="ref19">
        <mixed-citation>
          19.
          <string-name>
            <given-names>B.</given-names>
            <surname>Smith. Beyond Concepts</surname>
          </string-name>
          :
          <article-title>Ontology as Reality Representation</article-title>
          . In A. C. Varzi and L.
          <string-name>
            <surname>Vieu</surname>
          </string-name>
          (Eds.),
          <source>Proceedings of the 4th International Conference on Formal Ontology in Information Systems (FOIS</source>
          <year>2004</year>
          ), Torino, Italy, November 4-
          <issue>6</issue>
          ,
          <year>2004</year>
          , Amsterdam: IOS Press,
          <fpage>31</fpage>
          -
          <lpage>42</lpage>
          .
        </mixed-citation>
      </ref>
      <ref id="ref20">
        <mixed-citation>
          20.
          <string-name>
            <given-names>J. F.</given-names>
            <surname>Sowa</surname>
          </string-name>
          .
          <article-title>Knowledge Representation: Logical, Philosophical and Computational Foundations</article-title>
          . USA: Brooks/Cole,
          <year>2000</year>
          .
        </mixed-citation>
      </ref>
      <ref id="ref21">
        <mixed-citation>
          21.
          <string-name>
            <given-names>S.</given-names>
            <surname>Borgo</surname>
          </string-name>
          and
          <string-name>
            <given-names>C.</given-names>
            <surname>Masolo</surname>
          </string-name>
          .
          <article-title>Ontological Foundations of DOLCE</article-title>
          . In R. Poli,
          <string-name>
            <given-names>M.</given-names>
            <surname>Healy</surname>
          </string-name>
          and
          <string-name>
            <given-names>A</given-names>
            .
            <surname>Kameas</surname>
          </string-name>
          (Eds.),
          <source>Theory and Applications</source>
          of Ontology: Computer Applications, Netherlands: Springer,
          <year>2010</year>
          ,
          <fpage>279</fpage>
          -
          <lpage>295</lpage>
          .
        </mixed-citation>
      </ref>
      <ref id="ref22">
        <mixed-citation>
          22.
          <string-name>
            <given-names>B.</given-names>
            <surname>Smith</surname>
          </string-name>
          and
          <string-name>
            <given-names>A.</given-names>
            <surname>Varzi</surname>
          </string-name>
          . The Niche, Noûs,
          <volume>33</volume>
          :
          <fpage>2</fpage>
          ,
          <fpage>198</fpage>
          -
          <lpage>222</lpage>
          ,
          <year>1999</year>
          .
        </mixed-citation>
      </ref>
      <ref id="ref23">
        <mixed-citation>
          23.
          <string-name>
            <given-names>B.</given-names>
            <surname>Smith</surname>
          </string-name>
          and
          <string-name>
            <given-names>A.</given-names>
            <surname>Varzi</surname>
          </string-name>
          . Surrounding Space:
          <article-title>The Ontology of Organism-Environment Relations</article-title>
          .
          <source>Theory in Biosciences</source>
          ,
          <volume>121</volume>
          ,
          <fpage>139</fpage>
          -
          <lpage>162</lpage>
          ,
          <year>2002</year>
          .
        </mixed-citation>
      </ref>
      <ref id="ref24">
        <mixed-citation>
          24.
          <string-name>
            <surname>A. D. Spear</surname>
            ,
            <given-names>W</given-names>
          </string-name>
          , Ceusters and
          <string-name>
            <given-names>B.</given-names>
            <surname>Smith</surname>
          </string-name>
          .
          <source>Functions in Basic Formal Ontology. Applied Ontology</source>
          ,
          <volume>11</volume>
          (
          <issue>2</issue>
          ),
          <fpage>103</fpage>
          -
          <lpage>128</lpage>
          ,
          <year>2016</year>
          .
        </mixed-citation>
      </ref>
      <ref id="ref25">
        <mixed-citation>
          25.
          <string-name>
            <given-names>J.</given-names>
            <surname>Röhl</surname>
          </string-name>
          and
          <string-name>
            <given-names>L.</given-names>
            <surname>Jansen</surname>
          </string-name>
          .
          <article-title>Why functions are not special dispositions: an improved classification of realizables for toplevel ontologies</article-title>
          .
          <source>Journal of Biomedical Semantics</source>
          ,
          <volume>5</volume>
          :
          <fpage>27</fpage>
          ,
          <year>2014</year>
          .
        </mixed-citation>
      </ref>
      <ref id="ref26">
        <mixed-citation>
          26.
          <string-name>
            <given-names>L.</given-names>
            <surname>Jansen</surname>
          </string-name>
          . Functions, Malfunctioning, and
          <string-name>
            <given-names>Negative</given-names>
            <surname>Causation</surname>
          </string-name>
          . In A. Christian,
          <string-name>
            <given-names>D.</given-names>
            <surname>Hommen</surname>
          </string-name>
          ,
          <string-name>
            <given-names>N.</given-names>
            <surname>Retzlaff</surname>
          </string-name>
          and G. Schurz (Eds.),
          <source>Philosophy of Science. European Studies in Philosophy of Science</source>
          , vol.
          <volume>9</volume>
          . Springer, Cham,
          <fpage>117</fpage>
          -
          <lpage>135</lpage>
          ,
          <year>2018</year>
          .
        </mixed-citation>
      </ref>
      <ref id="ref27">
        <mixed-citation>
          27. S. de Cesare,
          <string-name>
            <given-names>F.</given-names>
            <surname>Gailly</surname>
          </string-name>
          , G. Guizzardi,
          <string-name>
            <given-names>M.</given-names>
            <surname>Lycett</surname>
          </string-name>
          ,
          <string-name>
            <given-names>C.</given-names>
            <surname>Partridge</surname>
          </string-name>
          and
          <string-name>
            <given-names>O.</given-names>
            <surname>Pastor</surname>
          </string-name>
          . 4th International Workshop on Ontologies and
          <article-title>Conceptual Modeling (Onto.Com)</article-title>
          . In O. Kutz and S. de Cesare (Eds.),
          <source>Proceedings of the 2nd Joint Ontology Workshops (JOWO</source>
          <year>2016</year>
          ), Annecy, France,
          <source>July 6-9</source>
          ,
          <year>2016</year>
          .
          <source>CEUR Workshop Proceedings</source>
          , vol.
          <volume>1660</volume>
          .
        </mixed-citation>
      </ref>
      <ref id="ref28">
        <mixed-citation>
          28.
          <string-name>
            <given-names>B.</given-names>
            <surname>Smith</surname>
          </string-name>
          and
          <string-name>
            <given-names>W.</given-names>
            <surname>Ceusters</surname>
          </string-name>
          .
          <article-title>Ontological realism: A methodology for coordinated evolution of scientific ontologies</article-title>
          .
          <source>Applied Ontology</source>
          ,
          <volume>5</volume>
          (
          <issue>3-4</issue>
          ),
          <fpage>139</fpage>
          -
          <lpage>188</lpage>
          ,
          <year>2010</year>
          .
        </mixed-citation>
      </ref>
      <ref id="ref29">
        <mixed-citation>
          29.
          <string-name>
            <given-names>G. H.</given-names>
            <surname>Merrill</surname>
          </string-name>
          . Ontological realism:
          <source>Methodology or misdirection? Applied Ontology</source>
          ,
          <volume>5</volume>
          (
          <issue>2</issue>
          ),
          <fpage>79</fpage>
          -
          <lpage>108</lpage>
          ,
          <year>2010</year>
          .
        </mixed-citation>
      </ref>
      <ref id="ref30">
        <mixed-citation>
          30.
          <string-name>
            <given-names>G. H.</given-names>
            <surname>Merrill</surname>
          </string-name>
          .
          <article-title>Realism and reference ontologies: Considerations, reflections and problems</article-title>
          . Applied Ontology,
          <volume>5</volume>
          (
          <issue>3-4</issue>
          ),
          <fpage>189</fpage>
          -
          <lpage>221</lpage>
          ,
          <year>2010</year>
          .
        </mixed-citation>
      </ref>
      <ref id="ref31">
        <mixed-citation>
          31.
          <string-name>
            <given-names>S.</given-names>
            <surname>Borgo</surname>
          </string-name>
          and
          <string-name>
            <given-names>P.</given-names>
            <surname>Hitzler</surname>
          </string-name>
          .
          <article-title>Some Open Issues After Twenty Years of Formal Ontology</article-title>
          . In S. Borgo,
          <string-name>
            <given-names>P.</given-names>
            <surname>Hitzler</surname>
          </string-name>
          and
          <string-name>
            <given-names>O.</given-names>
            <surname>Kutz</surname>
          </string-name>
          . (Eds.),
          <source>Proceedings of the 10th International Conference on Formal Ontology in Information Systems (FOIS</source>
          <year>2018</year>
          ), Cape Town, South Africa,
          <source>September 17-21</source>
          ,
          <year>2018</year>
          , Amsterdam: IOS Press, 1-
          <fpage>9</fpage>
          . doi:
          <volume>10</volume>
          .3233/978-1-
          <fpage>61499</fpage>
          - 910-2-1.
        </mixed-citation>
      </ref>
      <ref id="ref32">
        <mixed-citation>
          32.
          <string-name>
            <given-names>B.</given-names>
            <surname>Smith</surname>
          </string-name>
          .
          <article-title>New Desiderata for Biomedical Ontologies</article-title>
          . In K. Munn and
          <string-name>
            <given-names>B.</given-names>
            <surname>Smith</surname>
          </string-name>
          (Eds.),
          <source>Applied Ontology: An Introduction</source>
          , Frankfurt: Ontos Verlag,
          <year>2008</year>
          ,
          <fpage>84</fpage>
          -
          <lpage>107</lpage>
          .
        </mixed-citation>
      </ref>
      <ref id="ref33">
        <mixed-citation>
          33.
          <string-name>
            <given-names>B.</given-names>
            <surname>Smith</surname>
          </string-name>
          and
          <string-name>
            <given-names>W.</given-names>
            <surname>Ceusters</surname>
          </string-name>
          . Aboutness:
          <article-title>Towards Foundations for the Information Artifact Ontology</article-title>
          . In F. M.
          <article-title>Couto</article-title>
          and J.
          <string-name>
            <surname>Hastings</surname>
          </string-name>
          (Eds.),
          <source>Proceedings of the 6th International Conference on Biomedical Ontology (ICBO</source>
          <year>2015</year>
          ), Lisbon, Portugal,
          <source>July 27-30</source>
          ,
          <year>2015</year>
          , CEUR Workshop Proceedings, vol.
          <volume>1515</volume>
          .
        </mixed-citation>
      </ref>
      <ref id="ref34">
        <mixed-citation>
          34.
          <string-name>
            <given-names>W. R.</given-names>
            <surname>Hogan</surname>
          </string-name>
          and
          <string-name>
            <given-names>W.</given-names>
            <surname>Ceusters</surname>
          </string-name>
          .
          <article-title>Diagnosis, misdiagnosis, lucky guess, hearsay, and more: an ontological analysis</article-title>
          .
          <source>Journal of Biomedical Semantics</source>
          ,
          <volume>7</volume>
          :
          <fpage>54</fpage>
          ,
          <year>2016</year>
          . doi: 0.1186/s13326-016-0098-5.
        </mixed-citation>
      </ref>
      <ref id="ref35">
        <mixed-citation>
          35.
          <string-name>
            <given-names>R.</given-names>
            <surname>Mizoguchi</surname>
          </string-name>
          ,
          <string-name>
            <given-names>A.</given-names>
            <surname>Galton</surname>
          </string-name>
          ,
          <string-name>
            <given-names>Y.</given-names>
            <surname>Kitamura</surname>
          </string-name>
          and
          <string-name>
            <given-names>K.</given-names>
            <surname>Kozaki</surname>
          </string-name>
          .
          <article-title>Families of roles: A new theory of occurrent-dependent roles</article-title>
          .
          <source>Applied Ontology</source>
          ,
          <volume>10</volume>
          (
          <issue>3-4</issue>
          ),
          <fpage>367</fpage>
          -
          <lpage>399</lpage>
          ,
          <year>2015</year>
          .
        </mixed-citation>
      </ref>
      <ref id="ref36">
        <mixed-citation>
          36.
          <string-name>
            <given-names>R.</given-names>
            <surname>Arp</surname>
          </string-name>
          and
          <string-name>
            <given-names>B.</given-names>
            <surname>Smith. Function</surname>
          </string-name>
          , Role, and
          <article-title>Disposition in Basic Formal Ontology</article-title>
          .
          <source>In Proceedings of the BioOntologies Workshop, Intelligent Systems for Molecular Biology (ISMB</source>
          <year>2008</year>
          ), Toronto, Canada,
          <source>July 19-23</source>
          ,
          <year>2008</year>
          ,
          <fpage>45</fpage>
          -
          <lpage>48</lpage>
          .
        </mixed-citation>
      </ref>
      <ref id="ref37">
        <mixed-citation>
          37.
          <string-name>
            <given-names>L.</given-names>
            <surname>Jansen</surname>
          </string-name>
          .
          <source>Tendencies and other Realizables in Medical Information Sciences. The Monist</source>
          <volume>90</volume>
          ,
          <fpage>534</fpage>
          -
          <lpage>554</lpage>
          ,
          <year>2007</year>
          .
        </mixed-citation>
      </ref>
      <ref id="ref38">
        <mixed-citation>
          38.
          <string-name>
            <given-names>N.</given-names>
            <surname>Guarino</surname>
          </string-name>
          . BFO and
          <string-name>
            <surname>DOLCE: So</surname>
            <given-names>Far</given-names>
          </string-name>
          , So Close....
          <source>Cosmos + Taxis</source>
          ,
          <volume>4</volume>
          (
          <issue>4</issue>
          ),
          <fpage>10</fpage>
          -
          <lpage>18</lpage>
          ,
          <year>2016</year>
          .
        </mixed-citation>
      </ref>
      <ref id="ref39">
        <mixed-citation>
          39.
          <string-name>
            <given-names>R.</given-names>
            <surname>Mizoguchi</surname>
          </string-name>
          ,
          <string-name>
            <given-names>Y.</given-names>
            <surname>Kitamura</surname>
          </string-name>
          and
          <string-name>
            <given-names>S.</given-names>
            <surname>Borgo</surname>
          </string-name>
          .
          <article-title>A unifying definition for artifact and biological functions</article-title>
          .
          <source>Applied Ontology</source>
          ,
          <volume>11</volume>
          (
          <issue>2</issue>
          ),
          <fpage>129</fpage>
          -
          <lpage>154</lpage>
          ,
          <year>2016</year>
          .
        </mixed-citation>
      </ref>
      <ref id="ref40">
        <mixed-citation>
          40.
          <string-name>
            <given-names>W.</given-names>
            <surname>Ceusters</surname>
          </string-name>
          and
          <string-name>
            <given-names>B.</given-names>
            <surname>Smith.</surname>
          </string-name>
          <article-title>A Realism-Based Approach to the Evolution of Biomedical Ontologies</article-title>
          .
          <source>In Proceedings of the AMIA Symposium</source>
          , Washington, DC, USA, November
          <volume>11</volume>
          -
          <issue>15</issue>
          ,
          <year>2006</year>
          , AMIA, vol.
          <year>2006</year>
          ,
          <fpage>121</fpage>
          -
          <lpage>125</lpage>
          .
        </mixed-citation>
      </ref>
      <ref id="ref41">
        <mixed-citation>
          41.
          <string-name>
            <given-names>A.</given-names>
            <surname>Hüttemann</surname>
          </string-name>
          and
          <string-name>
            <surname>M. I. Kaiser.</surname>
          </string-name>
          <article-title>Potentiality in Biology</article-title>
          . In K. Engelhard and
          <string-name>
            <given-names>M.</given-names>
            <surname>Quante</surname>
          </string-name>
          (Eds.), Handbook of Potentiality, Netherlands: Springer,
          <year>2018</year>
          ,
          <fpage>401</fpage>
          -
          <lpage>428</lpage>
          .
        </mixed-citation>
      </ref>
      <ref id="ref42">
        <mixed-citation>
          42.
          <string-name>
            <surname>R. H. Scheuermann</surname>
            ,
            <given-names>W.</given-names>
          </string-name>
          <string-name>
            <surname>Ceusters</surname>
            and
            <given-names>B.</given-names>
          </string-name>
          <string-name>
            <surname>Smith</surname>
          </string-name>
          .
          <source>Toward an Ontological Treatment of Disease and Diagnosis. Summit on Translational Bioinformatics</source>
          ,
          <fpage>116</fpage>
          -
          <lpage>120</lpage>
          ,
          <year>2009</year>
          .
        </mixed-citation>
      </ref>
      <ref id="ref43">
        <mixed-citation>
          43.
          <string-name>
            <given-names>A.</given-names>
            <surname>Goldfain</surname>
          </string-name>
          ,
          <string-name>
            <given-names>B.</given-names>
            <surname>Smith</surname>
          </string-name>
          and
          <string-name>
            <given-names>L. G.</given-names>
            <surname>Cowell</surname>
          </string-name>
          .
          <article-title>Dispositions and the Infectious Disease Ontology</article-title>
          . In A. Galton and
          <string-name>
            <given-names>R.</given-names>
            <surname>Mizoguchi</surname>
          </string-name>
          (Eds.),
          <source>Proceedings of the 6th International Conference of Formal Ontology in Information Systems (FOIS</source>
          <year>2010</year>
          ), Toronto, Canada, May
          <volume>11</volume>
          -14,
          <year>2010</year>
          , Amsterdam: IOS Press,
          <fpage>400</fpage>
          -
          <lpage>413</lpage>
          .
        </mixed-citation>
      </ref>
      <ref id="ref44">
        <mixed-citation>
          44.
          <string-name>
            <given-names>A.</given-names>
            <surname>Barton</surname>
          </string-name>
          ,
          <string-name>
            <given-names>O.</given-names>
            <surname>Grenier</surname>
          </string-name>
          and
          <string-name>
            <given-names>J.-F.</given-names>
            <surname>Ethier</surname>
          </string-name>
          .
          <article-title>The Identity and Mereology of Pathological Dispositions</article-title>
          . In L. Cooper and P. Jaiswal (Eds.),
          <source>Proceedings of the 9th International Conference on Biological Ontology (ICBO</source>
          <year>2018</year>
          ), Corvallis, Oregon, USA,
          <year>August</year>
          7-
          <issue>10</issue>
          ,
          <year>2018</year>
          , CEUR Workshop Proceedings, vol.
          <volume>2285</volume>
          .
        </mixed-citation>
      </ref>
      <ref id="ref45">
        <mixed-citation>
          45.
          <string-name>
            <surname>M. Brochhausen</surname>
            ,
            <given-names>M. B.</given-names>
          </string-name>
          <string-name>
            <surname>Almeida</surname>
            and
            <given-names>L.</given-names>
          </string-name>
          <string-name>
            <surname>Slaughter</surname>
          </string-name>
          .
          <article-title>Towards a formal representation of document acts and resulting legal entities</article-title>
          . In C. Svennerlind,
          <string-name>
            <given-names>J.</given-names>
            <surname>Almäng</surname>
          </string-name>
          and
          <string-name>
            <given-names>R.</given-names>
            <surname>Ingthorsson</surname>
          </string-name>
          (Eds.), Johanssonian Investigations:
          <article-title>Essays in Honour of Ingvar Johansson on His Seventieth Birthday</article-title>
          , Walter de Gruyter,
          <year>2013</year>
          ,
          <fpage>120</fpage>
          -
          <lpage>139</lpage>
          .
        </mixed-citation>
      </ref>
      <ref id="ref46">
        <mixed-citation>
          46.
          <string-name>
            <given-names>B.</given-names>
            <surname>Donohue</surname>
          </string-name>
          .
          <article-title>Toward a BFO-Based Deontic Ontology</article-title>
          . In M. Horridge,
          <string-name>
            <given-names>P.</given-names>
            <surname>Lord</surname>
          </string-name>
          and
          <string-name>
            <given-names>J. D.</given-names>
            <surname>Warrender</surname>
          </string-name>
          (Eds.),
          <source>Proceedings of the 8th International Conference on Biomedical Ontology (ICBO</source>
          <year>2017</year>
          ),
          <article-title>Newcastle upon Tyne</article-title>
          , UK,
          <source>September 13-15</source>
          ,
          <year>2017</year>
          , CEUR Workshop Proceedings, vol.
          <volume>2137</volume>
          .
        </mixed-citation>
      </ref>
      <ref id="ref47">
        <mixed-citation>
          47.
          <string-name>
            <surname>J. J. Odell</surname>
            ,
            <given-names>H. V. D.</given-names>
          </string-name>
          <string-name>
            <surname>Parunak</surname>
            and
            <given-names>M.</given-names>
          </string-name>
          <string-name>
            <surname>Fleischer</surname>
          </string-name>
          .
          <article-title>Modeling agent organizations using roles</article-title>
          .
          <source>Software and System Modeling</source>
          ,
          <volume>2</volume>
          ,
          <fpage>76</fpage>
          -
          <lpage>81</lpage>
          ,
          <year>2003</year>
          . doi:
          <volume>10</volume>
          .1007/s10270-003-0017-y.
        </mixed-citation>
      </ref>
      <ref id="ref48">
        <mixed-citation>
          48.
          <string-name>
            <given-names>O.</given-names>
            <surname>Pacheco</surname>
          </string-name>
          and
          <string-name>
            <given-names>J.</given-names>
            <surname>Carmo</surname>
          </string-name>
          .
          <article-title>A Role Based Model of Normative Specification of Organized Collective Agency and Agents Interaction</article-title>
          .
          <source>Autonomous Agents and Multiagent Systems</source>
          ,
          <volume>6</volume>
          ,
          <fpage>145</fpage>
          -
          <lpage>184</lpage>
          ,
          <year>2003</year>
          .
        </mixed-citation>
      </ref>
      <ref id="ref49">
        <mixed-citation>
          49.
          <string-name>
            <surname>M. S. Fox</surname>
            ,
            <given-names>M.</given-names>
          </string-name>
          <string-name>
            <surname>Barbuceanu</surname>
            ,
            <given-names>M.</given-names>
          </string-name>
          <string-name>
            <surname>Gruninger</surname>
            and
            <given-names>J.</given-names>
          </string-name>
          <string-name>
            <surname>Lin</surname>
          </string-name>
          .
          <article-title>An organisation ontology for enterprise modelling</article-title>
          . In M. Prietula,
          <string-name>
            <given-names>K.</given-names>
            <surname>Carley</surname>
          </string-name>
          and L.
          <string-name>
            <surname>Gasser</surname>
          </string-name>
          (Eds.),
          <source>Simulating Organizations: Computational Models of Institutions and Groups</source>
          , Menlo Park, CA: AAAI/MIT Press,
          <year>1998</year>
          ,
          <fpage>131</fpage>
          -
          <lpage>152</lpage>
          .
        </mixed-citation>
      </ref>
      <ref id="ref50">
        <mixed-citation>
          50.
          <string-name>
            <given-names>G.</given-names>
            <surname>Boella</surname>
          </string-name>
          and
          <string-name>
            <given-names>L. van der</given-names>
            <surname>Torre</surname>
          </string-name>
          .
          <article-title>A Foundational Ontology of Organizations and Roles</article-title>
          . In M. Baldoni and U. Endriss (Eds.),
          <source>Declarative Agent Languages and Technologies IV (DALT 2006), Lecture Notes in Computer Science</source>
          , vol
          <volume>4327</volume>
          , Berlin, Heidelberg: Springer-Verlag,
          <year>2006</year>
          ,
          <fpage>78</fpage>
          -
          <lpage>88</lpage>
          .
        </mixed-citation>
      </ref>
      <ref id="ref51">
        <mixed-citation>
          51. E. Bottazzi and
          <string-name>
            <given-names>R.</given-names>
            <surname>Ferrario</surname>
          </string-name>
          .
          <article-title>Preliminaries to a DOLCE Ontology of Organizations</article-title>
          .
          <source>International Journal of Business Process Integration</source>
          and
          <article-title>Management (Special Issue on Vocabularies, Ontologies and Business Rules for Enterprise Modeling</article-title>
          ),
          <volume>4</volume>
          (
          <issue>4</issue>
          ),
          <fpage>225</fpage>
          -
          <lpage>238</lpage>
          ,
          <year>2009</year>
          .
        </mixed-citation>
      </ref>
      <ref id="ref52">
        <mixed-citation>
          52.
          <string-name>
            <given-names>R.</given-names>
            <surname>Ferrario</surname>
          </string-name>
          ,
          <string-name>
            <given-names>C.</given-names>
            <surname>Masolo</surname>
          </string-name>
          and
          <string-name>
            <given-names>D.</given-names>
            <surname>Porello</surname>
          </string-name>
          . Organisations and
          <string-name>
            <given-names>Variable</given-names>
            <surname>Embodiments</surname>
          </string-name>
          . In S. Borgo,
          <string-name>
            <given-names>P.</given-names>
            <surname>Hitzler</surname>
          </string-name>
          and
          <string-name>
            <given-names>O.</given-names>
            <surname>Kutz</surname>
          </string-name>
          . (Eds.),
          <source>Proceedings of the 10th International Conference on Formal Ontology in Information Systems (FOIS</source>
          <year>2018</year>
          ), Cape Town, South Africa,
          <source>September 17-21</source>
          ,
          <year>2018</year>
          , Amsterdam: IOS Press,
          <fpage>127</fpage>
          -
          <lpage>140</lpage>
          . doi:
          <volume>10</volume>
          .3233/978-1-
          <fpage>61499</fpage>
          -910-2-127.
        </mixed-citation>
      </ref>
      <ref id="ref53">
        <mixed-citation>
          53. I. Horrocks,
          <string-name>
            <given-names>P.-F.</given-names>
            <surname>Patel-Schneider</surname>
          </string-name>
          ,
          <string-name>
            <given-names>D. L.</given-names>
            <surname>McGuinness</surname>
          </string-name>
          and
          <string-name>
            <given-names>C. A.</given-names>
            <surname>Welty</surname>
          </string-name>
          .
          <article-title>OWL: a Description-Logic-Based Ontology Language for the Semantic Web</article-title>
          . In F. Baader,
          <string-name>
            <given-names>D.</given-names>
            <surname>Calvanese</surname>
          </string-name>
          ,
          <string-name>
            <given-names>D. L.</given-names>
            <surname>McGuinness</surname>
          </string-name>
          ,
          <string-name>
            <given-names>D.</given-names>
            <surname>Nardi and P. F. PatelSchneider</surname>
          </string-name>
          (Eds.),
          <source>The Description Logic Handbook: Theory, Implementation and Applications (Second Edition)</source>
          , Cambridge: Cambridge University Press,
          <year>2007</year>
          ,
          <fpage>458</fpage>
          -
          <lpage>486</lpage>
          .
        </mixed-citation>
      </ref>
    </ref-list>
  </back>
</article>