The talk gives an overview of the Education for Life in the 21st Century Programme of the Fondazione Mondo Digitale (FMD), illustrating its reason and content. It addresses briefly the contextual aspects characterized by the continuous scientific-technological and socioeconomic changes and their consequent impact on companies, jobs, and school education in terms of tools, environments, and pedagogical offer. This is followed by the description of the components of the FMD's Education for Life Programme: (i) The Education for Life in the 21st Century Model (a person-centred, holistic educational model); (ii) The Self-Entrepreneurship and Personal Ecosystem Approach (sustaining that the objective of education in the 21st Century should be to equip people to become entrepreneurs of themselves); (iii) The InnovationGym and Network of InnovationGyms (a multi-lab and activity environment to realize the concepts of education for life and self-entrepreneurship); and (iv) The Inclusive Self-Entrepreneurship Accelerator (a practical programme integrating the above aspects and focused on youngsters) The talk also presents an example of a project focused on combatting educational poverty. The holistic and flexible approach of the Education for Life Programme supports educational players in their understanding and practice of systemic educational innovation. In practice, the Programme is an integrated set of innovative aspects and, simultaneously, an approach to systemic innovation in the school world.