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  <front>
    <journal-meta />
    <article-meta>
      <title-group>
        <article-title>Comparative Study of Biomedical Physiological based ECG Signal heart monitoring for Human body</article-title>
      </title-group>
      <contrib-group>
        <contrib contrib-type="author">
          <string-name>Pushparaj</string-name>
          <email>pushparajpal.ece20@nitttrchd.ac.in</email>
        </contrib>
        <contrib contrib-type="author">
          <string-name>Amod Kumar</string-name>
          <email>csioamod@yahoo.com</email>
        </contrib>
        <contrib contrib-type="author">
          <string-name>Garima Saini</string-name>
          <email>garima@nitttrchd.ac.in</email>
        </contrib>
      </contrib-group>
      <abstract>
        <p>Cardiovascular disease the major challenges in the current 21st century in terms of health care and related to diagnostic developments. In this pandemic COVID-19 scenario, the cardiovascular disease or non-cardiovascular disease has been increased like cardiac arrest or silent heart attack. According to WHO has guidelines, it is set to reduce 25% overall mortality rate due to cardiovascular disease upto 2025 on the priority basis kept as prevention and control. Some techniques developed for heart rate estimation from multimodal physiological signals namely ECG, AB, and PPG, EEG, EMG and EOG etc. are the part of cardiovascular and non-cardiovascular signals have been reviewed.</p>
      </abstract>
      <kwd-group>
        <kwd>1 ECG</kwd>
        <kwd>Arterial Blood Pressure (ABP)</kwd>
        <kwd>Electroencephalogram (EEG)</kwd>
        <kwd>Electro-oculogram (EOG) and Electromyogram (EMG)</kwd>
      </kwd-group>
    </article-meta>
  </front>
  <body>
    <sec id="sec-1">
      <title>1. Introduction</title>
      <p>
        Human body consists of various major parts and heart [
        <xref ref-type="bibr" rid="ref1">1</xref>
        ] plays the main important role for the
body to be alive else it is dead body. If other part of the body is infected but not related to heart then
with that problem the person can survive or alive with special care as per the infected disease. The
heart is the main system of the body to pump the blood throughout the body due to contraction of
muscles. Electrical signals [
        <xref ref-type="bibr" rid="ref2 ref3">2,3</xref>
        ] generated through the body, provoking variations in the electrical
potential of skin surface. These signals (ECG related to heart) are captured with the help of
electronics devices like electrode and related measurement equipment. At first these signals captured
in 1887 for human ECG [
        <xref ref-type="bibr" rid="ref4">4</xref>
        ] signals, the electrical activity of the heart is recorded. But now we have
so many approaches to measure or record ECG signals in three ways as ECG methods
[
        <xref ref-type="bibr" rid="ref3 ref5">3,5</xref>
        ]1.in-the-person
2.on-the-person
3.off-the-person
      </p>
      <p>
        When a person report for treatment or surgery then if certain designed equipments are used inside
the human body or ingested in the form of pills are well known as in-the-person category. If some
electrodes or sensors are used over the human body or touch the outer skin for ECG measurements is
well known to be on-the-person category and majorly used devices for ECG monitoring. In case of
off-the-person category it is found that minimal skin contact or ECG without skin contact. It is based
on the capacitive devices which measures the electric field changes induced by body allow ECG
measurement at distances of 1cm or more even with the help of sensors[
        <xref ref-type="bibr" rid="ref6">6,7</xref>
        ].
      </p>
      <p>
        Various tests are used to diagnose heart disease[
        <xref ref-type="bibr" rid="ref6">6-8</xref>
        ] and doctor enquires about personal and
family medical history [8,9]and records the present and past symptoms. Based on the assessment
enquiries doctor recommend for the related laboratory test. These tests may be invasive or
noninvasive test. If laboratory tests are taken with the help of instrument inserted into the body is called
non-invasive otherwise it is understood invasive tests[8-10].
Types of Test:
1. Invasive test
2. Non-Invasive Test
      </p>
      <p>Invasive Test: It is a medical practice of cut skin and insert into the body opening for test using
instruments while doing such types of test [10, 11] biopsy, endoscopy, and cryotherapy etc is
required.</p>
      <p>
        Non-Invasive test: Non-invasive disease does not damage other organs of human body [
        <xref ref-type="bibr" rid="ref2 ref5">2,5</xref>
        ]. In
this case when there is no need of tools that break the skin physically enter the body the skin. For
instances [
        <xref ref-type="bibr" rid="ref4 ref5">4, 5, 9</xref>
        ] x-ray, CT Scan, MRI, ECG. Hearing aids, external splints and casts fall under this
category as a related device.
      </p>
      <p>Cardiac Catheterization: common procedure that helps to diagnose heart disease [7,8] it can also
be used to treat heart disease by opening blocked arteries with balloon angioplasty and stent
placement.</p>
      <p>These signals can be classified through the classifier [16,18] as SVM-support vector machine.
Multimodal physiological [10-12] signals are helpful to monitor continuously the health of patients
either in ICU or at home at night. In high-tech hospitals [9, 11] there are the availability of intelligent
bed system [11-13] for the patients whom automatically health monitors[12,14] and send the signal to
the cloud server. Mainly focused signals are Electrocardiogram (ECG), Arterial Blood Pressure
(ABP), Electromyogram (EMG), Electroencephalogram (EEG) and Photoplethysmogram
(PPG)[11,12,15] etc. The signals directly helpful to monitor the heartbeat are related to cardiovascular
and these are ECG, ABP and PPG etc and those physiological signals are indirectly connected or
helpful are called non-cardiovascular signals such as EEG,EMG and EOG etc.</p>
      <p>In Figure 3, it represents the heart signal observed as ECG signal and shows some up-down lines
like half sinewave and sharp peak like sawtooth waveform as monitored in electrons analog signals.
Basically these have been termed as the English alphabets namely P; Q; R; S; T; U. These are the
heart monitored ECG signals and termed as P-wave, T-wave, U-wave, and QRS complex wave. If we
go through all the waves shows unique patterns. So these have defined as P-wave as atrial
depolarization, T-wave as ventricular repolarization, U-wave as Papillary muscle repolarization and
the last one is QRS complex wave as ventricular depolarization.</p>
    </sec>
    <sec id="sec-2">
      <title>2. Literature</title>
      <p>
        Eduardo Jose da S. Luz, et al [
        <xref ref-type="bibr" rid="ref1">1</xref>
        ], authors described in their work about the current scenario
stateof-art-methods of ECG-based automatic abnormalities heart beat classification, ECG signal
processing heartbeat segmentation techniques, feature description methods and learning algorithms
used.
      </p>
      <p>
        Tian Zhou, et al [
        <xref ref-type="bibr" rid="ref3">3</xref>
        ], results have compared the performance of different classifier, sensor fusion
schemes, physiological modalities such as heart rate variability, electrodermal, and
Electroencephalogram (ECG), (single vs multiple based on the prediction). In this case multisensors
approach is used and got the individual performance which predicts cognitive workload levels of
83.2% of the time during basic and complex surgical skills tasks.
      </p>
      <p>
        Wei Wei, et al, [
        <xref ref-type="bibr" rid="ref4">4</xref>
        ], proposed a decision level weight fusion strategy for emotion recognition in
multichannel physiological signals. Study focused on the four types of physiological signals includes
EEG, ECG, Respiration Amplitude RA, and Galvanic Skin Response GSR. Various analysis domains
have been used in physiological emotion features extraction. Secondly, adopted feedback strategy for
weight definition, according to recognition rate of each emotion of each physiological signal based on
Support Vector Machine, SVM classifier independently.
      </p>
      <p>
        Luis J.Mena et.al [
        <xref ref-type="bibr" rid="ref5">5</xref>
        ], developed wearable ECG monitoring device integrated with self-designed
wireless sensor for ECG signal acquisition. It is native purposively designed smartphone application
based on machine learning techniques, for automated classification of captured ECG beats from aged
people.
      </p>
      <p>Deger Ayata, et al [8], proposed a novel emotion recognition algorithm from multimodal
physiological signals for emotions aware healthcare systems. The physiological signals are collected
from respiratory belt RB, photoplethysmography PPG, and fingertip temperature FTT sensors. The
collection of the signal is done by wearable technologies. The results shows improved accuracy for
arousal (69.86 to 73.08%) and from (69.53 to 72.18%) for valence. This is due to the multiple sources
of physiological signals and their fusion increases the accuracy rate of emotion recognition.</p>
      <p>Xiaowei Zhang, et al [9], proposed a regularized deep fusion of kernel machine framework for
emotion recognition based on multimodal physiological signals. Experimental study shows two
benchmark datasets which improve the subjects-independent emotion recognition and compared to
single-modal classifiers or other fusion methods.</p>
      <p>Chen Wang et al [10], proposed various methodologies to monitor or detection of heart rate (HR)
using human face recording. This is done as there is motion in the cardiovascular activities or subtle
color changes as the method used.</p>
      <p>Syem Ishaque et al [11], restricted the physiological signals ECG, EDA (Electrodermal Activity),
PPG (photoplethysmography), and respiration (RESP) analyzed the heart rate variability between
each heartbeat w.r.t time. Various analysis of various research work have been analyzed HRV
associated with morbidity and stress. Detection of HRV in motion is far from perfect situations
involving exercise or driving reported accuracy as high as 85% and as low as 59%. This can be
improved with the advancement of machine learning techniques.</p>
      <p>Fanny Larradet et al [12], focused on the methodological issues in real life data collection in the
wild based on physiological signals like emotion recognition. In the paper common technique used to
induce emotions for the physiological dataset creation to compare with existing dataset of real-life
applications. Author also proposed a set of categories visual tool called Graphical assessment of
reallife application-focused emotional dataset (GARAFED) and compared with existing physiological
datasets for EMSR in the wild.</p>
      <p>Quentin Meteier et al [13], discussed about the workload and task of drivers requested to regain
the control of the car while performing the secondary task. In future, no longer of primary task for the
driver as the automation of cars introduced. Measuring drivers workload continuously essential to
support the driver and hence to limit the no. of accidents in takeover situations. For this purpose
machine learning techniques is used to evaluate and classify the workload in real-time.</p>
      <p>Haoran Xu et al [17], prepared the system for the hospital general ward to monitor wirelessly
(wearable and artificial intelligence) using physiological signals (ECG, RESP and transmit data
wireless). The system consists of multi-sensor wearable device, database servers and user interface.
Hospital needs to be highly integrated with the existing hospital information system and then explored
the set of processes of physiological signals acquisition, storage, analysis and combination with the
ehealth records. Once the system is implemented in the general ward of the hospitals and starts
collecting more than 1000cases from the clinics and so continues the whole system repeatedly to give
the clinic feedback. With this system helps in reliable physiological monitoring of patients of general
ward in the hospitals and generates more personalized pathophysiological signals/information to
diagnose the disease and treatment form continuously monitored physiological data.</p>
      <p>Throughout the latest 20 years, beat screens (HRMs) have become a for the most part used guide
for a grouping of employments [18]. The improvement of new HRMs has in like manner progressed
rapidly during the latest two decades. Despite beat (HR) responses, look at has starting late revolved
more around beat capriciousness (HRV).</p>
      <p>Existing approach for separating heart-related signs fall under two classes: wearable sensor
advancements [19] and non-contact (fusing) structures. The conventional framework for checking
beat surveyed the spikes of the potential made by heart at each weight beat for example
electrocardiogram, or ECG. Physiological estimations, for example, ECG signals, are unbelievable
considering the way that they are obliged by means of modified actuations of the autonomic
unmistakable structure (ANS).</p>
      <p>In any case, existing sensors that can separate these signs require physical contact with subject's
body, and causes impedance with the client experience. Various wearable advances, for example, a
versatile ECG contraption, worn as a chest band holds the sensor focused over the heart, may move
the readings remotely to the host PC. Unfortunately, the chest band is ungainly when worn for
extended periods. It has a task to do in helpful and practice settings, at any rate it's unquestionably not
a feasible choice for consistent use. Subsequently, wristband or a sharp have inadequacies [20].</p>
    </sec>
    <sec id="sec-3">
      <title>3. Inferences from Literature</title>
      <p>
        Eduardo Jose da S. Luz, et al [
        <xref ref-type="bibr" rid="ref1">1</xref>
        ], The depth and detailed discussion has been concise related to
limitations, drawback methods found the literature which concludes and remarks the same and future
challenge. Finally authors proposed the evaluation workflow process.
      </p>
      <p>
        Tian Zhou, et al [
        <xref ref-type="bibr" rid="ref3">3</xref>
        ], Authors discussed about the frame work leverages wireless sensors to monitor
surgeons’ cognitive load and predicts their cognitive load and predict their cognitive states.
Continuous multiple physiological modalities had simultaneously recorded for 12 surgeons
performing surgical skill task on the validated da Vinci Skills Simulator.
      </p>
      <p>
        Wei Wei, et al, [
        <xref ref-type="bibr" rid="ref4">4</xref>
        ], The experiments on the MAHNOB-HCI database show the highest accuracy.
The result also provide evidence and suggest a way for further developing a more specialized emotion
recognition system based on multichannel data using weight fusion strategy.
      </p>
      <sec id="sec-3-1">
        <title>Evaluation Metrics</title>
        <sec id="sec-3-1-1">
          <title>Sensitivity</title>
        </sec>
        <sec id="sec-3-1-2">
          <title>Specificity</title>
        </sec>
        <sec id="sec-3-1-3">
          <title>Accuracy</title>
        </sec>
        <sec id="sec-3-1-4">
          <title>Precision</title>
          <p>
            Luis J.Mena et.al [
            <xref ref-type="bibr" rid="ref5">5</xref>
            ], When tested on 100older adults, the monitoring system discriminated normal
and abnormal ECG signals with a high degree of accuracy 97%, sensitivity 100%, and specificity
96.6% With further verification, the system could be useful for detecting cardiac abnormalities in the
home environment and contribute to prevention, early diagnosis, and effective treatment of
cardiovascular diseases, while keeping costs down and increasing access to healthcare services for
older persons.
          </p>
          <p>Deger Ayata, et al [8], The study shows a framework for emotion recognition using multimodal
physiological signals from RB, PPG, and FTT. The paper concluded that the decision level fusion</p>
        </sec>
      </sec>
      <sec id="sec-3-2">
        <title>Low-power microchip 8-bit AVR RISC-Based</title>
      </sec>
      <sec id="sec-3-3">
        <title>Microcontroller</title>
        <p>3.3V
100M-ohm</p>
        <sec id="sec-3-3-1">
          <title>Range 0.1Hz and Internal 8Mhz calibrated</title>
        </sec>
        <sec id="sec-3-3-2">
          <title>Oscillator</title>
        </sec>
        <sec id="sec-3-3-3">
          <title>More than 90dB</title>
          <p>45
9.6KHz</p>
        </sec>
        <sec id="sec-3-3-4">
          <title>8bits 3.3V</title>
        </sec>
      </sec>
      <sec id="sec-3-4">
        <title>Low-power microchip 8-bit AVR RISC-Based</title>
      </sec>
      <sec id="sec-3-5">
        <title>Microcontroller</title>
        <p>3.3V
100M-ohm</p>
        <sec id="sec-3-5-1">
          <title>Range 0.1Hz and Internal 8Mhz calibrated</title>
        </sec>
        <sec id="sec-3-5-2">
          <title>Oscillator</title>
        </sec>
        <sec id="sec-3-5-3">
          <title>More than 90dB</title>
          <p>45
9.6KHz</p>
        </sec>
        <sec id="sec-3-5-4">
          <title>8bits</title>
        </sec>
      </sec>
      <sec id="sec-3-6">
        <title>Values (%)</title>
        <p>100
96.6
97
81.3</p>
        <sec id="sec-3-6-1">
          <title>Random Forest</title>
        </sec>
        <sec id="sec-3-6-2">
          <title>Random Forest</title>
        </sec>
        <sec id="sec-3-6-3">
          <title>Random Forest FS-14 FS-10 FS-10</title>
          <p>from multiple classifiers improved the accuracy rate of emotion recognition both for arousal and
valence dimensions.</p>
          <p>Xiaowei Zhang, et al [9], Final fusion representation exhibits higher class-separability power for
emotion recognition.</p>
          <p>Table 12</p>
        </sec>
        <sec id="sec-3-6-4">
          <title>Data dimension output of each module of the RDFKM Framework for each modality during the training phase on DEAP and DECAF datasets</title>
          <p>Chen Wang et al [10], Several other approaches have been proposed as signal processing and
machine learning. The algorithms analyzed and compared with the public database MAHANOB-HCI.</p>
        </sec>
      </sec>
      <sec id="sec-3-7">
        <title>Stage</title>
        <sec id="sec-3-7-1">
          <title>Face video processing (extracted skin area)</title>
        </sec>
        <sec id="sec-3-7-2">
          <title>Blood volume pulse signal extraction</title>
          <p>(independent component analysis)</p>
        </sec>
        <sec id="sec-3-7-3">
          <title>Heart rate computing (peak detection)</title>
          <p>Note: Mean error (M)-Performance measured; Standard Deviation (SD), RMSE(Root mean
squared error) ; ρ-correlation co-efficient</p>
          <p>Quentin Meteier et al [13], The author concluded a high level of drivers’ mental workload can be
accurately detected while driving in conditional automation based on 4-min recordings of respiration
and skin conductance.</p>
        </sec>
      </sec>
      <sec id="sec-3-8">
        <title>Selected signals</title>
      </sec>
    </sec>
    <sec id="sec-4">
      <title>4. Conclusion</title>
      <p>I have studied last 6years paper and their linked referenced papers too previously cited paper in the
literature papers. From all those papers it has been concluded that various types of physiological
signals, various parameters as per the papers have been reviewed. The physiological signal (ECG)
has been used to detect for some abnormalities in heartbeat classifications, segmentation techniques,
and feature descriptions and learning algorithms used. In some papers different datasets used,
different modalities, signal extraction and classifiers used, discussion of wearable technologies, and
surgical skill task validated with da Vinci Skills Simulator. With different modalities signals found
results to individual accuracy and precision four types of physiological signals includes EEG, ECG,
Respiration Amplitude RA, and Galvanic Skin Response GSR. Various analysis domains have been
used in physiological emotion features extraction.</p>
    </sec>
    <sec id="sec-5">
      <title>5. Acknowledgment</title>
      <p>We are thankful to the department of Electronics and Communication Engineering, National
Institute of Technical Teachers Training and Research, Chandigarh for their interest in this work and
useful comments to draft the final form of the paper. The support of AICTE QIP (Poly) Schemes
department, Government of India is gratefully acknowledged. We would like to thank NITTTR
Chandigarh for lab facilities and research environment to carry out this work.
6. References
[7] Bassett, D.R. Device-based monitoring in physical activity and public health research. Physiol.</p>
      <p>Meas.2012, 33, 1769. Sensors 2020, 20, 6778 14 of 16
[8] [8] Ayata, D., Yaslan, Y., &amp; Kamasak, M. E. (2020). Emotion recognition from multimodal
physiological signals for emotion aware healthcare systems. Journal of Medical and Biological
Engineering, 40(2), 149-157.
[9] Zhang, X., Liu, J., Shen, J., Li, S., Hou, K., Hu, B., ... &amp; Zhang, T. (2020). Emotion recognition
from multimodal physiological signals using a regularized deep fusion of kernel machine. IEEE
transactions on cybernetics.
[10] Wang, C., Pun, T., &amp; Chanel, G. (2018). A comparative survey of methods for remote heart rate
detection from frontal face videos. Frontiers in bioengineering and biotechnology, 6, 33.
[11] Ishaque, S., Khan, N., &amp; Krishnan, S. (2021). Trends in Heart-Rate Variability Signal Analysis.</p>
      <p>Frontiers in Digital Health, 3, 13.
[12] Larradet, F., Niewiadomski, R., Barresi, G., Caldwell, D. G., &amp; Mattos, L. S. (2020). Toward
emotion recognition from physiological signals in the wild: approaching the methodological
issues in real-life data collection. Frontiers in psychology, 11, 1111
[13] Meteier, Q., Capallera, M., Ruffieux, S., Angelini, L., Abou Khaled, O., Mugellini, E., ... &amp;
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Future Prospects for Skin-Attachable Devices for Health Monitoring, Robotics, and Prosthetics.</p>
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[17] Xu, H., Li, P., Yang, Z., Liu, X., Wang, Z., Yan, W., ... &amp; Zhang, Z. (2020). Construction and
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    </sec>
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