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  <front>
    <journal-meta />
    <article-meta>
      <title-group>
        <article-title>Improved-STCN Network with Enhanced Strategy for Sequence Polyp Segmentation</article-title>
      </title-group>
      <contrib-group>
        <contrib contrib-type="author">
          <string-name>Quan He</string-name>
          <xref ref-type="aff" rid="aff0">0</xref>
        </contrib>
        <contrib contrib-type="author">
          <string-name>Xiaobo Hu</string-name>
          <xref ref-type="aff" rid="aff0">0</xref>
        </contrib>
        <contrib contrib-type="author">
          <string-name>Feng Sun</string-name>
          <xref ref-type="aff" rid="aff0">0</xref>
        </contrib>
        <contrib contrib-type="author">
          <string-name>Lulu Zhou</string-name>
          <xref ref-type="aff" rid="aff0">0</xref>
        </contrib>
        <contrib contrib-type="author">
          <string-name>Jing Wang</string-name>
          <xref ref-type="aff" rid="aff0">0</xref>
        </contrib>
        <contrib contrib-type="author">
          <string-name>Qiming Wan</string-name>
          <xref ref-type="aff" rid="aff0">0</xref>
        </contrib>
        <aff id="aff0">
          <label>0</label>
          <institution>Hangzhou Hikvision Digital Technology Co.,ltd</institution>
          ,
          <addr-line>Hangzhou</addr-line>
          ,
          <country country="CN">China</country>
        </aff>
      </contrib-group>
      <abstract>
        <p>The detection of polyps is helpful to the diagnosis of early colorectal cancer. With the rapid development of deep learning, more and more researchers apply detection and segmentation technology to assist polyp detection. This work is our solution to the polyp segmentation subtask in the EndoCV2022 challenge. We come up with the idea from the semi-supervised video object segmentation and build on STCN [1] for this challenge. STCN is built for the task when the correct segmentation mask of the first frame of the video is given as input, then the model just tracks the target, no matter what it is. We modify STCN into a sequence polyp segmentation network named improved-STCN, which can not only segment the polyps but also track the polyps. As EndoCV2022 challenge [2] [3] is a sequence challenge, the images in the same sequence are very similar, which will lead to bad performance. Thus, we adopt semi-supervised learning to get more abundant data for training. We also carry out experiments on how to make the segmentation results more credible, that single frame detection and reverse sequence information will help in this part. Finally, on the round-II test, our system achieves a segmentation score of 0.7654 and ranked the second.</p>
      </abstract>
      <kwd-group>
        <kwd>eol&gt;Polyp segmentation</kwd>
        <kwd>Sequence data</kwd>
        <kwd>Deep learning</kwd>
        <kwd>Semi-supervised learning</kwd>
        <kwd>Improved-STCN</kwd>
      </kwd-group>
    </article-meta>
  </front>
  <body>
    <sec id="sec-1">
      <title>1. Introduction</title>
      <p>
        Colorectal cancer (CRC) is a common malignant tumor in
the gastrointestinal tract. Its incidence rate and mortality
rate are the second most important in digestive system
cancer, followed by gastric cancer, esophageal cancer
and primary liver cancer. Polyp is considered a sign of
precancerous lesions, thus, finding it at any time during
precancerous lesions and blocking it not only reduce the
mortality of colorectal cancer, but also reduce the
incidence rate. Colorectal lesions are usually diagnosed by Figure 1: Example of EndoCV2022 challenge sequence data
colonoscopy, but unfortunately, it is estimated that about
6-27% of pathological missed diagnosis in colonoscopy
[
        <xref ref-type="bibr" rid="ref4">4</xref>
        ]. Colonoscopy image analysis and decision support the context in the image. The encoder is just a
tradisystem have shown great potential in improving examina- tional convolution and maximum pool layer stack. The
tion eficiency and reducing the number of missed lesions second path is the symmetric spread path (also known
[
        <xref ref-type="bibr" rid="ref5">5</xref>
        ]. Deep learning is more and more widely used in the as the decoder), which is used for precise positioning
ifeld of medical images. Since MICCAI 2015 Automatic using transpose convolution. This structure has been
Polyp. proved to be able to segment medical images efectively.
      </p>
      <p>
        Detection in Colonoscopy Videos challenge, more and However, for sequence data in real scenes, this kind of
more datasets and challenges have been launched, which method can not efectively model timing information.
further promote the application of deep learning-based In the field of video object segmentation, the model is
endoscopic vision [
        <xref ref-type="bibr" rid="ref6">6</xref>
        ]. Among them, the most widely trained to extract the relationship between video frames
used deep learning model is Unet [
        <xref ref-type="bibr" rid="ref7">7</xref>
        ] and its variants. to improve the performance of segmentation. Masktrack
The Unet consists of two paths. The first path is a com- [
        <xref ref-type="bibr" rid="ref8">8</xref>
        ] is a typical network of video object segmentation.
pression path (also known as an encoder) that captures Taking the mask of the previous frame and the current
frame as the model input, the trained model will outputs
the mask of the current frame with high segmentation
accuracy. However, the performance of this method often
depends on the accuracy of the output of the previous
frame, which has the risk of cumulative error. This work
is our solution to the polyp segmentation subtask in the
4th International Workshop and Challenge on Computer Vision in
Endoscopy (EndoCV2022) in conjunction with the 19th IEEE
International Symposium on Biomedical Imaging ISBI2022, March
28th, 2022, IC Royal Bengal, Kolkata, India
$ whut2014hq@163.com (Q. He)
      </p>
      <p>© 2022 Copyright for this paper by its authors. Use permitted under Creative Commons License
CPWrEooUrckReshdoinpgs IhStpN:/c1e6u1r3-w-0s.o7r3g ACttEribUutRion W4.0oInrtekrnsahtioonpal (PCCroBYce4.0e).dings (CEUR-WS.org)
EndoCV2022 challenge. The proposed approach is built encoder and a value encoder respectively. The key
enon STCN, a semi-supervised video object segmentation coder encodes the images into the key feature space and
network. In particular, we modify STCN into a sequence the value encoder encode both the images and mask into
polyp segmentation network ,which can not only seg- the value feature space. The key correspond with value
ment the polyps but also track the polyps. In short, our one by one will be stored in the memory bank. Then,
main contribution for this work are as follows: when a new frame in the video sequence is collected, the
frame will be encoded into the key feature space firstly,
• We modify STCN into a sequence polyp seg- and then calculate the similarity with the key features
mentation network, which will no need the first of the previous frame stored in the memory bank. The
frame’s mask to predict like it used to be. And we most similar features will be combined into the feature
also practice the experiment on training strategy space of the current frame for model outputs. Here, the
to find a stronger model. negative square Euclidean distance is used as similarity
• We learn from semi-supervised learning to gener- functions, which is defined as follows:
ate more training data, as the image of the same
sequence have great similarity, which is not con-  = −||  −  ||22 (1)
ducive to the improvement of network
generalization and feature extraction ability. where  represents the previous frames’ key
features,  represents the current frames’ key feature.
• We propose an enhanced scheme to make the Then the aggregated readout feature   for the current
segmentations results more credible. Overall, frame can be computed as a weighted sum of the memory
our method is proved to be efective in the En- features with an eficient matrix multiplication:
doCV2022 challenge round-I and round-II.
  =  .
(2)</p>
    </sec>
    <sec id="sec-2">
      <title>2. Method</title>
      <p>
        which is then passed to the decoder for mask generation
[
        <xref ref-type="bibr" rid="ref1">1</xref>
        ].
2.1. Overview of the framework STCN is used to meet the semi-supervised video object
Figure 2 shows the overall process of the improved-STCN. segmentation task where the first frame of the video is
The network use ResNet50 and ResNet18 to build a key needed. We have specially improved the STCN’s
structure named improved-STCN for EndoCV2022 challenge.
In particular, we firstly hidden memory bank and
afinity compute module, then add a convolution module to
get the single frame segmentations network (SFSN), as
shown in the red dashed box in the figure 2. In the train- Figure 4: EndoCV2022 challenge Dataset statistical
ing phase, we train the SFSN only to make the encoder
and decoder strong. Then the parameter of SFSN will be
the pre-training parameters for STCN’s training. In the of the network output response in the segmentation
tarinference phase, for the first frame, SFSN will outputs get area. Then the key encoder and value encoder of
the result firstly, then STCN will track the mask and com- STCN will encode the segmentation results with higher
plete the predictions of all subsequent sequences. In this confidence and store the coding results in the memory
way, improved-STCN build the ability of single frames’ bank. The prediction of all subsequent sequences will be
segmentation without the help of other frames. Finally, completed next.
the improved-STCN can not only segment the polyps but Sequence information is helpful for model
segmenalso track the polyps that appear in the previous frame. tation. Usually, we use forward sequence information.
As for ofline diagnosis, such as capsule endoscopy
di2.2. Semi-supervised learning agnosis, we can take advantage of backward sequence
information. Thus, we reverse the input sequence data
Due to the small field of vision of the endoscope and and make the model to predict. Then, fuse the forward
the slow movement during endoscopy, the sequence data sequence data results and the backward sequence data
collected over a period of time are highly approximate, results as the final output of the network. Here, fuse
as figure 1 shows. These approximate data are not con- method is the same as the above, that is comparing the
ducive to the improvement of network generalization confidence in the segmentation result and select the one
ability and feature extraction ability. We learn from semi- with higher confidence as the final result.
supervised learning to generate more training data. In
practice, firstly, we use all the EndoCV2022 challenge
Dataset and STCN to train the polyp tracking model. 3. EXPERIMENTAL RESULTS
Then we manually annotate the first frame of the
HyperKvasir videos [
        <xref ref-type="bibr" rid="ref9">9</xref>
        ], and the polyp tracking model will gen- The experimental part is mainly composed of two
parterate the pseudo labels. In this way, we get more abun- snamed baseline experiments and experiments used for
dant sequence data with labels, which is helpful for our the challenge. In part one, the baseline experiments were
model’s learning. used to find the suitable hyper-parameters and data
augmentation strategy for the training of improved-STCN.
      </p>
      <p>Besides, we carried out the semi-supervised learning
men2.3. Enhanced scheme tioned in the Subsection 2.2. We also explored the efects
Although the model mentioned in the Subsection 2.1 of illumination and size on model’s performance. In part
has the ability to segment and track the polyps, we find two, we used the same train strategy as the part one to
that train two models to segment and track polyps sepa- train model with all the dataset we have, and tested model
rately will get better results. As figure 3 shows, SFSN that with the Endocv2022 challenge unseen dataset. The
enchange from STCN is used to segment the polyps in the hanced scheme was adopted to get the more credible
ifrst few frames of the sequence data. Meanwhile, STCN segmentation results.
will also outputs the segmentation results. The results of
the two models will use the same calculation method to
obtain confidence, which is defined as the average value</p>
      <sec id="sec-2-1">
        <title>3.1. Dataset</title>
        <sec id="sec-2-1-1">
          <title>The EndoCV2022’s organizing committee provided a to</title>
          <p>
            tal of 46 sequence data for all participants. According to
the statistics, the EndoCV2022 challenge Dataset consists
3348 frames sampled in the real-world clinical scenario.
As figure 4 shows, most polyps are around 400 in size
while a few polyps are larger than 800. Due to the
diferent sizes of polyps and images, we need to pay attention
to using some strategies to reduce the sensitivity of the
network to resolution, such as Multi-scale training.
Although polyps have diferent shapes and sizes, the image
of the same sequence data have great similarity, which is
not conducive to the improvement of network’s
generalization and feature extraction ability. Thus, in baseline
experiments, we split the EndoCV2022 challenge Dataset
into 80% for training and 20% for validation in sequence.
To enhance the generalization and feature extraction
ability of our model, we also utilized three well-known
publicly endoscopy sequence datasets, ETIS-Larib Polyp [
            <xref ref-type="bibr" rid="ref10">10</xref>
            ],
CVC-Clinic [
            <xref ref-type="bibr" rid="ref11">11</xref>
            ], and Hyper-Kvasir dataset. ETIS-Larib
Polyp DB were used directly as a training set. CVC-Clinic
were used as validation set as more data can better
evaluate the generalization of the model. As HyperKvasir
dataset has only video data and no labels, we adopted
the method mentioned in the subsection 2.2 to generate
labels. Then, these sequence data with pseudo labels
were also used as a training set. In the experiments for
challenge, we used the same train strategy as the baseline
experiments, and trained model with all the dataset we
have
          </p>
        </sec>
        <sec id="sec-2-1-2">
          <title>EndoCV2022 leaderboard also chosen the Dice coeficient as the scores to evaluate the performance of the model.</title>
        </sec>
      </sec>
      <sec id="sec-2-2">
        <title>3.3. Training Details</title>
        <sec id="sec-2-2-1">
          <title>We chose PyTorch to train our model, and both the train</title>
          <p>
            and inference were run on the NVIDIA TESLA V100
GPU. Here, we minimized the cross-entropy loss using
Adam optimizer with default momentum  1 = 0.9,  2
= 0.999. The learning rate lr=0.0001 and the batch size
was set to 16. The input image size of the model was
384 × 384 pixels As it was an sequential learning task,
the maximum temporal distance between frames was
set to be [
            <xref ref-type="bibr" rid="ref10 ref5 ref5">5,10,15,20,25,5</xref>
            ] at the corresponding iterations
of [0%,10%,20%,30%,40%,90%] of the total 20000 training
iterations We also adopted the strategy to make the model
pay more attention to the learning of dificult pixels. After
15000 iterations, only the top-20% pixels that had the
highest loss would be selected to compute gradients. As
we describes in the subsection 3.1, we added multi-scale
training strategy to train model. The initial input image
size of the model was 384 × 384 pixels, the model would
be trained with multi-scale training parameters 0.75, 1,
1.25.
          </p>
        </sec>
      </sec>
      <sec id="sec-2-3">
        <title>3.4. Experimental Results</title>
        <p>
          Table 1 shows the Ablation study result of Endocv2022
validation and CVC-Clinic datasets. Firstly, we see that
when we use semi-supervised learning, the dice
coeficient of the model in the Validation Set (EndoCV2022
validation + CVC-Clinic) has increased by 3%. It proves
3.2. Evaluation Metrics that adding more sequence data for model to learn does
help .Secondly, colonoscopy is a product of a combined
The EndoCV2022’s organizing committee provided par- light source, thus, the collected images are either very
ticipants a toolbox to calculate the scores between the bright or very dark. We set color jitter of (brightness=0.5,
predicted mask and the ground truth mask at github contrast=0.03, saturation=0.03) to simulated light change.
[
          <xref ref-type="bibr" rid="ref12 ref13">12, 13</xref>
          ]. There are seven metrics in the toolbox: Jaccard In this way, the dice coeficient improves to 0.7694.
Fig(Jac), Dice, F2-score, Precision (Positive Predictive Value, ure 5 shows that images cases which the base model can
PPV), Recall (Rec), Accuracy (Acc), and Hausdorf dis- not segment benefit from this approach. Lastly, we see
tance (Hdf). As these metrics are similar, and to make that the scale of images will afect the performance of
experiments more eficient, we chose the most commonly the model. The multi-scale training strategy reduces the
used metrics for the medical image segmentation, the Jac- sensitivity of the model to image resolution, as the dice
card and the Dice coeficient. The Jaccard is defined as coeficient of the model improves to 0.7800.
follows: Table 2 provides our model’s segmentation results on
  EndoCV2022 challenge segmentation task. Firstly, the
  = 2 *   +   +   (3) improved-STCN model we have trained for polyp
segmentation have an excellent performance on the unseen
        </p>
        <p>Where TP represents true positive "polyp", while FP dataset while the dice coeficient is up to 0.7423.This
reand FN represents false positive and false negative re- sult already make us ranked the top5 on the leaderboards.
spectively. Similarly, the Dice coeficient is calculated as When we adopt the two methods mentioned in the
subfollows: section 2.3, the dice coeficient has increased by 2% and
by 3% respectively. From the results, we see that our
en = (4) hance scheme mentioned above does help. Unfortunately,
2 *  
2 *   +   +</p>
      </sec>
    </sec>
    <sec id="sec-3">
      <title>4. Conclusion</title>
      <p>In this work, we have detailed our solution for the polyp
segmentation subtask in the EndoCV2022 challenge. We
have proposed improved-STCN network with a
semisupervised learning method to improve model’s
generalization and an enhanced scheme to make model output
more credible results. Limited experimental results show
that our method achieves consistently high Dice scores
at very low standard deviations, suggesting its suitability
for polyp segmentation on endoscopic sequence data.</p>
    </sec>
  </body>
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