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<article xmlns:xlink="http://www.w3.org/1999/xlink">
  <front>
    <journal-meta>
      <journal-title-group>
        <journal-title>Arequipa,
Peru
* Corresponding author
$ mercy.agilam@ug.edu.ec (M. Agila); larry.yumibandam@ug.edu.ec (L. Yumibanda); diana.merchang@ug.edu.ec
(D. Merchán)</journal-title>
      </journal-title-group>
    </journal-meta>
    <article-meta>
      <title-group>
        <article-title>Bio-Business of Polymer Derived from Cassava Waste for the Industrial Plastic Sector</article-title>
      </title-group>
      <contrib-group>
        <contrib contrib-type="author">
          <string-name>Mercy Agila</string-name>
          <xref ref-type="aff" rid="aff0">0</xref>
        </contrib>
        <contrib contrib-type="author">
          <string-name>Larry Yumibanda</string-name>
          <xref ref-type="aff" rid="aff0">0</xref>
        </contrib>
        <contrib contrib-type="author">
          <string-name>Diana Merchán</string-name>
          <xref ref-type="aff" rid="aff0">0</xref>
        </contrib>
        <aff id="aff0">
          <label>0</label>
          <institution>Universidad de Guayaquil</institution>
          ,
          <country country="EC">Ecuador</country>
        </aff>
      </contrib-group>
      <pub-date>
        <year>2022</year>
      </pub-date>
      <volume>000</volume>
      <fpage>0</fpage>
      <lpage>0002</lpage>
      <abstract>
        <p>This work deals with the design of a bio-business for the production of polymer-based cassava waste, located in the city of Guayaquil, for which several aspects were reviewed: theoretical, regulatory, labor, administrative, technical and financial. This business opportunity is propitious to take advantage of the solid organic waste produced in the markets. The target demand was the entrepreneurs of the plastics industry in the city of Guayaquil. Descriptive, analytical, and cross-sectional method was used, and data collection was done through interviews and surveys to analyze the supply of raw materials and the need for the purchase of the sector. The B2B model was proposed to commercialize the biopolymer. The technical processes were analyzed with semi-mechanize manufacturing to cover the demand and the economic and financial evaluation of the project generated positive indicators for the financial feasibility and sustainability of the project.</p>
      </abstract>
      <kwd-group>
        <kwd>eol&gt;Bio-business</kwd>
        <kwd>Polymer</kwd>
        <kwd>Cassava Waste</kwd>
        <kwd>B2B Model</kwd>
        <kwd>Industrial sector</kwd>
      </kwd-group>
    </article-meta>
  </front>
  <body>
    <sec id="sec-1">
      <title>1. Introduction</title>
      <p>
        A large amount of the plastic industry worldwide is produced based on chemical components
derived from petroleum known as synthetic polymers, which have diferent uses for various
economic sectors: for the home, construction, industrial inputs, textile industry, white goods,
electrical and electronic equipment, computer equipment, automotive, etc. being a very desirable
material for its resistance to decomposition by microorganisms and durability. According to
Cahuana [
        <xref ref-type="bibr" rid="ref1">1</xref>
        ], plastic bags take between 100 to 400 years to degrade, making the generation of
waste on a global scale a serious problem.
      </p>
      <p>To mitigate the negative impact caused by the excessive use of plastic, some alternatives arise
such as the production of biodegradable polymer, and the most relevant quality is that it can be
obtained from organic waste residues that are present in nature.</p>
      <p>Bio-businesses emerge as a response to the global need to reduce food waste and the use of
polymers that can be made from organic waste in the industry. The problem lies in the fact that
the solid organic waste generated in homes, restaurants, food markets, etc., when not managed
properly, causes a series of problems such as unpleasant smells that afect the sense of smell, an
increase in flies, rodents and other insects that get close to the waste, a bad appearance to the
eye, and not least the increase in ambient temperature as a result of the decomposition of the
waste, the inconvenience caused in the open air rubbish dumps in the markets in the various
cities of the planet.</p>
      <p>
        According to the Sustainable Development Goals Roadmap [
        <xref ref-type="bibr" rid="ref2">2</xref>
        ], Ecuador is no exception
because "375,000 tons of solid urban waste are generated each year, but only 4% of this waste is
recycled", i.e. 96% of the waste is buried, according to El Universo, ecología [
        <xref ref-type="bibr" rid="ref3">3</xref>
        ].
      </p>
      <p>
        To counteract this problem, multiple actions have been established at a global level, such
as the circular economy, which is linked to the production of biodegradable products. Facing
this reality is what leads to the search for solutions to replace synthetic polymers with more
environmentally friendly polymers since the vast majority of industries are based on
petroleumbased chemicals such as synthetic polymers [
        <xref ref-type="bibr" rid="ref4">4</xref>
        ].
      </p>
      <p>
        The idea of the bio-business is focused on the design of a company dedicated to the production
of polymer that uses as raw material, organic material called starch, which is obtained from
cassava waste. The biopolymer obtained from the process is intended to be marketed as a
substitute raw material for industries that use synthetic polymer based on petroleum, this
bio-business proposal represents an environmentally friendly solution [
        <xref ref-type="bibr" rid="ref5">5</xref>
        ].
      </p>
    </sec>
    <sec id="sec-2">
      <title>2. Development</title>
      <p>
        Since ancient times, the Egyptians 2000 BC used natural resins to preserve the deceased, thus it
is stated that [
        <xref ref-type="bibr" rid="ref1">1</xref>
        ] "rubber, an isoprene polymer obtained from the latex of the Hevea brasiliensis
tree, was used by the American Indians, such as the Aztecs or the Mayans, to make balls or
shoes", in the 20th century Charles Goodyear by accident discovered that when rubber was
exposed to heat it became resistant and elastic, which is known as thermosetting elastomer, in
1869 John Wesley Hyatt created cellulose, in 1909 the chemist Leo Baekelan discovered the first
synthetic polymer known as Bakelite, named in his honor, which consists of a phenol resin plus
formaldehyde in the presence of a catalyst, in 1912 cellophane was created.
      </p>
      <p>
        After the Second World War and with industrial development, polyvinyl chloride (PVC,
1936), polyurethane (PU, 1937), and unsaturated polyester (PET, 1942), the raw materials used
to manufacture plastic bottles, emerged. With the oil crisis of the 1970s, new research was
carried out into the development of bioplastics, also known as biopolymers [
        <xref ref-type="bibr" rid="ref1">1</xref>
        ]. The most
common polymers on the planet are: "polyethylene (PE), polyethylene terephthalate (PET),
polyvinyl chloride (PVC), polypropylene (PP), polystyrene (PS), and polyamide (PA), due to
their mechanical properties and low production costs" (p.5). Polyhydroxybutyrate (PHB) is a
natural polymer synthesized by a variety of microorganisms. This polymer is biocompatible,
biodegradable, and widely studied for medical applications" [
        <xref ref-type="bibr" rid="ref2">2</xref>
        ].
      </p>
      <p>
        Biopolymers come from resources that are extracted from nature, such as cellulosic polymer,
obtained from wood, polylactic acid (PLA) obtained from corn, PHA which is produced by
enzyme complexes that are present in bacteria, and Thermoplastic Search (TPS) [
        <xref ref-type="bibr" rid="ref3">3</xref>
        ]. These
biopolymers have the quality of being biodegradable and do not release toxic elements in their
degradation process. Biopolymers are emerging as an alternative to conventional
petroleumbased polymers to reduce environmental pollution.
      </p>
      <p>
        A "polymer is a large molecule composed of many smaller repeating units called monomers
bonded together" [
        <xref ref-type="bibr" rid="ref3">3</xref>
        ]. Among the best-known polymers are elastomers, known as rubber, which
is a natural or artificial material that has great elasticity, plastics are synthetic materials that are
moldable and whose chemical composition includes cellulose, proteins, and resins. The main
sources of biopolymers are those of animal origin (collagen or gelatin), marine origin (chitin or
chitosan), agricultural origin (lipids and fats and hydrocolloids: proteins and polysaccharides),
and microbial origins such as polylactic acid (PLA) and polyhydroxyalkanoates (PHA) [
        <xref ref-type="bibr" rid="ref4">4</xref>
        ].
      </p>
      <p>
        Biopolymers have various applications, they can be used as raw material to manufacture
containers for packaging products with short shelf life such as fresh fruits and vegetables, in
products with long shelf life such as crisps and pasta, according to the raw material used they
can be prepared for the following applications [
        <xref ref-type="bibr" rid="ref5">5</xref>
        ]:
a) Cellulose: packaging, household disposal, and electronic devices.
b) Starch: food packaging, agricultural foils, textiles, and construction.
c) PLA: films, food packaging
d) For PHA: food packaging.
e) PHB: medical applications.
      </p>
      <p>
        Several studies have demonstrated the production of flexible biodegradable films based on
the starch of cassava Manihot esculenta of the Euphorbiaceae family, Crantz (1766), native
to central South America for more than 5000 years, as demonstrated in their research by the
authors Almario [
        <xref ref-type="bibr" rid="ref6">6</xref>
        ] and Riera-Palma [
        <xref ref-type="bibr" rid="ref7">7</xref>
        ] "In Ecuador, yucca is grown in all geographical regions,
from sea level to 1,620 m above sea level" [
        <xref ref-type="bibr" rid="ref8">8</xref>
        ]. It is grown by small and medium-sized farmers
alongside other crops in the Amazon region, in the coastal zone as a monoculture, and in the
low valleys of the Ecuadorian highlands as shown in Figure 1.
      </p>
      <p>
        "The most cultivated varieties, especially on the Ecuadorian coast, are the following: INIAP
Portoviejo-650, INIAP Portoviejo-951 and Three Months for the tropics "Escancela", "Patucha",
"Valencia", "Morada", INIAP-Portoviejo 650, INIAP Portoviejo 651 and the P-652 "La Rendidora"
[
        <xref ref-type="bibr" rid="ref8 ref9">8, 9</xref>
        ].
      </p>
      <p>
        The plastics industry in Ecuador is a dynamic sector that contributes 1.2% of the national
GDP, generates around 20 thousand direct jobs and 120 thousand indirect jobs, producing
about 500 thousand tons annually, figures provided by the Ecuadorian Association of Plastics,
this association is composed of about 600 companies nationwide, of which 120 belong to the
association, of these, most are located in Guayaquil, For the study, 27 plastic industries were
considered, which seek to reduce the amount of material derived from synthetic polymer, so
they are "working to incorporate recycled materials in their production processes, especially in
those related to the transport of goods, covers and primary packaging for food preservation"
[
        <xref ref-type="bibr" rid="ref4">4</xref>
        ].
      </p>
      <p>
        According to the Ministerio de Producción, Comercio Exterior [
        <xref ref-type="bibr" rid="ref10">10</xref>
        ]. The demand for plastic
in Ecuador is 20 kilos per capita per year, equivalent to 531,461 tons per year. The average of
this figure corresponds to the consumption of soft plastic packaging-use packaging, such as
sleeves or expanded polystyrene, which are dificult to recycle. This is 11.43% of the total waste
generated in the country.
      </p>
      <p>
        One of the actions by strategic line inserted in the White Paper on the Circular Economy
of Ecuador, in paragraph three, states "Invest in research and development of new alternative
materials and materials produced with a fraction of recycled plastic, reducing the use of additives
that prevent its subsequent recyclability" [
        <xref ref-type="bibr" rid="ref10">10</xref>
        ]. Based on this strategic action in the line of plastic,
the bio-business proposal is based, to ofer alternatives that contribute to reducing pollution
from plastic waste.
      </p>
      <p>
        In terms of trade, the White Paper for the Circular Economy of Ecuador indicates that "new
business models (servitization) must be implemented" [
        <xref ref-type="bibr" rid="ref10">10</xref>
        ]. For this purpose, the
commercialization model for the study is focused on B2B, a business-to-business service, considering the
benefits of the model as a distribution strategy.
      </p>
      <p>
        The B2B e-commerce strategy consists of commercial operations carried out directly from
company to company (business to business) through the use of technology and the internet, to
achieve eficiency, boost sales, improve customer-supplier relations and enter various markets
[
        <xref ref-type="bibr" rid="ref11">11</xref>
        ], E-commerce allows companies to innovate and be at the forefront, companies that do
not align themselves with this way of doing business are relegated or tend to be invisible
in the market, however, it is important to improve information services, networks, control
mechanisms, payment systems, among others.
      </p>
      <p>
        Currently, there is limited progress on new business models, despite being an important
pillar for the growth and sustainability of companies, as it mentions that [
        <xref ref-type="bibr" rid="ref12">12</xref>
        ] "The ability
to move quickly and successfully towards new business models is an important source of
sustainable competitive advantage and a key lever for improving the sustainability performance
of organizations".
      </p>
      <p>The bio-business proposal is to consider the cassava waste generated in the municipal markets,
which is a good opportunity to take advantage of this source of raw material that, in most cases,
ends up in open-air rubbish dumps, damaging the environment due to the toxic waste that is
spread into nature, as there is no good management of organic solid waste.</p>
    </sec>
    <sec id="sec-3">
      <title>3. Materials and methods</title>
      <p>
        For the development of this research, the mixed quantitative-qualitative approach was used
as a scientific method, because it fits the object of study and a pragmatic stance is taken for a
specific analysis as it refers to the specific situation in which the research was carried out [
        <xref ref-type="bibr" rid="ref13">13</xref>
        ].
The scope is descriptive because the situations related to the object of study were reviewed
to place them in the context, as it indicates "detailing how they are and how they manifest
themselves", as well as particularizing the properties of the plastic manufacturing industries
and the characteristics they possess to classify them and devise a sample to obtain the data for
a cross-sectional study.
      </p>
      <p>
        According to Hernández-Sampieri et al. [
        <xref ref-type="bibr" rid="ref14">14</xref>
        ], the mixed method represents a set of systematic,
empirical, and critical research processes and involves the collection and analysis of quantitative
data, as well as their integration and joint discussion, to make inferences from all the information
collected (meta-inferences) and to achieve a better understanding of the phenomenon under
study [
        <xref ref-type="bibr" rid="ref14 ref15">14, 15</xref>
        ].
      </p>
      <p>The research design is non-experimental because the data were collected and analyzed in
their natural state, without manipulating the independent variable because they are phenomena
that have already occurred and the researcher only collects, processes, and displays the results.</p>
      <p>
        According to the Superintendence of Companies, Securities and Insurance of Ecuador [
        <xref ref-type="bibr" rid="ref16">16</xref>
        ],
there are around 80 manufacturing companies in the plastics industry that use synthetic and
organic polymers, 41 industries in the coastal region, and 39 industries in the highlands. For the
study, the 37 industries located in the province of Guayas were considered as the population,
corresponding to 46% of the total plastics industries that use polymers in Ecuador.
      </p>
      <p>The 27 active plastic industries located in the city of Guayaquil, which correspond to the
total number of industries, were taken as an intentional non-probabilistic non-experimental
sample, so the calculation of the sample for a finite population with the statistical formula was
not carried out, because it was decided to consider all industries that wanted to participate by
answering the structured questionnaire with thirteen closed questions under the Likert scale,
online, for the survey that was previously prepared and validated, then it was taken to a format
on the google forms platform.</p>
      <p>The instrument for the collection of quantitative data was the survey, application of the
questionnaire was selected for the directors or purchasing managers of the plastic industries
that use polymers, through the use of the technological means of e-mail. On the other hand,
interviews were conducted under the person-to-person strategy, using an interview guide with
10 open questions, which were validated by experts and applied to three purchasing managers of
plastic industries that use biodegradable polymers, for the processing of data from the interviews
was performed in the Excel tool, to organize, tabulate and schematize the results.</p>
      <p>Once the survey data had been collected, they were processed by constructing frequency
tables with the Excel tool, using descriptive statistics for each of the variables, which resulted
in frequency tables and figures, arranged in the diferent categories. The results were then
analyzed to determine the interests, characteristics, and purchasing trends of raw materials
in the plastic manufacturing industries in Guayaquil. With the results obtained from both the
survey and the interview, key data were obtained to build the structure of the bio-business
under the B2B model proposed in the study.</p>
    </sec>
    <sec id="sec-4">
      <title>4. Discussion</title>
      <p>
        After reviewing the literature concerning the bio-business of polymers with cassava waste
for the plastics industry, which uses biodegradable polymers that arise from nature in their
production process, it was possible to outline a structure of a bio-business plan using the B2B
(business-to-business) business to the business model, as referred to by Pedraza [
        <xref ref-type="bibr" rid="ref17">17</xref>
        ], which
should contain the following stages as a basis: (a) business description, (b) product portfolio, (c)
market, (d) competition, (e) operating procedures, (f) organization, (g) economic and financial
aspects, and (h) supporting documents, as shown in Figure 2.
      </p>
      <p>Each stage describes the activities that were carried out to prepare the bio-business, after
the theoretical and conceptual review of each of the components allowed to know, organize
and incorporate in each stage of the bio-business plan, as well as identifying the technological
elements, machinery, and equipment that are necessary for the implementation of a business,
in addition to carrying out the organizational, administrative, legal and documentary analysis
necessary to establish the business plan.</p>
      <p>The results of the interviews and surveys can be summarized as follows:</p>
      <p>The segment of the industry interested in acquiring organic polymers was the food sector at
44%, the industrial sector at 37%, and the agricultural sector at 18%, this information is very
valuable because it gives the guideline of the sector with which the negotiations of organic
polymers based on cassava waste will be established. Another element is that the industries
involved in the production of plastic know a lot about organic biopolymers and seek to replace
the synthetic polymer with another raw material by the regulations in favor of the environment
66–76
that are circumscribed in the White Paper on Circular Economy of Ecuador, constituting a good
business opportunity to promote our product. It was also found that 55% of the industries have
incorporated between 5% and 40% of the organic polymer as raw material in their production
processes, justified by the limited supply of organic polymers in the market, which shows a
great opportunity for investors wishing to venture into this type of bio-business.</p>
      <p>The characteristics of the suppliers of organic biopolymers sought by the plastics industries
are competitive prices at 48%, punctuality at 4%, product quality at 19%, responsiveness at 15%,
and supply capacity at 14%, so it can be inferred that we are facing an elastic demand because
they are looking for price rather than quality. The quantity demanded of organic biopolymers is
between 1 to 40 metric tons per month, this data gives an idea of how much should be produced
in the month according to the demand, who would be willing to pay between US $1,200 to US
$1,600 US dollars per ton of organic polymer, so this data is key to determine the selling price
that should be in this range.</p>
      <p>
        The frequency of purchase 37% of the industries acquire the raw material weekly and
fortnightly, this purchase behavior is because for the biopolymer to maintain its quality it must be
supplied in the shortest possible time, i.e. it should not be stored for a longer period [
        <xref ref-type="bibr" rid="ref16">16</xref>
        ]. The
biopolymer manufacturing process was worked out on a semi-mechanized scale, for which a
lfow chart was drawn up with the yarn model in which each of the process stages was specified.
      </p>
      <p>To establish the economic and financial aspects of the bio-business, a five-year horizon
was estimated for the project, macroeconomic variables such as GDP, inflation rate, system
risks, microeconomic variables such as labor rules and regulations, interest rates, credit, and
business amounts and terms, taxes, among others, were considered to incorporate them into
the calculation of product costs and sales, and the amounts of the initial investment and the
corresponding financing were established as shown in Table 1.</p>
      <p>To calculate the electricity costs for the production of one ton of organic polymer, two and
a half tons of cassava waste are needed, which, when processed in the respective machines,
should be considered as US$3,196 per kilowatt-hour as shown in Table 2.</p>
      <p>The raw material for processing the cassava waste does not have a cost as such, but the
cost of mobilizing the raw material from the recycling facility to the processing plant, i.e. the
cost of freight, is included. To produce 380 tons of biopolymer in a year, the average cost is
approximately US$846.00 per metric ton, which represents a total cost of US$321,480.00, while
the unit price for the sale of each ton of biopolymer is US$1,184.00, which represents US$450,018
for a sale of 380 tons in a year.</p>
      <p>Table 3 shows the calculations of break-even quantities and prices for the production and
marketing of biopolymer derived from cassava waste, in metric tons projected for five years,
this information is key to knowing how much the minimum amount that must be produced
and sold in order not to lose.</p>
      <p>On the other hand, Table 4 shows the calculation of the projected Cash Flow for five years.
With this information, the calculations of the financial indicators that will provide the guideline
to know the profitability, viability, and sustainability of the bio-business will be carried out as
shown in Table 5.</p>
      <p>
        With the projected cash flow data we proceeded to calculate the Weighted Average Cost of
Capital [
        <xref ref-type="bibr" rid="ref18">18</xref>
        ] (WACC), taking into account the values of the financing of the investment, both
the internal financing provided by investors for equity and working capital, In this case, a
      </p>
      <p>Year 3
$81.457
$1.234
$881
231
$285.099</p>
      <p>Year 4
$83.576
$1.451
$1.036
202
$292.517</p>
      <p>Year 5
$89.004
$1.611
$1.151
193
$311.516</p>
      <p>Description
Net cash flow 26.390
Cumulative flow -79.407</p>
      <p>Initial Investment -105.797
three-year bank loan was considered with an annual interest rate of 10.21% per year in one
of the entities of the national financial system, with this information an estimate of the CPPC
of 12.90%, a value at which the NPV of the project is calculated, resulting in a positive value
of US$105,448.27, which shows that the project is viable. The IRR is also calculated for the
ifve-year flows, resulting in an IRR of 35.27%, which means that the project can return the initial
investment, plus the financing costs and there is also a favorable return on investment, On the
other hand, the IRRM was calculated in which the project is required to reinvest the flows at a
WACC rate of 10.21%, it is convenient or not to reinvest, as a result, it was obtained that the
project gives an IRRM of 27.69%, which can be concluded that the project is sustainable over
time since it returns the investment in 28 months by calculating the payback.</p>
      <p>The business idea proposed aims to design a bio-business based on the cassava waste produced
in municipal markets, which, when not reused, ends up in open-air dumps, causing pollution
and damage to the environment, so that at the end of the study and after an exhaustive review
of literature on the study variables, applying a methodology with a mixed approach, descriptive
in nature, Therefore, at the end of the study and after an exhaustive literature review of the
study variables, applying a descriptive and explanatory mixed approach methodology, it was
determined that the price elasticity of demand is elastic, that the plastics industry is willing
to purchase the biopolymer produced with cassava waste, so this bio-business proposal could
be of interest to investors who are committed to environmental protection and bet on a new
profitable, viable and sustainable business opportunity, as shown by the economic valuation
indicators of the project, which were favorable and which return the investment in the medium
term. On the other hand, it generates sources of employment and contributes to the care of
nature, avoiding the contamination of the soil, air, water, and living beings that live around the
open-air dumps. New lines of research are opened to generate new businesses from solid and
liquid organic waste.</p>
    </sec>
    <sec id="sec-5">
      <title>5. Conclusions</title>
      <p>The proposed business idea aims to design a bio-business based on the cassava waste produced
in municipal markets, which when not reused ends up in open dumps, causing pollution and
damage to the environment, so that at the end of the study and after a thorough review of
literature on the study variables, applying a descriptive, explanatory methodology, it was
determined that the price elasticity of demand is elastic, The plastic industry is willing to
purchase the biopolymer produced from cassava waste, so this bio-business proposal could
be of interest to investors who are committed to caring for the environment and are betting
on a new profitable, viable and sustainable business opportunity, as shown by the economic
valuation indicators of the project, which were favorable and which return the investment in
the medium term. On the other hand, it generates sources of employment and contributes to
the care of nature, avoiding the contamination of the soil, air, water, and living beings that live
around the open-air dumps. New lines of research are opened to generate new businesses from
solid and liquid organic waste.</p>
    </sec>
    <sec id="sec-6">
      <title>Acknowledgements</title>
      <p>We are grateful for the participation of the students; Nicole Guerra, Norma Andrade, and Marcos
García of the undergraduate course of Commercial Engineering belonging to the Faculty of
Administrative Sciences of the University of Guayaquil, who collaborated with the fieldwork in
the collection of the information. This research work is part of the FCI-034-Polymero 2021-C2
of the Faculty of Chemical Engineering of the University of Guayaquil.</p>
    </sec>
  </body>
  <back>
    <ref-list>
      <ref id="ref1">
        <mixed-citation>
          [1]
          <string-name>
            <given-names>A.</given-names>
            <surname>Labeaga</surname>
          </string-name>
          ,
          <article-title>Polímeros biodegradables. importancia y potenciales aplicaciones</article-title>
          ,
          <source>Files. Bartolomevazquezbernal</source>
          (
          <year>2018</year>
          )
          <fpage>1</fpage>
          -
          <lpage>50</lpage>
          .
        </mixed-citation>
      </ref>
      <ref id="ref2">
        <mixed-citation>
          [2]
          <string-name>
            <given-names>A.</given-names>
            <surname>Marques</surname>
          </string-name>
          , S. M. d. Luz,
          <article-title>Use of biodegradable polymer for development of environmental tracers: a bibliometric review</article-title>
          ,
          <source>Polímeros</source>
          <volume>31</volume>
          (
          <year>2021</year>
          ).
        </mixed-citation>
      </ref>
      <ref id="ref3">
        <mixed-citation>
          [3]
          <string-name>
            <given-names>B. J.</given-names>
            <surname>Polo-Cambronell</surname>
          </string-name>
          ,
          <article-title>Estudio de mercado de las empresas que actualmente se encuentran desarrollando materiales poliméricos</article-title>
          .,
          <year>2020</year>
          .
        </mixed-citation>
      </ref>
      <ref id="ref4">
        <mixed-citation>
          [4]
          <string-name>
            <given-names>H. S.</given-names>
            <surname>Villada</surname>
          </string-name>
          ,
          <string-name>
            <given-names>H.</given-names>
            <surname>Acosta</surname>
          </string-name>
          ,
          <string-name>
            <given-names>R.</given-names>
            <surname>Velasco</surname>
          </string-name>
          ,
          <article-title>Biopolímeros naturales usados en empaques biodegradables</article-title>
          ,
          <source>Temas agrarios 12</source>
          (
          <year>2007</year>
          )
          <fpage>5</fpage>
          -
          <lpage>13</lpage>
          .
        </mixed-citation>
      </ref>
      <ref id="ref5">
        <mixed-citation>
          [5]
          <string-name>
            <given-names>M.</given-names>
            <surname>Shah</surname>
          </string-name>
          ,
          <string-name>
            <given-names>S.</given-names>
            <surname>Rajhans</surname>
          </string-name>
          ,
          <string-name>
            <given-names>H. A.</given-names>
            <surname>Pandya</surname>
          </string-name>
          ,
          <string-name>
            <given-names>A. U.</given-names>
            <surname>Mankad</surname>
          </string-name>
          ,
          <article-title>Bioplastic for future: A review then and now</article-title>
          ,
          <source>World Journal of Advanced Research and Reviews</source>
          <volume>9</volume>
          (
          <year>2021</year>
          )
          <fpage>056</fpage>
          -
          <lpage>067</lpage>
          .
        </mixed-citation>
      </ref>
      <ref id="ref6">
        <mixed-citation>
          [6]
          <string-name>
            <given-names>A.</given-names>
            <surname>Almario</surname>
          </string-name>
          ,
          <string-name>
            <given-names>L.</given-names>
            <surname>Durango</surname>
          </string-name>
          , E. Arizal,
          <article-title>Estudio de las propiedades absorbentes de un biopolímero a base de almidón de yuca (manihot esculenta crantz</article-title>
          ),
          <source>Revista Espacios</source>
          <volume>15</volume>
          (
          <year>2018</year>
          ).
        </mixed-citation>
      </ref>
      <ref id="ref7">
        <mixed-citation>
          [7]
          <string-name>
            <given-names>M. A.</given-names>
            <surname>Riera</surname>
          </string-name>
          ,
          <string-name>
            <given-names>R. R.</given-names>
            <surname>Palma</surname>
          </string-name>
          ,
          <article-title>Obtención de bioplásticos a partir de desechos agrícolas. una revisión de las potencialidades en ecuador</article-title>
          ,
          <source>Avances en Química</source>
          <volume>13</volume>
          (
          <year>2018</year>
          )
          <fpage>69</fpage>
          -
          <lpage>78</lpage>
          .
        </mixed-citation>
      </ref>
      <ref id="ref8">
        <mixed-citation>
          [8]
          <string-name>
            <given-names>N. Paredes</given-names>
            <surname>Andrade</surname>
          </string-name>
          ,
          <string-name>
            <given-names>L. Lima</given-names>
            <surname>Tandazo</surname>
          </string-name>
          ,
          <string-name>
            <given-names>J. Pico</given-names>
            <surname>Rosado</surname>
          </string-name>
          ,
          <string-name>
            <given-names>Y.</given-names>
            <surname>Vargas Tierras</surname>
          </string-name>
          ,
          <string-name>
            <given-names>C.</given-names>
            <surname>Caicedo Vargas</surname>
          </string-name>
          ,
          <string-name>
            <given-names>F.</given-names>
            <surname>Fernández Anchundia</surname>
          </string-name>
          ,
          <string-name>
            <given-names>C.</given-names>
            <surname>Subía García</surname>
          </string-name>
          ,
          <string-name>
            <given-names>L. Tinoco</given-names>
            <surname>Jaramillo</surname>
          </string-name>
          ,
          <string-name>
            <given-names>D.</given-names>
            <surname>Sotomayor</surname>
          </string-name>
          <string-name>
            <surname>Akopyan</surname>
          </string-name>
          , Á. Monteros-Altamirano,
          <article-title>Guía para la producción y manejo integrado del cultivo de yuca para la amazonia ecuatoriana</article-title>
          ,
          <year>2021</year>
          .
        </mixed-citation>
      </ref>
      <ref id="ref9">
        <mixed-citation>
          [9]
          <string-name>
            <given-names>A.</given-names>
            <surname>Rustichini</surname>
          </string-name>
          ,
          <article-title>The role of intelligence in economic decision making</article-title>
          ,
          <source>Current Opinion in Behavioral Sciences</source>
          <volume>5</volume>
          (
          <year>2015</year>
          )
          <fpage>32</fpage>
          -
          <lpage>36</lpage>
          .
        </mixed-citation>
      </ref>
      <ref id="ref10">
        <mixed-citation>
          [10]
          <string-name>
            <given-names>M.</given-names>
            <surname>Valencia</surname>
          </string-name>
          , Libro blanco de economía circular de ecuador, Centro de Innovación y Economía
          <source>Circular CIEC</source>
          <volume>6</volume>
          (
          <year>2021</year>
          )
          <fpage>212</fpage>
          .
        </mixed-citation>
      </ref>
      <ref id="ref11">
        <mixed-citation>
          [11]
          <string-name>
            <given-names>A. E.</given-names>
            <surname>Pesántez-Calva</surname>
          </string-name>
          ,
          <string-name>
            <given-names>J. A.</given-names>
            <surname>Romero-Correa</surname>
          </string-name>
          ,
          <string-name>
            <given-names>M. L.</given-names>
            <surname>González-Illescas</surname>
          </string-name>
          ,
          <article-title>Comercio electrónico b2b como estrategia competitiva en el comercio internacional: Desafíos para ecuador</article-title>
          ,
          <source>INNOVA Research Journal</source>
          <volume>5</volume>
          (
          <year>2020</year>
          )
          <fpage>72</fpage>
          -
          <lpage>93</lpage>
          .
        </mixed-citation>
      </ref>
      <ref id="ref12">
        <mixed-citation>
          [12]
          <string-name>
            <given-names>M.</given-names>
            <surname>Geissdoerfer</surname>
          </string-name>
          ,
          <string-name>
            <given-names>D.</given-names>
            <surname>Vladimirova</surname>
          </string-name>
          ,
          <string-name>
            <given-names>S.</given-names>
            <surname>Evans</surname>
          </string-name>
          ,
          <article-title>Sustainable business model innovation: A review</article-title>
          ,
          <source>Journal of cleaner production 198</source>
          (
          <year>2018</year>
          )
          <fpage>401</fpage>
          -
          <lpage>416</lpage>
          .
        </mixed-citation>
      </ref>
      <ref id="ref13">
        <mixed-citation>
          [13]
          <string-name>
            <given-names>R.</given-names>
            <surname>Hernández-Sampieri</surname>
          </string-name>
          ,
          <string-name>
            <given-names>C.</given-names>
            <surname>Fernández Collado</surname>
          </string-name>
          ,
          <string-name>
            <given-names>P.</given-names>
            <surname>Baptista Lucio</surname>
          </string-name>
          , et al.,
          <source>Metodología de la investigación</source>
          , volume
          <volume>4</volume>
          ,
          <string-name>
            <surname>McGraw-Hill Interamericana</surname>
            <given-names>México</given-names>
          </string-name>
          ,
          <year>2018</year>
          .
        </mixed-citation>
      </ref>
      <ref id="ref14">
        <mixed-citation>
          [14] F. y
          <string-name>
            <given-names>B.</given-names>
            <surname>Hernández</surname>
          </string-name>
          ,
          <string-name>
            <surname>Estudios De Caso Hacia Una Definición Del Estudio De Caso</surname>
          </string-name>
          ,
          <source>McGrawHill Interamericana México</source>
          ,
          <year>2008</year>
          .
        </mixed-citation>
      </ref>
      <ref id="ref15">
        <mixed-citation>
          [15]
          <string-name>
            <given-names>O.</given-names>
            <surname>Reyes-Lopez</surname>
          </string-name>
          ,
          <string-name>
            <given-names>M. del Consuelo</given-names>
            <surname>Hernandez-Moncada</surname>
          </string-name>
          , Criterios de eficiencia en el diseño de entornos virtuales de aprendizaje (eva),
          <source>Memorias del Encuentro Internacional de Educación a Distancia</source>
          (
          <year>2013</year>
          ).
        </mixed-citation>
      </ref>
      <ref id="ref16">
        <mixed-citation>
          [16]
          <string-name>
            <surname>M. E. García</surname>
            <given-names>Castillo</given-names>
          </string-name>
          ,
          <article-title>Diseño de una empresa para la creación de un nuevo polímero orgánico a partir de</article-title>
          los desechos de mercados municipales, B.S. thesis, Universidad de Guayaquil, Facultad de Ciencias Administrativas,
          <year>2021</year>
          .
        </mixed-citation>
      </ref>
      <ref id="ref17">
        <mixed-citation>
          [17]
          <string-name>
            <given-names>O. E.</given-names>
            <surname>Contreras-Pacheco</surname>
          </string-name>
          ,
          <string-name>
            <given-names>A. C. P.</given-names>
            <surname>Avella</surname>
          </string-name>
          ,
          <string-name>
            <surname>M. J. M. Pérez</surname>
          </string-name>
          ,
          <article-title>La inversión de impacto como medio de impulso al desarrollo sostenible: una aproximación multicaso a nivel de empresa en colombia</article-title>
          ,
          <source>Estudios Gerenciales</source>
          <volume>33</volume>
          (
          <year>2017</year>
          )
          <fpage>13</fpage>
          -
          <lpage>23</lpage>
          .
        </mixed-citation>
      </ref>
      <ref id="ref18">
        <mixed-citation>
          [18]
          <string-name>
            <given-names>J. F.</given-names>
            <surname>Stephen</surname>
          </string-name>
          ,
          <string-name>
            <given-names>A.</given-names>
            <surname>Ross</surname>
          </string-name>
          ,
          <string-name>
            <given-names>R. W.</given-names>
            <surname>Westerfield</surname>
          </string-name>
          , Finanzas corporativas,
          <year>2012</year>
          .
        </mixed-citation>
      </ref>
    </ref-list>
  </back>
</article>