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<article xmlns:xlink="http://www.w3.org/1999/xlink">
  <front>
    <journal-meta>
      <journal-title-group>
        <journal-title>German meat process-
ing plant, EMBO Molecular Medicine</journal-title>
      </journal-title-group>
    </journal-meta>
    <article-meta>
      <article-id pub-id-type="doi">10.1101/2020.12.17.202</article-id>
      <title-group>
        <article-title>A scalable pipeline for COVID-19: the case study of Germany, Czechia and Poland.</article-title>
      </title-group>
      <contrib-group>
        <contrib contrib-type="author">
          <string-name>Wildan Abdussalam</string-name>
          <xref ref-type="aff" rid="aff0">0</xref>
        </contrib>
        <contrib contrib-type="author">
          <string-name>Adam Mertel</string-name>
          <xref ref-type="aff" rid="aff0">0</xref>
        </contrib>
        <contrib contrib-type="author">
          <string-name>Kai Fan</string-name>
          <xref ref-type="aff" rid="aff0">0</xref>
        </contrib>
        <contrib contrib-type="author">
          <string-name>Lennart Schüler</string-name>
          <xref ref-type="aff" rid="aff0">0</xref>
          <xref ref-type="aff" rid="aff2">2</xref>
        </contrib>
        <contrib contrib-type="author">
          <string-name>Weronika Schlechte-Wełnicz</string-name>
          <xref ref-type="aff" rid="aff0">0</xref>
        </contrib>
        <contrib contrib-type="author">
          <string-name>Justin M. Calabrese</string-name>
          <xref ref-type="aff" rid="aff0">0</xref>
          <xref ref-type="aff" rid="aff1">1</xref>
          <xref ref-type="aff" rid="aff3">3</xref>
        </contrib>
        <aff id="aff0">
          <label>0</label>
          <institution>Center for Advanced Systems Understanding, Helmholtz-Zentrum Dresden-Rossendorf</institution>
          ,
          <addr-line>Untermarkt 20, 02826 Görlitz</addr-line>
          ,
          <country country="DE">Germany</country>
        </aff>
        <aff id="aff1">
          <label>1</label>
          <institution>Department of Biology, University of Maryland</institution>
          ,
          <addr-line>College Park MD, Maryland</addr-line>
          ,
          <country country="US">USA</country>
        </aff>
        <aff id="aff2">
          <label>2</label>
          <institution>Department of Computational Hydrosystems, Helmholtz Centre for Environmental Research (UFZ)</institution>
          ,
          <addr-line>Permoserstraße 15, 04318 Leipzig</addr-line>
          ,
          <country country="DE">Germany</country>
        </aff>
        <aff id="aff3">
          <label>3</label>
          <institution>Department of Ecological Modelling, Helmholtz Centre for Environmental Research (UFZ)</institution>
          ,
          <addr-line>Permoserstraße 15, 04318 Leipzig</addr-line>
          ,
          <country country="DE">Germany</country>
        </aff>
      </contrib-group>
      <pub-date>
        <year>2020</year>
      </pub-date>
      <volume>12</volume>
      <issue>2020</issue>
      <fpage>64</fpage>
      <lpage>75</lpage>
      <abstract>
        <p>Throughout the coronavirus disease 2019 (COVID-19) pandemic, decision makers have relied on forecasting models to determine and implement non-pharmaceutical interventions (NPI). In building the forecasting models, continuously updated datasets from various stakeholders including developers, analysts, and testers are required to provide precise predictions. Here we report the design of a scalable pipeline which serves as a data synchronization to support inter-country top-down spatiotemporal observations and forecasting models of COVID-19, named the where2test, for Germany, Czechia and Poland. We have built an operational data store (ODS) using PostgreSQL to continuously consolidate datasets from multiple data sources, perform collaborative work, facilitate high performance data analysis, and trace changes. The ODS has been built not only to store the COVID-19 data from Germany, Czechia, and Poland but also other areas. Employing the dimensional fact model, a schema of metadata is capable of synchronizing the various structures of data from those regions, and is scalable to the entire world. Next, the ODS is populated using batch Extract, Transfer, and Load (ETL) jobs. The SQL queries are subsequently created to reduce the need for pre-processing data for users. The data can then support not only forecasting using a version-controlled Arima-Holt model and other analyses to support decision making, but also risk calculator and optimisation apps [1, 2]. The data synchronization runs at a daily interval, which is displayed at https://www.where2test.de.</p>
      </abstract>
    </article-meta>
  </front>
  <body>
    <sec id="sec-1">
      <title>1. Introduction</title>
      <p>
        realise the data surveillance and outbreak response
management, which have been implemented in fighting other
In building forecasting models of COVID-19, many re- endemic diseases [
        <xref ref-type="bibr" rid="ref4 ref5 ref6 ref7">4, 5, 6, 7</xref>
        ].
searchers employ the training datasets provided by each To date, the data management have been applied in
country’s representative institutions, e.g., Robert Koch controlling the outbreak of COVID-19 [8, 9, 10, 11, 12,
Institute in Germany. The publicly accessible COVID- 13, 14, 15, 16, 17, 18, 19, 20, 21, 22]. Most of them
pro19 data provided in raw textual format, such as CSV, vide maps and the prevalent data in the following
reJSON, and XML are downloaded and analysed by the gional level: (i) National level, e.g., COVID-19 data of
researchers employing either statistical or machine learn- World wide [
        <xref ref-type="bibr" rid="ref10">10</xref>
        ], Europe [
        <xref ref-type="bibr" rid="ref11 ref12 ref13">11, 12, 13</xref>
        ], and Latin
Amering approaches. However, the data are unwell struc- ica [
        <xref ref-type="bibr" rid="ref14">14</xref>
        ]; (ii) State and county levels, e.g., the COVID-19
tured and require heavy pre-processing as well as in- data warehouse for Italy [
        <xref ref-type="bibr" rid="ref15">15</xref>
        ], COVID-19 dashboard for
gestion activities for further analysis. This method is UK [
        <xref ref-type="bibr" rid="ref17">17</xref>
        ], the COVID-19 dashboard for Maryland [18],
inherently ineficient due to identical and manual paral- and for Germany [19].; (iii) County level, e.g., Dresden,
lel pre-processing of the RKI data (using e.g. python or Germany [20]. More completed version is provided by
R scripts) performed by each researcher. This reduces the John Hopkins University [21], which serves the
dashthe eficiency of each and everyone’s work as all have to board and the prevalent data for each regional level in
spend hours and days in pre-processing data before com- the USA as well as for most of countries around the
ing to modeling and forecasting. Advanced computing world. Likewise, the similar method in the presence
infrastructures and novel software pipelines are crucial of semi-automatic validation strategy was conducted to
tools to synchronize the data structures which originate check the data quality of daily updated numbers with
from various sources and to extremely reduce heavy pre- governmental/oficial data sources [ 22]. However, most
processing [
        <xref ref-type="bibr" rid="ref3">3</xref>
        ]. They serve as essential prerequisites to of dashboards and data warehouses have not provided
the features to let the users perform an inter-country
Proc. of the First International Workshop on Data Ecosystems (DEco’22), top-down spatiotemporal observation, i.e., observing the
September 5, 2022, Sydney, Australia inter-country prevalence and simultaneously being able
* Corresponding author to observe to the microscopic level (nation → state →
($J. Mw..aCbadluasbsraelsaem)@hzdr.de (W. Abdussalam); j.calabrese@hzdr.de county → municipality). The features could provide
in© 2022 Copyright for this paper by its authors. Use permitted under Creative Commons License sights, for example, to study COVID-19 border
dynamCPWrEooUrckReshdoinpgs IhStpN:/c1e6u1r3-w-0s.o7r3g ACttEribUutRion W4.0oInrtekrnsahtioonpal (PCCroBYce4.0e).dings (CEUR-WS.org) ics which have been so far attracted considerable
attentions [23, 24, 25, 26]. Moreover, they are lack of
forecasting features, which play a key role in predicting the
future prevalence as well as determining non
pharmaceutical interventions (NPI). A tremendous number of
forecasting models, e.g., agent-base [27], machine
learning [
        <xref ref-type="bibr" rid="ref18 ref19">28, 29</xref>
        ], combination model [
        <xref ref-type="bibr" rid="ref20 ref21">30, 31</xref>
        ], compartment
model [
        <xref ref-type="bibr" rid="ref22 ref23 ref24 ref25 ref26">32, 33, 34, 35, 36</xref>
        ], time series [
        <xref ref-type="bibr" rid="ref27">37, 38, 39, 40, 41, 42,
43</xref>
        ] have employed government datasets to provide
essential inputs for public decisions. However, most of datasets
that were used in those studies are limited to the specific
time window which are likely to produce diferent results
when the datasets are updated. Establishing a system of
daily-updated-datasets assisted forecasts, therefore, is an
alternative to improve their consistency and precision.
      </p>
      <p>In this paper, we address the aforementioned issues
by proposing the design of a scalable pipeline which
allow us to perform the top-down spatiotemporal
observation among Germany, Czechia, and Poland as well as
to perform daily forecasts. The method of the pipeline
which consists of extraction of various data sources and
the ODS is described in subsec 2.1. More specifically,
we will describe the dimensional fact database model
and a daily migration process which underline the data
synchronization between various data sources and our Figure 1: (a) A workflow of data pipeline Hospitals,
retiredatabase server. We employ the dimensional fact model ment houses, and schools of Germany, Czechia and Poland
due to more flexibility and versatility in building spa- update the data of COVID-19 cases, vaccines and tests to the
tiotemporal aggregation functions than the nanocubes representative government institutions. A daily automatic ETL
model [44, 45]. Next, in subsec 2.2 we will describe the step is performed to synchronize the data sources and central
time-series forecasting models which are supported by database of CASUS. A daily and weekly automatic forecast
the presence of the ODS. Furthermore, the automatic employing, e.g. Arima-Holt model, is applied to provide rapid
system of daily forecasts owing to the presence of the predictions. The predictions and the actual data are shown
pipeline will be laid out in this sub section. In Sec. 3, we in the where2test website; (b) The scalable dimensional fact
will describe facilities that have been established due to wmhoidleelr.eDgiaotnavtyalpueessaannddtdimateapvearliuoed ttyyppeess rreepprreesseenntt smpaetaiasularnesd,
the presence of the ODS. In order to demonstrate the temporal dimensions, respectively.
inter-country top-down spatiotemporal observations, an
analysis will begin from the macroscopic scale in which
the study of the virus spread across the national borders
is described in subsec 3.1. Herein we consider the border 2. Methods
among Germany, Czechia and Poland as a study case.</p>
      <p>In subsec 3.2, we explore more microscopic level by ap- 2.1. Data Pipeline
plying a daily-updated-datasets assisted forecast for the Fig. 1a shows a workflow of the data pipeline. The
hosprevalence in the state of Saxony, Germany. Last but pitals, retirement houses and schools register the daily
not least, in subsec 3.3, most microscopic level that we number of the COVID-19 cases and vaccines to the
repwill demonstrate is a superspreading event at a slaugh- resentative government. In order to consolidate these
ter house in Gütersloh, Lower Saxony, Germany. As the data, the relational database is built based on
dimenCOVID-19 situation begins to enter an endemic phase, sional fact model [46]. Having established the relational
a study of superspreading event will provide essential database, the daily automatic extract, transfer and load
information to trace the COVID-19 transmission after a (ETL) step is performed to migrate and integrate the data
mass event. sources to the PostgreSQL database of CASUS HZDR
(see Suplementary materials 7.1). Next, we create SQL
inquiries-based views to be analysed by our researchers
using the forecast and machine learning methods. The
tested and completed analysis methods are set in the
master stage and the other tested methods are set in the
develop stage. Only the forecasting method in the master 2.2. Forecasts
stage is integrated in the automatic pipeline.</p>
      <p>
        The dimensional fact model is shown in Fig. 1b. The We employ auto regression integrated moving average
model consists of three main concepts: (i) Facts, that (ARIMA) and Holt’s linear trend models to forecast the
refer to a subject of study (e.g., the study of infected, infected, test, and hospitalised data of COVID-19 for
dead, recovered, hospitalised, test and vaccinated cases Saxony (Germany), Czechia, and Poland. The ARIMA
due to COVID-19); (ii) Measures, that refer to the quan- model has been successfully employed in predicting other
titative data of the concept (i). The measured data are endemic diseases [
        <xref ref-type="bibr" rid="ref28 ref29 ref30 ref31">47, 48, 49, 50</xref>
        ]. The model features
stored in the table of datavalues. The tables of datavalues suitable prediction based on time analysis series which
contain the number of infected, dead, recovered, hospi- is capable of providing short horizon forecast for most
talised, test, and vaccinated cases due to COVID-19 in COVID-19 cases around the world [38, 39, 40, 41, 42, 43].
a given time and place. To date, the schema consists of To make the model consistent and avoid overfitting, the
three datavalues, i.e., datavalues of Germany, Czechia order parameter of the ARIMA model is fixed instead of
and Poland; (iii) Dimensions, that refer to temporal and using the auto ARIMA model. The ARIMA is improved
spatial attributes. As the measured data are provided in a by employing the Holt’s linear trend model [
        <xref ref-type="bibr" rid="ref32">51</xref>
        ]. The
given time and place, the table of time period types and Holt’s model uses the exponential smoothing method to
regions is necessary. The former stores the type of time compute the weighted average of the past observation
period which consists of day and week data type; and the data [
        <xref ref-type="bibr" rid="ref33">52</xref>
        ]. The forecasts from the Holt’s linear model have
latter stores the necessary information of regions which a trend, so the damped parameter is turned on to avoid
consist of the name, abbreviation, ID of regions, ID of this trend [
        <xref ref-type="bibr" rid="ref33 ref34 ref35">53, 54, 52</xref>
        ]. A self-defined mix function is used
region type, geometry and population. The table of re- to compute the probability parameter m to combine the
gions depends on the table of region types. The regions forecasts from two models and minimize the error. The
are categorised based on their sizes. The order of as- Box-Cox transformation is used to normalize the input
cending sizes starts from municipality, county, state and data [
        <xref ref-type="bibr" rid="ref33 ref36">55, 52</xref>
        ].
nation. For Germany, the order of region type starts from Our model provides a weekly forecast at first. In order
Gemeinde, Kreise and Bundesland. Similar to Germany, to improve the daily variation and provide more
realPoland consist of Gmina, Powiat, and Wojewodztwo. Dif- time forecasts, we have built a daily forecast model. As
ferent from Germany and Poland, Czechia consist of 4 the daily data have a clear weekly variation, the
sealevel, Obec, Orp, Okres and Kraj. The spatial and tempo- sonal parameters are added to the model; and seasonal
ral attributes are connected by means of hierarchies to ARIMA (SARIMA) and Holt-Winters’ seasonal model are
represent a -to-one relationship between them. The table employed for the daily forecasts [
        <xref ref-type="bibr" rid="ref32 ref37">56, 51, 57</xref>
        ]. Similar to
of mapping_types contains the hierarchical type of the the ARIMA model, the seasonal ARIMA model uses the
spatial attributes, e.g., for Germany (Gemeinde to Kreise, ifxed order and seasonal parameters. After comparing
Kreise to Bundesland), for Czechia (Obec to Orp, Orp to the errors from multiple methods, the additive method is
Okres and Okres to Kraj), and Poland (Gmina to Powiat selected for the Holt-Winters’ seasonal model. The mix
and Powiat to Wojewodztwo). Next, a many-to-one re- function is also used for the daily forecasts to combine
lationship between those spatial hierarchies are stored the forecasts from two models and improve the
forecastin the table of mapping_regions. Moreover, the table of ing accuracy. For study cases of (S)Arima-Holt model,
timeperiod_types consists of the hierarchical type of the in Sec. 3.2, we will provide the number of infections for
temporal attributes. Saxony, Germany. In addition to (S)ARIMA-Holt model,
      </p>
      <p>
        Aggregation functions are applicable on the measures we employ outlier detection to identify and quantify
Sualong the temporal and spatial dimensions. For the for- perspreading events. As suggested in [
        <xref ref-type="bibr" rid="ref25">35</xref>
        ], we identify
mer dimension, the weekly data are cumulative 7–day and quantify superspreading events by using time
sedata. For example, a 7–day case reported on 13.03.2022 is ries analysis based outlier detection methods. The rate
an accumulation of the daily case for 07-13.03.2022. More- of newly infected is modeled by an appropriate model,
over, for the latter dimension, county data are cumulative- which could be something as simple as a rolling average
municipality data. Not only accumulating the data from to more elaborate ones as SIR-based models. The residues
the municipality to a county level, in the presence of of the reported cases is used to identify outliers. At the
mapping regions table, it is possible to accumulate the same time, the residues can be used to quantify the size
data from the county to the state level as well as the state of a superspreading event.
to the nation level. This allows us to scale the pipeline
to other areas provided that the data of municipality are 3. Results
available from the sources.
      </p>
      <p>
        The presence of the pipeline has allowed us to provide
following facilities: (i) The released data hub for dead and
infected cases of all counties and states in Germany [58],
which allows a collaboration between CASUS research
stafs and other external collaborators. The post-processing
data serve as the clean data of daily infected and dead
cases for county and state levels. In addition, we have
also pre-processed the vaccination and hospitalization
data for the county and municipal levels; (ii) The daily
updated value of background risk for optimisation [
        <xref ref-type="bibr" rid="ref1">1</xref>
        ]
and risk calculator apps [
        <xref ref-type="bibr" rid="ref2">2</xref>
        ], which defines the chance of
an average person who lives in the focal area, and
carries out daily activities, will be infected over a one week
period; (iii) Blog posts which update current COVID-19
situations in Germany. An interesting example of the
posts would be the relation between the vaccination rate
and the 7-day incidence in all states of Germany [59];
(iv) Forecast- and model-based analysis. We explore the
study cases mentioned in Sec. 1, and begin by
investigating of the virus spread across the national borders of
Germany, Czechia, and Poland.
wise correlations for each region considering the regions
in the radius of 100 kilometers, (i) within the same
coun3.1. Analysis of the virus spread across try, (ii) outside this country. The diference of these
valthe national borders ues can be seen in Fig. 2. The bigger diference represents
regions where the incidence correlates much better than
COVID-19 spread among people. Therefore, human mo- the regions within the same country, indicating a strong
bility is one of the most important factors defining the national border efect on the virus spread.
trend of spatiotemporal spreading of the virus. Under- In the next step [63], we quantified the mitigation efect
standing human mobility allows us to predict the spa- of the national border in more detail. We picked the state
tiotemporal character of spread, evaluate the government of Saxony in Germany and the neighboring regions in
steps restrictions, and provide efective non-pharmaceutical Czechia. For both countries, we collected and integrated
interventions. Primarily due to the heterogeneity of the the incidence data on the level of single municipalities.
sources and the interest scope of the particular research For each municipality, we constructed a local regression
groups and communities, most of the COVID-19 research model which estimated the efect of three parameters, (i)
stays within the boundaries of one country. While most border presence, (ii) municipality size, and (iii) temporal
human mobility happens in the extent of one country or distance from other municipalities, on the spread of the
region, notably in Europe, the national border’s mitigat- virus. Based on this model, we identified very
smalling efect is generally diminishing. To study the impact scale areas susceptible to a more intensive inter-national
of the national border, several research papers [60, 61] ap- spread of the COVID-19.
plied various methodologies of geostatistics and geospa- The top-down approach we selected for the study on
tial modeling. More thorough quantification of the efect the national border efect is possible thanks to the
scalaof border presence and international mobility on the epi- bility of the implemented dimensional-fact model. This
demy requires a data storage integrating heterogeneous principle allows the ODS to comprise various
adminisdatasets across more countries. trative levels and combine various relevant topics within
      </p>
      <p>The presented ODS infrastructure ofers a possibility the perspective of spacetime.
to study the spatiotemporal character of the virus spread
on more levels, considering the efect of the national
border. First, for our case study comprising the coun- 3.2. Weekly and daily forecast of
tries of Germany, Poland, and Czechia, we explored the Arima-Holt and Sarima-Holt
correlation of new cases in the region, the distance and For the case study, we provide a short-time forecast of
7the border presence. We observed that the neighbour day incidence up to 4 horizons performed on 13-04-2022
regions tend to have similar incidence values in the ab- using Arima-Holt model for Saxony, Germany. We used
sence of barrier in the form of a national border among a training dataset of 13-04-2022 version which consists of
them. This step followed the research of McMahon et al. the historical weekly data of Saxony and its counties from
[62], which showed a strong spatial autocorrelation of 01-03-2020 to 10-04-2022. The weekly data are
automatedincidence values in the USA. daily-updated data which are aggregated on Sunday (see
Further, we calculated the average time-lagged
paira diferent day, a deviation from the actual data for the
following 4 horizons is likely to occur. Additional
realisations of Arima-Holt forecast in Saxony and its counties,
therefore, were performed to improve statistics. The
realisations were performed every Wednesday from
05-012022 to 18-05-2022 in which the version-control dataset
were employed as training and test datasets. An example
would be a realisation of the Forecast on 05-01-2022. We
Figure 3: 7-day incidence of infected cases Jan - 8 May 2022 used the weekly data version of 05-01-2022 as its training
for Saxony, Germany. The black dots denote the historical dataset and the weekly data version of the following 1st,
data, the blue line (—) denotes a line guidance for the historical 2nd, 3rd and 4th week as its test datasets. For each region,
data, and the green (—), orange (—), and red line (—) denotes we then recorded a deviation of the forecast result from
tgohrneey1r0ea-sr0ue4al-t2so0hf2of2wo,rs1e1tch-a0es4tl-ou2w0si2enr2g,aatnhndeduA1p3rpi-me0r4al--i2mH0oi2tl2st,omrfeosthdpeeelcftpoireverecfloayrs.mtTfheoder tpheerchenisttaogreicearlrodrat(MaAanPdE)q. uAasnsthifieodwint iansFmige. a4n,thabeswoleuetkely
13-04-2022. Arima-Holt provides relatively low MAPE for the first
and second horizon. For the third and fourth horizon,
however, the range of MAPE tends to be wider than the
ifrst and second.</p>
      <p>Sec. 2.1). Although we update the data daily, for the Therefore, we performed the Sarima-Holt model to
case of Germany, the current and previous-day data are improve the performance of forecast for the third and
unavailable. In addition, the previous third day data are fourth horizon. Owing to daily-updated data, the
versionstill to be updated from the source. When the forecast was control of daily data is employed as the seasonal
paperformed on Sunday 10-04-2022, the number of infection rameters. In addition to the daily data, the Sarima-Holt
on that day was less than the number of the same day forecast was performed using the same version-control
for the following-day version. As a result, this produces weekly data employed to the Arima-Holt model. For the
inaccurate forecast (see Fig. 3). As the day elapsed, more daily data, we removed the current and two
previouscases were automatically added and aggregated to the last day data due to zero values for current and yesterday
Sunday data. Consequently, the performed forecast on data, and inconsistent data for the previous third day. We
13-04-2022 provides higher exponent than the one with then compared its performance in the presence and the
the dataset version of 10 and 11-04-2022. Moreover, the absence of the Box-Cox transformation (BCT) used to
dataset of Wednesday consists of relatively-stable version. normalize the input data. As shown in Fig. 4, the
SarimaTherefore, the forecast is performed every Wednesday Holt model in the absence of the BCT provides lower
due to the consistency of data source for the last Sunday. MAPE than either the Arima-Holt or the Sarima-Holt in
the presence of the BCT for not only the first and second
horizons, but also the third and four horizons.</p>
      <sec id="sec-1-1">
        <title>3.3. Superspreading events</title>
        <p>conditions combined with relatively close physical dis- The Sarima-Holt model is trained by the daily data, and
tance between workers were likely the main reason for the variation of the data could make the model more
eficient aerosol transmission [ 66]. We take this event as sensitive to the infection change compared to the
Arimaan example to show the result of a Z-score based outlier Holt model trained by the weekly data. However, the
detection method (Fig. 5). BCT reduces the variation of the daily data, and
consequently the daily forecasts perform worse than in the
absence of the BCT.</p>
      </sec>
    </sec>
    <sec id="sec-2">
      <title>5. Conclusion</title>
      <sec id="sec-2-1">
        <title>Our work has demonstrated the utility of the data pipeline</title>
        <p>
          for top-down spatiotemporal analysis. We have first
shown the macroscopic analysis, in which the
investigation of the virus spread across the national border is
presented. At more microscopic level, we have
demonFigure 5: The oficial reported COVID-19 daily incidence strated data-driven approach due to the presence of the
spperre1a0d0i.n0g00evinehnatbiintaantms einatthperodciesstsriicntgopflGanütteirnslJouhn.eA2s0u2p0eirs- pipeline which is applied to the prevalence of the county
successfully identified by an outlier detection method based region. The daily-updated data has improved the
precion the Z-score (the black dot). sion of the model for longer horizon. This data-driven
epidemic models provide more realistic forecast results
than either the parsimonious [
          <xref ref-type="bibr" rid="ref24">34</xref>
          ] or more number of
parameters with agent-based method [27] due to the
us4. Discussions age of daily-updated data. This may contribute to public
health policy making, including contributing to public
Our analysis, implementing the pipeline in the presence health forecasting teams. Last but not least, exploring
of dimensional fact model has allowed us to daily mi- to lower level of region, we have demonstrated that the
grate the data eficiently due to the functions of spa- outlier model is applicable to capture the superspreading
tiotemporal aggregation. To provide the weekly data of event which occurred in 2020. These have shown that
counties, states, and nations, we only migrate the data of our work is capable of performing top-down analysis as
daily municipalities/counties (depends on the data avail- well as rapid and precise forecasts due to the presence of
ability of each nation) to the database server which are the pipeline.
then aggregated to the higher spatiotemporal level. This
model provides more advantages than the nanocubes 6. Data sources
model [44, 45]. For the nanocubes model, each spatial
(municipality, county, state and nation) and temporal • COVID-19 data for Germany, Czechia and Poland.
(daily and weekly) data are required to be migrated to
the database server. Consequently, this leads to a longer – Robert Koch Institute
migration process than the one performed using the di- – Czech Ministry of Health
mensional fact model. Moreover, its spatiotemporal map- – Polish Ministry of Health
ping enables us to perform an eficient table join among – Age-based hospitalisation of state level for
national data which is confirmed by the application on Germany (https://github.com/KITmetricsl
the Subsec. 3.1. ab/hospitalization-nowcast-hub/blob/ma
        </p>
        <p>The presence of daily-updated data due to the presence in/data-truth/COVID-19/).
of the pipeline has allowed us to develop the Sarima-Holt – Age-based and type-based doses of vaccine
model. The model shows more robust prediction for for county level (https://github.com/rober
longer horizon than the Arima-Holt one. More specifi- t-koch-institut/COVID-19-Impfungen_i
cally, the Sarima-Holt in the absence of the BCT outper- n_Deutschland/blob/master/Aktuell_De
forms the Arima-Holt model for the third and fourth hori- utschland_Landkreise_COVID-19-Impfu
zon. This performance is due to the seasonal-parameter ngen.csv).
contribution to the model. As a result, the forecast tends – COVID-19 infected, recovered, hospitalised
to better predict for the third and fourth horizon. In con- and dead cases of Dresden (http://daten.dr
tradiction, the Sarima-Holt in the presence of the BCT esden.de/duva2ckan/f iles/de-sn-dresden
provides lower performance than the absence one due to -corona_-_covid-19_-_fallzahlen_md1_d
less variation of the training data after BCT (see Fig. 7). resden_2020ff/content).
– COVID-19 infected, dead, and test cases
of Czechia for Municipality level (https:
//onemocneni-aktualne.mzcr.cz/api/v2/c
ovid-19/).
– Age-based and gender-based infected and
dead cases for county level of Germany
(https://experience.arcgis.com/experience
/478220a4c454480e823b17327b2bf1d4).
– COVID-19 cases for municipality level of</p>
        <p>Saxony, Germany (https://www.coronavi
rus.sachsen.de/corona-statistics/rest/inf
ectionOverview.jsp).
– COVID-19 cases for county level of Saxony,</p>
        <p>Germany (https://media.githubuserconten
t.com/media/robert-koch-institut/SARS
-CoV-2_Infektionen_in_Deutschland/ma
ster/Aktuell_Deutschland_SarsCov2_Infe
ktionen.csv)
– COVID-19 infected, dead, and test cases
for county level of Poland (https://wojewo
dztwa-rcb-gis.hub.arcgis.com/pages/dane
-do-pobrania).
– COVID-19 vaccine for county level of Poland
(https://www.gov.pl/web/szczepimysie/ra
port-szczepien-przeciwko-covid-19).
– COVID-19 types in Sachsen (https://www.</p>
        <p>coronavirus.sachsen.de/infektionsfaelle-i
n-sachsen-4151.html).
• Dictionaries of regions.</p>
        <p>– Administrative areas in Germany (https:
//gdz.bkg.bund.de/index.php/default/digi
tale-geodaten/verwaltungsgebiete.html).
– Administrative areas in Poland (https://gi
s-support.pl/baza-wiedzy-2/dane-do-pob
rania/granice-administracyjne/)
– Administrative areas in Czechia (https://ge
oportal.cuzk.cz/(S(1nhx02lray0vkrhce1y2
d53d))/Default.aspx?mode=TextMeta&amp;te
xt=dSady_RUIAN&amp;side=dSady_RUIAN)
– Population numbers in Czech
municipalities (https://www.czso.cz/csu/czso/pocet
-obyvatel-v-obcich-k-112021)
– Postal codes in Germany (https://www.ge
onames.org/postal-codes/postleitzahle
n-deutschland.html)
– Population numbers in Poland (https://st
at.gov.pl/obszary-tematyczne/ludnosc/lu
dnosc/ludnosc-stan-i-struktura-ludnosc
i-oraz-ruch-naturalny-w-przekroju-teryt
orialnym-stan-w-dniu-30-06-2021,6,30.h
tml)</p>
        <sec id="sec-2-1-1">
          <title>7.1. Data workflow</title>
        </sec>
      </sec>
      <sec id="sec-2-2">
        <title>We use https://www.talend.com/products/talend-openstudio/ to perform data migration. The migration between the data sources and the PostgreSQL database of CASUS HZDR has been performed as follows:</title>
        <p>Poland, we add ’DE’, ’CZ’, ’PL’, respectively,
followed by the intrinsic ID. For the table of regions,
the primary key of region_types serves as its
foreign key. The intrinsic IDs are categorised
based on the ID of region types. A specific
example would be Dresden, whose the intrinsic ID
14162. After cleaning processes, the intrinsic ID
will be DE 14162 and categorised to the state level
of Kreise.</p>
        <p>Having migrated the data to the aforementioned
tables, the table of mapping_regions is
occupied by the spatial-relation data. It contains the
foreign key of the mapping type ID. An example
would be a county Dresden. Dresden are mapped
onto the state of Saxony and categorized to the
mapping type Kreis_To_Bundesland. Next, the
table of datavalues for nations is occupied by the
data input. The datavalues table consists of three
foreign keys which originate from the tables of
timeperiod_types, regions, datavalues_types.
In the presence of these foreign keys, a data
merging process is feasible, which is described on the
following item.
4. Data merging In addition to the aforementioned
three-foreign keys, date is set as the fourth
attribute which allow us to perform data merging
through inner join of tables. The inner join is
employed to cleanly merge and avoid duplicated
data on the table of datavalues. For instance, daily
infected data of the lowest-level region for
period of date are migrated to the table of
datavalues_germany. When the data sources are
updated, they sometimes update the cases of the
elapsed date. Inner join method allows us to
automatically update the value of the elapsed date
by the latest value. Moreover, when the new data
with the latest date are present from the source, it
allows automatic addition of the data to the table.
5. Data aggregation The presence of daily data of
the lowest regions allow us to perform both time
and spatial aggregations. Using functions, the
time aggregation from daily to weekly period is
feasible. Moreover, as mentioned on the Sec. 2,
the spatial aggregation from the low to the high
region level is allowable in the presence of the
mapping_regions table.</p>
        <sec id="sec-2-2-1">
          <title>7.2. Additional forecasting results</title>
        </sec>
      </sec>
    </sec>
    <sec id="sec-3">
      <title>Acknowledgments</title>
      <sec id="sec-3-1">
        <title>This work was partially funded by the Center of Advanced Systems Understanding (CASUS), which is financed by Germany’s Federal Ministry of Education and</title>
      </sec>
      <sec id="sec-3-2">
        <title>Research (BMBF) and by the Saxon Ministry for Science,</title>
        <p>Culture and Tourism (SMWK) with tax funds on the basis
of the budget approved by the Saxon State Parliament.
We thank to Jens Steiner for providing us virtual server
of HZDR.</p>
      </sec>
    </sec>
  </body>
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