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    <journal-meta>
      <journal-title-group>
        <journal-title>These authors contributed equally.
" andrea.apicella@unina.it (A. Apicella); francesco.isgro@unina.it (F. isgrò); rprevete@unina.it (R. Prevete)</journal-title>
      </journal-title-group>
    </journal-meta>
    <article-meta>
      <title-group>
        <article-title>XAI approach for addressing the dataset shift problem: BCI as a case study</article-title>
      </title-group>
      <contrib-group>
        <contrib contrib-type="author">
          <string-name>Andrea Apicella</string-name>
          <xref ref-type="aff" rid="aff0">0</xref>
          <xref ref-type="aff" rid="aff1">1</xref>
          <xref ref-type="aff" rid="aff2">2</xref>
        </contrib>
        <contrib contrib-type="author">
          <string-name>Francesco isgrò</string-name>
          <xref ref-type="aff" rid="aff0">0</xref>
          <xref ref-type="aff" rid="aff1">1</xref>
          <xref ref-type="aff" rid="aff2">2</xref>
        </contrib>
        <contrib contrib-type="author">
          <string-name>Roberto Prevete</string-name>
          <xref ref-type="aff" rid="aff0">0</xref>
          <xref ref-type="aff" rid="aff1">1</xref>
          <xref ref-type="aff" rid="aff2">2</xref>
        </contrib>
        <aff id="aff0">
          <label>0</label>
          <institution>Department of Electrical Engineering and Information Technology, University of Naples Federico II</institution>
        </aff>
        <aff id="aff1">
          <label>1</label>
          <institution>Laboratory of Artificial Intelligence, Privacy &amp; Applications, AIPA Lab</institution>
        </aff>
        <aff id="aff2">
          <label>2</label>
          <institution>Laboratory of Augmented Reality for Health Monitoring</institution>
          ,
          <addr-line>ARHeMLab</addr-line>
        </aff>
      </contrib-group>
      <pub-date>
        <year>2022</year>
      </pub-date>
      <volume>000</volume>
      <fpage>0</fpage>
      <lpage>0002</lpage>
      <abstract>
        <p>In the Machine Learning (ML) literature, a well-known problem is the Dataset Shift problem where, diferently from the ML standard hypothesis, the data in the training and test sets can follow diferent probability distributions leading ML systems toward poor generalisation performances. Therefore, such systems can be unreliable and risky, particularly when used in safety-critical domains. This problem is intensely felt in the Brain-Computer Interface (BCI) context, where bio-signals as Electroencephalographic (EEG) are used. In fact, EEG signals are highly non-stationary signals both over time and between diferent subjects. Despite several eforts in developing BCI systems to deal with diferent acquisition times or subjects, performance in many BCI applications remains low. Exploiting the knowledge from eXplainable Artificial Intelligence (XAI) methods can help develop EEG-based AI approaches, overcoming the performance returned by the current ones. The proposed framework will give greater robustness and reliability to BCI systems with respect to the current state of the art, alleviating the dataset shift problem and allowing a BCI system to be used by diferent subjects at diferent times without the need for further calibration/training stages.</p>
      </abstract>
      <kwd-group>
        <kwd>eol&gt;XAI</kwd>
        <kwd>EEG</kwd>
        <kwd>cross-subject</kwd>
        <kwd>dataset shift</kwd>
        <kwd>BCI</kwd>
      </kwd-group>
    </article-meta>
  </front>
  <body>
    <sec id="sec-1">
      <title>1. Introduction</title>
      <p>
        Supervised Machine Learning (ML) models can learn from human-classified examples (labelled
data) to generalise toward new unknown data (unlabelled data). In a nutshell, two diferent
stages are needed for a supervised ML system to work properly, i) a Training stage, where a set
of labelled examples are fed to the system, so that it can learn a good mapping between examples
and the provided labels, and ii) a Running/Production stage, where unlabelled examples are fed
to the system which returns the most probable labels using the mapping learned in the training
stage. However, if labelled data not used in the training stage are available, they can be used to
evaluate the trained model (Evaluation stage). ML classical methods start from the hypothesis
that all the used data in any stage come from the same distribution probability. This assumption
can be strong in real environments since the real distributions of the data are often unknown. As
a consequence, the trained model could not perform well on the production data if its distribution
probability is diferent from the training one, failing in generalisation. Or, even worse, if the
data used in the training and evaluation stage come from the same distribution, there may be
an overestimation of the model performance if the production stage data come from a diferent
distribution. In the ML literature, this is known as the Dataset Shift problem [
        <xref ref-type="bibr" rid="ref1">1</xref>
        ]. Summarising,
Dataset Shift arises when the distribution of the training data difers from the data distribution
used outside of the training stage (that is, running or evaluation stages); therefore the starting
ML assumption does not hold. Consequently, standard ML approaches can produce ML systems
which exhibit poor generalisation performances making such systems unreliable and risky,
especially when used in safety-critical domains. This problem is particularly felt in Brain
Computer Interface (BCI, [
        <xref ref-type="bibr" rid="ref2">2</xref>
        ]) context, where some bio-signals acquired from the brain, such as
the Electroencephalographic (EEG) ones, can continually change their statistical characteristics.
This implies that even under the same conditions and for the same task, significantly diferent
signals can be acquired just as time passes, also occur using the same stimuli-reaction (e.g., same
emotions with the same stimuli in an emotion detection task) on the same subject. This problem
is even more evident in diferent subjects who, given the same stimuli and responses, can
produce very diferent acquisitions between them. For these reasons, EEG is considered a
nonstationary signal [
        <xref ref-type="bibr" rid="ref3">3</xref>
        ]. Because of this, big diferences across acquisitions made at diferent times
or across diferent subjects can arise leading to diferent data probability distributions. More in
detail, the following cases in an EEG-based task can arise: i) a model trained on a set of EEG
data acquired from a given subject at a specific time could not work on data acquired from the
same subject at diferent times (Cross-Session generalisation problem), or ii) a model trained on
data acquired from one or more subjects could not work as expected in classifying EEG signals
acquired from a diferent subject at diferent times (Cross-Subject generalisation problem).
These conditions lead the model toward poor generalisation performance, and the construction
of unreliable ML systems. Several strategies have been proposed to overcome the dataset shift,
considering the diferences between the possible distributions involved. Several proposals are
based on Transfer Learning (TL) methods [
        <xref ref-type="bibr" rid="ref4">4</xref>
        ], a family of approaches to transfer knowledge
learned from a Machine Learning system to another. TL approaches can be categorised into
several subfamilies, such as Domain Adaptation (DA) [
        <xref ref-type="bibr" rid="ref4">4</xref>
        ] and Domain Generalisation (DG) [
        <xref ref-type="bibr" rid="ref5">5</xref>
        ]
approaches. However, Existing DA and DG solutions are still far from being able to be adopted
in real EEG-based tasks because of their low classification performances. On another side, a
sub-field of Artificial Intelligence, eXplainable Artificial Intelligence (XAI), wants to explain the
behaviour of AI systems, such as ML ones. In general, an explanation describes why an ML
model returns a given output given a specific input. In particular, several XAI methods applied to
Deep Neural Networks are giving promising results, such as [
        <xref ref-type="bibr" rid="ref6 ref7">6, 7</xref>
        ]. Our idea is that explanations
about the outputs of a trained ML model can help to overcome/mitigate the dataset shift problem,
in general, and to generalise across subjects/sessions in case of EEG signals, in particular. In
the XAI context, several explanations are built by inspecting the model’s inner mechanism
to understand the input-output relationships. Therefore, explanations of an ML system can
be used to locate and exploit, for each given output, the main input characteristics to build a
new ML system able to generalise toward diferent data, also coming from diferent probability
distributions. In this research work, explanations built by an Artificial Explainer are used to
improve the generalisation performance by analysing a set of ML models and understanding
their inner input/output relations. In particular, we plan to develop solutions in the context of
EEG signal classification problems which can lead to Subject-Independent models.
      </p>
    </sec>
    <sec id="sec-2">
      <title>2. Related works</title>
      <p>
        In recent years, BCI systems based on Electroencephalographic (EEG) input signals are receiving
a strong interest by the scientific community thanks to the opportunity to exploit ML together
with the EEG qualities, such as non-invasiveness and high temporal resolution [
        <xref ref-type="bibr" rid="ref8">8</xref>
        ], in several
BCI applications such as healthcare [
        <xref ref-type="bibr" rid="ref10 ref11 ref12 ref9">9, 10, 11, 12</xref>
        ] and education [
        <xref ref-type="bibr" rid="ref13">13</xref>
        ]. However, Modern ML
approaches, as Deep learning, are characterised by a lack of transparency of their internal
mechanisms, making it not easy for the AI scientist to understand the real reasons behind the
inner behaviours. In this case, the relationships between the classifier’s output and the EEG
input are often challenging to understand. In the EEG-based applications, works based on
features selection to choose the best EEG features are widely proposed in the literature, such as
[14]. However, the greatest part of these studies does not take into account the inner state of the
model, relying only on its input-output functional relations. XAI is a branch of AI concerned to
“explain” ML behaviours. This is made providing methods for generating possible explanations
of the model’s outputs. To the best of our knowledge, the number of research works which
attempt to improve the performance of ML models on the basis of XAI’s methods is enough
limited, especially in the context of bio-signal classification problems. For example, in [ 15, 16]
feature selection procedures are carried out on biomedical data leveraging on feature selection
and swarm intelligence methods. In [17] an occlusion sensitivity analysis strategy [18] to locate
the most relevant cortical areas in a motor imagery task is used. In [19] the use of XAI methods
to interpret the answer of Epilepsy Detection systems is discussed.
      </p>
    </sec>
    <sec id="sec-3">
      <title>3. Methods</title>
      <p>We start from the hypothesis that possible hidden relationships between the input EEG signal
and the ML outputs can be identified by XAI methods, allowing the scientist to focus on the
best features for the used model and, on the other side, if there are features leading to poor
results as they are, for example, subject-specific features. In this work, we want to exploit XAI
methods to select the best features, or the best feature functional transformations, involved in
an EEG classification task. Our hypothesis relied on the fact that XAI methods can be used to
locate which part of the input are more relevant for the model classification. Indeed, leveraging
on the model inner parameters, several XAI methods are able to trace which input features are
more involved for a given output, that can be interpreted as explanations about the produced
output. Consequently, we propose to take advantage of XAI methods to select/transform suitable
features to enhance the performance of a ML system in the context of domain-shift problems.
A key step of this research work is to investigate the ability of the current main XAI methods
to select the best input features for our aims. Therefore, a first step is to select a proper EEG
feature transformation among those proposed in literature [20] for the task in exam. Next,
existing methods able to build explanations suitable for the EEG domain in the selected feature
used for</p>
      <p>explanation
EEG
feature
extraction
and selection</p>
      <p>ML system</p>
      <p>generate
examines
prediction</p>
      <p>Artificial
explainer
space will be investigated, leveraging on classical XAI evaluation metrics (e.g., MoRF curves
[21, 22]). Thereafter, an Artificial Explainer built upon a selected XAI method will provide an
explanation to the model outputs. This explanation will be used to select/extract the proper
feature space for a ML system, suppressing the features that can lead toward bad classification.
In Fig. 1 a functional schema of the proposed work is reported. The proposed framework can be
validated both for cross-session and cross-subject generalisation, comparing the performances
obtained with the current state-of-art strategies.</p>
    </sec>
    <sec id="sec-4">
      <title>4. Conclusions</title>
      <p>This research project’s main value is exploring XAI’s use to overcome/mitigate the dataset
shift problem. Overall this could lead to safer, more reliable and more transparent AI systems.
In particular, we take advantage of this new approach in the context of BCI classification
problems, where the dataset shift is especially relevant. In particular, we have the following
main advantages: i) Improved BCI performances: selecting efective features exploiting methods
such XAI-based can lead Subject-Independent BCI systems toward performances comparable to
Subject-dependent ones, but without the main disadvantages of Subject-Dependent systems. ii)
less expensive classification models: XAI method will be able to guide the model to select the best
features for better performances, avoiding the problems related to the non-stationarity of the
EEG signal in an automatic way, without any further operator interaction; iii) more comfortable
systems: the lack of need for subject-specific training data leads to less time required for the
users, resulting in greater comfort and less stress for the subjects; iv) development of more
specific acquisition devices: a better understanding of the relationships between the system
inputs and outputs provided by XAI explanations can lead toward developing and producing
more efective EEG acquisition devices.</p>
    </sec>
    <sec id="sec-5">
      <title>Acknowledgments</title>
      <p>This work is supported by the European Union - FSE-REACT-EU, PON Research and Innovation
2014-2020 DM1062/2021 contract number 18-I-15350-2 and by the Ministry of University and
Research, PRIN research project "BRIO – BIAS, RISK, OPACITY in AI: design, verification and
development of Trustworthy AI.", Project no. 2020SSKZ7R .
[14] A. Wosiak, A. Dura, Hybrid method of automated eeg signals’ selection using reversed
correlation algorithm for improved classification of emotions, Sensors 20 (2020) 7083.
[15] E. Laxmi Lydia, C. Anupama, N. Sharmili, Modeling of explainable artificial intelligence
with correlation-based feature selection approach for biomedical data analysis, in:
Biomedical Data Analysis and Processing Using Explainable (XAI) and Responsive Artificial
Intelligence (RAI), Springer, 2022, pp. 17–32.
[16] R. P. Selvam, A. S. Oliver, V. Mohan, N. Prakash, T. Jayasankar, Explainable artificial
intelligence with metaheuristic feature selection technique for biomedical data classification,
in: Biomedical Data Analysis and Processing Using Explainable (XAI) and Responsive
Artificial Intelligence (RAI), Springer, 2022, pp. 43–57.
[17] C. Ieracitano, N. Mammone, A. Hussain, F. C. Morabito, A novel explainable machine
learning approach for eeg-based brain-computer interface systems, Neural Computing
and Applications 34 (2022) 11347–11360.
[18] M. D. Zeiler, R. Fergus, Visualizing and understanding convolutional networks, in:</p>
      <p>European conference on computer vision, Springer, 2014, pp. 818–833.
[19] P. Rathod, S. Naik, Review on epilepsy detection with explainable artificial intelligence, in:
2022 10th International Conference on Emerging Trends in Engineering and
TechnologySignal and Information Processing (ICETET-SIP-22), IEEE, 2022, pp. 1–6.
[20] X. Li, D. Song, P. Zhang, Y. Zhang, Y. Hou, B. Hu, Exploring eeg features in cross-subject
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[21] S. Bach, A. Binder, G. Montavon, F. Klauschen, K.-R. Müller, W. Samek, On pixel-wise
explanations for non-linear classifier decisions by layer-wise relevance propagation, PloS
one 10 (2015) e0130140.
[22] A. Apicella, S. Giugliano, F. Isgró, R. Prevete, Explanations in terms of hierarchically
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    </sec>
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