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  <front>
    <journal-meta>
      <journal-title-group>
        <journal-title>ORCID:</journal-title>
      </journal-title-group>
    </journal-meta>
    <article-meta>
      <title-group>
        <article-title>Numerical Modeling of the Coronary Artery using ANSYS Fluent</article-title>
      </title-group>
      <contrib-group>
        <contrib contrib-type="author">
          <string-name>Bakhyt Alipova</string-name>
          <email>alipova.bakhyt@gmail.com</email>
          <xref ref-type="aff" rid="aff0">0</xref>
          <xref ref-type="aff" rid="aff1">1</xref>
        </contrib>
        <contrib contrib-type="author">
          <string-name>Yevgeniya Daineko</string-name>
          <email>y.daineko@iitu.edu.kz</email>
          <xref ref-type="aff" rid="aff0">0</xref>
        </contrib>
        <contrib contrib-type="author">
          <string-name>Zhiger Bolatov</string-name>
          <email>zh.bolatov@iitu.edu.kz</email>
          <xref ref-type="aff" rid="aff0">0</xref>
        </contrib>
        <aff id="aff0">
          <label>0</label>
          <institution>International Information Technology University</institution>
          ,
          <addr-line>Manas St. 34/1, Almaty, 050040</addr-line>
          ,
          <country country="KZ">Kazakhstan</country>
        </aff>
        <aff id="aff1">
          <label>1</label>
          <institution>University of Kentucky</institution>
          ,
          <addr-line>Lexington, Kentucky, 40506</addr-line>
          ,
          <country country="US">USA</country>
        </aff>
      </contrib-group>
      <pub-date>
        <year>1945</year>
      </pub-date>
      <volume>000</volume>
      <fpage>0</fpage>
      <lpage>0003</lpage>
      <abstract>
        <p>Cardiovascular disease (CVD) (Doost et al., 2016) are abnormalities that distort the effective flow of blood to and away from the heart. To be able to fully understand how these things happen, CFD tool (ANSYS Fluent) is used to model how blood flows into and away from the coronary artery. Blood, air and aluminum was used as main materials in the simulation. The present study aimed to establish a relationship between actual hemodynamic conditions and the parameters that define with ANSYS Fluent. And, to obtain numerical solution to research the best physical model to determine viscosity and pulsatile velocity in a healthy human. Cardiovascular disease, coronary artery, blood flow, Navier Stokes equation, ANSYS Fluent Governing Equation Proceedings of the 7th International Conference on Digital Technologies in Education, Science and Industry (DTESI 2022), October 20-21,</p>
      </abstract>
    </article-meta>
  </front>
  <body>
    <sec id="sec-1">
      <title>1. Introduction</title>
      <p>
        Cardiovascular disease (CVD) [
        <xref ref-type="bibr" rid="ref1">1</xref>
        ] are abnormalities that distort the effective flow of blood to and
away from the heart. To be able to fully understand how these things happen, CFD tool (ANSYS Fluent)
is used to model how blood flows [
        <xref ref-type="bibr" rid="ref2">2</xref>
        ] into and away from the coronary artery.
      </p>
      <p>(
ẟ
ẟ + .(</p>
      <p>) = 0
+v. v) =- p+µ 2v+f</p>
      <sec id="sec-1-1">
        <title>Continuity</title>
      </sec>
      <sec id="sec-1-2">
        <title>Navier Stokes equation</title>
      </sec>
      <sec id="sec-1-3">
        <title>With</title>
      </sec>
      <sec id="sec-1-4">
        <title>The power model [5]</title>
        <p>µ</p>
      </sec>
      <sec id="sec-1-5">
        <title>Blood viscosity is modeled using the Carreau fluids model [3]</title>
        <p>
          ( ̇ ) = ̇ µ
+ (µ − µ
)(1 + (   ̇ )2) 2
 −1
The Carreau model [
          <xref ref-type="bibr" rid="ref4">4</xref>
          ] for the velocity profile is given as
µ
 = 0.056 (
), µ
= 0.0035 (
) ,  = 3.313
        </p>
        <p>= 0.3568
v
( ) = {
0.10
0.5 sin[4 ( + 0.0160236)]</p>
        <p>: 0.5 &lt;  ≤ 0.5 + 0.218
: 0.5 + 0.218 &lt;  ≤ 0.5( + 1)
 
= 2 ∗ 0.988[1 + 0.624 ∗ 
(7.854.  )] / for the power law.
Bolatov)</p>
        <p>2022 Copyright for this paper by its authors.</p>
        <p>
          Another velocity model proposed by [
          <xref ref-type="bibr" rid="ref6">6</xref>
          ] is used in simulation. This model considers the duration of
a cycle to be 0.8s.
        </p>
      </sec>
    </sec>
    <sec id="sec-2">
      <title>2. Physical model</title>
      <p>
        The first step in building physical models (figure 1) is the first step in running a CFD simulation [
        <xref ref-type="bibr" rid="ref7">7</xref>
        ].
      </p>
      <sec id="sec-2-1">
        <title>The Ansys Design modeler is used in drawing the coronary artery [8, 9].</title>
        <p>2.1.</p>
      </sec>
    </sec>
    <sec id="sec-3">
      <title>Meshing and Grid independence study</title>
      <p>In the mesh workspace in Ansys, various surfaces corresponding to boundary conditions are named
to create these boundaries for simulation. The generated geometry is then meshed to obtain simpler
elements. Default settings are used. Grid independence analysis is conducted by running simulations
with grid cells numbers obtained as a result of varying element sizes.
2.2.</p>
    </sec>
    <sec id="sec-4">
      <title>Numerical Setup in ANSYS Fluent</title>
      <p>Under general, pressure-based solver is selected and problem is solved in transient state. Energy
equation is selected and laminar is chosen for viscous model. K-epsilon model is chosen, and standard
wall functions is selected for Near Wall Treatment.</p>
      <p>The materials used for this simulation are blood and air (fluids) and aluminum (solid). Blood is
treated as an incompressible fluid in simulation and material properties are considered as constants.
Density of blood is assumed to be 1050kg/m3, cp=3513j/kg-K, thermal conductivity(K)=0.44W/mK,
viscosity(µ)=0.0035kg/ms. When blood is treated as compressible, a user defined function (udf) is
written and inserted into ANSYS Fluent to account for differences in properties. Properties of air are
written in ANSYS Fluent. Aluminum is material selected for aorta with properties already written in</p>
      <sec id="sec-4-1">
        <title>ANSYS Fluent.</title>
        <p>2.4.</p>
      </sec>
    </sec>
    <sec id="sec-5">
      <title>Boundary Conditions</title>
      <sec id="sec-5-1">
        <title>All boundaries are considered to be in the mixture phase. Inlet_blood-is considered as a velocity inlet, with magnitude, normal to boundary chosen as velocity specification method and an initial value of 0.3m/s. The initial temperature is 37̊C (310K). Mathematical description [4] for the velocity profile is given as</title>
        <p>v</p>
      </sec>
      <sec id="sec-5-2">
        <title>Interior_solid is the internal boundary and the interior wall boundary condition is applied. Outlet_blood is the outlet boundary, and the pressure outlet boundary condition is applied with a gauge pressure of 13332Pa. Under momentum, Pressure profile multiplier of 1 is applied with a normal to boundary backflow direction specification method.</title>
        <p>Outlet_small is the outlet boundary and the pressure outlet boundary condition is also applied here.</p>
      </sec>
      <sec id="sec-5-3">
        <title>Wall_artery- wall boundary conditions are applied.</title>
      </sec>
    </sec>
    <sec id="sec-6">
      <title>Solver Settings</title>
      <sec id="sec-6-1">
        <title>Hybrid initialization. Explicit method is used for discretization.</title>
        <p>
          According to literature [
          <xref ref-type="bibr" rid="ref11">11</xref>
          ], the mean velocity of blood inside the artery ranges from 0.11-0.13m/s.
        </p>
      </sec>
      <sec id="sec-6-2">
        <title>From the results above (figure 3), case A was closer with a value of 0.1399163m/s.</title>
        <p>
          The lowest pressure recorded was 13444.24Pa also in case A. The average shear stress that acts on
the artery wall is between 2.48-4.27Pa [
          <xref ref-type="bibr" rid="ref12">12</xref>
          ] depending on sex and age and it is observed that case A and
        </p>
      </sec>
      <sec id="sec-6-3">
        <title>C had values in this range.</title>
      </sec>
    </sec>
    <sec id="sec-7">
      <title>3. Conclusion</title>
      <p>In this numerical investigation, ANSYS Fluent was used to investigate the best model to determine
viscosity and pulsatile velocity in a healthy human. The coronary artery was the main organ for study.
The numerical results showed that varying the viscosity of blood had a direct impact on viscosity and
wall shear stress.</p>
      <p>Models provided in ANSYS Fluent used for the simulation provided ranges that were above normal
for average pressure and velocity with values between 13564.89Pa and 13618.12Pa for case Carreau
and power law respectively. The highest shear stress was recorded for the Carreau model with a value
of 6.03 which was way above normal values. Generally, ANSYS Fluent works better when values of
viscosity and velocity are kept constant.</p>
    </sec>
    <sec id="sec-8">
      <title>4. Acknowledgements</title>
      <p>The project was accomplished with the financial support of the Science Committee of the Ministry
of Science and Higher Education of the Republic of Kazakhstan according to the Program of grant
funding of scientific and (or) scientific-technical projects in 2022-2024 (Grant No.AP14871641).</p>
    </sec>
    <sec id="sec-9">
      <title>5. References</title>
    </sec>
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