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  <front>
    <journal-meta>
      <journal-title-group>
        <journal-title>M. R. Johannessen);</journal-title>
      </journal-title-group>
    </journal-meta>
    <article-meta>
      <title-group>
        <article-title>Research Priorities in eHealth in four African Countries - A survey</article-title>
      </title-group>
      <contrib-group>
        <contrib contrib-type="author">
          <string-name>Shegaw Anagaw Mengiste</string-name>
          <email>Shegaw.Mengiste@usn.no</email>
          <xref ref-type="aff" rid="aff2">2</xref>
        </contrib>
        <contrib contrib-type="author">
          <string-name>Konstantinos Antypas</string-name>
          <email>Konstantinos.Antypas@sintef.no</email>
          <xref ref-type="aff" rid="aff0">0</xref>
        </contrib>
        <contrib contrib-type="author">
          <string-name>Marius Rohde Johannessen</string-name>
          <email>Marius.Johannessen@usn.no</email>
          <xref ref-type="aff" rid="aff2">2</xref>
        </contrib>
        <contrib contrib-type="author">
          <string-name>Jörn Klein</string-name>
          <email>Jorn.Klein@usn.no</email>
          <xref ref-type="aff" rid="aff2">2</xref>
        </contrib>
        <contrib contrib-type="author">
          <string-name>Gholamhossein Kazemi</string-name>
          <xref ref-type="aff" rid="aff2">2</xref>
        </contrib>
        <contrib contrib-type="author">
          <string-name>Jens Kassbøll</string-name>
          <xref ref-type="aff" rid="aff1">1</xref>
        </contrib>
        <aff id="aff0">
          <label>0</label>
          <institution>SINTEF</institution>
          ,
          <addr-line>Forskningsveien 1, 0373 Oslo</addr-line>
          ,
          <country country="NO">Norway</country>
        </aff>
        <aff id="aff1">
          <label>1</label>
          <institution>University of Oslo</institution>
          ,
          <addr-line>Problemveien 11, 0313 Oslo</addr-line>
          ,
          <country country="NO">Norway</country>
        </aff>
        <aff id="aff2">
          <label>2</label>
          <institution>University of South-Eastern Norway</institution>
          ,
          <addr-line>Raveien 215, 3184 Borre</addr-line>
          ,
          <country country="NO">Norway</country>
        </aff>
      </contrib-group>
      <pub-date>
        <year>2022</year>
      </pub-date>
      <volume>000</volume>
      <fpage>0</fpage>
      <lpage>0002</lpage>
      <abstract>
        <p>There is a huge interest by stakeholders in the potentials of eHealth. Accordingly, there is a strong demand from donors, and other stakeholders for eHealth research outputs to address infrastructural, policy, and human challenges. The BETTEReHEALTH project explores infrastructure, policy, and human factors impacting eHealth in Ethiopia, Ghana, Malawi, and Tunisia. This study applies the National eHealth Strategy Toolkit introduced by WHO and ITU to assess the conformity of the research landscape and research priorities of these countries with the building blocks defined in the toolkit. The status of ICT, policy, and human factors of partner countries indicates that there is a serious lack of policies and skilled workers along with infrastructural challenges. Collected data revealed that Infrastructure-Policy-Human is a fundamental triangle for successful eHealth implementation while Ethiopia, Ghana, Malawi, and Tunisia, as a sample representing Africa, sufer from lack of policies the most both at the governmental and research communal level.</p>
      </abstract>
    </article-meta>
  </front>
  <body>
    <sec id="sec-1">
      <title>1. Introduction</title>
      <p>
        There is a huge interest by local, national, and international actors in harnessing the potentials
of eHealth in providing solutions and enhancing the quality and safety of health care delivery
at diferent levels, particularly in the context of developing countries. Accordingly, there is a
strong interest and demand from donors, consumers, and other stakeholders for research outputs
that enable them to explore and address technical, human, policy, structural, and cultural
challenges in implementing eHealth initiatives for the purpose of tackling health service challenges
(e.g. lack of holistic, standardized, and interoperable systems) and improving performance,
decision making and communication capabilities of health professionals at diferent levels [
        <xref ref-type="bibr" rid="ref1">1</xref>
        ].
As such, there should be cooperation and coordination between the actors to avoid isolated
nEvelop-O
adaptation and non-interoperable implementation of eHealth systems. For instance, in Low
and Middle-Income Countries (LMICs), or in other words, in developing countries, most of the
time the standardization is left far behind from the fast-growing implementation, resulting in
less efective isolated healthcare systems [ 2]. On the one hand, eHealth systems are dependent
on two fundamental factors of health and information and communication technologies (ICT)
which both require knowledge, coordination, and communication. On the other hand, clinical
discoveries and ICT are changing rapidly and far outpacing the eHealth research due to the fact
that the process of submitting a grant, designing, conducting the research, analyzing the data,
and publishing the results takes a way longer time [3]. Hence, lack of a unified holistic view
over the status of the body of knowledge and strategic alignment of health and ICT will impact
technical infrastructure implementation, legislation, service accessibility, sociocultural factors,
and financial resources [ 4]. As a result, a continuous eHealth research approach that perceives
the ever-changing technological, scientific, and e-social environment is vital for the successful
implementation of eHealth [3].
      </p>
      <p>Considering the importance of research outputs for the involved parties and considering the
significance of the status of the body of knowledge for an appropriate eHealth implementation,
this study aims to explore the eHealth research status of four developing African countries that
are part of the BETTEReHEALTH project (https://betterehealth.eu/) to provide implications
for the coordination of stakeholders. This project addresses three strategic areas of public
policy, technical factors, and human factors for the successful deployment, development, and
implementation of eHealth in the partner countries of Ethiopia, Ghana, Malawi, and Tunisia.
BETTEReHEALTH is a 2021-2023 project and is funded by European Union’s Horizon 2020
research and innovation program under grant agreement No 101017450 (Norwegian Center
for eHealth Research, 2021). This project includes 11 members from 7 countries, which are the
Norwegian Center for eHealth Research, Norwegian Foundation for Industrial and Technical
Research (SINTEF), University of South-Eastern Norway, Belgian company of Establissements
Lievens Lanckman, University of Oslo, Tunisian company of Cluster Sfax Health Tech, Ghana
Health Service, Jimma University, University of Gondar, Health Information Systems Program
in Malawi, and Helder Resultaat which is based in the Netherlands [5].</p>
      <p>Since the environment challenges the eHealth research, researchers need to consider the
interdisciplinary collaboration of environmental factors and the ideals of stakeholders that
govern the research [6]. Accordingly, this study applies the National eHealth Strategy Toolkit
introduced by WHO and the International Telecommunications Union (ITU) to assess the
conformity of the research landscape and research priorities of the partner countries with the
building blocks defined in the aforementioned toolkit. This toolkit categorizes the necessary
building blocks of eHealth into seven groups (1-Leadership and Governance; 2-Strategy and
Investment; 3-Services and Applications; 4-Infrastructure; 5-Standards and Interoperability;
6-Legislation, Policy, and Compliance; 7-Workforce) [5]. In this regard, an online survey has
been designed and used to collect researchers’ opinions for understanding the research agenda,
research priorities, and research topics of eHealth researchers and research groups in Ethiopia,
Ghana, Malawi, and Tunisia. This survey will be used as input to report the state of eHealth
research in African partner countries of the BETTEReHEALTH project and improve their health
outcomes through better implementation of eHealth.</p>
      <p>eHealth is here defined as the use of systems and ICTs that support healthcare service
provision, delivery, and management activities, resulting in a wide area of applications ranging
from telemedicine to global research collaborations made possible via e-Infrastructures,
worldwide systems of integrated advanced high-performance networking, and computing ICT [7].
Eventually, this study scrutinizes the research landscape and research priorities of Ethiopia,
Ghana, Malawi, and Tunisia to extract the untouched or neglected areas of research by the body
of knowledge in the above-mentioned countries. Accordingly, areas of focus of assessment
are policy, technical, and human factors in the framework of the toolkit introduced by WHO
and ITU. Related data will be collected via an online survey that is sent to top research group
members of these countries. Extracted data will be analyzed to answer the question “Which
of these areas of research are not addressed at all or properly in Ethiopia, Ghana, Malawi,
and Tunisia?”. In the rest of this study, background and literature review, methodology and
approach, results, discussion, and conclusion and future work will be presented.</p>
    </sec>
    <sec id="sec-2">
      <title>2. Background and Literature Review</title>
      <p>eHealth was first ever defined in 1999 by Mitchell and referred to as an umbrella term embracing
clinical, educational, and administrative purposes [7]. Exploring eHealth definition development
through the years via diferent lenses indicates that all of them unitedly emphasize the use of
ICT in the health sector. For instance, from an eHealth-research perspective, the use of ICT in
the health sector empowers researchers with global research collaboration opportunities [7].
eHealth projects can have diverse goals, outcomes, technologies, and stakeholders ranging from
remote monitoring, health information sharing, and learning to telemedicine and research [7].
2.1. eHealth Building Blocks
In 2012, a toolkit was introduced by WHO and ITU to help governments initiate, develop,
or revise their eHealth approach, planning, and monitoring. The national eHealth strategy
toolkit is defined as “a practical, comprehensive, step-by-step guide, directed chiefly towards
the most relevant government departments and agencies, particularly ministries of health and
ministries of information technology and communication” and can be customized based on
local preferences [5, 8]. This toolkit defines the seven essential building blocks of eHealth as in
the following. Leadership and governance, strategy and investment, services and application,
infrastructure, standards and interoperability, legislation, policy and compliance, and workforce.
However, this study digs deeper into infrastructure, legislation, policy and compliance, and
workforce due to the scope of focus. In this respect, infrastructure refers to essential hardware
and software technologies that are used for sharing health information beyond the health sector
boundaries to improve healthcare and health information management. Moreover, legislation,
policy, and compliance concern necessary regulations for the deployment and development
of eHealth. These rules are meant to monitor access, privacy, storage, and sharing of health
information. Finally, the workforce points to health information technology and healthcare
workers who, respectively, design, develop, and implement eHealth projects, and use eHealth
project outcomes to deliver healthcare [5].
First eHealth projects were implemented in Africa in the 1980s in the form of telediagnosis
and clinical conferencing. Another example is the WHO eLearning programs provided freely
for educational purposes in Africa. A 2015 study indicates that until then only 37 eHealth
projects had been implemented in Africa with the help of 85 donors while Ethiopia, Ghana,
Malawi, and Tunisia each had been, respectively, part of 11, 12, 5, and 9 projects [7]. From these
37 projects, 23 encompass health-related research goals while Ethiopia, Ghana, Malawi, and
Tunisia each had been, respectively, part of 8, 8, 3, and 7 research projects [7]. From these 23
health research projects, 16 had Internet, 6 Mobile phones, 5 Free and Open-Source Software,
3 Satellites, 3 Personal Digital Assistant, 2 Distributed Computation, 1 Cloud Computation, 1
Geographic Information System, and 1 Telephone as the core technology [7]. This variation of
participation and infrastructure in eHealth and eHealth research projects indicates that these
four countries are a good sample to show the diversity of eHealth and eHealth research status
across Africa. The Strength of BETTEReHEALTH is the diversity of the involved parties in
Africa that together represent a holistic approach towards eHealth status in Africa. eHealth
governance in Ethiopia is conducted by the Ministry of Health and Public Health Infrastructure
Directorate, and in Ghana is conducted by an interagency body that includes the Ministerial
Committee on eHealth and is chaired by the Ministry of Health. Moreover, Malawi conducts
governance through the Ministry of Health and Population with the help of the Department
for eGovernment in the Ministry of Informatics and Communication Technology. Finally, in
Tunisia, the Ministry of Health is the governing body that gains help from the Tunisian Society
of Telemedicine and eHealth, the National Authority for Protection of Personal Data, and
the Ministry of Communication technologies. There are also private parties and donors that
cooperate in the implementation of eHealth in all these four countries [5].</p>
      <p>Regarding infrastructure, Ethiopia has provided the necessary ICT hardware and accessories
at a country level while Ghana is trying to improve and coordinate its Information Systems and
ICT infrastructure to overcome the poor quality of computing infrastructure in the public sector.
In Malawi, a fiber network has been implemented as a communicational backbone for the future
of mHealth, although frequent power outage is a challenge that has provoked the government
to think of alternative sources of energy. Finally, in Tunisia, 51.5% of the households were
connected to the Internet in 2019, and the adoption of ICT is heavily dependent on the users’
digital perception and skills [5]. Regarding policy, unfortunately, there is no policy defining
medical jurisdiction, liability, or reimbursement of eHealth services in any of these countries.
Also, policies regarding patients’ safety and quality of care are only addressed indirectly in
Tunisia. Concerning access equity policies, only Malawi and Tunisia have addressed it briefly.
In respect of innovation, risk management, and e-service policies, only Tunisia has introduced
responsible bodies, and none of the countries have policies addressing eHealth outcomes and
clinical efectiveness [ 5]. Regarding the human factor, Ethiopia sufers lack of suficient eHealth
personnel, Ghana also has health staf with no competent eHealth skills. In Ghana, the high
density of computerization is impacted by the loss of ICT professionality and training in the
health sector. Malawi also lacks competent staf within the area of digital health but there are
various related training programs at the university and college level and increasing access to
computing devices in the health sector. As well, Tunisia also sufers from the same problem
which is lack of recognized digital health skills accompanied by the low implementation of
eHealth systems. Though, there are related training programs at the country level [5].</p>
      <p>
        Accordingly, although Ethiopia, Ghana, Malawi, and Tunisia have assigned responsible bodies
for the implementation, deployment, and coordination of eHealth, there is still a need for capacity
building and training both at the health sector and society level. Moreover, there is a necessity
for eHealth standardization and policy designation to enable the successful implementation
of eHealth in Africa. Also, infrastructure implementation as an enabler should be in line with
other factors [5]. To address such issues, eHealth research must integrate relevant stakeholders
with relevant research agendas [9]. In the eHealth context, the term “stakeholders” refers to
patients and their caretakers, e-service receivers, the public, health professionals, governors,
policymakers, research funders, and researchers. Therefore, research agenda priorities must be
aligned with the needs of those being afected [
        <xref ref-type="bibr" rid="ref1">1</xref>
        ].
      </p>
    </sec>
    <sec id="sec-3">
      <title>3. Methodology and approach</title>
      <p>A qualitative survey has been designed based on the mentioned WHO toolkit to collect data and
measure the state of eHealth research in selected African countries. This survey extracts the
research agenda, research priorities, and research topics of interest in the community of eHealth
researchers of Africa. In this regard, the survey is divided into two sections namely, respondent
identification, and organizational approaches to eHealth research. The first section explores
location, qualification of respondents, primary areas of focus, and type of employer organization.
In contrast, the latter section scrutinizes organizational approaches toward addressing and
prioritizing diferent fields of eHealth research. Moreover, organizational research units are
being assessed to pinpoint the structure of research departments along with their challenges,
risks, and bottlenecks in conducting and implementing eHealth research at organizational and
national levels. To reach a proper number of qualified respondents, rich enough for the purpose
of this project, we used the regional hubs in Ethiopia, Ghana, Malawi, and Tunisia, personal and
academic international networks, and project participants from the European partners were used
to contact members of African universities, institutions, and organizations via email and phone.
Then, the survey was explained and sent to them via an active online link. Online surveys are
way more flexible than paper-based ones since the respondents can participate at any time they
prefer and in any location. Hence, the Nettskjema online survey introduced by the University
of Oslo has been chosen to overcome the time and distance challenges and to speed up the data
collection. After a month of data collection from July to August 2021 via the designed online
survey, the responses are collected in Excel and pdf files containing qualitative data. Afterward,
the collected data is coded and broken down into more comprehensible smaller segments and is
analyzed by eHealth experts to double-check its validity and reliability. Collected responses are
explained next.</p>
    </sec>
    <sec id="sec-4">
      <title>4. Results</title>
      <p>18 individuals from the countries that are participating in the BETTEReHEALTH project
responded to the survey, where around 75% of them are Professors, Associate Professors, and Ph.D.
candidates in the fields of Informatics, Health Informatics, Computer Science, Bioinformatics,
Information Systems, and Medical Sciences, and the rest have not stated their qualification. These
respondents are working in the academic or research institutions located in Ethiopia, Ghana,
Malawi, and Tunisia each with, respectively, 3, 4, 2, and 9 participants. When participants were
asked to define the eHealth topics that are addressed within their organizations, they declared
that Health Management Information Systems (HMIS), Electronic Medical Records, and Decision
Support Systems are at the center of attention in their organizations while priorities difer
from one organization to another. Table 1 shows the main addressed topics in the respondents’
organizations and their prioritized topics within diferent countries.</p>
      <p>In the following, participants were asked to reflect their personal opinion regarding preferred
eHealth research topics, the future of eHealth topics, and challenges and risks for successful
implementation of eHealth systems and research at the national and organizational level. As
a result, participants’ responses indicated that Electronic Health Record Systems that deliver
a confidential, integrated, and secure digital service are way more important to be addressed
followed by Intelligent Diagnosis Systems, Infrastructure, Health Data Science, and eHealth
Services Availability. Moreover, participants projected that in the next five years the most
prioritized topics are respectively, Electronic Health Record Systems, eHealth Data Science,
eHealth Services, and Policies. Regarding the challenges, risks, and bottlenecks of implementing
eHealth projects and research at the national and organizational level, participants declared that
Data, Cost, Supply, Quality, and Acceptance are the most challenging factors at the national
and organizational level. Table 2 shows the detailed information by country.</p>
      <p>Finally, when participants were asked about research departments and approaches in their
organizations, they indicated that all of their organizations consist of a research department
focusing on eHealth topics with 2 to 20 members. Based on our sample, Tunisia has the
biggest group of eHealth researchers followed by Ethiopia, Ghana, and Malawi. Research
departments responsible for eHealth topics focusing on policy implementation, technical and
human factor examination, pilot study consideration, eHealth topic identification, funding
application, decision support, security enhancement, disease diagnosis, data analysis, robotic
medical implants, monitoring, and training. Accordingly, Tunisia identifies eHealth topics
by collaborating with socio-economic partners, asking the medical staf, following national
priorities, recommendations of experts, competencies, and reviews. Ethiopia identifies topics via
analyzing actual problems, asking experts, following national agendas, and pursuing funders’
requests. Ghana extracts the gaps from literature, global health trends, industry, experts, and
social interest. Malawi focuses on the request of funders, scholarly literature, and situation
assessment to find gaps in eHealth.</p>
    </sec>
    <sec id="sec-5">
      <title>5. Discussion</title>
      <p>This study pinpoints addressed and prioritized research topics in each BETTEReHEALTH
African participant country to explore its potential impacts on governance, policy, human
resource, and infrastructure as well as interoperability and standardization of eHealth
implementations.</p>
      <p>The Ethiopian eHealth research community addresses mostly health information
manage</p>
      <p>Cardiovascular Disease, Secure
Healthcare
Monitoring, Patient Privacy,
Anomalous Data Detection, Mobile
Health,
Liver and Breast Cancer Detection,
Medical Implants like Bio Sensors,
Robotic Diagnostic, Stroke Prediction,
Intelligent Monitoring, Verification
ment systems and their applications like telemedicine and decision support systems, and they
prioritize implementation, data, mHealth, and digital applications. Basic infrastructural
readiness has laid the foundation for implementation; however, policies are not addressed at all
neither at the governmental level nor at the research communal level. Moreover, lack of
suficient eHealth workers is another challenge that has been neglected by the stakeholders. The
research community also has notified the need for adaptation, policymaking, and mHealth
while they indicate that infrastructure and lack of skilled workers hinder further development.
According to these points and focused areas of the aforementioned toolkit, Ethiopia sufers lack
of coordination between the government and the research community to be able to overcome
mHealth infrastructure, policy, and workforce challenges. In this regard, policies should be
implemented to align the research community and stakeholders’ points of view, adapt and
standardize diferent health information management systems, and strategize infrastructural
and workforce readiness for the future implementation of mHealth. To make it happen, a strong
mutual exchange of information and outputs is required between the governing body and the
research community.</p>
      <p>In Ghana, like Ethiopia, the research community addresses mostly health information
management systems and their applications like decision support and telemedicine systems. Ghana’s
research community prioritizes implementation, acceptance, data, capacity building, and
monitoring the most. System coordination and infrastructure improvement are being addressed
by the government; however, policy is not addressed either at the governmental or research
communal level. Also, lack of ICT professionality of health workers is another challenging factor.
The research community in Ghana has notified the need to focus on infrastructure, policy, data,
and skilled workers. According to these points and considering the toolkit, Ghana also sufers
lack of coordination between the governing body and the research community to be able to
overcome acceptance, capacity building, and infrastructural adaptation. In this regard, policies
are required to improve ICT professionality and adapt its pace to infrastructural developments
via training and acceptance elevation. To make it happen, like in Ethiopia, the governing
body and the research community should be able to coordinate and exchange information and
outputs.</p>
      <p>In Malawi, the research community only focuses on health information systems and
prioritizes the design and implementation of such systems. The futuristic approach of infrastructure
implementation has prepared Malawi for further development of eHealth and mHealth; however,
policymaking has been left far behind since only some minor regulations regarding access equity
have been introduced. Regarding human resources, although Malawi has created academic
pieces of training and programs, there is still a gap in the required number of skilled health
workers to maximize outputs. The Malawi eHealth research community has recognized the need for
innovation, sustainability, and policy while they also state that more health information worker
is required. Considering these points, Malawi’s government has prepared the infrastructural
and academic foundation for a futuristic eHealth implementation, but professional workforce is
hard to find. Possibly, lack of concentration both at the governmental and research communal
level on the acceptance and eHealth culture has led Malawi’s eHealth to this situation. In this
respect, policies should be fortified in all aspects, especially cultural acceptance and movement
towards digital health, to coordinate the government and research community’s eforts and
outputs towards maximizing the use of infrastructural and academic readiness.</p>
      <p>The focus of the Tunisian eHealth research community also is on health information
management systems and their applications such as decision support and telemedicine with a
client-centricity while prioritizing security, privacy, monitoring, and digital diagnosis.
Regarding infrastructures, only half of the households have an internet connection and ICT
implementation is heavily culture-dependent. Policies only address security, quality, safety,
innovation, risk, and e-service, and professional health work is scarce despite the availability of
country-wide academic programs. The Tunisian eHealth research community has realized the
need to focus on availability, infrastructure, implementation, and digital applications while they
indicate that equipment and health information worker is a challenge. It seems that Tunisia’s
government and research community are aligned regarding security and privacy which is the
result of implemented policies; however, the government has neither prepared a futuristic
infrastructural foundation nor addressed the cultural efects on digitalization. Accordingly, wider
coordination of the government and eHealth research community covering these challenges
prepares the ground for acceptance, implementation, and availability of eHealth.</p>
    </sec>
    <sec id="sec-6">
      <title>6. Conclusion and Future Work</title>
      <p>The BETTEReHEALTH project explores infrastructure, policy, and human factors in eHealth
implementation in Africa. Accordingly, this study scrutinized the coverage of these motifs by
the eHealth research community of Ethiopia, Ghana, Malawi, and Tunisia. An online qualitative
survey collected the required data and revealed that Infrastructure-Policy-Human readiness and
coordination is a must triangle in which any deficiency on any side can lead to a downfall of
successful implementation of eHealth. For instance, lack of policies in Ethiopia and Ghana has led
to the miscoordination of governmental and research communal approaches towards futuristic
implementation of mHealth regarding required infrastructure and skilled workforce. Moreover,
standardization and interoperability are impossible without a central regulated policy. Or in
Malawi, despite infrastructural and academic readiness, lack of suficient policies and human
consideration has led to the hindrance of mHealth implementation and cultural congruity with
digital health. Tunisia as an example clearly shows the importance of policies, areas in which
policies are defined are covered by the research community. Policies as a central regulation
coordinate the stakeholders’ approaches and eforts and help interoperability and
standardization; however, infrastructure and human factors are neglected by Tunisia’s government
leading to implementation and health information workforce challenges despite the availability
of academic programs. As a result, future work should concern the thorough designation and
implementation of eHealth policies as a central regulation and coordination factor. Policies as a
foundation must be agile and flexible in addressing futuristic plans, situational struggles, and
cultural transformations.</p>
    </sec>
    <sec id="sec-7">
      <title>Acknowledgments</title>
      <p>We deliver our sincere gratitude to the European Commission for funding this research through
the Horizon 2020 funding scheme and to the regional hub coordinators and BETTEReHEALTH
partners in Ethiopia, Ghana, Malawi, and Tunisia for their support in conducting the survey in
their respective regions.
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