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  <front>
    <journal-meta />
    <article-meta>
      <title-group>
        <article-title>Integration of Blockchain and IoT for securing and exchanging health records</article-title>
      </title-group>
      <contrib-group>
        <contrib contrib-type="author">
          <string-name>Suela Maxhelaku</string-name>
          <email>suela.maxhelaku@fshn.edu.al</email>
          <xref ref-type="aff" rid="aff1">1</xref>
        </contrib>
        <contrib contrib-type="author">
          <string-name>Alda Kika</string-name>
          <email>alda.kika@fshn.edu.al</email>
          <xref ref-type="aff" rid="aff1">1</xref>
        </contrib>
        <contrib contrib-type="author">
          <string-name>Ridvan Alimehmeti</string-name>
          <email>ridvanalimehmeti@gmail.com</email>
          <xref ref-type="aff" rid="aff0">0</xref>
        </contrib>
        <aff id="aff0">
          <label>0</label>
          <institution>Neurosurgery University Service</institution>
          ,
          <addr-line>Tirana</addr-line>
          ,
          <country country="AL">Albania</country>
        </aff>
        <aff id="aff1">
          <label>1</label>
          <institution>Tirana University, Faculty of Natural Sciences</institution>
          ,
          <addr-line>Tirana</addr-line>
          ,
          <country country="AL">Albania</country>
        </aff>
      </contrib-group>
      <abstract>
        <p>In recent years, the healthcare industry has been on the forefront of adopting cutting-edge technologies in order to deal with data integrity, security of the information, interoperability and information sharing between patients and healthcare providers. This paper proposes a model to improve the Radiology Information System (RIS) by integrating blockchain technology and the Internet of Things (IoT). The integration of these technologies has the potential to improve patient care by ensuring real-time monitoring of patients, a secure and tamper-proof system, as well as secure management and exchange of patient data. In addition, this paper discusses the advantages of using blockchain technology and IoT in healthcare, as well as the ways in which these technologies can address the challenges that currently exist within healthcare systems.</p>
      </abstract>
    </article-meta>
  </front>
  <body>
    <sec id="sec-1">
      <title>1. Introduction</title>
      <p>
        Health technologies have the potential to
enhance access to healthcare, address health
disparities and contribute to the overall health of
the population [
        <xref ref-type="bibr" rid="ref1">1</xref>
        ] by ensuring that individuals
receive timely and appropriate medical care.
      </p>
      <p>According to the World Health Organization
(WHO), the majority of digital technology's
potential uses for improving the health of
populations have not yet been explored and there
is a huge amount of potential for the
implementation of digital health solutions, despite
the widespread use of digital technologies and the
fact that digital technology is the field where
innovation is most evident.</p>
      <p>
        Meanwhile, blockchain technology has huge
potential in the healthcare industry, especially in
health information exchange (HIE). According to
many studies, blockchain-powered platforms can
take the place of current HIE mechanisms because
of their cost-effective, efficient, and secure
environment. However, despite these proposals,
few blockchain-based projects have been
implemented in the healthcare sector to date. [
        <xref ref-type="bibr" rid="ref2">2</xref>
        ]
      </p>
      <p>
        One of the most fundamental challenges that a
modern healthcare management system must
overcome is the process of storing and
transmitting data. In addition, several problems
exist with centralized EHR systems, such as
healthcare data breaching issues, a single point of
failure, personal and sensitive personal
information privacy concerns, and
interoperability issues with multiple systems and
data sources [
        <xref ref-type="bibr" rid="ref3">3</xref>
        ]. In addition, there are several
other challenges associated with healthcare
records, including access control, user trust, and
authentication.[
        <xref ref-type="bibr" rid="ref4">4</xref>
        ] [
        <xref ref-type="bibr" rid="ref5">5</xref>
        ]
      </p>
      <p>
        The adoption of digital health technologies has
the potential to transform healthcare by enabling
remote patient monitoring, improving patient
outcomes, reducing healthcare costs, and securely
exchanging and storing health information.
Meanwhile, IoT devices, including sensors and
wearables, have the potential to collect and
transmit real-time patient data, enabling
healthcare providers to provide care that is both
more individualized and more preventative with
more information regarding the patient's current
state of health. However, implementing a
clientserver architecture result in increased security
risks, which can be mitigated by taking advantage
of blockchain technology, which implements a
distributed architecture. [
        <xref ref-type="bibr" rid="ref6">6</xref>
        ]
      </p>
      <p>
        The use of blockchain technology has the
potential to enhance the interoperability and
security of healthcare data. Blockchain, which
uses a decentralized and secure ledger system, can
help ensure the privacy of patient data as well as
the data's integrity, while also enabling the secure
sharing of information. The findings indicate that
blockchain technology has a wide variety of
potential applications and uses within the
healthcare industry.[
        <xref ref-type="bibr" rid="ref7">7</xref>
        ]
      </p>
      <p>The remainder of this study is organized as
follows: In section 2, the principles of blockchain
and IoT are discussed, as well as the significance
of integrating IoT and Blockchain into healthcare.
Section 3 discusses the work related to the
existing approaches for integration of Blockchain
and IoT into healthcare. The proposed model
based on the integration of blockchain, and IoT
into the Radiological Information System is
proposed in Section 4. In addition, the conclusions
as well as future work are presented in Section 5.</p>
    </sec>
    <sec id="sec-2">
      <title>2. Background</title>
      <p>
        A blockchain is a digital ledger that serves as
a public, decentralized, and distributed database
that is managed by multiple participants across
multiple nodes, where each node communicates
and shares information through a peer-to-peer
(P2P) network.[
        <xref ref-type="bibr" rid="ref8">8</xref>
        ] The development of
blockchain technology as described in [
        <xref ref-type="bibr" rid="ref9">9</xref>
        ]
describes the development of blockchain
technology, which includes the following stages:
The first stage is Blockchain 1.0-Bitcoin, which
introduced the decentralization of virtual
currency. The second stage is Blockchain 2.0—
Ethereum, which introduced smart contract
authentication. The third stage is Blockchain
3.0—IOTA, where IoT connectivity was
established.
      </p>
      <p>
        In a private blockchain system, smart contracts
are compiled using the Solidity programming
language, and each node represents a unique
private blockchain account. The smart contract is
a type of computer protocol that is executable via
the account. The deployment of smart contracts is
illustrated in Figure 1. [
        <xref ref-type="bibr" rid="ref10">10</xref>
        ]
      </p>
      <p>
        The policies and restrictions that are
associated with privileges and services are
outlined in the smart contract. Access control
policies are turned into smart contracts, and then
the smart contracts are deployed on blockchain
platforms, which offer a decentralized and
tamper-proof network that ensures the contract is
executed in accordance with its rules. [
        <xref ref-type="bibr" rid="ref11">11</xref>
        ]
      </p>
      <p>
        A blockchain network employs a consensus
algorithm to establish its level of trust and ensure
that transactions are recorded properly on blocks.
In blockchain networks, some of the consensus
algorithms that are used most frequently include
Proof of Work (PoW), Proof of Stake (PoS),
Delegated Proof of Stake (DPoS), and Practical
Byzantine Fault Tolerance (PBFT). [
        <xref ref-type="bibr" rid="ref12">12</xref>
        ]
      </p>
      <p>
        Decentralization, which represents the
openness of blockchain technology as well as the
difficulty of avoiding being manipulated by
people, is an essential indicator of blockchain
technology. The Proof-of-Stake (PoS),
Distributed Proof-of-Stake (DPoS), and Casper
consensus algorithms are fully decentralized,
whereas the Proof-of-Equity (PoET), and Raft
consensus algorithms are semi-decentralized. [
        <xref ref-type="bibr" rid="ref13">13</xref>
        ]
      </p>
      <p>
        The Internet of Things (IoT) refers to a
collection of equipment, people, objects, and
everything else that has the capacity to
communicate and transfer data over a network
without the intervention of any external agents. In
the meantime, IoT presents users with a wide
variety of risks that endanger their privacy and
security. Internet of Things vulnerabilities can
lead to attacks on the integrity of data and
equipment, as well as on users' privacy, network
access, and service provisioning.[
        <xref ref-type="bibr" rid="ref14">14</xref>
        ]
      </p>
    </sec>
    <sec id="sec-3">
      <title>2.1 Importance of IoT and Blockchain healthcare</title>
      <p>
        The integration of blockchain with IoT
applications in healthcare can help address some
of the key challenges related to trust,
confidentiality, integrity, and privacy of data.[
        <xref ref-type="bibr" rid="ref15">15</xref>
        ]
      </p>
      <p>Their integration has the potential to bring
significant changes to healthcare, such as better
outcomes for patients, lower costs, more
efficiency, better security, interoperability, and
better coordination of care. IoT devices can be
used to monitor patients in real time, and
blockchain can ensure the integrity and privacy of
patient data. This can help reduce the risk of data
breaches and protect sensitive patient
information. The decentralized architecture of
blockchain and a secure ledger system can help
ensure the integrity and privacy of patient data.</p>
      <p>
        Blockchain technology has the potential to
address some of the challenges facing the
healthcare sector, as it can provide a secure and
tamper-proof environment [
        <xref ref-type="bibr" rid="ref16">16</xref>
        ] for storing and
sharing sensitive healthcare data and ensure that
patient health records are protected against
unauthorized access and tampering through the
use of smart contracts. The use of smart contracts
reduces the risk of tampering since their execution
is not dependent on any third party, nor can any
entity modify the rules defined in them.[
        <xref ref-type="bibr" rid="ref17">17</xref>
        ]
      </p>
      <p>
        Additionally, blockchain technology can
facilitate interoperability among healthcare
systems while offering patient-centered access
and allowing the users to exchange and share
health information in a standardized and secure
manner, as the users can communicate with the
blockchain only by using recognized
interoperability standards such as FHIR, [
        <xref ref-type="bibr" rid="ref18">18</xref>
        ] as
FHIR also improves the exchange of health care
data as presented in our previous work in [
        <xref ref-type="bibr" rid="ref19">19</xref>
        ].
      </p>
      <p>
        Blockchain offers numerous opportunities for
usage in the healthcare sector, e.g., in public
health management, user-oriented medical
research based on personal patient data as well as
drug counterfeiting [
        <xref ref-type="bibr" rid="ref20">20</xref>
        ]. Meanwhile, the
advantages of using blockchain technology in
healthcare are summarized in the following table
[
        <xref ref-type="bibr" rid="ref21">21</xref>
        ]:
      </p>
      <p>
        In addition, blockchain is used in integrating
distributed health records in a unified, safe, and
interoperable manner for use by health providers
and patients, sharing of PHRs among health care
providers, with the possibility of knowledge and
consent of the patient [
        <xref ref-type="bibr" rid="ref22">22</xref>
        ].
      </p>
      <p>
        In the current era of digital technologies, IoT
has become an increasingly important component
of smart healthcare, especially in light of the
COVID-19 pandemic. Patients can benefit from
the exceptional care made possible by the IoT,
which enables them to receive more targeted
treatment [
        <xref ref-type="bibr" rid="ref23">23</xref>
        ].
      </p>
      <p>
        Figure 1 provides an overview of the general
architecture of EHR systems that are based on
Blockchain technology and IoT [
        <xref ref-type="bibr" rid="ref24">24</xref>
        ].
in
      </p>
    </sec>
    <sec id="sec-4">
      <title>3. Related works</title>
      <p>
        Gohar et.al proposed a Patient-Centric
Healthcare Framework (PCH) using blockchain
technology to protect health data sources,
specifically by implementing a smart contract
design on top of the Hyperledger blockchain
platform on Amazon cloud to exploit smart
contracts and blockchain access control
capabilities for managing healthcare business and
system integrity. Their study details the
architectural design and implementation of data
sharing design using Blockchain, Cloud, and IoT
in healthcare systems [
        <xref ref-type="bibr" rid="ref3">3</xref>
        ].
      </p>
      <p>
        Alam et.al proposed Blockchain based EHR
framework that allows IoT device integration an
can be upgraded to integrate with other healthcare
facilities that need patient monitoring and
personal health record integration. It consists of
four layers as below [
        <xref ref-type="bibr" rid="ref24">24</xref>
        ] and presented in Figure
3:
•
•
•
•
      </p>
      <p>EHR layer: Healthcare provider layer,
healthcare providers share their records
regardless of EHR storage type),
Blockchain layer: An interface that
translates records into a unified format
and uses IPFS storage to support
interoperability. Smart contract, storage
policy, EHR manager, consensus
mechanism, and IPFS storage comprise
the BC layer.</p>
      <p>IoT-based patient monitoring layer: The
patient sensor layer to measures patient
inputs
User Layer: Users interact with the
system. They can enter or view health
information in a standard template
regardless of storage format.</p>
      <p>
        Meanwhile in [
        <xref ref-type="bibr" rid="ref25">25</xref>
        ] is presented and the
architecture of Blockchain-Assisted
Cybersecurity for the IoMT, which can overcome
cybersecurity and privacy problems and
comprises of the following stages:
• Healthcare instrument state which is
equipped with numerous IoMT healthcare
instruments;
• Blockchain state;
• Edge network state;
• Data synthesis state.
      </p>
    </sec>
    <sec id="sec-5">
      <title>4. Proposed Model</title>
      <p>
        In [
        <xref ref-type="bibr" rid="ref26">26</xref>
        ] we proposed a Radiology Information
System designed to assist physicians in managing
patient information. The system provides a
userfriendly interface for storing and retrieving
relevant patient data, including techniques and
results. In addition, the system is capable of
displaying DICOM scan images of the patient,
allowing for a comprehensive view of the patient's
medical history.
      </p>
      <p>In this paper, we propose to enhance the
system by incorporating blockchain technology
and IoT.</p>
      <p>Blockchain technology can improve the
security of the system by providing a
decentralized and tamper-proof record of all
transactions and data exchanges. To ensure the
confidentiality of the information participants
share with one another, it is essential that they
authenticate one another using blockchain
technology. Implementation of blockchain
technology can significantly enhance the level of
trust and security associated with the exchange of
information between parties. This step is essential
for ensuring the integrity and confidentiality of
the shared information. The use of smart contracts
can guarantee that all participants with access to
patient data are authenticated and authorized and
granted access to the appropriate data and records.</p>
      <p>In addition, by integrating IoT devices, the
patients can be monitored in real-time. This data
can be transmitted in a secure manner to the RIS
using blockchain technology.</p>
    </sec>
    <sec id="sec-6">
      <title>5. Conclusion and Future work</title>
      <p>This article presents a model that we proposed
with the intention of improving the Radiology
Information System (RIS) by incorporating
blockchain technology and the Internet of Things
(IoT). By integrating these technologies into the
system, we can guarantee real-time monitoring of
patients, a secure and tamper-proof system, as
well as the secure management and exchange of
patient data.</p>
      <p>
        In our future work we will provide security
analysis of the proposed model. In addition, the
integration of Blockchain and IoT will require
further investigation in GDPR compliance,
resources constraints, bandwidth constraint,
connectivity constraint and memory constraint
[
        <xref ref-type="bibr" rid="ref24">24</xref>
        ].
      </p>
    </sec>
    <sec id="sec-7">
      <title>6. References</title>
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