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  <front>
    <journal-meta>
      <journal-title-group>
        <journal-title>Affective Computing</journal-title>
      </journal-title-group>
    </journal-meta>
    <article-meta>
      <article-id pub-id-type="doi">10.1016/j.inffus.2017.02.003</article-id>
      <title-group>
        <article-title>Digital Health: A literature review</article-title>
      </title-group>
      <contrib-group>
        <contrib contrib-type="author">
          <string-name>Juan Apablaza</string-name>
          <email>juan.apablaza.n@mail.pucv.cl</email>
          <xref ref-type="aff" rid="aff0">0</xref>
          <xref ref-type="aff" rid="aff1">1</xref>
        </contrib>
        <contrib contrib-type="author">
          <string-name>Sandra Cano</string-name>
          <email>sandra.cano@pucv.cl</email>
          <xref ref-type="aff" rid="aff0">0</xref>
          <xref ref-type="aff" rid="aff1">1</xref>
        </contrib>
        <aff id="aff0">
          <label>0</label>
          <institution>Affective Computing, Medical Informatics, Digital Health</institution>
          ,
          <addr-line>e-health, e-Healthcare, User</addr-line>
        </aff>
        <aff id="aff1">
          <label>1</label>
          <institution>Pontificia Universidad Católica de Valparaíso</institution>
          ,
          <addr-line>Av. Brasil 2241, Valparaíso</addr-line>
          ,
          <country country="CL">Chile</country>
        </aff>
      </contrib-group>
      <pub-date>
        <year>2017</year>
      </pub-date>
      <volume>13</volume>
      <issue>1</issue>
      <fpage>0000</fpage>
      <lpage>0001</lpage>
      <abstract>
        <p>Digital Health has become one of the area's most important from SARS-CoV2. Therefore, Covid-19 pandemic has accelerated the rise of new apps centered on digital health, which can help in healthcare. A review literature is conducted, whose objective is to show what are the research advances in the field of affective computing in the context of Digital Health. In addition, a set of questions are formulated to understand the concepts and how it could be related. Therefore, Clarivate Analytics' Web of Science, Scopus and PubMed databases were used in this search. Experience and Affective medicine.</p>
      </abstract>
    </article-meta>
  </front>
  <body>
    <sec id="sec-1">
      <title>1. Introduction</title>
      <p>Who has not had a failure with a computer system or with our computer where we get a message
with unintelligible codes where a button appears with the only option: "OK" and the program closes?
or worse, the program closes without giving any explanation. Certainly, it would have been much
friendlier if, when the catastrophic failure occurred, he had sent me a message with empathic
characteristics and tried to reassure us, so as to achieve a much more natural interaction. What if this
happens in the health field, e.g., with a patient?</p>
      <p>In the health field we find users who are in a particular condition, they have health problems, and in
many cases, they are also worried about how much the treatment or the examination that the doctor has
prescribed will cost. They are tired, they feel bad, and these problems not only affect the patient himself,
but often also his environment.</p>
      <p>Affective Computing (AC) is related to arises from or intentionally influences emotion. Therefore,
it explores how technology can inform an understanding of emotion, how interactions between people
and technologies can be impacted by affect, and how sensing and affective strategies can transform
human and computer interaction [1]. For example, by using physiological measures, such as face
recognition, heart-rate variability and skin conductance, a computer can recognize key emotional states
and related changes in the user. Therefore, emotions and health are highly connected.</p>
      <p>Smith and Frawley [2] integrated emotions applied in medicine in two scenarios, such as (1)
emotional user interfaces in virtual environments for healthcare for patients, and (2) emotions in
computers as support for psychiatry. Picard integrated the term affective medicine, whose objective is
to enable computers to recognize some of the most frequent emotions that people experience while
6th workshop on ICTC for improving patients rehabilitation research techniques. Rehab 2022, Teruel, Spain</p>
      <p>2022 Copyright for this paper by its authors.
interacting with technology [3]. Cohen showed that people in depression and with poor social
interaction have high risks of suffering from a common cold [4]. Nowadays, applications of AC are
included in areas such as mental health, health monitoring systems, personal wellness, diagnostics,
among others.</p>
      <p>Digital health is related with a variety of terms such as e-health, m-health and telehealth, which is
related with applications of electronic patient records, remote monitoring, connected devices,
rehabilitation, and more. Digital health includes information technology, big data, artificial intelligence
to collect, share and analyze data of the patient to help healthcare professionals make informed decisions
and to improve care.</p>
      <p>In the literature review three main research questions. RQ1: What is the relationship between
affective computing and digital health RQ2: What is Digital Health? RQ3: How could it be defined as
Affective Health Digital?</p>
    </sec>
    <sec id="sec-2">
      <title>2. Background</title>
      <p>In this section we will describe a brief definition with affective computing and digital health.
2.1.</p>
    </sec>
    <sec id="sec-3">
      <title>Affective Computing</title>
      <p>Affective Computing: computing that relates to, arises from, or influences emotions [2]. Emotions
and feelings are part of our lives, helping in decision making, learning and communication. In recent
times, researchers have attempted to provide machines with the ability to recognize, interpret and
express emotions and feelings. Is a multidisciplinary field that ranges from computer science to
psychology to social sciences to cognitive sciences. The objectives of affective computing can be
divided into: (1) the initial objective is to design a computer system capable of recognizing and
expressing emotions, and (2) the final objective is to continue with the design so that the computer can
have emotions and use them in decision making [5].</p>
      <p>Another way of defining affective computing is: "the set of techniques aimed at performing affect
recognition from data, in different modalities and at different scales of granularity" [6]. Sentiment
analysis, for example, performs coarse-grained affect recognition, as it is usually considered a binary
classification task (positive vs. negative), while emotion recognition performs fine-grained affect
recognition, as it aims to classify data according to a large set of emotion labels.</p>
      <p>
        The work mainly addresses, among others, helping children with autism spectrum disorder to
understand their emotions through facial expression [7] recognition and mobile technologies, pain
detection from spontaneous facial expressions, emotional support through virtual agents [8],
emotionaware systems to promote human well-being, multimodal emotion recognition through deep neural
networks, depression detection through vocal [9], facial and semantic communication signals, and
automated mental state detection for mental health care [
        <xref ref-type="bibr" rid="ref1">10</xref>
        ]. Therefore, affective computing has a
greater potential in the care and treatment of brain health disorders, which means that AC can recognize,
interpret, process and simulate emotions [
        <xref ref-type="bibr" rid="ref2">11</xref>
        ].
      </p>
      <p>
        Affective computing can be related with Human Computer Interaction (HCI) from emotions. HCI
has studied emotions to evaluate interactions between user and computer. Wadley et al. [
        <xref ref-type="bibr" rid="ref3">12</xref>
        ] present a
discussion with emotions from HCI, where authors present dimensions of emotion from HCI such as:
Emotion may be either designed for, emotion is shaped, the mechanism of influence may vary, emotions
may be desirable or undesirable, emotions may result from technology use immediately or may arise
later, among others. Therefore, some studies are more focused on emotion recognition from facial
expressions, sounds, body gesture and physiological signals. Those signals are used to evaluate the User
eXperience [
        <xref ref-type="bibr" rid="ref4">13</xref>
        ] herefore, User eXperience can be defined as is defined by ISO 9241-210 a person’s
perceptions and response that result from the use or anticipated use of a product, system, or service [
        <xref ref-type="bibr" rid="ref5">14</xref>
        ]
some studies refer as emotional experience [
        <xref ref-type="bibr" rid="ref6">15</xref>
        ].
2.2.
      </p>
    </sec>
    <sec id="sec-4">
      <title>Digital Health</title>
      <p>
        According to WHO, Digital Health is the field of knowledge and practice associated with the
development and use of digital technologies to improve health [
        <xref ref-type="bibr" rid="ref7">16</xref>
        ]. Digital health expands the concept
of eHealth to include digital consumers, with a wider range of smart devices and connected equipment.
It also encompasses other uses of digital technologies for health such as the Internet of things, artificial
intelligence, big data and robotics.
      </p>
      <p>Digital health is a broad, multidisciplinary concept where technology and medical care intersect.
Digital health applies digital transformation to the field of healthcare, incorporating software, hardware
and services. In this context, stakeholders in the field of digital health include patients, physicians,
researchers, application developers, manufacturers and distributors of medical devices.</p>
    </sec>
    <sec id="sec-5">
      <title>3. Method 3.1. Keywords</title>
      <p>
        In order to have an overview regarding the relationship between Affective Computing and Digital
Health, a review of the scientific publications related to these keywords was carried out in this work.
Although this is not a systematic review, to achieve this goal, the guidelines described in the flowchart
presented in the PRISMA 2020 statement [
        <xref ref-type="bibr" rid="ref8">17</xref>
        ] were followed.
      </p>
      <p>In this preliminary search, we can see that when we search for "Affective Computing" adding
another criterion to focus the search on the healthcare field with keywords such as "eHealthcare",
"eHealth" the results decrease radically, which leads us to change the search approach. Table 1 shows
keywords selected: "Affective Computing" (AC), "e-Healthcare (EHc)", "eHealth (eH)" and "Health
(H)".</p>
      <p>Table 2 shows the results of the search without eliminating duplicate articles, where the total number
of publications in Scopus and PubMed stand out, with 355 and 99 articles on this topic published to
date, respectively. On the other hand, eliminating duplicates, the total number of published scientific
articles amounts to 402 papers. Figure 2 shows the upward trend of this research focus.</p>
      <p>Research in the field of Affective Computing has been relatively prolific in recent years, only in
Scopus from 2018 to date we found 2,019 articles, even higher is the number of articles we found in
the research areas of eHealth and Digital Health with 5,994 and 5.368 papers published from 2018 to
date as shown in Table 1.</p>
      <p>However, the number of articles decreases radically when we search by relating the concepts, thus
when we search Affective Computing "AND" eHealth the total number of articles from 2018 to date is
4, similar is the case when we search by the keywords "Affective Computing" AND "eHealthcare" with
only 3 results; on the other hand, when we narrow the search to show articles containing the keywords
Affective Computing and Digital Health, the result is 5.</p>
      <p>
        When we refine the search to the domains of Affective Computing, Digital Health, and User
eXperience, using the STR search string, we find a total of 117 results: 81 articles in Scopus, 25 in Web
of Science and 11 in National Library of Medicine (PubMed), the immediate next step is to discard
repeated articles. When the keyword Health comes into play in the query chain, as proposed in STR_2,
the scenario changes, we notice a growing focus of research, among the most recent works are topics
such as autism spectrum disorder [
        <xref ref-type="bibr" rid="ref10 ref11 ref12 ref9">18, 19, 20, 21</xref>
        ], pain detection and recognition [
        <xref ref-type="bibr" rid="ref13 ref14">22, 23</xref>
        ], social and
affective robots [
        <xref ref-type="bibr" rid="ref15 ref16 ref17">24, 25, 26</xref>
        ], agents [
        <xref ref-type="bibr" rid="ref18 ref19">27, 28</xref>
        ], remote health care [
        <xref ref-type="bibr" rid="ref20 ref21">29, 30</xref>
        ], among many other topics.
      </p>
      <p>It is well known that there has been a growing interest in mental health, during the period of the
COVID 19 pandemic, which is also reflected in the field of Affective Computing research. Figure 3
shows that as of 2020 of the 159 articles that consider Affective Computing and Digital Health, 45 are
related to mental health, corresponding to 28.3%, this considering that publications prior to 2020 that
are related to mental health within the topics described, are only 34 out of 242, which is equivalent to
14%.</p>
    </sec>
    <sec id="sec-6">
      <title>Inclusion and exclusion criteria’s</title>
      <p>Inclusion criteria:(1) Research that deals with experiences in the development of software for the
health care field; (2) using Affective Computing techniques; (3) articles published within the last 10
years.</p>
      <p>Exclusion criteria: (1) studies that refer to the use of wearables, other than “eye tracking”, are
excluded; (2) focus on hardware and electrical devices.
3.3.</p>
    </sec>
    <sec id="sec-7">
      <title>Research questions</title>
      <p>RQ1. What is the relationship between Affective Computing and Digital Health?</p>
      <p>According to what has been observed, there are only a few articles that relate digital health with
affective computing, as shown in Table 1, however, the search shows a greater number of articles when
searching with the entry: "health", in this sense we could extend the concept, based on the definition of
health provided by the WHO, we obtain that the relationship between affective computing and health
is becoming closer, making its way into digital health.</p>
      <sec id="sec-7-1">
        <title>RQ2. What is Digital Health?</title>
        <p>Digital Health is the concept that incorporates information and communication technologies (ICT)
into healthcare products, services, and processes, as well as organizations or institutions that can
improve the health and well-being of citizens. It can range from portable devices, sensors, mobile health
applications, artificial intelligence, robotic caregivers, and even electronic records. According to the
above, we can state that Digital Health is a concept that is composed of several dimensions, where the
union of affective computing with health is one of those dimensions.</p>
      </sec>
      <sec id="sec-7-2">
        <title>RQ3: How could it be defined as Affective Digital Health (ADH)?</title>
        <p>There is no formal definition of ADH in the literature reviewed; this is a new concept that brings
together the elements of health and digital health with the addition of those associated with artificial
intelligence, to capture the emotions of patients and act accordingly. It is the union of a new force to
digital health that can help us in the areas of mental health, wellness and remote care, detection and
recognition of pain, measurement of stress, as well as sessions with empathic agents.</p>
      </sec>
    </sec>
    <sec id="sec-8">
      <title>4. Conclusions</title>
      <p>According to what has been observed, the number of published articles related to Affective
Computing has been increasing steadily each year, the same occurs with areas such as Electronic Health
Care, Electronic Health, Digital Health. Something similar occurs when searching for articles
containing Affective Computing and Health, although the number of articles considering these two
concepts at the same time, drops considerably.</p>
      <p>Affective Computing focuses on emotions, on the essence of the human being, by reducing stress in
patients we can make their interaction with systems a less unpleasant clinical experience.</p>
      <p>There is no formal definition of affective digital health, however, this new concept brings together
elements of digital health along with artificial intelligence to capture patients' emotions and act
accordingly.</p>
    </sec>
    <sec id="sec-9">
      <title>5. Future Work</title>
      <p>The next step in this research work will be to conduct a systematic review of Affective Computing
and Digital Health, for which the PRISMA 2020 methodology will be used.</p>
    </sec>
    <sec id="sec-10">
      <title>6. Acknowledgments</title>
      <p>The authors would like to thank the School of Informatics Engineering of the Pontificia Universidad
Católica de Valparaíso (PUCV).</p>
    </sec>
    <sec id="sec-11">
      <title>7. References</title>
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