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  <front>
    <journal-meta>
      <journal-title-group>
        <journal-title>White Book on Physical and Rehabilitation Medicine (PRM) in Europe, European Journal of
Physical and Rehabilitation Medicine.</journal-title>
      </journal-title-group>
    </journal-meta>
    <article-meta>
      <article-id pub-id-type="doi">10.23736/S1973-9087.18.05144-4</article-id>
      <title-group>
        <article-title>Hospital Information Smart-System for Hybrid E-Rehabilitation</article-title>
      </title-group>
      <contrib-group>
        <contrib contrib-type="author">
          <string-name>Oleksandr Palagin</string-name>
          <email>palagin_a@ukr.net</email>
          <xref ref-type="aff" rid="aff0">0</xref>
        </contrib>
        <contrib contrib-type="author">
          <string-name>Kyrylo Malakhov</string-name>
          <email>malakhovks@nas.gov.ua</email>
          <xref ref-type="aff" rid="aff0">0</xref>
        </contrib>
        <contrib contrib-type="author">
          <string-name>Vitalii Velychko</string-name>
          <xref ref-type="aff" rid="aff0">0</xref>
        </contrib>
        <contrib contrib-type="author">
          <string-name>Tetiana Semykopna</string-name>
          <xref ref-type="aff" rid="aff0">0</xref>
        </contrib>
        <contrib contrib-type="author">
          <string-name>Oleksandr Shchurov</string-name>
          <xref ref-type="aff" rid="aff0">0</xref>
        </contrib>
        <aff id="aff0">
          <label>0</label>
          <institution>Glushkov Institute of Cybernetics of the National academy of sciences of Ukraine</institution>
          ,
          <addr-line>Academician Glushkov Avenue 40, Kyiv, 03187</addr-line>
          ,
          <country country="UA">Ukraine</country>
        </aff>
      </contrib-group>
      <pub-date>
        <year>2018</year>
      </pub-date>
      <volume>54</volume>
      <issue>2018</issue>
      <fpage>156</fpage>
      <lpage>165</lpage>
      <abstract>
        <p>The top-priority challenges were faced by the medical rehabilitation system in Ukraine. Particularly important tasks include, first, the rehabilitation of patients who have recovered from COVID-19 disease and people with Combat stress reaction. This fact is well understood both by the society and the leadership of the Ministry of Health of Ukraine, which is creating a special working group on this problem. Ukraine has a system of medical and prophylactic institutions designed for psychological and physical rehabilitation of military personnel; these use modern rehabilitation technologies. However, long-term rehabilitation in such centers is not available to everyone. Therefore, the use of telerehabilitation technology for patients with post-traumatic stress disorder and similar disorders in combination with a means of objective control of the functional state is extremely important. One of the most effective solutions in medical rehabilitation assistance is remote patient/person-centered rehabilitation. Rehabilitation also needs effective methods for the “Physical therapist - Patient - Multidisciplinary team” system, including the statistical processing of large volumes of data. Therefore, along with the traditional means of rehabilitation, as part of the “Transdisciplinary intelligent information and analytical system for the rehabilitation processes support in a pandemic (TISP)” in this paper, we introduce and define: the revised and completed basic concepts of the hybrid e-rehabilitation notion and its fundamental foundations; the formalization concept of the new Smart-system for remote support of hybrid e-rehabilitation services and activities; and the methodological foundations for the use of services (UkrVectōrēs and vHealth) of the remote patient/person-centered Smart-system. The software implementation of the services of the Smart-system has been developed.</p>
      </abstract>
      <kwd-group>
        <kwd>Keywords1</kwd>
        <kwd>Digital health</kwd>
        <kwd>Hybrid e-rehabilitation</kwd>
        <kwd>Telehealth</kwd>
        <kwd>Telemedicine</kwd>
        <kwd>Telerehabilitation</kwd>
        <kwd>Smartsystem</kwd>
        <kwd>Hospital information system</kwd>
        <kwd>Rehabilitation</kwd>
        <kwd>TISP</kwd>
        <kwd>UkrVectōrēs</kwd>
        <kwd>vHealth</kwd>
        <kwd>Ontology engineering</kwd>
        <kwd>Transdisciplinary research</kwd>
        <kwd>Knowledge</kwd>
        <kwd>Computational linguistics</kwd>
      </kwd-group>
    </article-meta>
  </front>
  <body>
    <sec id="sec-1">
      <title>1. Introduction</title>
      <p>The methodology of rehabilitation measures in a pandemic has several significant features
associated with the unpredictability and high rate of emergence of problems of high complexity,
limited communication between the therapist and the patient, the need for high responsiveness of
decision-making and their compliance, the scale of the process and the associated need to use scalable
operating tools, etc. One of the most effective solutions in medical rehabilitation assistance is remote
patient/personal-centered rehabilitation. It requires online monitoring tools, telemetry and
interventions focused on the patient's capabilities, developed Internet interaction, intelligent
information technologies, and services. Patient/Person-centered rehabilitation also needs effective
methods in the “Physical therapist – Patient – Multidisciplinary team” system, statistical processing of
large volumes of data, etc. Therefore, along with the traditional means of rehabilitation, as part of the
“Transdisciplinary intelligent information and analytical system for the rehabilitation processes
support in a pandemic (TISP)”[1] the Smart-system for remote support of hybrid e-rehabilitation
services and activities (Smart-system)[1–6] was developed. Combined with intelligent remote
biofeedback[7] devices and effective miniature remote monitoring, telemetry, and recovery devices
(embedded systems and wearable devices)[8], such systems hold great promise, as evidenced by
worldwide experience as well. That research would not have been possible without the financial
support of the National Research Foundation of Ukraine (NRFU)[9]. The project “Transdisciplinary
intelligent information and analytical system for the rehabilitation processes support in a pandemic
(TISP)” won the competition "Science for Human and Social Security" and received grant funding
in 2020 – 2021.</p>
      <p>The objective of the research described herein is to develop a formal model, software
implementation, and the methodological foundations for the use of services of the remote
patient/person-centered Smart-system for providing medical rehabilitation assistance to patients in a
pandemic (i.e., the novel coronavirus disease COVID-19).</p>
      <p>Smart-system for remote support of hybrid e-rehabilitation services and activities [2,4,5] is a
complex, integrated, patient/person-centered information subsystem of TISP for the provision of
medical care, solving various clinical, organizational, and research tasks in the field of rehabilitation
medicine: consultations; remote observation and support of rehabilitation processes and activities;
classification, forecasting, and knowledge extraction; research and review of the new domain areas;
use of remote communication technologies; elements of artificial intelligence, in particular, ontology
engineering[10–16], machine learning[17] and transdisciplinary research[18].</p>
    </sec>
    <sec id="sec-2">
      <title>2. Digital health, Telehealth, Telemedicine: current definitions and trends</title>
      <p>Digital health helps ensure patients receive optimal and timely healthcare by connecting them to
needed services through telecommunication, remote patient monitoring (RPM), store-and-forward
technologies, and mobile health (mHealth). Digital health promotes healthcare access, improves care,
and offers patients a level of convenience difficult to obtain with in-person care. A 2018 rapid review
by[19] shows Digital health interventions for certain conditions are equally effective as in-person
care. As a result of the COVID-19 pandemic, the majority of hospitals worldwide now use elements
of Digital health to connect with patients and practitioners who are not onsite. Despite recent policy
changes, many barriers remain that hinder the widespread and successful adoption of dHealth
technologies.</p>
      <p>Variations in Digital health, telehealth definitions and using two distinctly different terms
interchangeably[20] (i.e., “telehealth” and “telemedicine”) makes it challenging to understand which
is the appropriate term and definition. The many definitions for telehealth and telemedicine may
create confusion for healthcare professionals when providing telehealth. The various definitions may
also increase confusion among state and national legislators when writing laws and policies that
govern telehealth. The differences in how telehealth is defined may lead to variations in telehealth
reimbursement policies worldwide or at the national level.</p>
      <p>Historically, the term “telemedicine” was used to describe the subject of medicine at a distance.
The term “telehealth” gained popularity in the 1990s[21]. In 2005, a US federal subcommittee
identified both telemedicine and telehealth as key resources to advance patient care [21]. The number
of terms used in the field has continued to expand. The need to accurately define emerging terms is
timely given the increase in telehealth visits due to the COVID-19 pandemic[22]. Most organizations
and agencies consider the terms “telehealth” and “telemedicine” to be distinct. Those that recognize a
distinction state that the term “telehealth” is the broader term and “telemedicine” is the component of
“telehealth” specific to clinical care.</p>
      <p>“Telehealth” is the most used term. The telehealth definitions most commonly refer to the delivery
of healthcare at a distance through technology. Some definitions defined telehealth as being a larger
umbrella that encompasses more than just direct medical care delivery. In the academic literature [19–
21], “telehealth” was the term most used when describing the process of delivering healthcare across a
distance. The most cited “telehealth” definitions in the academic literature were from
telehealthrelated organizations or U.S. federal agencies (e.g., DHHS, HRSA ATA, CMS, WHO, etc.) [23–28].
The World Health Organization WHO definition was cited most often in the academic literature.
Some authors developed their own definition by combining various organizational definitions or
listing multiple definitions from telehealth-related organizations[28]. The WHO definition is:
“Telehealth is the delivery of health care services, where patients and providers are separated by
distance.”</p>
      <p>The term “Telemedicine” is the second most used term in the source data and has often been
defined as a subset of telehealth. For example, Health Resources and Services Administration
HRSA[29] describes telemedicine (the term telehealth includes telemedicine services but
encompasses a broader scope of remote healthcare services. Telemedicine is specific to remote
clinical services, whereas telehealth may include remote non-clinical services, such as provider
training, administrative meetings, and continuing medical education, in addition to clinical services)
as being specific to clinical services under the broader umbrella of telehealth, which encompasses
nonclinical aspects as components of healthcare. These services include, but are not limited to,
administrative meetings, provider training, and patient education. Some organizations, however, use
the terms “telemedicine” and “telehealth” interchangeably.</p>
      <p>The term “Virtual care” occurred infrequently and the scope of it is unclear. The American
Telemedicine Association ATA describes virtual care as follows: “Virtual care is so much more than
online urgent care; it is healthcare you can access from the comfort and safety of your home. It is all
four modes of care; asynchronous, chat, phone, and video visits.”[30]. The expanse of what is
included in the definition ranges widely from “virtual care” being synonymous with “telemedicine” to
“virtual care” going beyond traditional “telehealth” to include self-management tools driven by
artificial intelligence.</p>
      <p>Digital Health. Many organizations and worldwide agencies use the term “digital health” as a
synonym of the terms “telehealth” and “telemedicine;” however, some posit telehealth is under the
digital health umbrella. For example, WHO described digital health as, “a broad category
encompassing electronic health, mobile health, telehealth and health data, among others.”[31]. Digital
health is a broad category encompassing electronic health, mobile health, telehealth, and health data,
among others. It offers solutions that can strengthen health systems, such as bringing health services
directly to people’s homes and to underserved communities, helping to map outbreaks of disease, and
integrating digital tools that make health care more responsive and productive.</p>
      <p>As with the terms “telehealth” and “telemedicine,” discrepancies exist on whether the term “digital
health” is an umbrella term encompassing more than direct clinical care or if it is specific to the
delivery of care between a clinician and a patient. For example, U.S. Centers for Disease Control and
Prevention CDC blog provides a description of the applications of the term “digital health,” stating
that “numerous measurement technologies such as personal wearable devices, internal devices, and
sensors that could be used to identify health status and help with disease diagnosis and
management.”[32]. The same CDC blog lists wearable devices that capture continuous patient data as
technologies included under digital health but does not state that the term “digital health”
encompasses the terms of “telehealth” and “telemedicine” in its scope or provide an official definition
of the term[32,33]. Frequently, “digital health” is used as a general term that includes direct patient
care visits as well as the collection of health data using wearable devices.</p>
      <p>Terms related to telehealth, including terms such as asynchronous, synchronous,
store-andforward, remote patient monitoring, remote physiological monitoring, and remote therapeutic
monitoring. There is less diversity and more congruency in these ancillary definitions than among the
overarching definitions of telehealth, telemedicine, virtual care, and digital health.
“Asynchronous”[33] refers to not happening in real-time, allowing for a more relaxed schedule, with
participants accessing information in their own time during different hours and from multiple
locations. In most cases, “asynchronous” is synonymous with “store-and-forward.” Asynchronous,
also known as store-and-forward, refers to the use of prerecorded information used to deliver services.
The term “synchronous”[33] is stated to be the use of live technology to deliver services. Remote
Patient Monitoring (RPM) can include peripheral medical equipment (e.g., digital stethoscopes,
otoscopes, ultrasounds) to conduct a remote evaluation of the patient in addition to the traditional
remote monitoring devices (e.g., glucometers, blood pressure monitors, scales)[34]. Remote
physiological monitoring is sometimes used interchangeably with RPM. All sources [33,34] consider
asynchronous, store-and-forward, synchronous, and RPM to fall under the umbrella of “telehealth”
and/or “telemedicine”. The “telehomecare” and “point-of-care” (POC) are the new ancillary terms
related to telehealth. In [33] POC describes as the remote care needed to allow people with chronic
conditions, dementia, or those at high risk of falling to remain living in their own homes. The
approach focuses on reacting to emergency events and raising a help response quickly.</p>
      <p>The term “eHealth” or Electronic Health is noted to have originated in the business world when
terms associated with electronic commerce (e-commerce) started being used to describe various
business areas[35]. The [35] publication defines the term “eHealth” as “an emerging field in the
intersection of medical informatics, public health, and business, referring to health services and
information delivered or enhanced through the Internet and related technologies.”</p>
      <p>Telehealth terms are continuously evolving as the field continues to expand. The commonly used
terms are “telehealth” and “telemedicine”. The terms “virtual care” and “digital health” are emerging
but are not as commonly used compared to telehealth and telemedicine. The term “digital health” was
first used in 2017 but has become more common within the academic literature and websites since
2019. In comparison to “virtual health”, the term “digital health” is currently used more often. It can
be noted that during the period of this review the use of the term “telehealth” was replaced with
“digital health” on the WHO’s website[31]. The term “virtual care” was first presented in 2018 but is
not used in a way that would make it distinct from the term “digital health.” Figure 1 conceptualizes
the relationship between the terms in a Venn diagram. Conceptually eHealth has been noted to be an
umbrella term that includes the subtopics of mHealth, telemedicine, and electronic health
records[36,37]. However, the term eHealth is used less commonly in this umbrella context than the
term “digital health.” As such, the term “digital health” is considered an umbrella term above the term
“telehealth” and “telemedicine.”</p>
    </sec>
    <sec id="sec-3">
      <title>3. Basic concepts of the Hybrid e-rehabilitation notion</title>
      <p>The rapid development of telerehabilitation worldwide and the acquisition by this direction of
medicine of transdisciplinary connections with various subject areas that go beyond the modern
paradigm of e-health, led to the emergence of the most modern type of rehabilitation medicine –
Hybrid e-rehabilitation medicine. The Hybrid e-rehabilitation notion (shown in Figure 2) consists of
the following fundamental methods, approaches, and technologies (revised and completed in
comparison with[2,5]):
 Telecommunication technologies. This means the delivery of rehabilitation services over
telecommunication networks and the internet. Also, this allows patients to interact with
providers remotely and can be used both to assess patients and to deliver therapy.
 Rich Internet Applications (RIA). These are chiefly the Hospital Information Systems (HIS).</p>
      <p>A HIS is a comprehensive, integrated information system designed to manage all aspects of a
hospital's operation, such as medical, administrative, financial, and legal issues and the
corresponding processing of services. Another feature of such systems is the provision of
communication between patients and doctors from the multidisciplinary rehabilitation team.



</p>
      <p>Telemetry. This is a set of technologies that allow remote measurement, and collection and
transmission of information about performance indicators (physiological parameters) of the
patient's body in real-time or store-in-forward.</p>
      <p>Wearable devices and Embedded systems. Wearables may be for widespread use in which
case they are just a particularly small example of mobile computing. Alternatively, they may
be for special purposes such as fitness trackers or medical devices. They may incorporate
special sensors such as accelerometers, heart rate monitors, or on the more advanced side,
electrocardiogram (ECG), blood oxygen saturation (SpO2) monitors and blood pressure
monitoring devices. These functions are often bundled together in a single unit, like an
activity tracker or a smartwatch like the Apple Watch Series or Samsung Galaxy Gear Sport.
Devices such as these are used for physical training and monitoring overall physical health, as
well as for alerting to serious medical conditions such as seizures (e.g., Empatica Embrace).
Currently, other applications within healthcare are being explored, such as: forecasting
changes in mood, stress, and health; measuring blood alcohol content; measuring athletic
performance; long-term monitoring of patients with heart and circulatory problems that
records an electrocardiogram and is self-monitoring; health risk assessment applications,
including measures of frailty and risks of age-dependent diseases; and automatic
documentation of care activities.</p>
      <p>Biofeedback (BF). Biofeedback is the process of gaining greater awareness of many
physiological functions of one's own body. Biofeedback[7] may be used to improve health,
performance, and the physiological changes that often occur in conjunction with changes to
thoughts, emotions, and behavior. Recently, technologies have aided with intentional
biofeedback. Humans conduct BF naturally all the time, at varied levels of consciousness and
intentionality. BF and the biofeedback loop can also be thought of as self-regulation. Some of
the processes that can be controlled include brainwaves, muscle tone, skin conductance, heart
rate, and pain perception. The essence of BF-method from a technical point of view is
computer registration in real-time of certain physiological parameters that are not available
for direct human perception (EEG, electrical resistance of the skin, the heart rate, body
temperature, etc.) and their transformation into a form natural to humans. The method is based
on the principle of translating information in the form of electrical physiological signals
received from a human body using special sensors into feedback information in the form of
images, natural messages, multimedia, games, and other forms of information and material
interaction in each range of values. BF, along with other well-known methods, is included in
the list of treatments officially used in medical rehabilitation in Europe, and in the United
States alone, BF-methods are implemented in more than 700 clinical centers.</p>
      <p>Intelligent virtual / personal assistants. These assistants are the software agents that can
perform tasks or services for an individual based on commands or questions. Virtual assistants
use natural language processing to match user text or voice input to executable commands.
Many such assistants continually learn using artificial intelligence techniques including
machine learning and computational linguistics with distributional semantic modeling in
vector spaces[17]. Modern software agents of the class of intelligent virtual assistants can
interact with each other to perform a certain class of tasks. The term "chatbot" is sometimes
used to refer to virtual assistants generally or specifically accessed by online chat. Some
virtual assistants are able to interpret human speech and respond via synthesized voices. In
particular, within the framework of the project and the TISP system[38], a universal dialogue
subsystem (UDS) was developed and implemented within the Physical Medicine and
Rehabilitation (PM&amp;R) domain area in the form of a web application and a virtual
interlocutor in the “Telegram” service. The developed UDS of TISP system uses the
ontology-related approach, in particular, the ontology representations of the White Book on
Physical and Rehabilitation Medicine in Europe [39] WB and the International Classification
of Functioning, Disability and Health (ICF; ICF, n.d.). The UDS [38] is based on the new
technique which assumes the presence of several query templates with each corresponding to
a special semantic type of question. Meaningful entities extracted from the user’s natural
language phrase are substituted into the corresponding query template. For the most suitable
query template selection a tree based semantic analysis method is proposed. The method
assumes that the frame is shifting through the words list of the phrase, considering on each
step one or several words. These words are analyzed to match one of the conditions on the
current tree position. The most matching condition determines the following position on the
next level of the tree. The process proceeds until there will remain the only option of query
template and all the sufficient conditions for the corresponding semantic type are proved to be
observed. Then depending on the selected query template input entities for it are taken from
the given positions of the previous consideration.</p>
      <p>Artificial Intelligence methods and applications for big data processing to knowledge
extraction and solving analytical tasks[40]. For Knowledge Discovery and solving the main
analytical tasks, such as classification, diagnostics, or prediction we use the method called
Growing Pyramidal Network (GPN)[40]. GPN inductive training is performed on the basis of
precedents sets. The result of training is a regularity in the form of a logical function. GPN
belongs to the class of statistical methods. Intelligence information search is based on
predictive models of distributional semantics. The GPN method and GPN based software has
some unique features. These are: search for all possible combinations of values of objects
attributes for allocating the most important combinations of attributes’ values for building the
model of classes of objects; guaranteed finding the most significant combinations of attributes
values using the principle of minimal length of the hypothesis description (logical
expression); always 100% correct classification of all objects from training set; works with
data of any complexity and possibility to discover a regularity however complex it be; and
automatic clustering of objects set. In a pyramidal network, the complexity of decision
functions is automatically adjusted to the data from the training set, depending on the
compactness of the training set. There is no need for a test set to verify the quality of the
found logical regularities. In the process of using regularities, the amount of information
contained in the logical regularities is counted. If it has changed, then a decision to retrain the
system is made. There is high speed recognition of new objects (i.e., constant, not depending
on the volume of stored information). If no exact solution found – all possible solutions
(Including the decision “I do not know”) is presented and ranked according to the confidence
level for each. There is an available explanation mode in which there are explained grounds of
the decision for each of the recognizable objects. GPN methods powered the clinical decision
support subsystem of TISP.</p>
      <p>Biomedical Robotics and Bionics. The Biomedical Robotics research focus area is centered on
the design, development, and evaluation of medical robotics systems and smart assistive
robotic platforms that enhance the physical capabilities of both patients and clinicians via
advancements in mechanical design, modeling and control, sensors and instrumentation,
computing, and image processing. Core research topics in this area include medical robotics,
haptic interfaces, machine learning, soft robotics, robot-assisted surgery and rehabilitation,
tissue modeling, human augmentation, biomechanics, and human-robot interaction.
Biomedical robotics research innately draws from several disciplines including mechanical,
biomedical and electrical engineering, interactive computing, applied physiology, and
materials. Key areas of application and translation include feedback-enabled robotic surgery
systems, robot-assisted caregiving, macro-meso-micro-scale image-guided surgical
interventions, wearable devices for occupational training and injury prevention, and
neurointegrated prosthetic devices (also, mathematical modelling and computer simulation of
human-exoskeleton systems with energy-efficient actuators, and computer vision and deep
learning for autonomous exoskeleton control and decision making during legged locomotion).
system</p>
      <p>:</p>
      <sec id="sec-3-1">
        <title>Where:</title>
        <p>(2)</p>
      </sec>
    </sec>
    <sec id="sec-4">
      <title>4. Formalization concept of Smart-system for remote support of hybrid erehabilitation services and activities</title>
      <p>The generalized formalization concept of the Smart-system for remote support of rehabilitation
activities and services is represented as a three-tuple using the revised formalism given in[2,5,13]:
(1)</p>
      <sec id="sec-4-1">
        <title>Where:</title>
        <p>– is the Smart-system for remote support of rehabilitation activities and services (subsystem of TISP).
Processes of smart system are described analytically by means of [41].</p>
        <p>– is a set of web services (RIA) and desktop applications that are available for usage in the
Smart– is a web service or desktop application that implements specific algorithms, processes, and
functions of the Smart-system
(
– the number of developed web services and
desktop applications that are part of the Smart-system
).
– is a set of functions, the functional filling-up of the Smart-system
each function is the result of coordination and interaction of the Smart-system
elements.</p>
        <p>– is a subset of web services and desktop applications that
are required to implement the -th function of Smart-system . The formation of this subset allows
creating personalized pipelines and scenarios for using the developed web services and desktop
applications (as well as the use of additional external software), which enables more flexibly in use of
the services of the Smart-system for PM&amp;R doctors. The formation of such pipelines and scenarios is
beyond the scope of this article and should be considered separately.</p>
        <p>– is a set of elements (represented as layers) that combine into the
Cloudintegrated Environment (CIE);
– physical resource layer represents physical hardware and facility resources;
– middle layer (using in the concepts of cloud service orchestration model[13,42] represents
resource abstraction and control layer. It is supposed to use OpenStack software platform;
– operating system layer represents guest operating system. It is supposed to use Ubuntu server
with LXDE (abbreviation for Lightweight X11 Desktop Environment) desktop environment or Xfce
desktop environment. web services (RIA) and desktop applications runs on the operating system
layer –</p>
        <p>;</p>
        <p>At the current stage of development, the Smart-system includes various technologies, web
services, and desktop applications, in particular:
(3)
Where:</p>
        <p>– Remote consulting service – Smart-system's telemedicine module (which provides online
video and audio communication) using modified open-source software Jitsi Meet[43].</p>
        <p>– Digital doctor's office of specialized medical care service, in particular the PM&amp;R doctors. In
the personal digital office, there are services for managing online appointments, including video
consultations, personal doctor's and patient's profiles, fiscal management, a calendar for scheduling
and planning consultations, access to the electronic health records (i.e., patient's profiles and health
history), and a module for carrying out electronic advisory conclusions on the results of the video
consultation.</p>
        <p>– Service for automated processing and integration of all basic workflows of a medical
institution for interaction between an administrator, a doctor, and a patient.</p>
        <p>– Collaborative service for the creation and use of file-sharing and exchange services, in
particular, for interacting and exchanging medical digital images via Digital Imaging and
Communications in Medicine (DICOM). DICOM is the standard for the communication and
management of medical imaging information and related data. DICOM is most used for storing and
transmitting medical images enabling the integration of medical imaging devices such as scanners,
servers, workstations, printers, network hardware, and picture archiving and communication systems
(PACS) from multiple manufacturers. It has been widely adopted by hospitals and is making inroads
into smaller applications such as dentists' and doctors' offices. DICOM incorporates standards for
imaging modalities such as radiography, ultrasonography, computed tomography, magnetic resonance
imaging, and radiation therapy. DICOM includes protocols for image exchange (e.g., via portable
media such as SD cards), image compression, 3-D visualization, image presentation, and results
reporting.</p>
        <p>– UkrVectōrēs [44] web service. This is an NLU-powered toolkit for knowledge discovery,
classification, diagnostics, and prediction – an entities similarity tool. You can think about
UkrVectōrēs as a kind of "cognitive-semantic calculator." The online toolkit UkrVectōrēs covers the
following elements of distributional analysis[17]: calculates semantic similarity between pairs of
words; finds words semantically closest to the query word; applies simple algebraic operations to
word vectors (addition, subtraction, finding average vector for a group of words and distances to this
average value); draws semantic maps of relations between input words (it is useful to explore clusters
and oppositions, or to test your hypotheses about them); gets the raw vectors (arrays of real values)
and their visualizations for words in the chosen model; downloads default models; and uses other
prognostic models distributive semantics freely distributed, by adjusting the configuration file.</p>
        <p>– vHealth Electronic Library service[45]. This is a distributed information system that allows
you to store, use and share various collections of electronic documents (video and audio content) of
arbitrary domain areas for distance learning of patients and their relatives, in particular, a
rehabilitation complex of exercises and activities.</p>
        <p>Consider in detail some services and applications developed according to the generalized
formalization concept of the Smart-system for telemedicine support of rehabilitation measures, in
particular, UkrVectōrēs and vHealth services.</p>
        <p>– knowledge-oriented digital library/repository of scientific publications. Nowadays, numerous
applications and tools are known that implement information retrieval technologies in various text
sources in accordance with specified parameters. Moreover, the search results are provided to the user
for each search parameter individually and not related to each other. And the application of Semantic
Web technologies for the purpose of multi-parameter and related information retrieval in various
sources in Ukraine is at the initial stage of development. A separate problem is the multimedia
presentation of search results and their comparison with the conceptual structure of the domain of
interest (Knowledge Domain) with the goal of extracting new knowledge. From this point of view, it
is relevant for scientific research to process the scientific publications of one author, authors of a
scientific unit and the academic institute, using the Semantic Web technologies, multimedia
presentation of information, and effective support for the process of extracting new knowledge.</p>
        <p>Consider in detail some services and applications developed according to the generalized
formalization concept of the Smart-system for telemedicine support of rehabilitation measures, in
particular, UkrVectōrēs and vHealth services.</p>
      </sec>
    </sec>
    <sec id="sec-5">
      <title>5. UkrVectōrēs – an NLU-powered tool for classification, diagnostics, and prediction knowledge discovery,</title>
      <p>The distributed numerical feature representations of words (word embeddings) and word vector
space models, as a result, are well established in the field of computational linguistics and have been
here for decades, see [46] and [17] for an extensive review. However, recently they received
substantially growing attention. Learning word representations lies at the very foundation of many
natural language processing (NLP) tasks because many NLP tasks rely on good feature
representations for words that preserve their semantics as well as their context in a language.</p>
      <p>The network service UkrVectōrēs computes the semantic relations (similarity) between the entities
of the Ukrainian language within the selected distributional semantic model of the vector
representation of entities (entities embeddings). UkrVectōrēs is a natural language distributional
analysis and distributional semantic modeling web service (toolkit), a natural language research
technique based on the study of the environment (distribution), individual entities in the text without
the full lexical or grammatical meanings of these entities. In the general case, distributional analysis,
and distributional semantic modeling [17] use, base, and examine the essence of a natural language,
such as words or phrases. Within the framework of this method, an ordered set of universal
procedures is applied to texts in natural language, which makes it possible to single out the basic units
of the language (phonemes, morphemes, words, phrases), to classify them, and to learn the relation of
semantic similarity between them.</p>
      <p>The network service UkrVectōrēs is a tool that allows exploring the semantic relationships
between entities in the framework of predictive models of distributional semantics (PMDS), using an
open-source software library genism (Genism, n.d.) for processing and mathematical modeling of the
natural language (including an application programming interface for different algorithms such as
Word2vec, fastText, etc.). The user can choose one or several carefully prepared predictive models of
distributional semantics (or use other models of vector representation for words of the Ukrainian
language) learned on various text corpora, in particular, the WB [39] dataset.</p>
      <p>The UkrVectōrēs service covers the following elements of the distributional semantic
analysis / modeling:
 computation of semantic similarity between pairs of entities (words) within the selected</p>
      <p>PMDS;
 computation of the entity closest to a given one within the selected PMDS (computation of
semantic associates). In distributional semantics, words are usually represented as vectors in a
multi-dimensional space of their contexts. Semantic similarity between two entities is then
calculated as a cosine similarity between their corresponding vectors; it takes values between
-1 and 1 (usually only values above 0 are used in practical tasks). 0 value roughly means the
entities lack similar contexts, and thus their meanings are unrelated to each other. 1 value
means that the entities’ contexts are identical, and thus their meaning is quite similar;
 applying simple algebraic operations to entity vectors (addition, subtraction, finding average
vector for a group of entities and distances to this average value) within the selected PMDS;
 generation of the semantic maps (using the open-source software toolkit TensorFlow) of
relations between input entities (it is useful to explore clusters and oppositions, or to test your
hypotheses about them);
 using other freely shared PMDS via special configuration file.</p>
      <p>Let us consider the methodology of a user experience with the graphical user interface of the
UkrVectōrēs single-page application, in particular, for the distributional semantic analysis of natural
language texts.</p>
      <p>Computation of the semantic associates for a given entity (word) within the selected
distributionsemantic model. To use this function, you need to:
1. Open the graphical user interface (GUI) of the UkrVectōrēs Single Page Application (SPA)
using the current version of Google Chrome, Mozilla Firefox, or Microsoft Edge web
browser. To do this, enter the following link in the address bar of the web browser:
https://ukrvectores.ai-service.pp.ua/ (the link may differ, it depends on the deployment
features of the UkrVectōrēs service) and select the Semantic Associates operation mode in the
main menu, as shown in Figure 3.
2. Using the drop-down list of the select component named Models (in Ukrainian – Моделі) in
Figure 4, choose the desired distributional semantic model, within which the computation of
semantic associates will be carried out (by default the neural vector model for words
representation "White Book" is used (using the "White Paper on Physical and Rehabilitation
Medicine in Europe" dataset), word2vec word embeddings algorithm with the dimension of
500d. The entity is a word, lemmatized, reduced to lower case. Hyperparameters of word2vec
are: -size 500 -negative 5 -window 5 -threads 24 -min_count 10 -iter 20).
3. In the field of the input component named “Enter the word lemma,” specify the desired word
lemma for which you want to compute semantic associates (for example, rehabilitation (in
Ukrainian – реабілітація), as shown in Figure 3) and press the “Enter” key or the “Compute”
button.
4. Semantic Associates will be displayed on the screen as shown in Figure 3 (by default, the first
100 associates for decreasing the cosine similarity coefficient are displayed) for the given
lemma of the word rehabilitation (in Ukrainian – реабілітація) within the selected
distributional semantic model "White Book".
5. Using the “Entity” (in Ukrainian – “Сутність”) element, the user can choose to display the
semantic associates alphabetically as shown in Figure 5.</p>
      <p>Using the “Cosine similarity” (in Ukrainian – “Косинусна близькість”) element, the user can
choose to display the semantic associates by the cosine similarity coefficient (by increasing or
decreasing) as shown in Figure 6.</p>
      <p>Generation of semantic maps (using the open-source software toolkit TensorFlow, namely
TensorBoard) of relations between words within the selected distributional semantic model. To use
this function, you need to:
1. Open the GUI of the UkrVectōrēs SPA using the current version of Google Chrome, Mozilla
Firefox, or Microsoft Edge web browser. To do this, enter the following link in the address
bar of the web browser: https://ukrvectores.ai-service.pp.ua/ (the link may differ, it depends
on the deployment features of the UkrVectōrēs service) and select the Semantic map mode in
the main menu, as shown in Figure 7.
2. Using the drop-down list of the select component named Models (in Ukrainian – Моделі) in
Figure 7, choose the desired distributional semantic model, within which the computation of
semantic associates will be carried out (by default the neural vector model for words
representation "White Book" is used (using the "White Paper on Physical and Rehabilitation
Medicine in Europe" dataset), word2vec word embeddings algorithm with the dimension of
500d. The entity is a word, lemmatized, reduced to lower case. Hyperparameters of word2vec
are: -size 500 -negative 5 -window 5 -threads 24 -min_count 10 -iter 20).</p>
      <p>An example of visualization of the semantic associates of the lemma of the word
“rehabilitation” (in Ukrainian – реабілітація) is shown in Figure 8.</p>
      <p>The compilation &amp; deployment technologies, and more detailed description of the source code of
the UkrVectōrēs service, as well as the methodology for training the distributional semantic model of
the vector representation of entities (using the dataset - "White Paper on Physical and Rehabilitation
Medicine (PRM) in Europe"), are available in [40].</p>
      <p>Currently, the most recent version of the UkrVectōrēs service is available at
https://ukrvectores.aiservice.pp.ua and is free for use in R&amp;D and teaching purposes.</p>
    </sec>
    <sec id="sec-6">
      <title>6. vHealth – the digital library of media content</title>
      <p>The digital library of media content of the TISP Smart-system subsystem – the vHealth
service [41] is a distributed information system that allows the storage, use, and sharing of various
collections of electronic documents (video and audio content) of arbitrary domain areas, for distance
learning of patients and their relatives, in particular, a rehabilitation set of exercises.</p>
      <p>One of the main tasks and purposes of the vHealth service is the integration of information
resources and efficient navigation within them. Integration of information resources is their
unification to use different information while preserving its properties, presentation features, and the
ability to process it. The pooling of resources can occur both physically and virtually. However, at the
same time, such a combination should provide the user with the perception of the necessary
information as a single information space: an electronic library should ensure work with databases
and high efficiency of the information search. Effective navigation in the electronic library is the
ability of the user to find the information of interest to them in all available information space with the
greatest completeness and accuracy at the least effort. To solve this problem, the vHealth service uses
smart search based on predictive models of distributional semantics.</p>
      <p>The vHealth service has the following features:
 complete control over media content and user data;
 support for multiple publishing workflows: public, private, unlisted, and custom;
 types of multiple media support: video, audio, image, pdf (and docx in future releases);
 multiple media classification options: categories, tags, and custom;
 intelligent information search in real time based on the predictive models of distributional
semantics (lexical, symbolic, and attribute search);
 playlists for audio and video content: create playlists, add, and reorder content;
 SPA responsive design: including light and dark themes;
 advanced users’ management: allows self-registration, invite only, closed;
 configurable actions: allows download, add comments, add likes, dislikes, report media;
 enhanced video player: customized video.js player with multiple resolution and playback
speed options;
 multiple transcoding profiles: sane defaults for multiple dimensions (240p, 360p, 480p, 720p,
1080p) and multiple profiles (h264, h265, vp9);
 chunked file uploads: for pausable/resumable upload of content;
 logging of the user's session with the system with the ability to switch to each of the
previously existing system states;
 manipulating the structure of the description of the media content object;
 support of the appliance of hypertext and hypermedia links, which provides the user with a
quick transition from an object or its element to another interrelated object or element.</p>
      <p>The compilation, deployment, and a more detailed description of the source code of the vHealth
service, as well as the methodology of user interaction with the GUI of the vHealth application,
require a separate review and is beyond the scope of this article. Currently, the most recent version of
the vHealth service is available at https://vhealth.ai-service.pp.ua/ and is free for use for R&amp;D and
teaching purposes. To start working with the vHealth service, you need to be an authorized user (log
in), so the demo account was created to demonstrate how the service works. You can log in using the
login and password of the demo profile account (login: demouser; password: JyMyuC6nMdD494T).</p>
    </sec>
    <sec id="sec-7">
      <title>7. Conclusion</title>
      <p>The purpose of our research was to develop a formal model, software implementation, and the
methodological foundations for the use of services of the remote Patient / Personal-centered
Smartsystem for providing medical rehabilitation assistance to patients in a pandemic.</p>
      <p>In this paper, we introduced and defined:
 the basic concepts of the new Hybrid E-rehabilitation notion and its fundamental foundations;
 the formalization concept of the new Patient / Person-centered Smart-system for remote
support of rehabilitation activities and services;
 the methodological foundations for the use of services (UkrVectōrēs and vHealth) of the
remote Patient / Person-centered Smart-system.
 The software implementation of the services of the Smart-system for remote support of
rehabilitation activities and services has been developed, in particular:
 the digital library of media content of the telerehabilitation subsystem of TISP – the vHealth
service;
 the UkrVectōrēs service – NLU-powered network tool for knowledge discovery,
classification, diagnostics, and prediction.</p>
      <p>The research results were presented by our team on the All-Ukrainian forum "Ukraine 30:
Education and Science" in section – “Big data Ukraine platform”. Also, the research results (in
teleconference and offline) were presented during the workshop “Digital services and devices for
rehabilitation measures support”.</p>
    </sec>
    <sec id="sec-8">
      <title>8. Further research</title>
      <p>This study can be extended by future research in several directions, both in theory and in
practice[3,6,47]. Further research is also planned in the definition and application of efficient
mathematical methods for big data analysis; modeling and creating scenarios (workflows) for
predicting and optimizing the entire complex of rehabilitation procedures and their routing using
system tools; and technologies, and experience in the development of rehabilitation systems and
complexes that have already been tested by our team.</p>
      <p>In a future study, our teams plan to implement HIS to optimize the time spent by specialists of the
multidisciplinary team in the use of ICF in the rehabilitation of cancer patients (including breast
cancer). Further research will aim to determine and apply effective mathematical methods of big data
analysis, modeling and developing of prediction scenarios, and optimization of the full set of
rehabilitation procedures and their routing. This will employ tools already tested in the team system,
technologies, and experience in developing rehabilitation systems.</p>
    </sec>
    <sec id="sec-9">
      <title>9. Acknowledgements</title>
      <p>Corresponding author Kyrylo Malakhov, on behalf of himself and co-authors Vitalii Velychko,
Tetiana Semykopna, and Oleksandr Shchurov thanks first author Oleksandr Palagin, Academician of
the National Academy of Sciences of Ukraine, Doctor of Technical Sciences, Professor, Honored
Inventor of Ukraine, Deputy Director for Research of the V.M. Glushkov institute of Cybernetics of
the National Academy of Sciences of Ukraine, Head of the Microprocessor Technology Department,
who served as the scientific supervisor for this research.</p>
      <p>This study would not have been possible without the financial support of the National Research
Foundation of Ukraine[9]. Our work was funded by Grant contract № 159/01/0245 (07.05.2021) from
the National Research Foundation of Ukraine, at the intersection of work on projects entitled:
“Transdisciplinary intelligent information and analytical system for the rehabilitation processes
support in a pandemic (TISP)” and “Development of the cloud-based platform for patient-centered
telerehabilitation of oncology patients with mathematical-related modeling.”
10.In memoriam
11.References</p>
      <p>We are deeply saddened to inform that Dr. Vitalii Yuriiovych Velychko passed away at the age
of 60. In passing away, Vitalii leaves an enormous void, both in the scientific community and in the
lives of his many friends. We express our sincere condolences to the family, friends and colleagues of
the deceased in connection with this irreparable loss.
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