The International Research and Practice Conference “Information Technologies and Security” is an academic event, annually held by the Institute for Information Recording of the National Academy of Sciences of Ukraine. Although the Conference is headquartered in Ukraine, participants (authors, editors, organizing committee members, and paper authors) come from around the globe. Paper publication standards and requirements to authors are growing higher, while review process is becoming more rigorous with every coming year. The collection includes selected papers, presented at the XXII "Information Technologies and Security" Conference (ITS-2022, November 16, 2022, Kyiv, Ukraine). Out of 32 initial submissions 15 best papers have been selected for publication in the proceedings volume. Selected papers cover the latest advances in such areas of computer science as big data technologies, information and cybernetic security, security and survivability of critical infrastructures, modeling, analysis and forecasting of network interaction processes, analytical systems based on open source intelligence, complex systems modelling, decision-making support methods and systems. Hopefully, the present Conference proceedings volume will provide a valuable contribution to fundamental and applied knowledge in the field of computer science and related areas.