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  <front>
    <journal-meta />
    <article-meta>
      <title-group>
        <article-title>LiveHeart: AI-Augmented Lifestyle Habit Monitoring System for Decision Making in Digital Care Pathway</article-title>
      </title-group>
      <contrib-group>
        <contrib contrib-type="author">
          <string-name>Ashley Wang Sze Mei</string-name>
          <xref ref-type="aff" rid="aff2">2</xref>
        </contrib>
        <contrib contrib-type="author">
          <string-name>Pantea Keikhosrokiani</string-name>
          <xref ref-type="aff" rid="aff0">0</xref>
          <xref ref-type="aff" rid="aff1">1</xref>
          <xref ref-type="aff" rid="aff2">2</xref>
        </contrib>
        <contrib contrib-type="author">
          <string-name>Minna Isomursu</string-name>
          <xref ref-type="aff" rid="aff0">0</xref>
          <xref ref-type="aff" rid="aff1">1</xref>
        </contrib>
        <aff id="aff0">
          <label>0</label>
          <institution>Faculty of Information Technology and Electrical Engineering, University of Oulu</institution>
          ,
          <country country="FI">Finland</country>
        </aff>
        <aff id="aff1">
          <label>1</label>
          <institution>Faculty of Medicine, University of Oulu</institution>
          ,
          <country country="FI">Finland</country>
        </aff>
        <aff id="aff2">
          <label>2</label>
          <institution>School of Computer Sciences, Universiti Sains Malaysia</institution>
          ,
          <addr-line>11800, Penang</addr-line>
          ,
          <country country="MY">Malaysia</country>
        </aff>
      </contrib-group>
      <abstract>
        <p>The advancement of interoperable digital technology has had remarkable impacts on society especially in the healthcare area. Ischemic heart disease is a major cause of disability and premature death in many parts of the world that can still be mitigated through lifestyle changes. While the existing mHealth solutions that encourage users to maintain healthy lifestyle habits do exist, they lack the reliable advice of healthcare professionals to monitor patient's lifestyle habits remotely. The process of manually collecting patient data for analysis and clinical testing can also be time-consuming for healthcare professionals. Therefore, this study proposed a webbased information system to monitor lifestyle habits and habit-change of people prone to heart disease. The system collects lifestyle habit data from a smartwatch and smartphone. Then, the system utilizes machine learning techniques to classify the patient's lifestyle habit data such as diet, exercise, and sleep. Furthermore, the system is used to upload echocardiograms during the echocardiography test in the hospitals and receive the echocardiography results. The data analytical results are visualized on an intelligent dashboard that can be viewed by doctors using the web application. The system is expected to support doctors in decision-making for digital care pathways in order to provide timely intervention for lifestyle modifications.</p>
      </abstract>
      <kwd-group>
        <kwd>1 Heart Disease</kwd>
        <kwd>Habit Change</kwd>
        <kwd>Digital care pathway</kwd>
        <kwd>Internet of Things</kwd>
        <kwd>Machine learning</kwd>
        <kwd>Classification</kwd>
        <kwd>Web-based Application</kwd>
      </kwd-group>
    </article-meta>
  </front>
  <body>
    <sec id="sec-1">
      <title>1. Introduction</title>
      <sec id="sec-1-1">
        <title>Ischemic heart disease and stroke are</title>
        <p>
          considered as the global leading causes of
longterm disability and premature death [
          <xref ref-type="bibr" rid="ref1">1</xref>
          ]–[
          <xref ref-type="bibr" rid="ref7">7</xref>
          ]. The
primary risk factors that contribute to heart
disease and stroke are unhealthy diet, physical
inactivity, and tobacco use [
          <xref ref-type="bibr" rid="ref8">8</xref>
          ]. The American
Heart Association has defined ideal
cardiovascular health based on a set of risk
factors that can be mitigated through lifestyle
changes such as eating a healthy diet and
engaging in consistent physical activity [
          <xref ref-type="bibr" rid="ref9">9</xref>
          ].
Practicing these habits to maintain good
cardiovascular health could help to minimize
medical care expenditures [
          <xref ref-type="bibr" rid="ref10">10</xref>
          ].
        </p>
        <p>
          Personnel in the healthcare sector have been
utilizing wearable sensors to monitor the health of
patients. Physical sensors are used to collect
biomedical data which is pre-processed before
being sent to a cloud infrastructure to be stored and
analyzed through machine learning techniques to
produce a diagnosis. These results are interpreted
and visualized in the form of intelligent dashboards
that can be easily understood by patients and health
workers. However, the existing studies did not
facilitate the change of lifestyle habits other than
physical activity. Their main gap is related
classifying patients’ lifestyle habits for
providing timely advice from the doctor and for
better decision making. [
          <xref ref-type="bibr" rid="ref11">11</xref>
          ]–[
          <xref ref-type="bibr" rid="ref13">13</xref>
          ]. Therefore,
this study proposed a web-based system based
on Internet of Things (IoT) and big data
analytics which speeds up the decision-making
process for doctors so they can focus on
prescribing advice for disease prevention and
treatment.
        </p>
        <p>
          Studies have shown that healthy lifestyle
changes can contribute to the risk reduction of
developing heart disease [
          <xref ref-type="bibr" rid="ref14">14</xref>
          ]–[
          <xref ref-type="bibr" rid="ref16">16</xref>
          ]. Most
telehealth solutions that use machine learning
and big data analytics to facilitate the adoption
of healthy lifestyle habits focus on exercise and
physical activity, but not other lifestyle habits
like maintaining a healthy diet or regulating
blood pressure [
          <xref ref-type="bibr" rid="ref17">17</xref>
          ], [
          <xref ref-type="bibr" rid="ref18">18</xref>
          ]. While mHealth
solutions like Samsung Health and Google Fit
that encourage users to maintain healthy habits
do exist, they lack the reliable advice of a health
professional to guide them to take care of their
heart health.
        </p>
        <p>
          For most of the existing clinical decision
support systems, doctors still need to manually
collect lifestyle habit data from patients, such as
uploading CSV files or manually keying in data,
before they can analyze the data, which can be
time-consuming. Furthermore,
echocardiography is a recommended method to
detect the early onset of heart disease, but
echocardiography function has rarely been
integrated in clinical decision support systems
[
          <xref ref-type="bibr" rid="ref19">19</xref>
          ].
        </p>
        <p>Therefore, this study proposes a web-based
system to monitor the habit-change and
biomedical data of heart disease patients which
consists of diet habits, exercise habits, sleeping
habits. The system collects lifestyle habit data
from devices and carries out machine learning
on the data to generate an overall report of the
patient’s risk of developing heart failure. The
results of data analytics are visualized in the
form of an intelligent dashboard to be viewed by
doctors to gain insights from their patients’ data.
The system is expected to provide an effective
diagnosis of patients and thereby support
doctors in decision-making for digital care
pathway so they can focus on prescribing advice
for habit adjustment to mitigate disease.</p>
      </sec>
      <sec id="sec-1-2">
        <title>This paper introduced the proposed</title>
        <p>LiveHeart information system and reviewed the
existing studies. The system requirements, design,
development methodology, data analytics, tests, and
evaluation are included afterwards. The paper is
finally wrapped up with concluding remarks and
future directions.</p>
      </sec>
    </sec>
    <sec id="sec-2">
      <title>2. Related Works 2.1.</title>
    </sec>
    <sec id="sec-3">
      <title>Heart Disease and Lifestyle</title>
    </sec>
    <sec id="sec-4">
      <title>Habit</title>
      <p>
        Coronary heart disease, also known as ischemic
heart disease and coronary artery disease, occurs
when a blockage forms in the blood vessels that
supply blood to the heart, reducing the supply and
causing the heart muscle cells to die. This blockage
is usually made up of fatty deposits such as
cholesterol. As a result, patients suffering from
coronary heart disease experience a form of chest
pain [
        <xref ref-type="bibr" rid="ref20">20</xref>
        ].
      </p>
      <p>
        An important, controllable risk factor for
coronary heart disease is lifestyle habits – these
include unhealthy diet, physical inactivity, tobacco
use and excessive alcohol consumption, as these
activities contribute to the narrowing of the blood
vessels that supply blood to the heart. As such, the
risk of coronary heart disease can be managed by
adopting healthy habits, such as eating more fruits
and vegetables, reducing salt intake, engaging in
daily physical activity, and managing blood
pressure [
        <xref ref-type="bibr" rid="ref21">21</xref>
        ].
      </p>
      <p>
        There are a number of existing risk assessment
systems that assess the 10-year risk of
cardiovascular disease mortality such as
Framingham [
        <xref ref-type="bibr" rid="ref22">22</xref>
        ] and SCORE [
        <xref ref-type="bibr" rid="ref23">23</xref>
        ]. However, the
studies conducted to develop these systems were
limited to the American and European regions. As
for heart disease specifically, the Get With the
Guidelines-Heart Failure risk score is used to
predict in-hospital mortality [
        <xref ref-type="bibr" rid="ref24">24</xref>
        ], while the Seattle
Heart Failure Model predicts the 1-, 2- and 3-year
survival of heart failure patients [
        <xref ref-type="bibr" rid="ref25">25</xref>
        ]. Again, these
models were developed on a dataset of patients in
the American region.
      </p>
      <p>
        On the other hand, poor-quality diet, low
physical activity, and emotional stress can lead to
obesity, which in turn can lead to hypertension and
diabetes, which are risk factors for heart failure with
reduced ejection fraction. Adherence to diets rich in
plant-based foods such as food and vegetables and
low-sodium diets has been associated with a lower
incidence of heart failure. The risk can also be
lowered by carrying out enough physical activity to
balance out calorie intake [
        <xref ref-type="bibr" rid="ref27">27</xref>
        ] and sleeping 7-8
hours a day [
        <xref ref-type="bibr" rid="ref28 ref29">28-29</xref>
        ]. Overall, healthier lifestyle
habits are associated with a lower risk of
developing heart failure, and vice-versa [
        <xref ref-type="bibr" rid="ref14">14</xref>
        ]–
[
        <xref ref-type="bibr" rid="ref16">16</xref>
        ].
      </p>
      <p>2.2.</p>
    </sec>
    <sec id="sec-5">
      <title>Habit Classification</title>
      <p>
        Since healthcare systems are very sensitive,
they require high accuracy to provide a reliable
solution for doctors’ decision making. Thus, this
section focuses on the comparison of different
classification algorithms to find the most
suitable one with the best accuracy for
classifying lifestyle habit data. Various studies
were conducted for habit classification. For
instance, random Forests algorithm was used to
classify eating occasions as meals or snacks,
achieving an accuracy of 84% with time,
location, and time since last intake as the most
informative features [
        <xref ref-type="bibr" rid="ref30">30</xref>
        ]. Furthermore, feeding
gestures were used as an indicator of caloric
intake and thus used Random Forests to
differentiate between 10 types of feeding
gestures, achieving an accuracy of 94% [
        <xref ref-type="bibr" rid="ref31">31</xref>
        ]. In
another study, Random Forests was utilized to
classify food consumption level as overeating,
undereating and as usual, where a combination
of self-reported features such as social and
mood and passive smartphone sensing features
such as battery level and accelerometer
measurements yielded an accuracy of 87.81%
[
        <xref ref-type="bibr" rid="ref32">32</xref>
        ].
      </p>
      <p>
        Using Random Forests to predict the
probability of an individual reaching their daily
step count based on step count data collected
from a wrist-worn activity tracker yielded an
accuracy of 93% [
        <xref ref-type="bibr" rid="ref33">33</xref>
        ]. Support Vector Machine
(SVM) was used in another study to classify
ambulation, cycling, sedentary and other
activities based on accelerometer data [
        <xref ref-type="bibr" rid="ref34">34</xref>
        ].
When the classification uncertainty estimated
by the SVM exceeded a set threshold, the
proposed algorithm requested for the ground
truth activity label from the user and updated the
classification model. This method achieved an
accuracy of 89.2% Davidson et al. carried out a
pilot study to predict two classes of RPE
(RPE≤15 “Somewhat hard to hard” and
RPE&gt;15 “Hard to very hard” on Borg’s 6–20
scale) based on time-series data collected from
a smartwatch such as heart rate and peak oxygen
consumption [
        <xref ref-type="bibr" rid="ref35">35</xref>
        ]. Convolutional Neural
Network (CNN) was used for classification with
an accuracy of 86.0%.
      </p>
      <p>
        Another study collected raw respiratory signals and
used balanced bootstrapping and Long Short-term
Memory (LSTM) to detect sleep apnea, achieving
the best accuracy of 77.2% on the abdominal
respiratory belt signal [
        <xref ref-type="bibr" rid="ref36">36</xref>
        ]. An ensemble of bagged
tree classifier, which is a combination of the
bagging algorithm and decision tree classifier, was
used in one study to classify sleep disorders as
healthy, insomnia, sleep-disordered breathing, and
REM behavior disorder. The authors used a
preprocessing technique that used 30-seconds epoch of
ECG signal. The classifier used sleep quality
parameters such as wakefulness, total time in bed
and REM and achieved an accuracy of 86.27% [
        <xref ref-type="bibr" rid="ref37">37</xref>
        ].
In another study, ECG signals were subjected to
5level wavelet decomposition and norm features
were extracted to be fed to a KNN classifier with
10-fold cross-validation to classify healthy sleep
and insomnia in various sleep stages, achieving an
accuracy of 97.87% for the REM sleep stage [
        <xref ref-type="bibr" rid="ref38">38</xref>
        ].
2.3.
      </p>
    </sec>
    <sec id="sec-6">
      <title>Echocardiogram</title>
    </sec>
    <sec id="sec-7">
      <title>Classification</title>
      <p>
        There have been a limited number of studies that
integrate echocardiogram classification into
homebased clinical decision support systems. The
existing studies [
        <xref ref-type="bibr" rid="ref39 ref40 ref41 ref42">39-42</xref>
        ] did not extend the diagnosis
of heart chamber abnormalities to predict the risk of
developing heart disease and did not have the
potential to explore early detection of heart disease.
      </p>
      <p>
        Back Propagation Neural Network (BPNN),
KNearest Neighbor (KNN), and Support Vector
Machine (SVM) were used by [
        <xref ref-type="bibr" rid="ref40">40</xref>
        ] to classify the
echocardiogram as normal, dilated cardiomyopathy
or hypertrophic cardiomyopathy. Left ventricle
measurements are extracted, and principal
component analysis (PCA) and discrete cosine
transform (DCT) are applied in this study to reduce
the dimensionality of the data. The results showed
that BPNN classifier with PCA features had the best
accuracy of 90.2%.
      </p>
      <p>
        Furthermore, the CNN model was developed by
[
        <xref ref-type="bibr" rid="ref41">41</xref>
        ] for echocardiogram viewpoint classification.
The proposed CNN model was developed for image
segmentation of selected echocardiographic views
to locate cardiac chambers, and the output was used
to derive cardiac chamber measurements such as
area, volume, and mass. The authors also developed
separate CNNs to detect 3 types of heart diseases:
hypertrophic cardiomyopathy, pulmonary arterial
hypertension, and cardiac amyloidosis in A4c and
PLAX views, achieving C-statistics of 0.93, 0.87
and 0.85 respectively.
      </p>
      <p>
        Another study was done by [
        <xref ref-type="bibr" rid="ref39">39</xref>
        ] segmenting
the main field of view in echocardiograms
before utilizing an ensemble of CNN models for
viewing the classification. Then, the U-Net was
used to segment the left ventricle in A4c images
before utilizing a CNN model to detect left
ventricular hypertrophy. This method of
performing image segmentation before
classification resulted in detection of left
ventricular hypertrophy with an accuracy of
91.2%. The authors also trained a
semisupervised Generative Adversarial Network
(GAN) on labeled and unlabeled
echocardiograms to detect left ventricular
hypertrophy, achieving an accuracy of 92.3%.
      </p>
      <p>
        Finally, a CNN model was developed by [
        <xref ref-type="bibr" rid="ref42">42</xref>
        ]
for segmenting the left ventricle of the heart,
predicting ejection fraction, and classifying
heart failure with reduced ejection fraction. The
end systolic volume, end diastolic volume and
ejection fraction were included as features for
training. The model was able to classify heart
failure with reduced ejection fraction with an
area under the curve of 0.97.
      </p>
    </sec>
    <sec id="sec-8">
      <title>3. Development Methodology</title>
      <p>This study is developed using the Agile
methodology. Agile methodology is chosen to
provide more flexibility in revising the analysis,
design, and implementation of the system in the
event that the system does not meet user
requirements. As the system has many modules
which require the integration of web
development, machine learning and database
management, it is more efficient to develop
basic functionalities in earlier iterations and
develop finer-grained functionalities in later
iterations, with regular testing so that bugs can
be fixed early in development. Using the Agile
methodology, feedback can be continuously
collected which is useful for improving the
functionality of the system. For this study, the
system requirements were collected from
healthcare professionals as well as people prone
to heart disease. Ethic approval was granted to
collect data for system requirement gathering as
well as acceptance testing.</p>
      <p>The LiveHeart system was developed using
basic web programming languages with a Flask
application server and a MySQL cloud database.
The system makes calls to a RESTful API to
retrieve habit data and uses Random Forests and
decision trees with selected features to classify the
healthiness level of the data. The system also uses
3D CNNs to classify echocardiograms into
“normal” and “low ejection fraction”. It visualizes
the results of data analysis in an intelligent
dashboard. In addition, the system generates reports
outlining the relationship between the patient’s
lifestyle habits and their heart health and allows the
doctor to annotate and store these reports for future
viewing.</p>
      <p>LiveHeart is able to automate the collection of
lifestyle habit data by collecting data through IoT
devices such as smartphone and smartwatch,
allowing doctors to receive real-time updates of
patient’s habit-change. Moreover, LiveHeart helps
doctors to gain meaningful insights from data
visualizations of analyzed habit data to support
decision-making in digital care pathway. LiveHeart
also speeds up the clinical workflow of diagnosis,
treatment, and prevention through the application of
machine learning.</p>
      <p>3.1.</p>
    </sec>
    <sec id="sec-9">
      <title>System Overall</title>
    </sec>
    <sec id="sec-10">
      <title>Architecture and Module Design</title>
      <p>The proposed solution is a web-based system to
monitor habit-change and echocardiogram of heart
disease patients. The patient can upload lifestyle
habit data to their own personal devices while the
patient is at home and the data can be received by
the system to be viewed by the doctor at the hospital.
The system can also be used at the hospital for
nurses to upload echocardiograms during the
echocardiography test and receive the
echocardiography results.</p>
      <p>The data for diet habits, exercise habits and sleeping
habits of heart disease patients is collected from a
smartwatch and the Samsung Health mobile
application. This data is stored in a cloud database
that can be accessed via a desktop application with
an Internet connection.</p>
      <p>In the web-based system, machine learning is
carried out to classify the healthiness level of the
patient’s diet habit data, exercise habit data and
sleeping habit data separately. The healthiness level
is classified into five categories: very unhealthy,
unhealthy, moderate, healthy, and very healthy.</p>
      <p>The average healthiness level of the patient’s
diet, exercise and sleep are calculated to determine
the patient’s forecasted heart health. An overall
healthiness level that is unhealthy indicates that the
patient has a risk of developing heart failure with
reduced ejection fraction, while an overall
healthiness level that is moderate to healthy
indicates that the patient has normal heart
function.</p>
      <p>A web application is developed (Figure 1) to
enable the doctor to view the results of
habitchange and biomedical data analysis on a digital
dashboard, visualized in the form of graphs and
tables. heart disease.</p>
      <p>The web application also generates a report
that summarizes the patient’s lifestyle habits
and their impact on the patient’s heart health, as
well as a list of preventive measures to improve
the patient’s health. The doctor can annotate
these reports, which are stored so they can be
viewed anytime as a form of electronic health
record. This feature supports doctors in the
decision-making process of prescribing advice
for habit adjustment to minimize the risk of</p>
      <p>The overall architecture diagram of the
proposed system is shown in Figure 1. The
proposed system consists of four main modules
which are user management, Internet of Things
(IoT) device, habit classification, and intelligent
dashboard.</p>
      <p>A two-tier architecture was chosen for this
web-based system because it is simple to
develop and make modifications. As the
backend server is completely developed using
Python, machine learning models can be
directly run on the server without the need of an
API. The two-tier architecture of the system is
shown in Figure 2.</p>
    </sec>
    <sec id="sec-11">
      <title>4. System Implementation and Data</title>
    </sec>
    <sec id="sec-12">
      <title>Analytics Results 4.1.</title>
    </sec>
    <sec id="sec-13">
      <title>Data Collection</title>
      <p>To use this application, the patient must first
have the Samsung Health mobile application
installed on their smartphone. Secondly, the patient
must have a smartwatch that is paired with their
smartphone and the Samsung Health application.
Thirdly, the patient must have the FitnessSyncer
mobile application installed, and must enable
FitnessSyncer to read diet, exercise, and sleep data
from Samsung Health. FitnessSyncer is an
application that aggregates data from multiple
health and fitness applications and has an API that
allows users to access their own data.</p>
      <p>For this study, data was collected from only one
patient for few months to successfully design and
develop the system first. The process of habit data
collection from the user-facing side is as follows:
the patient records exercise and sleep data while
wearing a smartwatch, which is simultaneously
recorded in the Samsung Health mobile application;
for diet data, the patient records a meal on the
Samsung Health mobile application. Then, the
patient opens the FitnessSyncer mobile application
and allows FitnessSyncer to read their habit data
from Samsung Health by selecting their Samsung
Health data source and pressing the “Sync Now”
button. The habit data from Samsung Health gets
uploaded to the FitnessSyncer server and becomes
accessible to the LiveHeart system. The
Habitchange chart on the intelligent dashboard is updated
with the healthiness level of the newly uploaded
habit data. Figure 3 shows the example of Samsung
Smartwatch used for data collection in this study as
well as the sample collected data in Samsung health
application.</p>
      <sec id="sec-13-1">
        <title>The feature importance based on Mean</title>
        <p>Decrease in Impurity (MDI) of the Random
Forests classifier is used for diet classification
using the Scikit-learn library. The MDI is
defined as the total decrease in node impurity
weighted by the probability of reaching that
node, averaging over all trees in the ensemble.</p>
        <p>Based on the feature importance shown in
Figure 4, we can infer that the calories per
serving have a significantly larger effect on the
healthiness level of diet compared to other
features.</p>
        <p>The diet dataset consists of 293 rows of data
where each row contains the nutrient intake of a
meal taken on a particular day. The diet data was
collected using the Samsung Health mobile
application. The exercise dataset consists of 141
rows of data where each row contains
information about an exercise activity
undertaken on a particular day. The exercise
data was collected using a smartwatch and the
Samsung Health mobile application. The sleep
dataset consists of 123 rows of data where each
row contains information about an individual’s
sleep for a particular night. The sleep data was
also collected using a smartwatch and the
Samsung Health mobile application. The data in
all three lifestyle habit datasets was collected
from 1 October 2019 to 31 January 2020.</p>
        <p>In all three lifestyle habit datasets, each row
is labelled with a level of healthiness within the
range of 1-5, where 1 is the least healthy and 5
is the healthiest. The data labeling was verified
by experts. As such, the habit classification
consists of three main objectives as follows:
• To classify the healthiness level of diet
as 1 (very unhealthy), 2 (unhealthy), 3
(moderate), 4 (healthy) or 5 (very healthy)
• To classify the healthiness level of exercise
as 1 (very unhealthy), 2 (unhealthy), 3
(moderate), 4 (healthy) or 5 (very healthy)
• To classify the healthiness level of sleep as
1 (very unhealthy), 2 (unhealthy), 3 (moderate),
4 (healthy) or 5 (very healthy)</p>
        <p>The decision tree and Random Forest models
were used for classification. For diet classification,
the ReliefF algorithm with 50 nearest neighbors was
used to select 11 relevant features for training, and
the data was divided into a training dataset and a
testing dataset using a 70-30 split ratio. For sleep
classification, the ReliefF algorithm with 30 nearest
neighbors was used to select 10 relevant features for
training, and the data was divided into a training
dataset and a testing dataset using 80-20 split ratio.
For exercise classification, all features were
selected for training as feature selection did not
improve the accuracy of the model, and the data was
divided into a training dataset and testing dataset
using 80-20 split ratio. The exercise data was also
pre-processed by removing rows that contained
cells with zero values and converting the type of
workout activity into numerical values. The selected
features for each habit classification are listed in
Table 2.</p>
        <p>The performance metrics of diet classification,
exercise classification and sleep classification are
shown in Table 3, 4, and 5 respectively. For diet
classification, only the metrics for three categories
of healthiness level are reported as the diet data only
consisted of data that was labelled with a healthiness
level of 1-3.</p>
        <p>The best accuracy obtained for the diet,
exercise and sleep classifiers were 89.77%,
90.00% and 68.00% respectively. Based on
these performance metrics, the Random Forest
classifier was chosen for diet classification, the
decision tree classifier for exercise classification
and the decision tree classifier for sleep
classification in the developed system.</p>
        <p>
          This section focuses on the details of
echocardiogram classification as one of the main
features of the system. The echocardiography
87.50 dataset used in this study is the EchoNet-Dynamic
Dataset taken from the Stanford University School
of Medicine [
          <xref ref-type="bibr" rid="ref42">42</xref>
          ].
89.77 A Convolutional Neural Network (CNN) based
on the ResNet (2+1)D architecture was designed to
take in echocardiography videos as input, and
predict the value of ejection fraction. 32 frames
were sampled from each video across a period of 2
before being loaded into the model. The model was
built using the Torchvision library from the
PyTorch machine learning framework and trained
by running a Python script on the command-line for
2 epochs until it reached a validation loss of
167.145, before the model weights were saved. The
performance metrics of ejection fraction prediction
are shown in Table 6.
        </p>
        <p>An if-else statement is used to set the
classification of the echocardiogram based on the
Accuracy value of ejection fraction predicted by the model. If
(%) the ejection fraction predicted by the model is less
than 55, the echocardiogram is classified as “low
ejection fraction”. Otherwise, the echocardiogram is
90.00 classified as “normal”. This classification, along
with the value of ejection fraction is saved to the
database.</p>
        <p>A CNN model based on the DeepLabV3
ResNet50 architecture was built to carry out
semantic segmentation of the left ventricle in the
echocardiogram. Each video is divided into blocks
of frames before being passed through the model.
The model was built using the Torchvision library
from the PyTorch machine learning framework and
trained for 5 epochs until it reached a validation loss
of 0.0401. The performance metrics of
echocardiogram segmentation is approximately
0.912.</p>
        <p>
          Both models were built based on the deep
learning model for beat-to-beat cardiac function
assessment developed by [
          <xref ref-type="bibr" rid="ref43">43</xref>
          ]. For both models,
2099 echocardiography videos were selected for
training, 600 for validation and 300 for testing.
        </p>
        <p>In the Echocardiography section on the
Patient page, the nurse can click on a button in
the top-right corner that redirects them to a page
to upload an echocardiogram in .AVI format.</p>
        <p>Once the file is uploaded, the system runs the
ejection fraction prediction and echocardiogram
segmentation models on the echocardiogram.</p>
        <p>First, the predictEF() function is run and a
ResNet (2+1)D model is constructed. The
ejection fraction prediction model weights,
stored on the local file system as
“ef_model_weights.pt”, are loaded into the
model using the torch.load() method and the
model is run. Next, the drawLeftVentricle()
function is run and a DeepLabV3 ResNet50
model is constructed. The echocardiogram
classification model weights, stored on the local
file system as
“segmentation_model_weights.pt”, are loaded
into the model using the torch.load() method
and the model is run.</p>
        <p>After the models have been run, the nurse is
redirected back to the Echocardiography
section, where they can view a log of previous
echocardiography results, which consists of the
amount of ejection fraction and the
classification of the echocardiogram. Both the
doctor and nurse can click on the play button on
each log to view the echocardiogram uploaded
at that time, with a blue overlay over the left
ventricle. This will help them to verify the
ejection fraction prediction. The user interface
of the Echocardiography section is shown in
Figure 5.</p>
      </sec>
      <sec id="sec-13-2">
        <title>For the habit dashboard, the system uses the</title>
        <p>Flask-SQLAlchemy extension to retrieve habit
data from the cloud database, transforms the data
into the desired format and renders the data in a
dashboard format using the jinja2 template engine.
Some of the user interfaces are randomly selected
and shown in Figure 6-10.</p>
      </sec>
    </sec>
    <sec id="sec-14">
      <title>5. Discussion and Conclusion</title>
      <p>If we define digital care pathway for heart
disease as Figure 11, decision making can be
integrated into the various steps. For instance, to
identify people at risk for heart disease,
decision-making may be used to choose the
right risk assessment tools and screening
procedures. Healthcare professionals and
developers can choose which individual risk
variables to consider, including age, family
history, blood pressure, cholesterol levels, and
lifestyle choices, and can create algorithms to
determine the total cardiovascular risk score.
After receiving personalized risk evaluations,
users may decide what preventative steps to
take. Furthermore, decision making can occur
during the development of personalized
treatment plans for individuals with heart
disease. Based on the patient's medical history,
diagnostic tests, and risk factors, healthcare
providers can make decisions regarding
medication choices, lifestyle modifications, and
intervention strategies. The digital platform can
provide recommendations based on
evidencebased guidelines, assisting healthcare providers
and patients in making informed decisions about
the most appropriate treatment options.</p>
      <p>In addition, decision making can be incorporated
into remote monitoring systems for heart disease.
The frequency and intensity of monitoring vital
signs, such as heart rate, echocardiography,
heartbeat sounds, blood pressure, heart rate, and
oxygen saturation, can be set by healthcare
professionals dependent on the patient's condition.
Healthcare professionals can decide whether there
is a need for additional medical treatments, lifestyle
changes, or drug adjustments based on the data
gathered.</p>
      <p>Decision making can occur during virtual
consultations with cardiologists and other
healthcare professionals. Patients can discuss their
symptoms, test results, and treatment progress, and
healthcare providers can make decisions regarding
medication adjustments, diagnostic tests, or
referrals to other specialists. Patients can actively
participate in these discussions, ask questions, and
provide input on the decision-making process.
Finally, decision making is involved in guiding
individuals with heart disease to make healthy
lifestyle choices. The digital platform can provide
personalized recommendations for diet, exercise,
stress management, and smoking cessation. Users
can make decisions about adopting and adhering to
these lifestyle changes based on their preferences
and goals, with the guidance and support of
healthcare providers.</p>
      <p>LiveHeart combines the analysis of a variety of
lifestyle habit data with input from doctors to
professionally guide patients prone to heart disease
to adopt healthier lifestyle habits. Furthermore, the
proposed system is able to classify lifestyle habit
data, classify echocardiograms, visualize data
analytics on an intelligent report and manage reports
of patients’ overall health.</p>
      <p>This study contributes to SDG3 and SDG9,
which are Good Health and Well-being and
Industry, innovation, and infrastructure
respectively. With accelerated decision-making
processes in digital care pathway for heart disease,
the availability of doctors and nurses can be freed
up to treat a larger number of patients who are
suffering from heart disease. This addresses the
reoccurring problem of health worker shortage.
Furthermore, with the help of IoT, doctors can
continue to monitor patient’s health and provide
timely habit intervention even while the patient is at
home and not physically at the hospital. Meanwhile,
the patient receives the benefit of having convenient
access to healthcare facilities. Timely lifestyle habit
management can help to gradually improve the
cardiovascular health of heart disease patients if the
system were to be implemented on a larger
scale, contributing to the long-term plan to
reduce the burden of non-communicable
diseases.</p>
      <p>The proposed for monitoring lifestyle habits
can help with decision making by providing
valuable data and insights. By continuously
tracking and analyzing lifestyle habits such as
exercise, diet, sleep patterns, and stress levels,
individuals can gain a deeper understanding of
their behaviors and their impact on health and
well-being. This data can then be used to make
informed decisions about lifestyle changes, goal
setting, and preventive measures. For example,
if the system detects a lack of physical activity
or poor dietary choices, it can prompt the
individual to adjust and provide
recommendations for healthier alternatives.
Ultimately, the system empowers individuals to
make more informed decisions about their
lifestyle choices, leading to improved overall
health and well-being.</p>
      <p>The proposed system includes the features
for monitoring echocardiography that can
provide valuable information and aid in decision
making related to cardiovascular health. By
continuously monitoring and analyzing
echocardiographic data, such as heart function,
chamber size, and blood flow patterns,
healthcare professionals can gain insights into
the condition of the heart. This information can
be used to diagnose and monitor various cardiac
conditions, assess treatment effectiveness, and
make informed decisions regarding patient care.
For example, if abnormalities are detected in the
echocardiography results, healthcare providers
can determine the appropriate interventions,
such as medication adjustments or surgical
procedures. The system can also help track
changes over time, enabling healthcare
professionals to assess the progression or
improvement of a cardiac condition and adjust
treatment plans accordingly. Ultimately, the
system enhances decision making by providing
objective data and assisting healthcare
professionals in delivering optimal care for
patients with cardiovascular conditions.</p>
      <p>It is important to note that the integration of
decision making into the digital care pathway
for heart disease should involve collaboration
between healthcare providers, researchers, and
developers. The decisions made should be based
on evidence-based guidelines, clinical expertise,
and patient preferences to ensure optimal patient
outcomes and engagement.</p>
      <p>The future direction would be related to
functionalities to manage other lifestyle habits that
are risk factors for heart disease, such as the
regulation of blood pressure, blood glucose and
intervention for smoking habits. ChatGPT can be
integrated into the system for consultation and
recommendations. However, expert confirmation is
required. Additionally, the IoT device module of the
system could be extended to collect data from other
IoT devices such as blood pressure and blood
glucose monitoring devices. Finally, the system
could benefit from having the functionality to
predict the upcoming change in lifestyle habits in
the future.</p>
    </sec>
    <sec id="sec-15">
      <title>6. Acknowledgements</title>
      <p>The authors would like to appreciate School of
Computer Sciences, Universiti Sains Malaysia to
support the development of this study.
7. References</p>
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