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  <front>
    <journal-meta />
    <article-meta>
      <title-group>
        <article-title>Medico Multimedia Task at MediaEval 2022: Transparent Tracking of Spermatozoa</article-title>
      </title-group>
      <contrib-group>
        <contrib contrib-type="author">
          <string-name>Vajira Thambawita</string-name>
          <email>vajira@simula.no</email>
          <xref ref-type="aff" rid="aff1">1</xref>
        </contrib>
        <contrib contrib-type="author">
          <string-name>Steven Hicks</string-name>
          <email>steven@simula.no</email>
          <xref ref-type="aff" rid="aff0">0</xref>
          <xref ref-type="aff" rid="aff1">1</xref>
        </contrib>
        <contrib contrib-type="author">
          <string-name>Andrea M Storås</string-name>
          <email>andrea@simula.no</email>
          <xref ref-type="aff" rid="aff0">0</xref>
          <xref ref-type="aff" rid="aff1">1</xref>
        </contrib>
        <contrib contrib-type="author">
          <string-name>Jorunn M Andersen</string-name>
          <xref ref-type="aff" rid="aff0">0</xref>
        </contrib>
        <contrib contrib-type="author">
          <string-name>Oliwia Witczak</string-name>
          <email>oliwiaw@oslomet.no</email>
          <xref ref-type="aff" rid="aff0">0</xref>
        </contrib>
        <contrib contrib-type="author">
          <string-name>Trine B Haugen</string-name>
          <xref ref-type="aff" rid="aff0">0</xref>
        </contrib>
        <contrib contrib-type="author">
          <string-name>Hugo Hammer</string-name>
          <email>hugoh@oslomet.no</email>
          <xref ref-type="aff" rid="aff0">0</xref>
          <xref ref-type="aff" rid="aff1">1</xref>
        </contrib>
        <contrib contrib-type="author">
          <string-name>Thu Nguyen</string-name>
          <email>thu@simula.no</email>
          <xref ref-type="aff" rid="aff1">1</xref>
        </contrib>
        <contrib contrib-type="author">
          <string-name>Pål Halvorsen</string-name>
          <xref ref-type="aff" rid="aff0">0</xref>
          <xref ref-type="aff" rid="aff1">1</xref>
        </contrib>
        <contrib contrib-type="author">
          <string-name>Michael A Riegler</string-name>
          <email>michael@simula.no</email>
          <xref ref-type="aff" rid="aff1">1</xref>
          <xref ref-type="aff" rid="aff2">2</xref>
        </contrib>
        <aff id="aff0">
          <label>0</label>
          <institution>OsloMet</institution>
          ,
          <country country="NO">Norway</country>
        </aff>
        <aff id="aff1">
          <label>1</label>
          <institution>SimulaMet</institution>
          ,
          <country country="NO">Norway</country>
        </aff>
        <aff id="aff2">
          <label>2</label>
          <institution>UiT The Arctic University of Norway</institution>
          ,
          <country country="NO">Norway</country>
        </aff>
      </contrib-group>
      <abstract>
        <p>The Medico: Multimedia for Medicine Task is running for the sixth time as part of MediaEval 2022. This year, the task focuses on automatically detecting and tracking spermatozoa in video recordings of human semen. We provide a dataset with 20 video recordings of spermatozoa with manually annotated bounding-box coordinates and a set of sperm characteristics. The task consists of four subtasks.</p>
      </abstract>
    </article-meta>
  </front>
  <body>
    <sec id="sec-1">
      <title>1. Introduction</title>
      <p>The 2022 Medico task tackles the challenge of tracking spermatozoa cells in video recordings
of untreated semen samples. Manual evaluation of sperm motility using a microscope is
timeconsuming and expensive, and requires experts who have extensive training. Furthermore, the
validity of manual sperm analysis becomes unreliable due to limited reproducibility and high
inter-personnel variations due to the complexity of tracking, identifying, and counting sperm
in fresh samples. The existing computer-aided sperm analyzer systems are not working well
enough for application in a real clinical setting due to unreliability caused by the consistency of
the semen sample. Therefore, we need to research new methods for automated sperm analysis.</p>
      <p>The goal is to encourage task participants to track individual spermatozoa in real-time
and combine diferent data sources to predict common measurements used for sperm quality
assessment, specifically the motility of the spermatozoa.</p>
      <p>We hope that this task will encourage the multimedia community to aid in the development
of computer-assisted reproductive health and discover new and clever ways of analyzing
multimodal datasets. In addition to good analysis performance, an important aspect is also
the eficiency of the algorithms due to the fact that the assessment of the sperm is performed
in real-time and therefore requires real-time feedback. Furthermore, adding explainability to
predictions of machine learning algorithms can improve the trust between medical experts and
machine learning solutions.</p>
      <p>For the task, we will provide a dataset that contains in total 20 30-second videos, a set of sperm
characteristics (hormones, fatty acids data, etc.), frame-by-frame bounding box annotations,
some anonymized study participants-related data, and motility and morphology data following
the WHO recommendations.</p>
      <p>Based on this data, the participants will be asked to solve the following four subtasks, where
subtasks 3 and 4 are optional:
• Subtask 1: The goal of this subtask is real-time tracking of sperm cells in a given semen
video. Tracking should be performed by predicting bounding box coordinates with the
similar format to the bounding box coordinates provided with the development datasets.
In this task, models should track sperm in each frame of a provided video in real-time.</p>
      <p>Therefore, frames per second is an important factor to measure.
• Subtask 2: The goal of this task is to predict sperm motility1 in terms of the percentage
of progressive and non-progressive spermatozoa. The prediction needs to be performed
patient wise, resulting in one value per patient per predicted attribute. Sperm tracking or
bounding boxes predicted in task 1 are required in order to solve this task.
• Subtask 3: This task focuses on identifying the fastest sperm cells with corresponding
average speed and highest top speed. One specific challenge with this subtask is that the
video also changes the view of the sample. This happens because the sample is moved
below the microscope to observe the complete sample area. Therefore, the tracking has
to be performed per viewpoint on the sample.
• Subtask 4: This subtask builds on task 1, 2 and 3. The goal is to provide an explanation
of the model predictions to convince domain experts about the correctness of the results.
There are not any specific requirements for this task, and participants can choose for
which subtask they want to provide the explanations. A report should be provided that
can be given to medical domain experts.</p>
      <p>For subtasks 2 and 3, the participants are encouraged to consider the temporal aspect of the
videos. This is important due to the fact that single-frame-based analysis will not be able to
catch the movement of the sperm (motility), which contains important information to perform
proper predictions on subtasks 2 and 3.</p>
    </sec>
    <sec id="sec-2">
      <title>2. Dataset Details</title>
      <p>
        The 2022 Medico task uses the data set VISEM [
        <xref ref-type="bibr" rid="ref1">1</xref>
        ], which contains data from 85 male patients
aged 18 years or older. For this task, we provide annotations for 30 seconds video clips from
selected 20 videos and we call this new dataset as VISEM-Tracking [
        <xref ref-type="bibr" rid="ref2">2</xref>
        ].
      </p>
      <p>
        For each patient, we include a video of live sperm (video and extracted frames), manually
annotated bounding box details for each spermatozoon, a set of measurements from a standard
semen analysis for the whole sample, a sperm fatty acid profile, the fatty acid composition of
serum phospholipids, study participants-related data, and WHO analysis data. The bounding
box coordinates are provided in two separate folders, one has bounding box coordinates in
YOLO format [
        <xref ref-type="bibr" rid="ref3">3</xref>
        ] and the other folder contains feature identifiers in addition to the bounding
box coordinates. These feature identifiers can be used to identify the same bounding box in
diferent frames in a video. Each video has a resolution of 640x480 and runs at 50 frames per
second. The dataset contains five CSV lfies and folders containing the videos and bounding box
data. The name of each video file contains the video’s ID, the date it was recorded, and a small
optional description. Then, the end of the filename contains the ID of the person who assessed
the video. Furthermore, VISEM contains five CSV files for each of the other data provided, a
CSV file with the IDs linked to each video, and a text file containing * descriptions of some of
1Motility is the ability to move independently, where a progressive spermatozoon is able to "move forward" and a
non-progressive would move for example in circles without any forward progression.
the columns of the CSV files. One row in each CSV file represents a participant. The provided
CSV files are:
• semen_analysis_data: The results of standard semen analysis.
• fatty_acids_spermatozoa: The levels of several fatty acids in the sperm of the participants.
• fatty_acids_serum: The serum levels of the fatty acids of the phospholipids (measured
from the blood of the participant).
• sex_hormones: The serum levels of sex hormones measured in the blood of the
participants.
• study_participant_related_data: General information about the participants such as age,
abstinence time, and Body Mass Index (BMI).
      </p>
      <p>All study participants agreed to donate their data for the purpose of science and provided
the necessary consent for us to be able to distribute the data (checked and approved by the
Norwegian data authority and ethical committee).</p>
    </sec>
    <sec id="sec-3">
      <title>3. Evaluation</title>
      <p>For the first sub-task, sperm cell tracking, the mAP (mean average precision) will be calculated
as follows:

 = 1 ∑︁ 

=1
(1)
with two diferent threshold values of 0.5 and 0.5 : 0.95. For the second range of threshold
values, the average of incremental threshold values between 0.5 and 0.95 by 0.05 will be
calculated. Finally, a fitness value will be calculated as follows:
 _ = 0.1 × 0.5 + 0.9 × 0.5:0.95.
(2)</p>
      <p>In addition to the mAP and fitness values, we will calculate frames per second (FPS) for the
ifrst task to evaluate the speed of predictions. For the evaluation of the second task, we calculate
the mean squared error and mean absolute error. Additionally, the time required to predict the
output of the subtask 2 is also calculated.</p>
      <p>The optional third and fourth tasks will be evaluated using manual evaluation with the help
of three diferent experts within human reproduction. A fixed hardware setup will be used for
all evaluations to measure the speed of predictions.</p>
    </sec>
    <sec id="sec-4">
      <title>4. Discussion and Outlook</title>
      <p>Previous studies of applying deep learning solutions [4, 5, 6] in sperm analysis show the potential
of applying deep learning techniques to predict morphology and motility levels of given sperm
videos. However, the high values of mean average errors of the studies imply that pure video
input to deep learning models makes predictions less accurate. In this regard, we provide
additional manually annotated bounding boxes for three classes, namely sperm, sperm clusters
and small or pinhead sperms. We believe that these additional localization details will help to
improve the deep-learning-based sperm analysis, which again will help future assisted human
reproduction.
[4] S. A. Hicks, J. M. Andersen, O. Witczak, V. Thambawita, P. Halvorsen, H. L. Hammer, T. B. Haugen,
M. A. Riegler, Machine learning-based analysis of sperm videos and participant data for male fertility
prediction, Scientific reports 9 (2019) 1–10.
[5] V. Thambawita, P. Halvorsen, H. Hammer, M. Riegler, T. B. Haugen, Extracting temporal features
into a spatial domain using autoencoders for sperm video analysis, arXiv preprint arXiv:1911.03100
(2019).
[6] V. Thambawita, P. Halvorsen, H. Hammer, M. Riegler, T. B. Haugen, Stacked dense optical flows and
dropout layers to predict sperm motility and morphology, arXiv preprint arXiv:1911.03086 (2019).</p>
    </sec>
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